2454397-74-9 | Ethyl 4-amino-6-chloro-5-fluoronicotinate

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$9.00	$7.00
1g	98%	in stock	$25.00	$18.00
5g	98%	in stock	$93.00	$66.00
10g	98%	in stock	$176.00	$124.00
25g	98%	in stock	$437.00	$306.00

Description

• Catalog Number: BG18306
• Chemical Name: Ethyl 4-amino-6-chloro-5-fluoronicotinate
• CAS Number: 2454397-74-9
• Molecular Formula: C8H8ClFN2O2
• Molecular Weight: 218.6127
• MDL Number: MFCD34471315
• SMILES: CCOC(=O)c1cnc(c(c1N)F)Cl

Upstream Synthesis Route

The upstream synthesis route of Ethyl 4-amino-6-chloro-5-fluoronicotinate can be outlined in the following steps:

1. Start with ethyl 5-bromo-4-chloronicotinate as the initial compound.
2. Undergo a halogen exchange reaction using potassium fluoride (KF) to replace the bromine with a fluorine atom, yielding ethyl 4-chloro-5-fluoronicotinate.
3. Subject the product to a nucleophilic aromatic substitution with ammonia, which results in the displacement of the chlorine atom by an amino group, to yield the final product, ethyl 4-amino-6-chloro-5-fluoronicotinate.

Throughout the steps, one must carefully control reaction conditions such as temperature, pH, and solvent choice to optimize yields and purity. Each reaction step may require purification processes like recrystallization, column chromatography, or distillation to isolate the desired compound. It is important to note that this is a general synthetic route and actual industrial synthesis may involve specific catalysts, different starting materials, or additional steps to optimize the process.