26921-17-5 | (S)-3-[3-(tert-Butylamino)-2-hydroxypropoxy]-4-morpholino-1,2,5-thiadiazole monomaleate

Packsize	Purity	Availability	Price	Discounted Price
25mg	95%	in stock	$42.00	$29.00
50mg	95%	in stock	$58.00	$40.00
100mg	95%	in stock	$88.00	$62.00
200mg	95%	in stock	$139.00	$97.00
250mg	95%	in stock	$150.00	$105.00
1g	95%	in stock	$322.00	$225.00
5g	95%	in stock	$746.00	$522.00

Description

• Catalog Number: AB50307
• Chemical Name: (S)-3-[3-(tert-Butylamino)-2-hydroxypropoxy]-4-morpholino-1,2,5-thiadiazole monomaleate
• CAS Number: 26921-17-5
• Molecular Formula: C17H28N4O7S
• Molecular Weight: 432.4918
• MDL Number: MFCD00058356
• SMILES: O[C@H](COc1nsnc1N1CCOCC1)CNC(C)(C)C.OC(=O)C=CC(=O)O

Computed Properties

• Complexity: 429
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 12
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 9

Literature

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  American journal of ophthalmology 20160801

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  Retina (Philadelphia, Pa.) 20120101

• Twenty-four hour efficacy with the dorzolamide/timolol-fixed combination compared with the brimonidine/timolol-fixed combination in primary open-angle glaucoma.

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• Allosteric interactions between the oxytocin receptor and the β2-adrenergic receptor in the modulation of ERK1/2 activation are mediated by heterodimerization.

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  Biocontrol science 20120101

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  The British journal of ophthalmology 20110701

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  Molecular vision 20110101

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  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20110101

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  Drug metabolism and disposition: the biological fate of chemicals 20101201

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  The Annals of pharmacotherapy 20101201

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  Ophthalmology 20101101

• Ventral striatal noradrenergic mechanisms contribute to sensorimotor gating deficits induced by amphetamine.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Brinzolamide 1%/timolol 0.5%: safety and efficacy of a new fixed-combination IOP-lowering product for glaucoma.

  Current medical research and opinion 20101101

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  Japanese journal of ophthalmology 20101101

• Trans-scleral iontophoretic delivery of low molecular weight therapeutics.

  Journal of controlled release : official journal of the Controlled Release Society 20101015

• Improved ocular absorption kinetics of timolol maleate loaded into a bioadhesive niosomal delivery system.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20101001

• Efficacy of medical therapy in the initial management of acute primary angle closure in Asians.

  Eye (London, England) 20101001

• 24-h Intraocular pressure control with evening-dosed travoprost/timolol, compared with latanoprost/timolol, fixed combinations in exfoliative glaucoma.

  Eye (London, England) 20101001

• Comparison of Travoprost and Bimatoprost plus timolol fixed combinations in open-angle glaucoma patients previously treated with latanoprost plus timolol fixed combination.

  American journal of ophthalmology 20101001

• Effectiveness of dorzolamide–timolol (COSOPT) in patients who were treatment naive for open-angle glaucoma or ocular hypertension: the COSOPT first-line study.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20101001

• Association of CYP2D6 single-nucleotide polymorphism with response to ophthalmic timolol in primary open-angle Glaucoma--a pilot study.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20101001

• Bilateral simultaneous acute angle closure glaucoma precipitated by non-prescription cold and flu medication.

  Emergency medicine Australasia : EMA 20101001

• Observational study of patients switched to the fixed travoprost 0.004%/timolol 0.5% combination in Croatia.

  Methods and findings in experimental and clinical pharmacology 20101001

• Effects of drug solubility, state and loading on controlled release in bicomponent electrospun fibers.

  International journal of pharmaceutics 20100915

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• Comparison of the effects of dorzolamide/timolol and latanoprost/timolol fixed combinations upon intraocular pressure and progression of visual field damage in primary open-angle glaucoma.

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  American journal of veterinary research 20100901

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  Journal of the Indian Medical Association 20100901

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  Acta ophthalmologica 20100801

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  Journal of glaucoma 20100801

• Ion- and pH-activated novel in-situ gel system for sustained ocular drug delivery.

  Journal of drug targeting 20100801

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  Acta ophthalmologica 20100801

• Efficacy and safety of fixed combinations of latanoprost/timolol and dorzolamide/timolol in open-angle glaucoma or ocular hypertension.

  Eye (London, England) 20100701

• Comparison of ocular hypotensive actions of fixed combinations of brimonidine/timolol and dorzolamide/timolol.

  Current medical research and opinion 20100701

• Enalaprilat and enalapril maleate eyedrops lower intraocular pressure in rabbits.

  Acta ophthalmologica 20100501

• Beta-adrenergic receptors link NO/sGC/PKG signaling to BDNF expression during the consolidation of object recognition long-term memory.

  Hippocampus 20100501

• Hyaluronic acid modified chitosan nanoparticles for effective management of glaucoma: development, characterization, and evaluation.

  Journal of drug targeting 20100501

• Absence of corneal endothelium injury in non-human primates treated with and without ophthalmologic drugs and exposed to 2.8 GHz pulsed microwaves.

  Bioelectromagnetics 20100501

• Extended delivery of hydrophilic drugs from silicone-hydrogel contact lenses containing vitamin E diffusion barriers.

  Biomaterials 20100501

• Allergic contact dermatitis due to the beta-blocker betaxolol in eyedrops, with cross-sensitivity to timolol.

  Contact dermatitis 20100501

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  European review for medical and pharmacological sciences 20100501

• Reaction of Müller cells in an experimental rat model of increased intraocular pressure following timolol, latanoprost and brimonidine.

  Brain research bulletin 20100429

• Effects of selective serotonin reuptake inhibitors on timolol metabolism in human liver microsomes and cryo-preserved hepatocytes.

  Basic & clinical pharmacology & toxicology 20100401

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  Klinische Monatsblatter fur Augenheilkunde 20100401

• [Evaluation of the effect of bimatoprost/timolol fixed combination on ocular blood flow in patients with ocular hypertension using colour Doppler imaging. Preliminary study].

  Archivos de la Sociedad Espanola de Oftalmologia 20100401

• Effect of dorzolamide and timolol on ocular pressure: blood flow relationship in patients with primary open-angle glaucoma and ocular hypertension.

  Investigative ophthalmology & visual science 20100301

• [Atypical unilateral glaucoma in a young patient].

  Journal francais d'ophtalmologie 20100301

• Monitoring adherence rates in glaucoma patients using the Travatan Dosing Aid. A 6-month study comparing patients on travoprost 0.004% and patients on travoprost 0.004%/timolol 0.5% fixed combination.

  Expert opinion on pharmacotherapy 20100301

• WITHDRAWN: Interventions for normal tension glaucoma.

  The Cochrane database of systematic reviews 20100217

• Ocular blood flow and oxygen delivery to the retina in primary open-angle glaucoma patients: the addition of dorzolamide to timolol monotherapy.

  Acta ophthalmologica 20100201

• Experimental model of ocular hypertension in the rat: study of the optic nerve capillaries and action of hypotensive drugs.

  Investigative ophthalmology & visual science 20100201

• Twenty-four-hour intraocular pressure control with bimatoprost and the bimatoprost/timolol fixed combination administered in the morning, or evening in exfoliative glaucoma.

  The British journal of ophthalmology 20100201

• Fixed combination of latanoprost and timolol vs individual components for primary open-angle glaucoma or ocular hypertension: a randomized, double-masked study.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20100201

• Using diurnal intraocular pressure fluctuation to assess the efficacy of fixed-combination latanoprost/timolol versus latanoprost or timolol monotherapy.

  The British journal of ophthalmology 20100101

• Additive intraocular pressure reduction effect of fixed combination of maleate timolol 0.5%/dorzolamide 2% (Cosopt) on monotherapy with latanoprost (Xalatan) in patients with elevated intraocular pressure: a prospective, 4-week, open-label, randomized, controlled clinical trial.

  Journal of glaucoma 20100101

• Is the medication used to achieve the target intraocular pressure in glaucoma therapy of relevance?--an exemplary analysis on the basis of two beta-blockers.

  Progress in retinal and eye research 20100101

• Autonomic drugs and the accommodative system in rhesus monkeys.

  Experimental eye research 20100101

• The ability of short-wavelength automated perimetry to predict conversion to glaucoma.

  Ophthalmology 20100101

• Does the fixed combination of bimatoprost/timolol really produce a better benefit/risk balance than the fixed combination of latanoprost/timolol?

  European journal of ophthalmology 20100101

• A 12-week, randomized, double-masked study of fixed combination latanoprost/timolol versus latanoprost or timolol monotherapy.

  European journal of ophthalmology 20100101

• Combination brimonidine and timolol.

  Ophthalmology 20100101

• Predictors of additional intraocular pressure reduction in patients changed to latanoprost/timolol fixed combination.

  BMC ophthalmology 20100101

• Impact of once daily versus twice daily application of adjunctive timolol on the intraocular pressure-lowering effect of latanoprost.

  Ophthalmic research 20100101

• Long-term effect of latanoprost/timolol fixed combination in patients with glaucoma or ocular hypertension: a prospective, observational, noninterventional study.

  BMC ophthalmology 20100101

• Skin eruption and thrombocytopaenia in a woman with glaucoma: a case report.

  The West Indian medical journal 20100101

• Stimuli-sensitive hydrogels: a novel ophthalmic drug delivery system.

  Indian journal of ophthalmology 20100101

• Effects of topical 0.5% levobunolol alone or in association with 2% dorzolamide compared with a fixed combination of 0.5% timolol and 2% dorzolamide on intraocular pressure and heart rate in dogs without glaucoma.

  Veterinary therapeutics : research in applied veterinary medicine 20100101

• Cost effectiveness of latanoprost and timolol maleate for the treatment of glaucoma in Scandinavia and the United Kingdom using a decision-analytic health economic model.

  Eye (London, England) 20091201

• Fixed-combination brimonidine/timolol as adjunctive therapy to a prostaglandin analog: a 3-month, open-label, replacement study in glaucoma patients.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20091201

• Comparative study of topical application of timolol and verapamil in patients with glaucoma within 6 months.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20091201

• [Time course of changes in contrast sensitivity function after application of antiglaucomatous eyedrops].

  Nippon Ganka Gakkai zasshi 20091201

• Changes in optic nerve head blood flow induced by the combined therapy of latanoprost and beta blockers.

  Acta ophthalmologica 20091101

• Clinical inquiries. What are the best prophylactic drugs for migraine?

  The Journal of family practice 20091101

• Noradrenergic modulation of neuronal responses to glutamate in the vestibular complex.

  Neuroscience letters 20091030

• Influence of plasma protein binding on pharmacodynamics: Estimation of in vivo receptor affinities of beta blockers using a new mechanism-based PK-PD modelling approach.

  Journal of pharmaceutical sciences 20091001

• Effects of timolol and latanoprost on respiratory and cardiovascular status in elderly patients with glaucoma.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20091001

• Assessment of ion transfer amperometry at liquid-liquid interfaces for detection in CE.

