2465-59-0 | 1H-Pyrazolo[3,4-d]pyrimidine-4,6-diol

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$42.00	$30.00
500mg	98%	in stock	$55.00	$38.00
1g	98%	in stock	$73.00	$51.00
2500mg	98%	in stock	$146.00	$102.00
5g	98%	in stock	$245.00	$171.00
25g	98%	in stock	$1,131.00	$792.00

Description

• Catalog Number: AB25442
• Chemical Name: 1H-Pyrazolo[3,4-d]pyrimidine-4,6-diol
• CAS Number: 2465-59-0
• Molecular Formula: C5H4N4O2
• Molecular Weight: 152.11085999999997
• MDL Number: MFCD00056934
• SMILES: O=c1[nH]c(=O)c2c([nH]1)[nH]nc2
• NSC Number: 76239

Computed Properties

• Complexity: 217
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 3
• XLogP3: -0.9

Literature

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  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 20050701

• Simultaneous determination of 16 purine derivatives in urinary calculi by gradient reversed-phase high-performance liquid chromatography with UV detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050525

• Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase.

  Life sciences 20050304

• A defect of neuronal nitric oxide synthase increases xanthine oxidase-derived superoxide anion and attenuates the control of myocardial oxygen consumption by nitric oxide derived from endothelial nitric oxide synthase.

  Circulation research 20050218

• Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic beta-cell line, MIN6-a role of NAD(P)H oxidase in beta-cells.

  Biochemical and biophysical research communications 20050107

• Pharmacology of drugs for hyperuricemia. Mechanisms, kinetics and interactions.

  Contributions to nephrology 20050101

• Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate.

  Cardiovascular diabetology 20050101

• Cloning and functional characterization of two bacterial members of the NAT/NCS2 family in Escherichia coli.

  Molecular membrane biology 20050101

• Comparative substrate recognition by bacterial and fungal purine transporters of the NAT/NCS2 family.

  Molecular membrane biology 20050101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20050101

• Rationale, design and organisation of an efficacy and safety study of oxypurinol added to standard therapy in patients with NYHA class III - IV congestive heart failure.

  Expert opinion on investigational drugs 20041101

• Are allopurinol and metabolites found in HPRT deficient erythrocytes responsible for increased NAD synthesis?

  Nucleosides, nucleotides & nucleic acids 20041001

• Potential role of mycophenolate mofetil in the management of neuroblastoma patients.

  Nucleosides, nucleotides & nucleic acids 20041001

• Binding of xanthine oxidase to glycosaminoglycans limits inhibition by oxypurinol.

  The Journal of biological chemistry 20040903

• The use of pigment 'fingerprints' in the study of harmful algal blooms.

  Revista de biologia tropical 20040901

• Effect of simultaneous inhibition of TNF-alpha production and xanthine oxidase in experimental acute pancreatitis: the role of mitogen activated protein kinases.

  Annals of surgery 20040701

• Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation.

  Arteriosclerosis, thrombosis, and vascular biology 20040601

• Race-specific differences in endothelial function: predisposition of African Americans to vascular diseases.

  Circulation 20040601

• Rationale for a new generation of indicators for coastal waters.

  Environmental health perspectives 20040601

• Insulin generates free radicals by an NAD(P)H, phosphatidylinositol 3'-kinase-dependent mechanism in human skin fibroblasts ex vivo.

  Diabetes 20040501

• Liquid chromatographic method for the determination of uridine in human serum.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040425

• Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications.

  The Journal of physiology 20040316

• Oxidized low-density lipoprotein autoantibodies in patients with primary gout: effect of urate-lowering therapy.

  Clinica chimica acta; international journal of clinical chemistry 20040101

• Oxipurinol: alloxanthine, Oxyprim, oxypurinol.

  Drugs in R&D 20040101

• Management of acute and chronic gouty arthritis: present state-of-the-art.

  Drugs 20040101

• Nitric oxide -- superoxide cooperation in the regulation of renal Na(+),K(+)-ATPase.

  Acta biochimica Polonica 20040101

• Development of a capillary electrophoresis method for the determination of allopurinol and its active metabolite oxypurinol.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031225

• Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress.

  American journal of physiology. Heart and circulatory physiology 20031201

• The role of free radicals in the muscle vasodilatation of systemic hypoxia in the rat.

  Experimental physiology 20031101

• A renaissance of positive inotropic interventions to treat heart failure?

  Cardiovascular research 20030901

• Disproportionate enhancement of myocardial contractility by the xanthine oxidase inhibitor oxypurinol in failing rat myocardium.

  Cardiovascular research 20030901

• NADPH oxidase and enhanced superoxide generation in intrauterine undernourished rats: involvement of the renin-angiotensin system.

  Cardiovascular research 20030901

• Confirmation of superoxide generation via xanthine oxidase in streptozotocin-induced diabetic mice.

  Free radical research 20030701

• Determination of allopurinol by micelle-stabilised room-temperature phosphorescence in real samples.

  Journal of pharmaceutical and biomedical analysis 20030601

• Facile and rapid high-performance liquid chromatography method for simultaneous determination of allopurinol and oxypurinol in human serum.

  Journal of clinical pharmacy and therapeutics 20030601

• Differential regulation of xanthine and NAD(P)H oxidase by hypoxia in human umbilical vein endothelial cells. Role of nitric oxide and adenosine.

  Cardiovascular research 20030601

• Effect of allopurinol pretreatment on free radical generation after primary coronary angioplasty for acute myocardial infarction.

