245762-27-0 | 3-(5-Fluoro-1H-indol-3-yl)propan-1-amine

Packsize	Purity	Availability	Price	Discounted Price
50mg	85%	1 week	$300.00	$210.00
100mg	85%	1 week	$423.00	$297.00
250mg	85%	1 week	$581.00	$407.00
500mg	85%	1 week	$888.00	$622.00
1g	85%	1 week	$1,124.00	$787.00

Description

• Catalog Number: AB25035
• Chemical Name: 3-(5-Fluoro-1H-indol-3-yl)propan-1-amine
• CAS Number: 245762-27-0
• Molecular Formula: C11H13FN2
• Molecular Weight: 192.2327
• MDL Number: MFCD04966926
• SMILES: NCCCc1c[nH]c2c1cc(F)cc2

Computed Properties

• Complexity: 186
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 1

Upstream Synthesis Route

5-Fluoro-1H-indole-3-propanamine is a versatile compound that finds widespread application in chemical synthesis. It serves as a valuable building block in the creation of various pharmaceuticals, agrochemicals, and functional materials due to its unique structural properties and reactivity. In chemical synthesis, 5-Fluoro-1H-indole-3-propanamine can be utilized as a key intermediate in the preparation of diverse molecules, including but not limited to selective serotonin reuptake inhibitors, anticancer agents, and chiral ligands for asymmetric catalysis. Its presence enables the introduction of the fluorine moiety and the indole ring into target molecules, thereby imparting specific physicochemical and biological properties. Moreover, the propanamine functional group offers opportunities for further derivatization and modifications, allowing for the fine-tuning of the desired molecular characteristics. By strategically incorporating 5-Fluoro-1H-indole-3-propanamine into synthetic routes, chemists can access a wide array of structurally diverse compounds with potential applications in various fields of chemistry and beyond.

Literature

• Structure-based design, synthesis, and pharmacological evaluation of 3-(aminoalkyl)-5-fluoroindoles as myeloperoxidase inhibitors.

  Journal of medicinal chemistry 20101223