  Electrophoresis 20091001

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• A comparison of bimatoprost 0.03% versus the fixed-combination of latanoprost 0.005% and timolol 0.5% in adult patients with elevated intraocular pressure: an eight-week, randomized, open-label trial.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20091001

• The effects of combination glaucoma medications on ocular surface epithelial cells.

  Advances in therapy 20091001

• Short-term tolerability of once-daily timolol hemihydrate 0.5%, timolol maleate in sorbate 0.5%, and generic timolol maleate gel-forming solution 0.5% in glaucoma and/or ocular hypertension: a prospective, randomized, double-masked, active-controlled, three-period crossover pilot study.

  Clinical therapeutics 20091001

• Comparison of effects of topical levobunolol to a combination of timolol-dorzolamide on intraocular pressure and pulse rate of healthy dogs.

  Veterinary research communications 20090901

• Pneumatic trabeculoplasty vs latanoprost as adjunctive therapy to timolol in primary open-angle glaucoma or ocular hypertension.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20090801

• Dorzolamide-timolol combination and retinal vessel oxygen saturation in patients with glaucoma or ocular hypertension.

  The British journal of ophthalmology 20090801

• Assessing the efficacy of latanoprost vs timolol using an alternate efficacy parameter: the intervisit intraocular pressure range.

  American journal of ophthalmology 20090801

• Relationship between visual field severity and response to fixed combination dorzolamide/timolol or timolol alone.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090801

• Switching from concomitant latanoprost 0.005% and timolol 0.5% to a fixed combination of travoprost 0.004%/timolol 0.5% in patients with primary open-angle glaucoma and ocular hypertension: a 6-month, multicenter, cohort study.

  Expert opinion on pharmacotherapy 20090801

• Brinzolamide/timolol fixed combination: a new ocular suspension for the treatment of open-angle glaucoma and ocular hypertension.

  Expert opinion on pharmacotherapy 20090801

• Smoothing the intraocular pressure roller coaster: a new goal?

  American journal of ophthalmology 20090801

• Effect of the nature of the single-isomer anionic CD and the BGE composition on the enantiomeric separation of beta-blockers in NACE.

  Electrophoresis 20090801

• Betaxolol hydrochloride ophthalmic suspension 0.25% and timolol gel-forming solution 0.25% and 0.5% in pediatric glaucoma: a randomized clinical trial.

  Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus 20090801

• Sustained release and permeation of timolol from surface-modified solid lipid nanoparticles through bioengineered human cornea.

  Current eye research 20090801

• A medical device/drug delivery system for treatment of glaucoma.

  Clinical & experimental optometry 20090701

• Meta-analysis of medical intervention for normal tension glaucoma.

  Ophthalmology 20090701

• Three-month, randomized, parallel-group comparison of brimonidine-timolol versus dorzolamide-timolol fixed-combination therapy.

  Current medical research and opinion 20090701

• Corneal thickness and glaucoma medications.

  Ophthalmology 20090701

• Relative efficacy of prostaglandins.

  Ophthalmology 20090701

• Montmorillonite as a drug delivery system: intercalation and in vitro release of timolol maleate.

  International journal of pharmaceutics 20090605

• Nipradilol and timolol induce Foxo3a and peroxiredoxin 2 expression and protect trabecular meshwork cells from oxidative stress.

  Investigative ophthalmology & visual science 20090601

• Efficacy and safety of latanoprost in eyes with uveitic glaucoma.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20090601

• A comparison of the long-term effects of dorzolamide 2% and brinzolamide 1%, each added to timolol 0.5%, on retrobulbar hemodynamics and intraocular pressure in open-angle glaucoma patients.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090601

• Development and characterization of 99mTc-timolol maleate for evaluating efficacy of in situ ocular drug delivery system.

  AAPS PharmSciTech 20090601

• Decreased intraocular pressure in mice following either pharmacological or genetic inhibition of ROCK.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090601

• L-Carnosine: multifunctional dipeptide buffer for sustained-duration topical ophthalmic formulations.

  The Journal of pharmacy and pharmacology 20090601

• Synthesis of novel nitric oxide (NO)-releasing esters of timolol.

  Bioorganic & medicinal chemistry letters 20090515

• Changes in visual function after intraocular pressure reduction using antiglaucoma medications.

  Eye (London, England) 20090501

• Novel transdermal delivery of Timolol maleate using sugar esters: preclinical and clinical studies.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20090501

• Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators.

  Journal of computer-aided molecular design 20090501

• 24-hour intraocular pressure and blood pressure levels with latanoprost/timolol fixed combination versus timolol.

  Current eye research 20090501

• Bimatoprost/timolol fixed combination vs latanoprost/timolol fixed combination in open-angle glaucoma patients.

  Eye (London, England) 20090401

• Twenty-four-hour intraocular pressure control with the travoprost/timolol maleate fixed combination compared with travoprost when both are dosed in the evening in primary open-angle glaucoma.

  The British journal of ophthalmology 20090401

• An in vivo confocal microscopy analysis of effects of topical antiglaucoma therapy with preservative on corneal innervation and morphology.

  American journal of ophthalmology 20090401

• Physiological roles of A1 and A2A adenosine receptors in regulating heart rate, body temperature, and locomotion as revealed using knockout mice and caffeine.

  American journal of physiology. Heart and circulatory physiology 20090401

• Treatment of patients with primary open-angle glaucoma with a fixed combination of brimonidine 0.2%/timolol 0.5%: multicenter, open-label, observational study in Germany.

  Current medical research and opinion 20090401

• Cytochrome oxidase 2D6 gene polymorphism in primary open-angle glaucoma with various effects to ophthalmic timolol.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090401

• Efficacy, tolerability and safety of the fixed combination of bimatoprost 0.03% and timolol 0.5% in a broad patient population: multicenter, open-label observational study.

  Current medical research and opinion 20090401

• Effects of beta-adrenergic receptor blockers on cardiac function: a comparative study in male versus female rats.

  Canadian journal of physiology and pharmacology 20090401

• [Development of conjunctival hyperemia with the use of a fixed combination of latanoprost/timolol: systematic review and meta-analysis of clinical trials].

  Archivos de la Sociedad Espanola de Oftalmologia 20090401

• Biodegradable fumarate-based drug-delivery systems for ophthalmic applications.

  Journal of biomedical materials research. Part A 20090315

• Comparing diurnal and nocturnal effects of brinzolamide and timolol on intraocular pressure in patients receiving latanoprost monotherapy.

  Ophthalmology 20090301

• The effect of travoprost 0.004% as an adjuvant to timolol 0.5% therapy.

  Acta clinica Croatica 20090301

• Role of enhanced noradrenergic transmission within the ventral bed nucleus of the stria terminalis in visceral pain-induced aversion in rats.

  Behavioural brain research 20090211

• Sustained delivery of timolol maleate from poly(lactic-co-glycolic acid)/poly(lactic acid) microspheres for over 3 months.

  Journal of microencapsulation 20090201

• Effect of latanoprost and timolol on the histopathology of the human conjunctiva.

  The British journal of ophthalmology 20090201

• Intraocular pressure control over 24 hours using travoprost and timolol fixed combination administered in the morning or evening in primary open-angle and exfoliative glaucoma.

  Acta ophthalmologica 20090201

• Non-necrotizing herpetic vasculitis.

  Ophthalmology 20090201

• Efficacy and tolerability of latanoprost compared to dorzolamide combined with timolol in the treatment of patients with elevated intraocular pressure: a meta-analysis of randomized, controlled trials.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090201

• Cost-effectiveness of latanoprost and timolol maleate for the treatment of glaucoma in Scandinavia and the United Kingdom, using a decision-analytic health economic model.

  Eye (London, England) 20090101

• Sympathetic inhibition of accommodation after sustained nearwork in subjects with myopia and emmetropia.

  Investigative ophthalmology & visual science 20090101

• Prolongation of activity of single intravitreal bevacizumab by adjuvant topical aqueous depressant (Timolol-Dorzolamide).

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20090101

• Matrix modifications modulate ophthalmic drug delivery from photo-cross-linked poly(propylene fumarate)-based networks.

  Journal of biomaterials science. Polymer edition 20090101

• Efficacy of the fixed combinations of bimatoprost or latanoprost plus timolol in patients uncontrolled with prostaglandin monotherapy: a multicenter, randomized, investigator-masked, clinical study.

  European journal of ophthalmology 20090101

• Cost effectiveness of travoprost versus a fixed combination of latanoprost/timolol in patients with ocular hypertension or glaucoma: analysis based on the UK general practitioner research database.

  Clinical drug investigation 20090101

• Bimatoprost/timolol: a review of its use in glaucoma and ocular hypertension.

  Drugs & aging 20090101

• Adjunctive use of tafluprost with timolol provides additive effects for reduction of intraocular pressure in patients with glaucoma.

  European journal of ophthalmology 20090101

• [Efficacy of latanoprost versus travoprost assessed by daily intraocular pressure curve].

  Arquivos brasileiros de oftalmologia 20090101

• The safety and efficacy of brinzolamide 1%/timolol 0.5% fixed combination versus dorzolamide 2%/timolol 0.5% in patients with open-angle glaucoma or ocular hypertension.

  Journal of glaucoma 20090101

• Systematic review of intraocular pressure-lowering effects of adjunctive medications added to latanoprost.

  Ophthalmic research 20090101

• Ophthalmologist attitudes regarding fixed combination treatment for glaucoma in the European Union.

  European journal of ophthalmology 20090101

• Brinzolamide/timolol: in open-angle glaucoma and ocular hypertension.

  Drugs & aging 20090101

• Efficiency of travoprost versus fixed-combination latanoprost/timolol.

  Clinical drug investigation 20090101

• Aerobic exercise and intraocular pressure in normotensive and glaucoma patients.

  BMC ophthalmology 20090101

• [Drug therapy for glaucoma].

  Duodecim; laaketieteellinen aikakauskirja 20090101

• Visual function, optic nerve structure, and ocular blood flow parameters after 1 year of glaucoma treatment with fixed combinations.

  European journal of ophthalmology 20090101

• Study of the effects of ocular hypotensive drugs on number of neurons in the retinal ganglion layer in a rat experimental glaucoma.

  European journal of ophthalmology 20090101

• Xal-Ease: impact of an ocular hypotensive delivery device on ease of eyedrop administration, patient compliance, and satisfaction.

  European journal of ophthalmology 20090101

• [Bimatoprost therapy in glaucoma].

  Oftalmologia (Bucharest, Romania : 1990) 20090101

• The efficacy and safety of two fixed combinations: timolol-dorzolamide-brimonidine versus timolol-dorzolamide. A prospective, randomized, double-masked, multi-center, 6-month clinical trial.

  Annals of ophthalmology (Skokie, Ill.) 20090101

• Efficacy and safety of latanoprost versus pilocarpine/timolol maleate fixed combination in patients with primary open-angle glaucoma or ocular hypertension.

