247257-48-3 | Fimasartan

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$6.00	$4.00
5mg	98%	in stock	$7.00	$5.00
10mg	98%	in stock	$9.00	$6.00
25mg	98%	in stock	$11.00	$8.00
50mg	98%	in stock	$14.00	$10.00
100mg	98%	in stock	$20.00	$14.00

Description

• Catalog Number: AB25818
• Chemical Name: Fimasartan
• CAS Number: 247257-48-3
• Molecular Formula: C27H31N7OS
• Molecular Weight: 501.6463
• MDL Number: MFCD13194795
• SMILES: CCCCc1nc(C)c(c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)CC(=S)N(C)C

Computed Properties

• Complexity: 849
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 36
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 9
• XLogP3: 3.5

Literature

• Role of cytochrome P450 enzymes in fimasartan metabolism in vitro.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180501

• The effect of fimasartan, an angiotensin receptor type 1 blocker, on the pharmacokinetics and pharmacodynamics of warfarin in healthy Korean male volunteers: a one-sequence, two-period crossover clinical trial.

  Clinical therapeutics 20120701

• Fimasartan, a novel angiotensin II receptor antagonist.

  Archives of pharmacal research 20120701

• Efficacy and tolerability of fimasartan, a new angiotensin receptor blocker, compared with losartan (50/100 mg): a 12-week, phase III, multicenter, prospective, randomized, double-blind, parallel-group, dose escalation clinical trial with an optional 12-week extension phase in adult Korean patients with mild-to-moderate hypertension.

  Clinical therapeutics 20120301

• Synthesis and antihypertensive activity of pyrimidin-4(3H)-one derivatives as losartan analogue for new angiotensin II receptor type 1 (AT1) antagonists.

  Bioorganic & medicinal chemistry letters 20120215

• Assessment of the drug-drug interactions between fimasartan and hydrochlorothiazide in healthy volunteers.

  Journal of cardiovascular pharmacology 20120101

• The effect of the newly developed angiotensin receptor II antagonist fimasartan on the pharmacokinetics of atorvastatin in relation to OATP1B1 in healthy male volunteers.

  Journal of cardiovascular pharmacology 20111101

• Effect of age on the pharmacokinetics of fimasartan (BR-A-657).

  Expert opinion on drug metabolism & toxicology 20111101

• Safety, tolerability, pharmacokinetics, and pharmacodynamics of fimasartan following single and repeated oral administration in the fasted and fed states in healthy subjects.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20111001

• Fimasartan.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20110801

• Pharmacokinetic interaction of fimasartan, a new angiotensin II receptor antagonist, with amlodipine in healthy volunteers.

  Journal of cardiovascular pharmacology 20110601

• Effect of multiple doses of fimasartan, an angiotensin II receptor antagonist, on the steady-state pharmacokinetics of digoxin in healthy volunteers.

  International journal of clinical pharmacology and therapeutics 20110501