2645-32-1 | PR-619

Packsize	Purity	Availability	Price	Discounted Price
5mg	95%	in stock	$76.00	$54.00
10mg	95%	in stock	$134.00	$94.00
25mg	95%	in stock	$201.00	$141.00
100mg	95%	in stock	$263.00	$184.00
250mg	95%	in stock	$490.00	$343.00
1g	95%	in stock	$945.00	$661.00

Description

• Catalog Number: AB31073
• Chemical Name: PR-619
• CAS Number: 2645-32-1
• Molecular Formula: C7H5N5S2
• Molecular Weight: 223.2781
• MDL Number: MFCD00830384
• SMILES: N#CSc1cc(SC#N)c(nc1N)N

Computed Properties

• Complexity: 261
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 1.3

Literature

• Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes.

  Viruses 20170801

• Tetrachlorobenzoquinone Stimulates NLRP3 Inflammasome-Mediated Post-Translational Activation and Secretion of IL-1β in the HUVEC Endothelial Cell Line.

  Chemical research in toxicology 20160321

• The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases.

  Biochimica et biophysica acta 20121101

• Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.

  Molecular & cellular proteomics : MCP 20120501

• Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes.

  Chemistry & biology 20111123