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Exposure to valproic acid inhibits chondrogenesis and osteogenesis in mid-organogenesis mouse limbs.
Toxicological sciences : an official journal of the Society of Toxicology 20130101
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Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.
Disease models & mechanisms 20120301
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A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.
Epilepsia 20120101
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Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression.
PloS one 20120101
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Histone deacetylases are required for amphibian tail and limb regeneration but not development.
Mechanisms of development 20120101
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Valproic acid induces apoptosis in differentiating hippocampal neurons by the release of tumor necrosis factor-α from activated astrocytes.
Neuroscience letters 20110622
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[Observation on therapeutic effect of acupoint catgut-embedding combined western medicine for epilepsy of generalized seizures type].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20110601
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Molecular pharmacology in a simple model system: implicating MAP kinase and phosphoinositide signalling in bipolar disorder.
Seminars in cell & developmental biology 20110201
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Histone deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34 cells.
PloS one 20110101
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Characterization of Human Huntington's Disease Cell Model from Induced Pluripotent Stem Cells.
PLoS currents 20101028
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Metabolic activation capacity by primary hepatocytes expands the applicability of the embryonic stem cell test as alternative to experimental animal testing.
Reproductive toxicology (Elmsford, N.Y.) 20100801
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Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein.
The Journal of biological chemistry 20100402
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[Pharmacokinetics of biological tags in a case of acute valpromide self poisoning].
Annales de biologie clinique 20100101
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[Therapeutic drug monitoring of valproate].
Therapie 20100101
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Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia.
Molecular pain 20100101
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Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues.
Journal of medicinal chemistry 20091126
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Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation.
Journal of neurochemistry 20091101
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[Neonatal Volkmann's syndrome].
Annales de dermatologie et de venereologie 20091101
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Directed evolution of an enantioselective epoxide hydrolase: uncovering the source of enantioselectivity at each evolutionary stage.
Journal of the American Chemical Society 20090603
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Alpha-fluoro-2,2,3,3-tetramethylcyclopropanecarboxamide, a novel potent anticonvulsant derivative of a cyclic analogue of valproic acid.
Journal of medicinal chemistry 20090423
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Agomelatine: The evidence for its place in the treatment of depression.
Core evidence 20090101
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Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Journal of medicinal chemistry 20081113
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Application of a metabolizing system as an adjunct to the rat whole embryo culture.
Toxicology in vitro : an international journal published in association with BIBRA 20080801
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[Effects of acupuncture under guidance of qi street theory on endocrine function in the patient of epilepsy].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20080701
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Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells.
Neurochemical research 20080601
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Valproic acid extends Caenorhabditis elegans lifespan.
Aging cell 20080601
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Acute and long-term treatment of mania.
Dialogues in clinical neuroscience 20080601
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Evaluation of the enantioselective antiallodynic and pharmacokinetic profile of propylisopropylacetamide, a chiral isomer of valproic acid amide.
Neuropharmacology 20080301
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The effectiveness of anticonvulsants in psychiatric disorders.
Dialogues in clinical neuroscience 20080301
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Effect of valproic acid on radiation-induced DNA damage in euchromatic and heterochromatic compartments.
Cell cycle (Georgetown, Tex.) 20080215
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Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells.
British journal of pharmacology 20080201
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Modifications of antiepileptic drugs for improved tolerability and efficacy.
Perspectives in medicinal chemistry 20080101
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Lipid peroxidation in women with epilepsy.
Annals of Indian Academy of Neurology 20080101
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Potent anticonvulsant urea derivatives of constitutional isomers of valproic acid.
Journal of medicinal chemistry 20071213
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Agomelatine adjunctive therapy for acute bipolar depression: preliminary open data.
Bipolar disorders 20070901
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The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior.
Molecular pharmacology 20070301
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The antiepileptic and anticancer agent, valproic acid, induces P-glycoprotein in human tumour cell lines and in rat liver.
British journal of pharmacology 20061001
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S-2-pentyl-4-pentynoic hydroxamic acid and its metabolite s-2-pentyl-4-pentynoic acid in the NMRI-exencephaly-mouse model: pharmacokinetic profiles, teratogenic effects, and histone deacetylase inhibition abilities of further valproic acid hydroxamates and amides.
