23443-10-9 | 4H-Pyrido[1,2-a]pyrimidin-4-one

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$58.00	$40.00
250mg	98%	in stock	$72.00	$50.00
1g	98%	in stock	$172.00	$120.00
5g	98%	in stock	$572.00	$400.00
10g	98%	in stock	$945.00	$661.00
25g	98%	in stock	$1,878.00	$1,315.00

Description

• Catalog Number: AB23262
• Chemical Name: 4H-Pyrido[1,2-a]pyrimidin-4-one
• CAS Number: 23443-10-9
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.146
• MDL Number: MFCD07434961
• SMILES: O=c1ccnc2n1cccc2
• NSC Number: 607398

Computed Properties

• Complexity: 310
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 0.2

Literature

• Fused bicycles as arylketone bioisosteres leading to potent, orally active thiadiazole H3 antagonists.

  Bioorganic & medicinal chemistry letters 20120501

• Suzuki-Miyaura cross-coupling reactions of halo derivatives of 4H-pyrido[1,2-a]pyrimidin-4-ones.

  Organic & biomolecular chemistry 20111007

• Synthesis and antiproliferative activity of novel diaryl ureas possessing a 4H-pyrido[1,2-a]pyrimidin-4-one group.

  Archiv der Pharmazie 20100101

• Anti-ischaemic activity of an antioxidant aldose reductase inhibitor on diabetic and non-diabetic rat hearts.

  The Journal of pharmacy and pharmacology 20100101

• MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate.

  Bioorganic & medicinal chemistry 20071115

• Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity.

  Journal of medicinal chemistry 20071004

• MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: exploration of aromatic substituents.

  Bioorganic & medicinal chemistry 20061215

• MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position.

  Bioorganic & medicinal chemistry 20060315

• Isocyanate acting as a carbonyl precursor: pyridyl group-assisted formation of 4H-pyrido[1,2-a]pyrimidin-4-ones from ketimines and isocyanates.

  Organic & biomolecular chemistry 20060121

• Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.

  Journal of medicinal chemistry 19960607