  Acta ophthalmologica 20081201

• Anterior uveitis associated with fixed-combination latanoprost and timolol.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20081201

• Intraocular pressure lowering, change of antiapoptotic molecule expression, and neuroretinal changes by dorzolamide 2%/timolol 0.5% combination in a chronic ocular hypertension rat model.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081201

• A one-week comfort study of BID-dosed brinzolamide 1%/timolol 0.5% ophthalmic suspension fixed combination compared to BID-dosed dorzolamide 2%/timolol 0.5% ophthalmic solution in patients with open-angle glaucoma or ocular hypertension.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081201

• An eight-week, multicentric, randomized, interventional, open-label, phase 4, parallel comparison of the efficacy and tolerability of the fixed combination of timolol maleate 0.5%/brimonidine tartrate 0.2% versus fixed combination of timolol maleate 0.5%/dorzolamide 2% in patients with elevated intraocular pressure.

  Journal of glaucoma 20081201

• Bilateral acute onset myopia and angle closure glaucoma after oral topiramate: a case report.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20081201

• Persistence with migraine prophylactic treatment and acute migraine medication utilization in the managed care setting.

  Clinical therapeutics 20081201

• Twenty-four-hour efficacy of the brimonidine/timolol fixed combination versus therapy with the unfixed components.

  Eye (London, England) 20081101

• Recurrent serous macular detachment after topical ocular hypotensive medication.

  Clinical & experimental optometry 20081101

• Photocrosslinkable starch-based polymers for ophthalmologic drug delivery.

  International journal of biological macromolecules 20081101

• Second-line therapy with dorzolamide/timolol or latanoprost/timolol fixed combination versus adding dorzolamide/timolol fixed combination to latanoprost monotherapy.

  The British journal of ophthalmology 20081101

• Topical beta-blockers and mortality.

  Ophthalmology 20081101

• Electrochemically modulated liquid-liquid extraction of ionized drugs under physiological conditions.

  Analytical chemistry 20081101

• Efficacy, safety, and current applications of brimonidine.

  Expert opinion on drug safety 20081101

• A case of melancholic depression induced by beta-blocker antiglaucoma agents.

  The Medical journal of Australia 20081006

• Effects of the timolol-dorzolamide fixed combination and latanoprost on circadian diastolic ocular perfusion pressure in glaucoma.

  Investigative ophthalmology & visual science 20081001

• Intraocular pressure-lowering efficacy of brinzolamide 1%/timolol 0.5% fixed combination compared with brinzolamide 1% and timolol 0.5%.

  Ophthalmology 20081001

• Side effects of commonly used glaucoma medications: comparison of tolerability, chance of discontinuation, and patient satisfaction.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20081001

• Long-term efficacy and safety of bimatoprost for intraocular pressure lowering in glaucoma and ocular hypertension: year 4.

  The British journal of ophthalmology 20081001

• Changes in intraocular pressure following a switch from latanoprost monotherapy to latanoprost/timolol fixed combination therapy in patients with primary open-angle glaucoma or ocular hypertension: results from a clinical practice database.

  Current medical research and opinion 20081001

• Evaluation of aqueous humor concentrations of Istalol and Betimol following a single ocular instillation in rabbit eyes.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081001

• [Cost-efficacy analysis of fixed combinations of prostaglandin/prostamide for treating glaucoma].

  Archivos de la Sociedad Espanola de Oftalmologia 20081001

• The effects of dorzolamide 2% and dorzolamide/timolol fixed combination on retinal and optic nerve head blood flow in primary open-angle glaucoma patients.

  Eye (London, England) 20080901

• Estimation of ocular rigidity based on measurement of pulse amplitude using pneumotonometry and fundus pulse using laser interferometry in glaucoma.

  Investigative ophthalmology & visual science 20080901

• Comparison of allergy rates in glaucoma patients receiving brimonidine 0.2% monotherapy versus fixed-combination brimonidine 0.2%-timolol 0.5% therapy.

  Current medical research and opinion 20080901

• A comparison of dorzolamide/timolol-fixed combination versus bimatoprost in patients with open-angle glaucoma who are poorly controlled on latanoprost.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080801

• 24-hour control of intraocular pressure with 2% dorzolamide/0.5% timolol fixed-combination ophthalmic solution in open-angle glaucoma.

  Current medical research and opinion 20080801

• [Triamcinolone in anterior chamber].

  Archivos de la Sociedad Espanola de Oftalmologia 20080801

• Observational study results in glaucoma patients undergoing a regimen replacement to fixed combination travoprost 0.004%/timolol 0.5% in Germany.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080801

• Ocular pharmacokinetic/pharmacodynamic modeling for multiple anti-glaucoma drugs.

  Biological & pharmaceutical bulletin 20080801

• Methylphenidate amplifies long-term plasticity in the hippocampus via noradrenergic mechanisms.

  Learning & memory (Cold Spring Harbor, N.Y.) 20080801

• Meta-analysis of 24-hour intraocular pressure studies evaluating the efficacy of glaucoma medicines.

  Ophthalmology 20080701

• [Comparison of intraocular pressure lowering efficacy of bimatoprost / timolol fixed combination and other glaucoma medications in the treatment of glaucoma].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20080701

• Atrial fibrillation, pharmacological cardioversion and topical ophthalmic beta-blocker use.

  International journal of cardiology 20080606

• Noradrenaline modulates neuronal responses to GABA in vestibular nuclei.

  Neuroscience 20080602

• Predicting intraocular pressure change before initiating therapy: timolol versus latanoprost.

  Acta ophthalmologica 20080601

• Success rates for switching to dorzolamide/timolol fixed combination in timolol responders who are insufficiently controlled by latanoprost monotherapy.

  Acta ophthalmologica 20080601

• Intraocular pressure reduction with travoprost/timolol fixed combination, with and without adjunctive brinzolamide, in glaucoma.

  Current medical research and opinion 20080601

• Mechanisms underlying mechanical responses to Ephedra herb of isolated rabbit urinary bladder and urethra, a possible stress urinary incontinence therapeutic.

  Journal of pharmacological sciences 20080601

• A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.

  Structure (London, England : 1993) 20080601

• [Influence on tear film after instillation of timolol maleate ophthalmic gel-forming solution examination by a tear film stability analysis system].

  Nippon Ganka Gakkai zasshi 20080601

• Effects of dorzolamide 2% added to timolol maleate 0.5% on intraocular pressure, retrobulbar blood flow, and the progression of visual field damage in patients with primary open-angle glaucoma: a single-center, 4-year, open-label study.

  Clinical therapeutics 20080601

• Extended delivery of ophthalmic drugs by silicone hydrogel contact lenses.

  Biomaterials 20080501

• Beta2-adrenergic receptor signaling mediates corneal epithelial wound repair.

  Investigative ophthalmology & visual science 20080501

• Carotid cavernous sinus fistula presenting with pulsating exophthalmos and secondary glaucoma.

  Journal of the Indian Medical Association 20080501

• A cost-effectiveness analysis of fixed-combination therapies in patients with open-angle glaucoma: a European perspective.

  Current medical research and opinion 20080401

• Rebound tonometry in conscious, conditioned mice avoids the acute and profound effects of anesthesia on intraocular pressure.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080401

• Latanoprost-induced stabilization of central visual function in patients with primary open-angle glaucoma.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080401

• Deep corneal calcification associated with preservative-free eyedrops and persistent epithelial defects.

  Cornea 20080401

• Effectiveness and safety of dorzolamide-timolol alone or combined with latanoprost in open-angle glaucoma or ocular hypertension.

  The Annals of pharmacotherapy 20080401

• Travoprost/timolol fixed combination.

  Expert opinion on pharmacotherapy 20080401

• Meta-analysis of randomized controlled trials comparing timolol with brimonidine in the treatment of glaucoma.

  Clinical & experimental ophthalmology 20080401

• Antioxidant activity of timolol on endothelial cells and its relevance for glaucoma course.

  Eye (London, England) 20080301

• Circadian changes of intraocular pressure and ocular perfusion pressure after timolol or latanoprost in Caucasians with normal-tension glaucoma.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20080301

• Cell culture models of the human cornea - a comparative evaluation of their usefulness to determine ocular drug absorption in-vitro.

  The Journal of pharmacy and pharmacology 20080301

• Normal-tension glaucoma.

  Ophthalmology 20080301

• Direct inhibition of N-methyl-D-aspartate (NMDA)-receptor function by antiglaucomatous beta-antagonists.

  Journal of pharmacological sciences 20080301

• Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma.

  Saudi medical journal 20080301

• The effect of timolol maleate on tear film break-up time in Nigerians.

  African journal of medicine and medical sciences 20080301

• Prophylactic use of timolol maleate to prevent intraocular pressure elevation after Nd-YAG laser posterior capsulotomy.

  International ophthalmology 20080201

• Takotsubo cardiomyopathy in a patient with postural tachycardia syndrome.

  Clinical autonomic research : official journal of the Clinical Autonomic Research Society 20080201

• Topical WIN55212-2 alleviates intraocular hypertension in rats through a CB1 receptor mediated mechanism of action.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080201

• Dorzolamide/timolol fixed combination versus latanoprost/timolol fixed combination in patients with primary open-angle glaucoma or ocular hypertension.

  Current eye research 20080201

• New drug information. Combigan.

  JAAPA : official journal of the American Academy of Physician Assistants 20080201

• Intraocular pressure elevation within the first 24 hours after cataract surgery in patients with glaucoma or exfoliation syndrome.

  Ophthalmology 20080101

• Inhibition of associative long-term depression by activation of beta-adrenergic receptors in rat hippocampal CA1 synapses.

  Journal of biomedical science 20080101

• Effect of macromer molecular weight on in vitro ophthalmic drug release from photo-crosslinked matrices.

  Acta biomaterialia 20080101

• Efficacy and safety of bimatoprost/timolol fixed combination in the treatment of glaucoma or ocular hypertension.

  Expert opinion on pharmacotherapy 20080101

• Comparison of the 24-hour intraocular pressure-lowering effects of latanoprost and dorzolamide/timolol fixed combination after 2 and 6 months of treatment.

  Ophthalmology 20080101

• Drug modification of angiogenesis in a rat cornea model.

  Investigative ophthalmology & visual science 20080101

• Comparison of the effects of dorzolamide-timolol fixed combination and brimonidine on intraocular pressure after phacoemulsification surgery.

  Eye & contact lens 20080101

• Treatment carryover impacts on effectiveness of intraocular pressure lowering agents, estimated by a discrete event simulation model.

  European journal of ophthalmology 20080101

• Comparison of intraocular pressure lowering effect of once daily morning vs evening dosing of latanoprost/timolol maleate combination.

  European journal of ophthalmology 20080101

• Bimatoprost/timolol fixed combination: a 3-month double-masked, randomized parallel comparison to its individual components in patients with glaucoma or ocular hypertension.

  Journal of glaucoma 20080101

• Comparison of ocular hypotensive effect and safety of brinzolamide and timolol added to latanoprost.

  Journal of glaucoma 20080101

• The effect of a single dose of topical 0.005% latanoprost and 2% dorzolamide/0.5% timolol combination on the blood-aqueous barrier in dogs: a pilot study.

  Veterinary ophthalmology 20080101

• Topical antiglaucoma medications and lacrimal drainage system obstruction.

  Ophthalmic plastic and reconstructive surgery 20080101

• Timolol concentrations in breast milk of a woman treated for glaucoma: calculation of neonatal exposure.

