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PI3K/Akt/GSK3β induced CREB activation ameliorates arsenic mediated alterations in NMDA receptors and associated signaling in rat hippocampus: Neuroprotective role of curcumin.
Neurotoxicology 20180701
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Inhibitory Effects of Bisphenol-A on Neural Stem Cells Proliferation and Differentiation in the Rat Brain Are Dependent on Wnt/β-Catenin Pathway.
Molecular neurobiology 20151201
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Activation of β-catenin by inhibitors of glycogen synthase kinase-3 ameliorates cisplatin-induced cytotoxicity and pro-inflammatory cytokine expression in HEI-OC1 cells.
Toxicology 20140605
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Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells.
The Journal of biological chemistry 20140418
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Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130401
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Roles of glycogen synthase kinase 3 in Alzheimer's disease.
Current Alzheimer research 20120901
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Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20120822
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Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523
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A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.
Toxicology and applied pharmacology 20120115
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Canonical WNT signaling enhances stem cell expression in the developing heart without a corresponding inhibition of cardiogenic differentiation.
Stem cells and development 20111101
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GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulation.
International immunology 20111101
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Development of a cellular tau enzyme-linked immunosorbent assay method for screening GSK-3β inhibitors.
Assay and drug development technologies 20111001
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GSK-3β inhibition promotes cell death, apoptosis, and in vivo tumor growth delay in neuroblastoma Neuro-2A cell line.
Journal of neuro-oncology 20110801
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GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions.
Angiogenesis 20110501
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Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression.
Endocrinology 20110501
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Eutypoids B-E produced by a Penicillium sp. strain from the North Sea.
Journal of natural products 20110128
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P27(Kip1), regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells.
BMC cancer 20110101
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Lithium promotes neural precursor cell proliferation: evidence for the involvement of the non-canonical GSK-3β-NF-AT signaling.
Cell & bioscience 20110101
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
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Regulation of GSK-3beta by calpain in the 3-nitropropionic acid model.
Hippocampus 20100801
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Role of glycogen synthase kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus.
Medical mycology 20100601
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Neurites regrowth of cortical neurons by GSK3beta inhibition independently of Nogo receptor 1.
Journal of neurochemistry 20100601
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GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100421
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A new class of molecular targeted radioprotectors: GSK-3beta inhibitors.
International journal of radiation oncology, biology, physics 20100201
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Dependence of EGF-induced increases in corneal epithelial proliferation and migration on GSK-3 inactivation.
Investigative ophthalmology & visual science 20091001
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nature chemical biology 20091001
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A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286.
Journal of cellular and molecular medicine 20090901
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Chronic lithium treatment up-regulates cell surface Na(V)1.7 sodium channels via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells: enhancement of Na(+) influx, Ca(2+) influx and catecholamine secretion after lithium withdrawal.
Neuropharmacology 20090901
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Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models.
European journal of medicinal chemistry 20090601
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Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium.
Cellular signalling 20090401
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Glucocorticoids and lithium reciprocally regulate the proliferation of adult dentate gyrus-derived neural precursor cells through GSK-3beta and beta-catenin/TCF pathway.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090201
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Glycogen synthase kinase-3 inhibitors augment TRAIL-induced apoptotic death in human hepatoma cells.
Biochemical pharmacology 20090101
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Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal.
Endocrinology 20081201
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Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation.
Aging cell 20081201
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Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation.
Circulation research 20081024
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Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20080903
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GSK-3 beta inhibition and prevention of mitochondrial apoptosis inducing factor release are not involved in the antioxidant properties of SB-415286.
European journal of pharmacology 20080707
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Pharmacophore modeling, quantitative structure-activity relationship analysis, and in silico screening reveal potent glycogen synthase kinase-3beta inhibitory activities for cimetidine, hydroxychloroquine, and gemifloxacin.
Journal of medicinal chemistry 20080410
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Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20080101
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The selectivity of protein kinase inhibitors: a further update.
The Biochemical journal 20071215
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Glycogen synthase kinase 3 activity during development of bone marrow-derived dendritic cells (DCs) essential for the DC function to induce T helper 2 polarization.
Immunology 20071001
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Lithium desensitizes brain mitochondria to calcium, antagonizes permeability transition, and diminishes cytochrome C release.
The Journal of biological chemistry 20070622
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LTP inhibits LTD in the hippocampus via regulation of GSK3beta.
Neuron 20070301
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Inhibiting glycogen synthase kinase 3beta in sepsis.
Novartis Foundation symposium 20070101
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HaCaT keratinocyte migration is dependent on epidermal growth factor receptor signaling and glycogen synthase kinase-3alpha.
Experimental cell research 20060910
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A cellular assay for measuring the inhibition of glycogen synthase kinase-3 via the accumulation of beta-catenin in Chinese hamster ovary clone K1 cells.
Assay and drug development technologies 20060801
-
Glycogen synthase kinase-3 acts upstream of ADP-ribosylation factor 6 and Rac1 to regulate epithelial cell migration.
Experimental cell research 20060515
-
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Mechanical and chemical regulation of endothelial cell polarity.
Circulation research 20060414
-
Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta.
British journal of pharmacology 20060301
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Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells.
The Journal of biological chemistry 20060224
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Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells.
Cancer research 20051001
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GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat.
Critical care medicine 20050901
-
GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis.
International journal of oncology 20050701
-
Inhibition of GSK3beta is a common event in neuroprotection by different survival factors.
Brain research. Molecular brain research 20050613
-
Glycogen synthase kinase 3 activity mediates neuronal pentraxin 1 expression and cell death induced by potassium deprivation in cerebellar granule cells.
Molecular pharmacology 20050401
-
Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells.
The Journal of biological chemistry 20050311
-
Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity.
Cancer research 20050301
-
Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium.
Neuroscience 20050101
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Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds.
Bioorganic & medicinal chemistry letters 20041115
-
GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression.
Experimental cell research 20041101
-
Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth.
Oncogene 20041014
-
Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts.
Circulation research 20040416
-
Glycogen synthase kinase-3 regulates cytoskeleton and translocation of Rac1 in long cellular extensions of human keratinocytes.
Experimental cell research 20040201
-
Glycogen synthase kinase-3 regulates formation of long lamellipodia in human keratinocytes.
Journal of cell science 20030915
-
Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase.
European journal of biochemistry 20030901
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Glycogen synthase kinase-3 inhibitors protect central neurons against excitotoxicity.
Neuroreport 20030806
-
PI3-kinase-induced hyperreactivity in DOCA-salt hypertension is independent of GSK-3 activity.
Hypertension (Dallas, Tex. : 1979) 20030401
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Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin.
The Biochemical journal 20021015
-
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
The Journal of biological chemistry 20020419
-
GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity.
FEBS letters 20011102
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Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression.
Diabetes 20010501
-
Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death.
Journal of neurochemistry 20010401
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3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).
Bioorganic & medicinal chemistry letters 20010312
-
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.
Chemistry & biology 20001001
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Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.
Diabetes 20000201
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Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice.
Diabetes 19990801
-
Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America 19930815
