23948-77-8 | (3-Phenylphenyl)acetic acid

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$55.00	$39.00
250mg	95%	in stock	$108.00	$75.00
1g	95%	in stock	$198.00	$138.00
5g	95%	in stock	$758.00	$531.00

Description

• Catalog Number: AD23481
• Chemical Name: (3-Phenylphenyl)acetic acid
• CAS Number: 23948-77-8
• Molecular Formula: C14H12O2
• Molecular Weight: 212.2439
• MDL Number: MFCD01740400
• SMILES: OC(=O)Cc1cccc(c1)c1ccccc1

Computed Properties

• Complexity: 231
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 3.2

Literature

• A novel protocol for the oral administration of test chemicals to adult zebrafish.

  Zebrafish 20111201

• Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis.

  Bioorganic & medicinal chemistry letters 20111101

• Some pharmaceutical and inclusion properties of 2-hydroxybutyl-β-cyclodextrin derivative.

  International journal of pharmaceutics 20111031

• Effect of enoxacin, felbinac, and sparfloxacin on fatty acid metabolism and glucose concentrations in rat tissues.

  International journal of toxicology 20110501

• Fluorous derivatization and fluorous-phase separation for fluorometric determination of naproxen and felbinac in human plasma.

  Journal of pharmaceutical and biomedical analysis 20110428

• Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20110401

• Expression and modulation of connexin 30.2, a novel gap junction protein in the mouse retina.

  Visual neuroscience 20100701

• Design, synthesis and evaluation of mutual prodrug of 4-biphenylacetic acid and quercetin tetramethyl ether (BPA-QTME) as gastrosparing NSAID.

  European journal of medicinal chemistry 20100601

• The suitability of tris(hydroxylmethyl) aminomethane (THAM) as a buffering system for hydroxypropyl methylcellulose (HPMC) hydrophilic matrices containing a weak acid drug.

  International journal of pharmaceutics 20100315

• Towards the design of cyclooxygenase (COX) inhibitors based on 4',5 di-substituted biphenyl acetic acid molecules: a QSAR study with a new DFT based descriptor - nucleus independent chemical shift.

  Journal of molecular modeling 20091001

• Validated LC-MS/MS assay for the determination of felbinac: Application to a preclinical pharmacokinetics study of felbinac trometamol injection in rat.

  Journal of pharmaceutical and biomedical analysis 20090815

• Mechanisms of drug release in citrate buffered HPMC matrices.

  International journal of pharmaceutics 20090331

• Quantitative comparison of the convulsive activity of combinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents.

  Drug metabolism and pharmacokinetics 20090101

• Percutaneous penetration of felbinac after application of transdermal patches: relationship with pharmacological effects in rats.

  The Journal of pharmacy and pharmacology 20080101

• Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.

  BMC musculoskeletal disorders 20080101

• Synthesis and pharmacological evaluation of some dual-acting amino-alcohol ester derivatives of flurbiprofen and 2-[1,1'-biphenyl-4-yl]acetic acid: a potential approach to reduce local gastrointestinal toxicity.

  Chemistry & biodiversity 20061101

• Changes in brain interleukin-1beta following the coadministration of norfloxacin with biphenylacetic acid in rats.

  European journal of pharmacology 20060814

• Synthesis, characterization and in vitro evaluation of dimethyl-beta-cyclodextrin-4-biphenylylacetic acid conjugate.

  Journal of drug targeting 20030501

• Characterization of the interaction between a novel convulsant agent, norbiphen, and GABA(A) and other ligand-gated ion channels.

  Neuropharmacology 20020901

• A pharmacokinetic/pharmacodynamic approach to show that not all fluoroquinolones exhibit similar sensitivity toward the proconvulsant effect of biphenyl acetic acid in rats.

  The Journal of antimicrobial chemotherapy 20011201

• Intercalation and controlled release of pharmaceutically active compounds from a layered double hydroxide.

  Chemical communications (Cambridge, England) 20011121

• Biphenylacetic acid enhances the antagonistic action of fluoroquinolones on the GABA(A)-mediated responses of the isolated guinea-pig ileum.

  Pharmacological research 20010901

• Role of nitric oxide in the convulsive seizures induced by fluoroquinolones coadministered with 4-biphenyl acetic acid.

  General pharmacology 19971101

• Effect of bile duct ligation and unilateral nephrectomy on brain concentration and convulsant potential of the quinolone antibacterial agent levofloxacin in rats.

  Fundamental and applied toxicology : official journal of the Society of Toxicology 19960201

• Quantitation of GABAA receptor inhibition required for quinolone-induced convulsions in mice.

  The Journal of antimicrobial chemotherapy 19941101

• Biphenylacetate, but not theophylline, lethally interacts with ciprofloxacin in mice.

  Pharmacology & toxicology 19931101