  Journal of glaucoma 20080101

• Is there still a role for treatment with beta-adrenoceptor antagonists in post-myocardial infarction patients with well-preserved left ventricular systolic function?

  Acute cardiac care 20080101

• Comparison of daytime efficacy and safety of dorzolamide/timolol maleate fixed combination versus latanoprost.

  European journal of ophthalmology 20080101

• [Late postoperative choroidal detachment].

  Klinika oczna 20080101

• Performing meta-analysis with incomplete statistical information in clinical trials.

  BMC medical research methodology 20080101

• A European perspective on costs and cost effectiveness of ophthalmic combinations in the treatment of open-angle glaucoma.

  European journal of ophthalmology 20080101

• Intraocular pressure control with latanoprost/timolol and travoprost/timolol fixed combinations : a retrospective, multicentre, cross-sectional study.

  Clinical drug investigation 20080101

• [Fixed combinations of glaucoma medications].

  Oftalmologia (Bucharest, Romania : 1990) 20080101

• Central retinal artery occlusion in a 28-year-old man after 10 days of smoking cessation.

  Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 20080101

• Effect on diurnal intraocular pressure of the fixed combination of latanoprost 0.005% and timolol 0.5% administered in the evening in glaucoma.

  Annals of ophthalmology (Skokie, Ill.) 20080101

• [The role of Cosopt in glaucoma treatment].

  Oftalmologia (Bucharest, Romania : 1990) 20080101

• [Analysis of the effectiveness of beta-blockers for intraocular pressure and visual field in primary open-angle glaucoma].

  Oftalmologia (Bucharest, Romania : 1990) 20080101

• Comparison of the effects of bimatoprost and a fixed combination of latanoprost and timolol on circadian intraocular pressure.

  Ophthalmology 20071201

• Costs and effectiveness of travoprost versus a dorzolamide + timolol fixed combination in first-line treatment of glaucoma: analysis conducted on the United Kingdom General Practitioner Research Database.

  Current medical research and opinion 20071201

• Comparative efficacy of pilocarpine, timolol and latanoprost in experimental models of glaucoma.

  Methods and findings in experimental and clinical pharmacology 20071201

• Timolol transport from microemulsions trapped in HEMA gels.

  Journal of colloid and interface science 20071101

• Effect of antiglaucoma agents on postoperative intraocular pressure after cataract surgery with Viscoat.

  Journal of cataract and refractive surgery 20071101

• Sustained ocular drug delivery from a temperature and pH triggered novel in situ gel system.

  Drug delivery 20071101

• Chitosan nanoparticles for prolonged delivery of timolol maleate.

  Drug development and industrial pharmacy 20071101

• [Acute closed-angle glaucoma after gynecological surgery under general anesthesia].

  Revista espanola de anestesiologia y reanimacion 20071101

• Effects of topical antiglaucoma medications on corneal epithelium as evaluated by gene expression patterns.

  Cornea 20071001

• Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination: randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens.

  Journal of cataract and refractive surgery 20071001

• Effects of beta-adrenergic antagonist on width of nasolacrimal drainage system lumen.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20071001

• [Intraocular pressure (IOP) in rabbits after application of amino acids taurine and arginine with betablocker timolol].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20070901

• [Additive therapy with carboanhydrase inhibitors for open angle glaucoma previously treated with timolol 0.5% drops].

  Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20070901

• Resting heart rate in cardiovascular disease.

  Journal of the American College of Cardiology 20070828

• Ocular comfort of combination glaucoma therapies: brimonidine 0.2%/timolol 0.5% compared with dorzolamide 2%/timolol 0.5%.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070801

• Poly(N-isopropylacrylamide)-chitosan as thermosensitive in situ gel-forming system for ocular drug delivery.

  Journal of controlled release : official journal of the Controlled Release Society 20070731

• Robustness testing of a chiral NACE method for R-timolol determination in S-timolol maleate and uncertainty assessment from quantitative data.

  Journal of pharmaceutical and biomedical analysis 20070727

• Timolol metabolism in human liver microsomes is mediated principally by CYP2D6.

  Drug metabolism and disposition: the biological fate of chemicals 20070701

• [Effect of the mixture of timoptol and amino acid taurine in the bioregulation of the intraocular pressure in rabbits].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20070701

• Special considerations in low-tension glaucoma.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20070601

• [Glaucoma--the underestimated risk].

  Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20070601

• Retrobulbar haemodynamic effects of the latanoprost/timolol and the dorzolamide/timolol fixed combinations in newly diagnosed glaucoma patients.

  International journal of clinical practice 20070501

• A cardiovascular benefit of ophthalmic beta-blockade.

  Age and ageing 20070501

• Intravascularly administered epinephrine, injected inadvertently as part of an epidural test dose, failed to elicit tachycardia in a patient using timolol eye drops.

  Anesthesia and analgesia 20070501

• Reduced ocular allergy with fixed-combination 0.2% brimonidine-0.5% timolol.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20070501

• A comparison of the safety and intraocular pressure lowering of bimatoprost/timolol fixed combination versus latanoprost/timolol fixed combination in patients with open-angle glaucoma.

  Current medical research and opinion 20070501

• Influence of ocular hypotensive eyedrops on intraocular pressure fluctuation with postural change in eyes with normal-tension glaucoma.

  American journal of ophthalmology 20070401

• Acute visual loss due to serous retinal detachment from acquired optic pit may be a rare presentation of primary open-angle glaucoma.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20070401

• Clinical inquiries. Are there big differences among beta-blockers in treating essential hypertension?

  The Journal of family practice 20070401

• Comparing the fixed combination brimonidine-timolol versus fixed combination dorzolamide-timolol in patients with elevated intraocular pressure.

  Current medical research and opinion 20070401

• Hypotony and choroidal detachment as a complication of topical combined timolol and dorzolamide.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070401

• NMR analysis of ion pair formation between timolol and sorbic acid in ophthalmic preparations.

  Journal of pharmaceutical and biomedical analysis 20070312

• Effect of 2% dorzolamide on retinal blood flow: a study on juvenile primary open-angle glaucoma patients already receiving 0.5% timolol.

  British journal of clinical pharmacology 20070301

• Visual field and intraocular pressure asymmetry in the low-pressure glaucoma treatment study.

  Ophthalmology 20070301

• Two patients with the von Szily reaction: herpetic keratitis and contralateral retinal necrosis.

  American journal of ophthalmology 20070301

• Cellular cytotoxicity of antiglaucoma drugs in cultured corneal endothelial cells.

  The Kaohsiung journal of medical sciences 20070301

• Ketopinic acid and diisoproylideneketogulonic acid as chiral ion-pair selectors in capillary electrophoresis. Enantiomeric impurity analysis of S-timolol and 1R,2S-ephedrine.

  Journal of chromatography. A 20070209

• A 6-month assessment of bimatoprost 0.03% vs timolol maleate 0.5%: hypotensive efficacy, macular thickness and flare in ocular-hypertensive and glaucoma patients.

  Eye (London, England) 20070201

• Comparison of the ocular hypotensive effects of bimatoprost and timolol-dorzolamide combination in patients with elevated intraocular pressure: a 6-month study.

  Acta ophthalmologica Scandinavica 20070201

• Travoprost 0.004%/timolol 0.5% fixed combination.

  Drugs of today (Barcelona, Spain : 1998) 20070201

• Latanoprost versus timolol gel-forming solution once daily in primary open-angle glaucoma or ocular hypertension.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20070201

• Sinoatrial block induced by timolol eyedrops.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20070201

• Measurement of inflammatory cytokines by multicytokine assay in tears of patients with glaucoma topically treated with chronic drugs.

  The British journal of ophthalmology 20070101

• Intraocular pressure-lowering effect of adding dorzolamide or latanoprost to timolol: a meta-analysis of randomized clinical trials.

  Ophthalmology 20070101

• Circadian intraocular pressure control with dorzolamide versus timolol maleate add-on treatments in primary open-angle glaucoma patients using latanoprost.

  Ophthalmic research 20070101

• A double-masked, randomized, parallel comparison of a fixed combination of bimatoprost 0.03%/timolol 0.5% with non-fixed combination use in patients with glaucoma or ocular hypertension.

  European journal of ophthalmology 20070101

• Ophthalmic timolol: plasma concentration and systemic cardiopulmonary effects.

  Scandinavian journal of clinical and laboratory investigation 20070101

• A 1-year study to compare the efficacy and safety of once-daily travoprost 0.004%/timolol 0.5% to once-daily latanoprost 0.005%/timolol 0.5% in patients with open-angle glaucoma or ocular hypertension.

  European journal of ophthalmology 20070101

• Pheochromocytoma presenting with bithalamic infarction, dementia, and increased intraocular pressure.

  Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20070101

• Tolerability, quality of life, and persistency of use in patients with glaucoma who are switched to the fixed combination of latanoprost and timolol.

  Advances in therapy 20070101

• A double-masked, randomized, parallel comparison of a fixed combination of bimatoprost 0.03%/timolol 0.5% with non-fixed combination use in patients with glaucoma or ocular hypertension.

  European journal of ophthalmology 20070101

• Membrane electrodes for determination of some beta-blocker drugs.

  Journal of AOAC International 20070101

• Effects of latanoprost, timolol and GLC756, a novel dopamine D(2) agonist and D(1) antagonist on LTC(4) release after rat mast cell activation.

  Clinical & experimental ophthalmology 20070101

• [Ultrastructural evaluation of mitomycin C toxic effects on the ciliary epithelium of normal rabbits eyes with and without aqueous humor suppressant treatment].

  Arquivos brasileiros de oftalmologia 20070101

• Rabbit's intraocular pressure after instillation of timolol and aminoacid lysine, arginine, glycine or taurine mixture.

  Bratislavske lekarske listy 20070101

• Effects of topical 2% dorzolamide hydrochloride alone and in combination with 0.5% timolol maleate on intraocular pressure in normal feline eyes.

  Veterinary ophthalmology 20070101

• The effect of ocular hypotensive agents on macula.

  Annals of ophthalmology (Skokie, Ill.) 20070101

• Conjunctival changes induced by prostaglandin analogues and timolol maleate: a histomorphometric study.

  Arquivos brasileiros de oftalmologia 20070101

• Effect of GLC756, a novel mixed dopamine D1 receptor antagonist and dopamine D2 receptor agonist, on TNF-alpha release in vitro from activated rat mast cells.

  Experimental eye research 20061201

• Travoprost compared with other prostaglandin analogues or timolol in patients with open-angle glaucoma or ocular hypertension: meta-analysis of randomized controlled trials.

  Clinical & experimental ophthalmology 20061101

• The state of being noninferior.

  Ophthalmology 20061101

• 24-Hour control with a latanoprost-timolol fixed combination vs timolol alone.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20061101

• Nitric oxide synthase in retina and optic nerve head of rat with increased intraocular pressure and effect of timolol.

  Brain research bulletin 20061016

• Transport of timolol and tilisolol in rabbit corneal epithelium.

  Biological & pharmaceutical bulletin 20061001

• Comments on The cost-effectiveness of bimatoprost, latanoprost and timolol in treatment of primary open angle glaucoma in five European countries.