Drug metabolism and disposition: the biological fate of chemicals 20060401
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Management of epilepsy in adults. Diagnosis guidelines.
Postgraduate medicine 20051201
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Catalytic mechanism of limonene epoxide hydrolase, a theoretical study.
Journal of the American Chemical Society 20051019
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Induction of osteogenic differentiation of human mesenchymal stem cells by histone deacetylase inhibitors.
Journal of cellular biochemistry 20051015
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Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain.
British journal of pharmacology 20050901
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Histone deacetylases inhibition and tumor cells cytotoxicity by CNS-active VPA constitutional isomers and derivatives.
Biochemical pharmacology 20050515
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The role of histone acetylation in SMN gene expression.
Human molecular genetics 20050501
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Identification of early-responsive genes correlated to valproic acid-induced neural tube defects in mice.
Birth defects research. Part A, Clinical and molecular teratology 20050401
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[Management of bipolar disorders].
La Revue du praticien 20050315
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Mood stabilizer augmentation in apparently 'unipolar' MDD: predictors of response in the naturalistic French national EPIDEP study.
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[Valpromide poisoning associated with circulatory collapse].
Therapie 20050101
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Valproate decreases inositol biosynthesis.
Biological psychiatry 20041201
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Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds.
Bioorganic & medicinal chemistry letters 20041115
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Polycomb homologs are involved in teratogenicity of valproic acid in mice.
Birth defects research. Part A, Clinical and molecular teratology 20041101
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[Deep lactic acidosis after valproate self-poisoning].
Annales francaises d'anesthesie et de reanimation 20041001
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Characterization of the anticonvulsant profile of valpromide derivatives.
Bioorganic & medicinal chemistry 20040715
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Inhibition of histone deacetylase activity by valproic acid blocks adipogenesis.
The Journal of biological chemistry 20040430
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Delayed toxicity following acute ingestion of valpromide.
Human & experimental toxicology 20040301
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Valproate potentiates androgen biosynthesis in human ovarian theca cells.
Endocrinology 20040201
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Amidic modification of valproic acid reduces skeletal teratogenicity in mice.
Birth defects research. Part B, Developmental and reproductive toxicology 20040201
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[Valpromide, Valproic acid and removal of small intestine in the treatment of a chronic depression: a case report].
L'Encephale 20040101
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Mood-stabilizers: the archeology of the concept.
Bipolar disorders 20031201
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Pharmacokinetic-pharmacodynamic relationships of (2S,3S)-valnoctamide and its stereoisomer (2R,3S)-valnoctamide in rodent models of epilepsy.
Pharmaceutical research 20030801
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Valproate induces replication-independent active DNA demethylation.
The Journal of biological chemistry 20030725
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Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site.
The EMBO journal 20030602
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New CNS-active drugs which are second-generation valproic acid: can they lead to the development of a magic bullet?
Current opinion in neurology 20030401
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Lupus-like syndrome and vasculitis induced by valpromide.
The Journal of rheumatology 20030101
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[The Charles Bonnet syndrome: a case report and a brief review].
Actas espanolas de psiquiatria 20030101
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[Severe oedema after valproate and valpromide].
Therapie 20020101
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Stereoselective pharmacokinetic analysis and antiepileptic activity of N-2-hydroxypropyl valpromide, a central nervous system--active chiral valproylamide.
Therapeutic drug monitoring 20010801
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Clonic seizure associated with high clozapine plasma level.
The Journal of neuropsychiatry and clinical neurosciences 20010101
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Valpromide increases amplitude of heart rate circadian rhythm in remitted bipolar and unipolar disorders. A placebo-controlled study.
European psychiatry : the journal of the Association of European Psychiatrists 20001101
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In vivo study of the effect of valpromide and valnoctamide in the pilocarpine rat model of focal epilepsy.
Pharmaceutical research 20001101
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[Cerebral edema with hyperammonemia in valpromide poisoning. Manifestation in an adult, of a partial deficit in type I carbamylphosphate synthetase].
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