260264-93-5 | GI 254023X

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$58.00	$41.00
5mg	98%	in stock	$214.00	$150.00
10mg	98%	in stock	$354.00	$248.00
25mg	98%	in stock	$616.00	$432.00

Description

• Catalog Number: AB28636
• Chemical Name: GI 254023X
• CAS Number: 260264-93-5
• Molecular Formula: C21H33N3O4
• Molecular Weight: 391.5044
• MDL Number: MFCD19381832
• SMILES: CNC(=O)[C@H](C(C)(C)C)NC(=O)[C@@H]([C@@H](N(C=O)O)C)CCCc1ccccc1

Computed Properties

• Complexity: 512
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 3
• Heavy Atom Count: 28
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 10
• XLogP3: 2.9

Literature

• The xenoestrogens biphenol-A and nonylphenol differentially regulate metalloprotease-mediated shedding of EGFR ligands.

  Journal of cellular physiology 20180301

• Suppression of tunicamycin-induced CD44v6 ectodomain shedding and apoptosis is correlated with temporal expression patterns of active ADAM10, MMP-9 and MMP-13 proteins in Caki-2 renal carcinoma cells.

  Oncology reports 20121101

• Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels.

  Blood 20120503

• Genetic requirement for ADAM10 in severe Staphylococcus aureus skin infection.

  The Journal of investigative dermatology 20120501

• An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin.

  Nature neuroscience 20120501

• Soluble CD23 controls IgE synthesis and homeostasis in human B cells.

  Journal of immunology (Baltimore, Md. : 1950) 20120401

• Improved synthesis of ADAM10 inhibitor GI254023X.

  Neuro-degenerative diseases 20100101

• In silico prediction of pregnane X receptor activators by machine learning approaches.

  Molecular pharmacology 20070101

• Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.

  Combinatorial chemistry & high throughput screening 20050301

• The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.

  Blood 20030815

• CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.

  Drug metabolism and disposition: the biological fate of chemicals 20030701