  Current medical research and opinion 20061001

• Ocular powder: dry topical formulations of timolol are well tolerated in rabbits.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20061001

• A comparative analysis of the effects of the fixed combination of timolol and dorzolamide versus latanoprost plus timolol on ocular hemodynamics and visual function in patients with primary open-angle glaucoma.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20061001

• [Preparation and testing of buffered eye drops containing pilocarpine chloride with timolol maleate].

  Vojnosanitetski pregled 20061001

• In vivo confocal microscopic findings of interlamellar stromal keratopathy induced by elevated intraocular pressure.

  Journal of cataract and refractive surgery 20060901

• Successful management of orbital cellulitis and temporary visual loss after blepharoplasty.

  Plastic and reconstructive surgery 20060901

• Twice-daily 0.2% brimonidine-0.5% timolol fixed-combination therapy vs monotherapy with timolol or brimonidine in patients with glaucoma or ocular hypertension: a 12-month randomized trial.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20060901

• Travoprost versus latanoprost combinations in glaucoma: economic evaluation based on visual field deficit progression.

  Current medical research and opinion 20060901

• Comparison of the efficacy and safety of travoprost with a fixed-combination of dorzolamide and timolol in patients with open-angle glaucoma or ocular hypertension.

  Current medical research and opinion 20060901

• Promoting effect of borneol on the permeability of puerarin eye drops and timolol maleate eye drops through the cornea in vitro.

  Die Pharmazie 20060901

• Nonaqueous capillary electrophoresis method for the enantiomeric purity determination of S-timolol using heptakis(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin: validation using the accuracy profile strategy and estimation of uncertainty.

  Journal of chromatography. A 20060707

• Atishoo! Atishoo! we all fall down!

  Age and ageing 20060701

• Effects of topical hypotensive drugs on circadian IOP, blood pressure, and calculated diastolic ocular perfusion pressure in patients with glaucoma.

  Investigative ophthalmology & visual science 20060701

• Effects of topical antiglaucoma application on conjunctival impression cytology specimens.

  American journal of ophthalmology 20060701

• Open-angle glaucoma and cardiovascular mortality: the Blue Mountains Eye Study.

  Ophthalmology 20060701

• [The effect of glycine with timoptol on the rabbit IOP physiological values].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20060701

• Does timolol LA enhance the disrupting effect of travoprost on the blood-aqueous barrier?

  Acta ophthalmologica Scandinavica 20060601

• The effect of timolol-dorzolamide and timolol-pilocarpine combinations on ocular blood flow in patients with glaucoma.

  American journal of ophthalmology 20060601

• An evaluation of the rate of nonresponders to latanoprost therapy.

  Journal of glaucoma 20060601

• Effects of antiglaucoma drugs on collagen gel contraction mediated by human corneal fibroblasts.

  Journal of glaucoma 20060601

• Allergic contact dermatitis from timolol and dorzolamide eye drops.

  Contact dermatitis 20060601

• The effects of a timolol maleate gel-forming solution on normotensive beagle dogs.

  The Journal of veterinary medical science 20060601

• Screening for drug-induced spoliation of the hydrogel optic of the AlphaCor artificial cornea.

  Contact lens & anterior eye : the journal of the British Contact Lens Association 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• The cost-effectiveness of bimatoprost, latanoprost and timolol in treatment of primary open angle glaucoma in five European countries.

  Current medical research and opinion 20060501

• [Effect of topical glaucoma medications on optic disc topography in normal tension glaucoma].

  Nippon Ganka Gakkai zasshi 20060501

• Beta-blocker eye drops.

  Nursing times 20060501

• Syncope and falls due to timolol eye drops.

  BMJ (Clinical research ed.) 20060422

• A randomized, investigator-masked, 4-week study comparing timolol maleate 0.5%, brinzolamide 1%, and brimonidine tartrate 0.2% as adjunctive therapies to travoprost 0.004% in adults with primary open-angle glaucoma or ocular hypertension.

  Clinical therapeutics 20060401

• Effects of incorporated drugs on degradation of novel 2,2'-bis(2-oxazoline) linked poly(lactic acid) films.

  International journal of pharmaceutics 20060309

• Efficacy of latanoprost or fixed-combination latanoprost-timolol in patients switched from a combination of timolol and a nonprostaglandin medication.

  Ophthalmology 20060301

• A 6-week, double-masked, parallel-group study of the efficacy and safety of travoprost 0.004% compared with latanoprost 0:005%/timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension.

  Clinical therapeutics 20060301

• Latanoprost therapy reduces the levels of TGF beta 1 and gelatinases in the aqueous humour of patients with exfoliative glaucoma.

  Experimental eye research 20060201

• Effects of antiglaucoma drugs on calcium mobility in cultured corneal endothelial cells.

  The Kaohsiung journal of medical sciences 20060201

• A simple spectrophotometric method for the determination of beta-blockers in dosage forms.

  Journal of pharmaceutical and biomedical analysis 20060123

• Pharmacokinetics of timolol in aqueous humor sampled by microdialysis after topical administration of thermosetting gels.

  Biomedical chromatography : BMC 20060101

• A 12-week, randomized, double-masked, multicenter study of the fixed combination of latanoprost and timolol in the evening versus the individual components.

  Ophthalmology 20060101

• The state of being noninferior.

  Ophthalmology 20060101

• A comparison of the effects of 0.005% latanoprost and fixed combination dorzolamide/timolol on retrobulbar haemodynamics in previously untreated glaucoma patients.

  Current medical research and opinion 20060101

• [Reduction of the physiologic IOP value after instilation of the mixture of the 2 amino acid's (L-lysine and L-arginine) in timoptol--experiment on rabbit's].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20060101

• A comparison of travoprost, latanoprost, and the fixed combination of dorzolamide and timolol in patients with pseudoexfoliation glaucoma.

  European journal of ophthalmology 20060101

• Cost considerations in the medical management of glaucoma in the US: estimated yearly costs and cost effectiveness of bimatoprost compared with other medications.

  PharmacoEconomics 20060101

• Beta-blockers for the post-myocardial infarction patient: current clinical evidence and practical considerations.

  Reviews in cardiovascular medicine 20060101

• Prospective comparative switch study from timolol 0.5% and latanoprost 0.005% to bimatoprost 0.03%.

  Advances in therapy 20060101

• The fading of reported effectiveness. A meta-analysis of randomised controlled trials.

  BMC medical research methodology 20060101

• Effects of antiglaucoma drugs GLC756, a novel dopamine D2 agonist and D1 antagonist, and timolol on endotoxin-induced TNF-alpha release in serum of rats.

  European journal of ophthalmology 20060101

• A comparison of morning and evening instillation of a combination travoprost 0.004%/timolol 0.5% ophthalmic solution.

  European journal of ophthalmology 20060101

• Diagnostic and therapeutic challenges.

  Retina (Philadelphia, Pa.) 20060101

• Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs.

  Veterinary ophthalmology 20060101

• [Combined therapy in glaucoma treatment: travoprost 0.004% and brinzolamid].

  Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20060101

• Travoprost/timolol.

  Drugs & aging 20060101

• Topical brimonidine 0.2%/timolol 0.5% ophthalmic solution: in glaucoma and ocular hypertension.

  Drugs & aging 20060101

• Brimonidine/Timolol: a viewpoint by Richard Fiscella.

  Drugs & aging 20060101

• Brimonidine/Timolol: a viewpoint by Robert M. Feldman.

  Drugs & aging 20060101

• Brimonidine/Timolol: a viewpoint by Francisco J. Goñi.

  Drugs & aging 20060101

• [Effects of analysis of posterior subtenon injection of triamcinolone: a case series].

  Arquivos brasileiros de oftalmologia 20060101

• Topical dorzolamide 2%/timolol 0.5% ophthalmic solution: a review of its use in the treatment of glaucoma and ocular hypertension.

  Drugs & aging 20060101

• Effect and mechanism of betaxolol and timolol on vascular relaxation in isolated rabbit ciliary artery.

  Japanese journal of ophthalmology 20060101

• The efficacy and safety of timolol maleate versus brinzolamide each given twice daily added to travoprost in patients with ocular hypertension or primary open-angle glaucoma.

  European journal of ophthalmology 20060101

• A comparison of latanoprost monotherapy with a combination therapy of timolol/dorzolamide in patients with primary open-angle glaucoma.

  Annals of ophthalmology (Skokie, Ill.) 20060101

• Blockade of beta-adrenergic receptors prevents amphetamine-induced behavioural sensitization in rats: a putative role of the bed nucleus of the stria terminalis.

  The international journal of neuropsychopharmacology 20051201

• Application of substrate depletion assay for early prediction of nonlinear pharmacokinetics in drug discovery: assessment of nonlinearity of metoprolol, timolol, and propranolol.

  Journal of pharmaceutical sciences 20051201

• Continuous monitoring of circadian variations in intraocular pressure by telemetry system throughout a 12-week treatment with timolol maleate in rabbits.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201

• Physicochemical properties and in vivo assessment of timolol-loaded poly(D,L-lactide-co-glycolide) films for long-term intraocular pressure lowering effects.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201

• Dorzolamide and timolol saves retinal ganglion cells in glaucomatous adult rats.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201

• Comparison of the effects of brimonidine 0.2% and timolol 0.5% on retinal nerve fiber layer thickness in ocular hypertensive patients: a prospective, unmasked study.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201

• Comparison of latanoprost monotherapy and combined therapy of 0.5% timolol and 1% dorzolamide in chronic primary angle-closure glaucoma (CACG) in Japanese patients.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051201

• Efficacy and systemic side-effects of topical 0.5% timolol aqueous solution and 0.1% timolol hydrogel.

  Acta ophthalmologica Scandinavica 20051201

• The influence of diclofenac ophthalmic solution on the intraocular pressure-lowering effect of topical 0.5% timolol and 0.005% latanoprost in primary open-angle glaucoma patients.

  Experimental eye research 20051101

• Toxic epidermal necrolysis secondary to timolol, dorzolamide, and latanoprost eyedrops.

  Journal of the American Academy of Dermatology 20051101

• Analytic review of bimatoprost, latanoprost and travoprost in primary open angle glaucoma.

  Current medical research and opinion 20051101

• Effects of anti-glaucoma drugs timolol and GLC756, a novel mixed dopamine D2 receptor agonist and D1 receptor antagonist, on endotoxin-induced-uveitis and -arthritis in rats.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20051101

• Effects of a non-selective beta-blocker on adult rat anterograde axonal transport and retinal ganglion layer after increased intraocular pressure.

  Histology and histopathology 20051001

• A three-month, multicenter, double-masked study of the safety and efficacy of travoprost 0.004%/timolol 0.5% ophthalmic solution compared to travoprost 0.004% ophthalmic solution and timolol 0.5% dosed concomitantly in subjects with open angle glaucoma or ocular hypertension.

  Journal of glaucoma 20051001

• Effect of dorzolamide and timolol on ocular blood flow in patients with primary open angle glaucoma and ocular hypertension.

