2438-57-5 | (2S,4S)-4-Fluoropyrrolidine-2-carboxylic acid

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$12.00	$9.00
1g	97%	in stock	$98.00	$69.00
5g	97%	in stock	$258.00	$181.00
10g	97%	in stock	$515.00	$360.00

Description

• Catalog Number: AB42809
• Chemical Name: (2S,4S)-4-Fluoropyrrolidine-2-carboxylic acid
• CAS Number: 2438-57-5
• Molecular Formula: C5H8FNO2
• Molecular Weight: 133.1209
• MDL Number: MFCD02683983
• SMILES: OC(=O)[C@@H]1C[C@@H](CN1)F

Computed Properties

• Complexity: 128
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: -2.3

Literature

• Rational design of protein stability: effect of (2S,4R)-4-fluoroproline on the stability and folding pathway of ubiquitin.

  PloS one 20110101

• Thermodynamic consequences of incorporating 4-substituted proline derivatives into a small helical protein.

  Biochemistry 20100518

• Stereoelectronic effects on the transition barrier of polyproline conformational interconversion.

  Protein science : a publication of the Protein Society 20090901

• Direct and continuous assay for prolyl 4-hydroxylase.

  Analytical biochemistry 20090315

• Conformational preferences of substrates for human prolyl 4-hydroxylase.

  Biochemistry 20080909

• Stereoelectronic effects on polyproline conformation.

  Protein science : a publication of the Protein Society 20060101

• A stereoelectronic effect on turn formation due to proline substitution in elastin-mimetic polypeptides.

  Journal of the American Chemical Society 20051228

• Stereoelectronic and steric effects in the collagen triple helix: toward a code for strand association.

  Journal of the American Chemical Society 20051116

• Substituted 2-azabicyclo[2.1.1]hexanes as constrained proline analogues: implications for collagen stability.

  The Journal of organic chemistry 20041210

• Stereoelectronic effects on collagen stability: the dichotomy of 4-fluoroproline diastereomers.

  Journal of the American Chemical Society 20030806