  Journal of cardiovascular pharmacology 20030501

• Xanthine oxidase-catalyzed metabolism of 2-nitrofluorene, a carcinogenic air pollutant, in rat skin.

  Drug metabolism and disposition: the biological fate of chemicals 20030401

• Ischaemia-reperfusion injury in photodynamic therapy-treated mouse tumours.

  British journal of cancer 20030310

• Oxypurinol administration fails to prevent hypoxic-ischemic brain injury in neonatal rats.

  Brain research bulletin 20030215

• Deferoxamine, allopurinol and oxypurinol are not neuroprotective after oxygen/glucose deprivation in an organotypic hippocampal model, lacking functional endothelial cells.

  Brain research 20030214

• Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues.

  Biochemistry 20030204

• Late preconditioning by ethanol is initiated via an oxidant-dependent signaling pathway.

  Free radical biology & medicine 20030201

• Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells.

  American journal of physiology. Lung cellular and molecular physiology 20030101

• Further studies on the use of allopurinol to reduce plasma uric acid concentrations in the Red-tailed Hawk (Buteo jamaicensis) hyperuricaemic model.

  Avian pathology : journal of the W.V.P.A 20021201

• The impairment of endothelium-dependent arterial relaxation by 7-ketocholesterol is associated with an early activation of protein kinase C.

  British journal of pharmacology 20021101

• Effect of the angiotensin II receptor antagonist losartan on uric acid and oxypurine metabolism in healthy subjects.

  Internal medicine (Tokyo, Japan) 20021001

• Xanthine oxidase, but not neutrophils, contributes to activation of cardiac sympathetic afferents during myocardial ischaemia in cats.

  The Journal of physiology 20020815

• Effects of angiotensin II infusion on renal excretion of purine bases and oxypurinol.

  Metabolism: clinical and experimental 20020701

• Ischemia-reperfusion injury of retinal endothelium by cyclooxygenase- and xanthine oxidase-derived superoxide.

  Experimental eye research 20020401

• Effect of a high-salt diet on oxidant enzyme activity in skeletal muscle microcirculation.

  American journal of physiology. Heart and circulatory physiology 20020201

• In vivo evidence for antioxidant potential of estrogen in microvessels of female spontaneously hypertensive rats.

  Hypertension (Dallas, Tex. : 1979) 20020201

• Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes.

  Free radical biology & medicine 20020101

• Xanthine oxidase-derived reactive oxygen species convert flow-induced arteriolar dilation to constriction in hyperhomocysteinemia: possible role of peroxynitrite.

  Arteriosclerosis, thrombosis, and vascular biology 20020101

• Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus.

  Structure (London, England : 1993) 20020101

• [A case of allopurinol-induced muscular damage in a chronic renal failure patient].

  Nihon Jinzo Gakkai shi 20020101

• The oxpA5 mutation of Aspergillus nidulans is an allele of adB, the gene encoding adenylosuccinate synthetase.

  Molecular genetics and genomics : MGG 20011201

• [Hypersensitivity syndrome during therapy with allopurinol in asymptomatic hyperuricemia with a fatal outcome].

  Deutsche medizinische Wochenschrift (1946) 20011123

• Relation between adverse events associated with allopurinol and renal function in patients with gout.

  Annals of the rheumatic diseases 20011001

• Effect of norepinephrine on the urinary excretion of purine bases and oxypurinol.

  Metabolism: clinical and experimental 20011001

• Effect of fenofibrate on plasma concentration and urinary excretion of purine bases and oxypurinol.

  The Journal of rheumatology 20011001

• Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues.

  The Journal of biological chemistry 20010706

• Cardioprotective effect of propranolol from alcohol-induced heart muscle damage as assessed by plasma cardiac troponin-t.

  Alcoholism, clinical and experimental research 20010601

• Oxidative stress and lipid retention in vascular grafts: comparison between venous and arterial conduits.

  Circulation 20010515

• Photoreactivation of alloxanthine-inhibited xanthine oxidase.

  Photochemistry and photobiology 20010401

• Bioequivalence of allopurinol and its metabolite oxipurinol in two tablet formulations.

  Journal of clinical pharmacy and therapeutics 20010401

• Identification of a new point mutation in the human xanthine dehydrogenase gene responsible for a case of classical type I xanthinuria.

  Human genetics 20010401

• Elevated superoxide production by active H-ras enhances human lung WI-38VA-13 cell proliferation, migration and resistance to TNF-alpha.

  Oncogene 20010322

• Does xanthine oxidase contribute to the hydroxyl radical generation in ischemia and reperfusion of the cochlea?

  Hearing research 20010301

• Oxygen radicals mediate the final exacerbation of endothelin-1-induced gastric ulcer in rat.

  European journal of pharmacology 20010209

• Difficult gout and new approaches for control of hyperuricemia in the allopurinol-allergic patient.

  Current rheumatology reports 20010201

• Effect of furosemide on renal excretion of oxypurinol and purine bases.

  Metabolism: clinical and experimental 20010201

• Endothelial dysfunction and xanthine oxidoreductase activity in rats with human renin and angiotensinogen genes.

  Hypertension (Dallas, Tex. : 1979) 20010201

• Sodium nitroprusside-induced seizure and taurine release from rat hippocampus.

  Amino acids 20000101

• Reactive oxygen metabolite-induced toxicity to cultured bovine endothelial cells: status of cellular iron in mediating injury.

  Journal of cellular physiology 19940701

• Effect of antiperoxidative drugs on gastric damage induced by ethanol in rats.

  Life sciences 19870810