  The British journal of ophthalmology 20051001

• The efficacy and ocular discomfort of substituting brinzolamide for dorzolamide in combination therapy with latanoprost, timolol, and dorzolamide.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20051001

• A randomized trial assessing dorzolamide in patients with glaucoma who are younger than 6 years.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20050901

• Controlling drug release from imprinted hydrogels by modifying the characteristics of the imprinted cavities.

  Macromolecular bioscience 20050812

• Novel antiglaucoma prodrugs and codrugs of ethacrynic acid.

  Bioorganic & medicinal chemistry letters 20050801

• Efficacy and safety of a fixed combination of travoprost 0.004%/timolol 0.5% ophthalmic solution once daily for open-angle glaucoma or ocular hypertension.

  American journal of ophthalmology 20050801

• Glaucoma pharmacotherapy: implications for flying fitness.

  Aviation, space, and environmental medicine 20050801

• Brimonidine and timolol fixed-combination therapy versus monotherapy: a 3-month randomized trial in patients with glaucoma or ocular hypertension.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050801

• Reversal of laser in situ keratomileusis-induced ectasia with intraocular pressure reduction.

  Journal of cataract and refractive surgery 20050801

• Bilateral retinal venous occlusion in pigmentary glaucoma.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20050701

• Intraocular pressure-lowering effects of all commonly used glaucoma drugs: a meta-analysis of randomized clinical trials.

  Ophthalmology 20050701

• An uncommon presentation of acute angle closure glaucoma.

  The Journal of emergency medicine 20050701

• The safety and efficacy of travoprost 0.004%/timolol 0.5% fixed combination ophthalmic solution.

  American journal of ophthalmology 20050701

• Twenty-four-hour control with latanoprost-timolol-fixed combination therapy vs latanoprost therapy.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20050701

• Modern alchemy: fixed combinations of glaucoma drugs.

  American journal of ophthalmology 20050701

• Sympathetic innervation of ciliary muscle and oculomotor function in emmetropic and myopic young adults.

  Vision research 20050601

• Cost considerations of the new fixed combinations for glaucoma medical therapy.

  Journal of clinical pharmacy and therapeutics 20050601

• How to control measurement variation in estimating the mean intraocular pressure reducing effect at a specific point in time.

  Contemporary clinical trials 20050601

• Effects of antiglaucoma drugs timolol and GLC756, a novel dopamine D2 agonist and D1 antagonist, on endotoxin-induced-uveitis in rats.

  Experimental eye research 20050601

• Efficacy of the dorzolamide/timolol fixed combination versus latanoprost in the treatment of ocular hypertension or glaucoma: combined analysis of pooled data from two large randomized observer and patient-masked studies.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050601

• Ocular release of timolol from molecularly imprinted soft contact lenses.

  Biomaterials 20050401

• The effect of combination pharmacotherapy on the prescription trends of glaucoma medications.

  Journal of glaucoma 20050401

• Topically administered timolol and dorzolamide reduce intraocular pressure and protect retinal ganglion cells in a rat experimental glaucoma model.

  The British journal of ophthalmology 20050401

• Pharmacokinetic and pharmacodynamic analysis of systemic effect of topically applied timolol maleate ophthalmic gelling vehicle (Rysmon TG).

  Current eye research 20050401

• Origin and pharmacological response of atrial tachyarrhythmias induced by activation of mediastinal nerves in canines.

  Autonomic neuroscience : basic & clinical 20050331

• The Low-pressure Glaucoma Treatment Study (LoGTS) study design and baseline characteristics of enrolled patients.

  Ophthalmology 20050301

• Modeling the electrophoretic mobility of beta-blockers in capillary electrophoresis using artificial neural networks.

  Farmaco (Societa chimica italiana : 1989) 20050301

• The effect of a beta-adrenoceptor antagonist on accommodative adaptation in Hong Kong children.

  Current eye research 20050301

• Timolol LA: a double-masked, active-controlled, randomized, crossover, comfort, ocular safety, and systemic bioavailability study in healthy volunteers.

  Current medical research and opinion 20050301

• [The rabbit IOP and pupil values after application of aminoacid L-lysine and antiglaucomatic Timoptol mixture].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20050301

• Effect of multipurpose solutions for contact lens care on the in vitro drug-induced spoliation of poly(2-hydroxyethyl methacrylate) in simulated aqueous humour.

  Contact lens & anterior eye : the journal of the British Contact Lens Association 20050301

• Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system.

  International journal of pharmaceutics 20050216

• Calcitonin gene-related peptide in vivo positive inotropy is attributable to regional sympatho-stimulation and is blunted in congestive heart failure.

  Circulation research 20050204

• Comparison of additional intraocular pressure-lowering effects of latanoprost vs brimonidine in primary open-angle glaucoma patients with intraocular pressure uncontrolled by timolol-dorzolamide combination.

  Eye (London, England) 20050201

• Alphagan allergy may increase the propensity for multiple eye-drop allergy.

  Eye (London, England) 20050201

• Tales of two drugs.

  Journal of glaucoma 20050201

• Degree of angle closure and the intraocular pressure-lowering effect of latanoprost in subjects with chronic angle-closure glaucoma.

  Ophthalmology 20050201

• Bimatoprost versus timolol and dorzolamide.

  Ophthalmology 20050201

• Comparison of the efficacy and safety of dorzolamide 2% when added to brimonidine 0.2% or timolol maleate 0.5% in patients with primary open-angle glaucoma.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050201

• Brimonidine 0.2% vs unoprostone 0.15% both added to timolol maleate 0.5% given twice daily to patients with primary open-angle glaucoma or ocular hypertension.

  Eye (London, England) 20050101

• Configuration of the drainage angle, intraocular pressure, and optic disc cupping in subjects with chronic angle-closure glaucoma.

  Ophthalmology 20050101

• Bronchial reactivity in healthy individuals undergoing long-term topical treatment with beta-blockers.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20050101

• [IOP in rabbits after instillation of a mixture of the antiglaucomatic Cosopt and the aminoacid L-argininin HCL into the conjunctival sac].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20050101

• Safety and efficacy of bimatoprost 0.03% versus timolol maleate 0.5%/dorzolamide 2% fixed combination.

  European journal of ophthalmology 20050101

• 12-week study comparing the fixed combination of brimonidine and timolol with concomitant use of the individual components in patients with glaucoma and ocular hypertension.

  European journal of ophthalmology 20050101

• [Complete atrioventricular block secondary to application of timolol eyedrops: importance of the preanesthetic interview].

  Revista espanola de anestesiologia y reanimacion 20050101

• Comparative study on the combined effects of bunazosin and nipradilol or timolol on intraocular pressure in normotensive rabbits.

  Japanese journal of ophthalmology 20050101

• Comparative analysis of the efficacy and safety of latanoprost, travoprost and the fixed combination timolol-dorzolamide; a prospective, randomized, masked, cross-over design study.

  Oftalmologia (Bucharest, Romania : 1990) 20050101

• [Lethal polypharmacy in a patient with arterial hypertension].

  Deutsche medizinische Wochenschrift (1946) 20041210

• Daytime diurnal curve comparison between the fixed combinations of latanoprost 0.005%/timolol maleate 0.5% and dorzolamide 2%/timolol maleate 0.5%.

  Eye (London, England) 20041201

• A comparison of the effects of dorzolamide/timolol fixed combination versus latanoprost on intraocular pressure and pulsatile ocular blood flow in primary open-angle glaucoma patients.

  Acta ophthalmologica Scandinavica 20041201

• Nonequivalence behavior studies for the direct determination of enantiomeric purity and absolute configuration of timolol by NMR.

  Die Pharmazie 20041201

• Two-year follow-up of latanoprost 0.005% monotherapy after changing from previous glaucoma therapies.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20041201

• The effects on the intraocular pressure and visual field resulting from a switch in the treatment from timolol to betaxolol.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20041201

• Development of cultured rabbit corneal epithelium for drug permeation studies: a comparison with excised rabbit cornea.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20041201

• Falls in three patients due to timolol eye drops, tolterodine, and flecainide.

  The journals of gerontology. Series A, Biological sciences and medical sciences 20041201

• Persistency and treatment failure in newly diagnosed open angle glaucoma patients in the United Kingdom.

  The British journal of ophthalmology 20041101

• [Comparison of once-daily nonpreserved timolol and timolol maleate gel-forming solution associated with latanoprost].

  Journal francais d'ophtalmologie 20041101

• A three-year prospective, randomized and open comparison between latanoprost and timolol in Japanese normal-tension glaucoma patients.

  Eye (London, England) 20041001

• Efficacy and safety of the latanoprost/timolol maleate fixed combination vs concomitant brimonidine and latanoprost therapy.

  Eye (London, England) 20041001

• Short term efficacy and safety in glaucoma patients changed to the latanoprost 0.005%/timolol maleate 0.5% fixed combination from monotherapies and adjunctive therapies.

  The British journal of ophthalmology 20041001

• Switching from latanoprost to fixed-combination latanoprost-timolol: a 21-day, randomized, double-masked, active-control study in patients with glaucoma and ocular hypertension.

  Clinical therapeutics 20041001

• [Measurement of corneal thickness in cases where tonometry is contraindicated].

  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20041001

• Intraocular pressure and safety in glaucoma patients switching to latanoprost/timolol maleate fixed combination from mono- and adjunctive therapies.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20041001

• In vitro evaluation of a hydroxypropyl cellulose gel system for transdermal delivery of timolol.

  Current drug delivery 20041001

• Diurnal intraocular pressure reduction with latanoprost 0.005% compared to timolol maleate 0.5% as monotherapy in subjects with exfoliation glaucoma.

  Eye (London, England) 20040901

• A 6-month randomized clinical trial of bimatoprost 0.03% versus the association of timolol 0.5% and latanoprost 0.005% in glaucomatous patients.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20040901

• Comparison of the nocturnal effects of once-daily timolol and latanoprost on intraocular pressure.

  American journal of ophthalmology 20040901

• Concomitant administration of travoprost and brinzolamide versus fixed latanoprost/timolol combined therapy: three-month comparison of efficacy and safety.

  Current medical research and opinion 20040901

• Comparing the fixed combination dorzolamide-timolol (Cosopt) to concomitant administration of 2% dorzolamide (Trusopt) and 0.5% timolol -- a randomized controlled trial and a replacement study.

  Journal of clinical pharmacy and therapeutics 20040801

• Low incidence of iris pigmentation and eyelash changes in 2 randomized clinical trials with unoprostone isopropyl 0.15%.

  Ophthalmology 20040801

• [Short and long-term hypotensive effect of timolol-gel and latanoprost instillation in normal-tension glaucoma].

  Nippon Ganka Gakkai zasshi 20040801

• A comparison of the fixed combination of latanoprost and timolol with the unfixed combination of brimonidine and timolol in patients with elevated intraocular pressure. A six month, evaluator masked, multicentre study in Europe.

  The British journal of ophthalmology 20040701

• [Comparison of the effects of latanoprost and timolol gel-forming solution on diurnal variation of intraocular pressure in normal-tension glaucoma].

  Nippon Ganka Gakkai zasshi 20040701

• Inhibitory effects of anti-glaucoma drugs on corneal epithelial migration in a rabbit organ culture system.

  Journal of glaucoma 20040601

• Effects on aqueous flow of dorzolamide combined with either timolol or acetazolamide.

