2657-25-2 | 4'-Hydroxychalcone

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$9.00	$6.00
1g	97%	in stock	$15.00	$10.00
5g	97%	in stock	$20.00	$14.00
10g	97%	in stock	$36.00	$25.00
25g	97%	in stock	$66.00	$46.00
100g	97%	in stock	$241.00	$169.00
500g	97%	in stock	$976.00	$683.00

Description

• Catalog Number: AB31656
• Chemical Name: 4'-Hydroxychalcone
• CAS Number: 2657-25-2
• Molecular Formula: C15H12O2
• Molecular Weight: 224.2546
• MDL Number: MFCD00016484
• SMILES: Oc1ccc(cc1)C(=O)C=Cc1ccccc1

Computed Properties

• Complexity: 269
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 2.7

Literature

• Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein.

  Toxicological sciences : an official journal of the Society of Toxicology 20150201

• Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities.

  Chemical research in toxicology 20121119

• Large enhancement of skeletal muscle cell glucose uptake and suppression of hepatocyte glucose-6-phosphatase activity by weak uncouplers of oxidative phosphorylation.

  Biochimica et biophysica acta 20120201

• The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition.

  Biochemical pharmacology 20110915

• Sulfonate chalcone as new class voltage-dependent K+ channel blocker.

  Bioorganic & medicinal chemistry letters 20080101

• Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

  Journal of molecular graphics & modelling 20061101

• Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

  Journal of medicinal chemistry 20050908

• Antimalarial activity of ferrocenyl chalcones.

  Bioorganic & medicinal chemistry letters 20020902

• Antimalarial alkoxylated and hydroxylated chalcones [corrected]: structure-activity relationship analysis.

  Journal of medicinal chemistry 20011206

• Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway.

  Journal of medicinal chemistry 20010927