  Journal of glaucoma 20040601

• Accelerated idioventricular rhythm associated to ophthalmic timolol/dorzolamide solution.

  International journal of cardiology 20040601

• Cultivation and characterization of a bovine in vitro model of the cornea.

  Die Pharmazie 20040601

• Lichenoid drug eruption secondary to topical timolol and dorzolamide eye-drops.

  The Australasian journal of dermatology 20040501

• Conjunctival proinflammatory and proapoptotic effects of latanoprost and preserved and unpreserved timolol: an ex vivo and in vitro study.

  Investigative ophthalmology & visual science 20040501

• Immediate postoperative use of a topical agent to prevent intraocular pressure elevation after pars plana vitrectomy with gas tamponade.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20040501

• Ocular hypotensive effect and safety of brinzolamide ophthalmic solution in open angle glaucoma patients.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20040501

• Comparison of latanoprost with fixed-combination dorzolamide and timolol in adult patients with elevated intraocular pressure: an eight-week, randomized, open-label, parallel-group, multicenter study in Latin America.

  Clinical therapeutics 20040501

• [Comparison of the effectiveness of a mixture of 10% L-arginine and HCl combined with 0.5% Timoptol and with 2% Trusopt: and the individual components on intraocular pressure in an experiment on rabbits].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20040501

• Is addition of a third or fourth antiglaucoma medication effective?

  Journal of glaucoma 20040401

• Dorzolamide/Timolol fixed combination versus concomitant administration of brimonidine and timolol in patients with elevated intraocular pressure: a 3-month comparison of efficacy, tolerability, and patient-reported measures.

  Journal of glaucoma 20040401

• An evaluation of the fixed-combination of latanoprost and timolol for use in open-angle glaucoma and ocular hypertension.

  Expert opinion on pharmacotherapy 20040401

• Binding affinities of ocular hypotensive beta-blockers levobetaxolol, levobunolol, and timolol at endogenous guinea pig beta-adrenoceptors.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20040401

• A 12-month, multicenter, randomized, double-masked, parallel-group comparison of timolol-LA once daily and timolol maleate ophthalmic solution twice daily in the treatment of adults with glaucoma or ocular hypertension.

  Clinical therapeutics 20040401

• Improvement of the ocular bioavailability of timolol by sorbic acid.

  International journal of pharmaceutics 20040319

• The nature of backbone monomers determines the performance of imprinted soft contact lenses as timolol drug delivery systems.

  Biomaterials 20040301

• Ocular blood flow and systemic blood pressure in patients with primary open-angle glaucoma and ocular hypertension.

  Investigative ophthalmology & visual science 20040301

• 24-Hour IOP control with once-daily bimatoprost, timolol gel-forming solution, or latanoprost: a 1-month, randomized, comparative clinical trial.

  Survey of ophthalmology 20040301

• Two-year double-masked comparison of bimatoprost with timolol in patients with glaucoma or ocular hypertension.

  Survey of ophthalmology 20040301

• Intraocular pressure-reducing effects and safety of latanoprost versus timolol in patients with chronic angle-closure glaucoma.

  Ophthalmology 20040301

• Studies on the mechanism of action of timolol and on the effects of suppression and redirection of aqueous flow on outflow facility.

  Experimental eye research 20040301

• [Diffusion behaviors of drugs in thermosensitive in situ gels].

  Yao xue xue bao = Acta pharmaceutica Sinica 20040301

• Effectiveness of levobetaxolol and timolol at blunting retinal ischaemia is related to their calcium and sodium blocking activities: relevance to glaucoma.

  Brain research bulletin 20040215

• Chemometric determination of amiloride hydrochloride, atenolol, hydrochlorothiazide and timolol maleate in synthetic mixtures and pharmaceutical formulations.

  Journal of pharmaceutical and biomedical analysis 20040204

• Efficacy of bunazosin hydrochloride 0.01% as adjunctive therapy of latanoprost or timolol.

  Journal of glaucoma 20040201

• A 12 week study comparing the fixed combination of latanoprost and timolol with the concomitant use of the individual components in patients with open angle glaucoma and ocular hypertension.

  The British journal of ophthalmology 20040201

• Optic nerve oxygen tension: the effects of timolol and dorzolamide.

  The British journal of ophthalmology 20040201

• Crossover comparison of timolol and latanoprost in chronic primary angle-closure glaucoma.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20040201

• Efficacy and tolerability of the dorzolamide 2%/timolol 0.5% combination (COSOPT) versus 0.005% (XALATAN) in the treatment of ocular hypertension or glaucoma: results from two randomized clinical trials.

  Acta ophthalmologica Scandinavica 20040201

• Efficacy and safety of the fixed combinations latanoprost/timolol versus dorzolamide/timolol in patients with elevated intraocular pressure.

  Ophthalmology 20040201

• Brimonidine and latanoprost as adjunctive therapy.

  Ophthalmology 20040201

• Randomised controlled trial comparing the effect of brimonidine and timolol on visual field loss after acute primary angle closure.

  The British journal of ophthalmology 20040101

• Persistency with latanoprost or timolol in primary open-angle glaucoma suspects.

  American journal of ophthalmology 20040101

• Binding affinity of bunazosin, dorzolamide, and timolol to synthetic melanin.

  Japanese journal of ophthalmology 20040101

• [Long-term efficacy and safety of combined topical antiglaucoma therapy--timolol & unoprostone vs. betaxolol & unoprostone].

  Nippon Ganka Gakkai zasshi 20040101

• Effects of topical nipradilol and timolol maleate on intraocular pressure, facility of outflow, arterial blood pressure and pulse rate in dogs.

  Veterinary ophthalmology 20040101

• [Timolol topical ophthalmic combination].

  Oftalmologia (Bucharest, Romania : 1990) 20040101

• [Structural and immunohistochemical changes of conjunctiva induced by topical glaucoma medication].

  Oftalmologia (Bucharest, Romania : 1990) 20040101

• [Timolol 0.5%/dorzolamide 2% fixed combination versus timolol 0.5%/pilocarpine 2% fixed combination in primary open-angle glaucoma or ocular hypertensive patients].

  Klinika oczna 20040101

• Efficacy of latanoprost and timolol maleate in black and white patients.

  Advances in therapy 20040101

• Vitamin B2-sensitised photooxidation of the ophthalmic drugs Timolol and Pindolol: kinetics and mechanism.

  Redox report : communications in free radical research 20040101

• [Latanoprost topical ophthalmic combinations].

  Oftalmologia (Bucharest, Romania : 1990) 20040101

• In vitro effects of preserved and unpreserved antiglaucoma drugs on apoptotic marker expression by human trabecular cells.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20031201

• A 3-month randomized controlled trial of bimatoprost (LUMIGAN) versus combined timolol and dorzolamide (Cosopt) in patients with glaucoma or ocular hypertension.

  Ophthalmology 20031201

• Pooled-data analysis of three randomized, double-masked, six-month studies comparing intraocular pressure-reducing effects of latanoprost and timolol in patients with ocular hypertension.

  Journal of glaucoma 20031201

• Rate of response to latanoprost or timolol in patients with ocular hypertension or glaucoma.

  Journal of glaucoma 20031201

• Ocular factors relevant to anti-glaucomatous eyedrop-related keratoepitheliopathy.

  Journal of glaucoma 20031201

• Comparison of the short-term effects on the human corneal surface of topical timolol maleate with and without benzalkonium chloride.

  Journal of glaucoma 20031201

• Contrast sensitivity improves after brimonidine therapy in primary open angle glaucoma: a case for neuroprotection.

  The British journal of ophthalmology 20031201

• Regulation of glucose kinetics during intense exercise in humans: effects of alpha- and beta-adrenergic blockade.

  Metabolism: clinical and experimental 20031201

• Transdermal delivery of timolol and atenolol using electroporation and iontophoresis in combination: a mechanistic approach.

  Pharmaceutical research 20031201

• A study of replacement of timolol-pilocarpine with latanoprost in pseudoexfoliation glaucoma.

  Collegium antropologicum 20031201

• Atrial fibrillation (acute).

  Clinical evidence 20031201

• Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface.

  Cornea 20031101

• Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats.

  Psychopharmacology 20031001

• Evaluation of retinal haemodynamics and retinal function after application of dorzolamide, timolol and latanoprost in newly diagnosed open-angle glaucoma patients.

  Acta ophthalmologica Scandinavica 20031001

• In vitro effects of preserved or preservative-free antiglaucoma medications on human complement system.

  Current eye research 20031001

• A six-week, parallel, randomized, double-blind study comparing the efficacy and safety of the 0.5% timolol/2.0% MK-507 combination b.i.d. to the concomitant administration of 0.5% timolol b.i.d. and 2.0% MK-507 b.i.d.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031001

• Timolol + latanoprost: new preparation. Last-resort eye drops.

  Prescrire international 20031001

• Prescription of topical antiglaucoma agents for patients with contraindications to beta-blockers.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20031001

• [A combination of timoptol and L-arginine HCl: a regulator of intraocular pressure in rabbits].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20030901

• Effect of a fixed dorzolamide-timolol combination on intraocular pressure after small-incision cataract surgery with Viscoat.

  Journal of cataract and refractive surgery 20030901

• ESCRS Binkhorst lecture 2002: Pseudophakic preservative maculopathy.

  Journal of cataract and refractive surgery 20030901

• [Effects of ocular hypotensive agents on the circadian rhythm in intraocular pressure in rabbits as measured by telemetry].

  Nippon Ganka Gakkai zasshi 20030901

• AC/A ratios in myopic and emmetropic Hong Kong children and the effect of timolol.

  Clinical & experimental optometry 20030901

• Iontophoretic in vivo transdermal delivery of beta-blockers in hairless rats and reduced skin irritation by liposomal formulation.

  Pharmaceutical research 20030901

• Effects of burst stimulation during ventricular fibrillation on cardiac function after defibrillation.

  American journal of physiology. Heart and circulatory physiology 20030801

• Inhibition of neutrophil migration and oxygen free radical release by metipranolol and timolol.

  Pharmacology 20030801

• Ocular toxicity of some corneal penetration enhancers evaluated by electrophysiology measurements on isolated rabbit corneas.

  Toxicology in vitro : an international journal published in association with BIBRA 20030801

• Timolol 0.5%/dorzolamide 2% fixed combination versus timolol 0.5%/pilocarpine 2% fixed combination in primary open-angle glaucoma or ocular hypertensive patients.

  Acta ophthalmologica Scandinavica 20030801

• Aqueous humour flow after a single oral dose of isosorbide-5-mononitrate in healthy volunteers.

  Acta ophthalmologica Scandinavica 20030801

• Binding characteristics of fluoroquinolones to synthetic levodopa melanin.

  The Journal of pharmacy and pharmacology 20030801

• Real-time direct measurement of nitric oxide in bovine perfused eye trabecular meshwork using a clark-type electrode.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030801

• Mass spectrometric study of the photooxidation of the ophthalmic drugs timolol and pindolol.

  Die Pharmazie 20030801

• Twenty-four-hour diurnal curve comparison of commercially available latanoprost 0.005% versus the timolol and dorzolamide fixed combination.

  Ophthalmology 20030701

• Rapid and sensitive HPLC method for the simultaneous determination of dorzolamide hydrochloride and timolol maleate in eye drops with diode-array and UV detection.

  Die Pharmazie 20030701

• Enhancer effects on in vitro corneal permeation of timolol and acyclovir.

  Die Pharmazie 20030701

• Peak pressures: crossover study of timolol and latanoprost.

  European journal of ophthalmology 20030701

• Efficacy and safety of timolol maleate/latanoprost fixed combination versus timolol maleate and brimonidine given twice daily.

  Acta ophthalmologica Scandinavica 20030601

• Human lens epithelial cell damage and stimulation of their secretion of chemical mediators by benzalkonium chloride rather than latanoprost and timolol.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20030601

• Effects of commercial antiglaucoma drugs to glutamate-induced [Ca2+)]i increase in cultured neuroblastoma cells.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030601

• [Influence of rhinologic usual and unusual drugs on fibroblasts from nasal polyps in cell culture].

  Laryngo- rhino- otologie 20030601

• Atrial fibrillation (acute).

  Clinical evidence 20030601

• Unoprostone as adjunctive therapy to timolol: a double masked randomised study versus brimonidine and dorzolamide.

  The British journal of ophthalmology 20030501

• The efficacy and safety of brimonidine 0.2% compared with timolol 0.5% in glaucoma: a randomized clinical trial on Taiwanese patients.

  Journal of the Chinese Medical Association : JCMA 20030501

• Polymeric matrix membrane sensors for sensitive potentiometric determination of some beta-blockers in pharmaceutical preparations.

  Journal of pharmaceutical and biomedical analysis 20030424

• The beta-adrenoceptor antagonists metipranolol and timolol are retinal neuroprotectants: comparison with betaxolol.

  Experimental eye research 20030401

• The effect of latanoprost, brimonidine, and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with glaucoma or ocular hypertension.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20030401

• Comparison of the efficacy of the fixed-combination timolol/dorzolamide versus concomitant administration of timolol and dorzolamide.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030401

• Effect of changing from concomitant timolol pilocarpine to bimatoprost monotherapy on ocular blood flow and IOP in primary chronic angle closure glaucoma.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030401

• Transdermal delivery of timolol by electroporation through human skin.

  Journal of controlled release : official journal of the Controlled Release Society 20030307

• Dorzolamide/timolol combination versus concomitant administration of brimonidine and timolol: six-month comparison of efficacy and tolerability.

  Ophthalmology 20030301

• Vitrectomy for phacolytic glaucoma in a patient with ectopia lentis et pupillae.

  Eye (London, England) 20030301

• Four years later: a clinical update on latanoprost.

  European journal of ophthalmology 20030301

• Timolol 0.5%/dorzolamide 2% fixed combination vs timolol maleate 0.5% and unoprostone 0.15% given twice daily to patients with primary open-angle glaucoma or ocular hypertension.

  American journal of ophthalmology 20030201

• Spectrophotometric methods for determination of enalapril and timolol in bulk and in drug formulations.

  Analytical and bioanalytical chemistry 20030201

• [Glaucoma: an ocular blood flow disorder?].

  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20030201

• A randomised, double masked, multicentre clinical trial comparing bimatoprost and timolol for the treatment of glaucoma and ocular hypertension.

  The British journal of ophthalmology 20030101

• Characteristic effects of alpha1-beta1,2-adrenergic blocking agent, carvedilol, on [Ca2+]i in ventricular myocytes compared with those of timolol and atenolol.

  Circulation journal : official journal of the Japanese Circulation Society 20030101

• Comparison of efficacy and tolerability between two gel-forming timolol maleate ophthalmic solutions in patients with glaucoma or ocular hypertension.

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20030101

• The efficacy and safety of the timolol/dorzolamide fixed combination vs latanoprost in exfoliation glaucoma.

  Eye (London, England) 20030101

• Nurse prescribing in glaucoma.

  Eye (London, England) 20030101

• Influence of topical betaxolol and timolol on visual field in Japanese open-angle glaucoma patients.

  Japanese journal of ophthalmology 20030101

• Experience with COSOPT, the fixed combination of timolol and dorzolamide, gained in Swiss ophthalmologists' offices.

  Current medical research and opinion 20030101

• Brimonidine Purite and bimatoprost compared with timolol and latanoprost in patients with glaucoma and ocular hypertension.

  Advances in therapy 20030101

• Changing antiglaucoma therapy from timolol to betaxolol: effect on ocular blood flow.

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20030101

• Latanoprost : an update of its use in glaucoma and ocular hypertension.

  Drugs & aging 20030101

• The free amino acids and the aqueous humor pH after antiglaucomatics in vitro.

  Bratislavske lekarske listy 20030101

• Comparison of brimonidine/latanoprost and timolol/dorzolamide: two randomized, double-masked, parallel clinical trials.

  Advances in therapy 20030101

• Experience with Cosopt, the fixed combination of timolol and dorzolamide, after switch from free combination of timolol and dorzolamide, in Swiss ophthalmologists' offices.

  Current medical research and opinion 20030101

• Response to travoprost in black and nonblack patients with open-angle glaucoma or ocular hypertension.

  Advances in therapy 20030101

• Interventions for normal tension glaucoma.

  The Cochrane database of systematic reviews 20030101

• [A differentiated approach to the treatment of normal-pressure glaucoma].

  Vestnik oftalmologii 20030101

• Hypotony and choroidal effusion induced by topical timolol and dorzolamide in patients with previous glaucoma drainage device implantation.

  Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye 20030101

• Protective effects of timolol against the neuronal damage induced by glutamate and ischemia in the rat retina.

  Brain research 20021220

• Cloning, pharmacological characterization, and polymorphism screening of the guinea pig beta(2)-adrenoceptor.

  European journal of pharmacology 20021213

• Choroidal detachment induced by dorzolamide 20 years after cataract surgery.

  The British journal of ophthalmology 20021201

• A comparison of the effects on intraocular pressure of latanoprost 0.005% and the fixed combination of dorzolamide 2% and timolol 0.5% in patients with open-angle glaucoma.

  Acta ophthalmologica Scandinavica 20021201

• Evaluation of the intraocular pressure-reducing effect of latanoprost as monotherapy in open-angle glaucoma.

  Collegium antropologicum 20021201

• A prospective, long-term, randomized study of the efficacy and safety of the drug combination pilocarpine 1% with clonidine 0.06% or clonidine 0.125% versus timolol 0.25%.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20021201

• [Drug therapy for residual angle-closure glaucoma after laser iridectomy].

  [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20021201

• Myopia: attempts to arrest progression.

  The British journal of ophthalmology 20021101

• Primary glaucoma in Burmese cats.

  Australian veterinary journal 20021101

• A comparison of the fixed combination of latanoprost and timolol with its individual components.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20021101

• Timolol uptake and release by imprinted soft contact lenses made of N,N-diethylacrylamide and methacrylic acid.

  Journal of controlled release : official journal of the Controlled Release Society 20021004

• Soft contact lenses capable of sustained delivery of timolol.

  Journal of pharmaceutical sciences 20021001

• One-year, randomized study comparing bimatoprost and timolol in glaucoma and ocular hypertension.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20021001

• Progression of retinal nerve fibre layer damage in betaxolol- and timolol-treated glaucoma patients.

  Acta ophthalmologica Scandinavica 20021001

• Singlet molecular oxygen generation and quenching by the antiglaucoma ophthalmic drugs, Timolol and Pindolol.

  Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20021001

• Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model.

  Vision research 20020901

• Effect of beta-adrenoceptor antagonists on autonomic control of ciliary smooth muscle.

  Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) 20020901

• Sympathetic control of accommodation: evidence for inter-subject variation.

  Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) 20020901

• Calculation of electrophoretic mobility in mixed solvent buffers in capillary zone electrophoresis using a mixture response surface method.

  The Analyst 20020901

• Comparison of the neuroprotective effects of adrenoceptor drugs in retinal cell culture and intact retina.

  Investigative ophthalmology & visual science 20020801

• Discontinuation rates of topical glaucoma medications in a managed care population.

  The American journal of managed care 20020801

• Identification and characterization of the ocular hypotensive efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist, and AL-6598, a DP prostaglandin receptor agonist.

  Survey of ophthalmology 20020801

• The effect of latanoprost compared with timolol in African-American, Asian, Caucasian, and Mexican open-angle glaucoma or ocular hypertensive patients.

  Survey of ophthalmology 20020801

• The effect of latanoprost on circadian intraocular pressure.

  Survey of ophthalmology 20020801

• Bimatoprost and travoprost: a review of recent studies of two new glaucoma drugs.

  Survey of ophthalmology 20020801

• Efficacy of latanoprost in reducing intraocular pressure in patients with primary angle-closure glaucoma.

  Survey of ophthalmology 20020801

• Latanoprost versus combined timolol and dorzolamide.

  Survey of ophthalmology 20020801

• Combined therapy of pilocarpine or latanoprost with timolol versus latanoprost monotherapy.

  Survey of ophthalmology 20020801

• In vitro and in vivo evaluation of Pluronic F127-based ocular delivery system for timolol maleate.

  International journal of pharmaceutics 20020708

• Antiarrhythmic efficacy of combined I(Ks) and beta-adrenergic receptor blockade.

  The Journal of pharmacology and experimental therapeutics 20020701

• Travoprost--a new prostaglandin analogue for the treatment of glaucoma.

  Expert opinion on pharmacotherapy 20020701

• Effect of hyaluronic acid on intraocular pressure in rats.

  Investigative ophthalmology & visual science 20020701

• Latanoprost and timolol combination therapy vs monotherapy: one-year randomized trial.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20020701

• An accurate comparison of bimatoprost's efficacy and adverse effects.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20020701

• Degradation of and drug release from a novel 2,2-bis(2-oxazoline) linked poly(lactic acid) polymer.

  Journal of controlled release : official journal of the Controlled Release Society 20020617

• Controlled transport of timolol maleate through artificial membranes under passive and iontophoretic conditions.

  Journal of controlled release : official journal of the Controlled Release Society 20020617

• A comparison of once-daily morning vs evening dosing of concomitant latanoprost/timolol.

  American journal of ophthalmology 20020601

• Comparison of the cardiovascular effects of unoprostone 0.15%, timolol 0.5% and placebo in healthy adults during exercise using a treadmill test.

  Acta ophthalmologica Scandinavica 20020601

• Cardiovascular effects of timolol maleate, brimonidine or brimonidine/timolol maleate in concomitant therapy.

  Acta ophthalmologica Scandinavica 20020601

• Tolerability and efficacy of dorzolamide versus acetazolamide added to timolol.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020601

• Ocular drug delivery using 20-kHz ultrasound.

  Ultrasound in medicine & biology 20020601

• Neuroprotective effects of nipradilol on purified cultured retinal ganglion cells.

  Journal of glaucoma 20020601

• Comparison of tropical travoprost eye drops given once daily and timolol 0.5% given twice daily in patients with open-angle glaucoma or ocular hypertension. J. Glaucoma 2001;10:414-22.

  Journal of glaucoma 20020601

• [Comparison of latanoprost monotherapy with timolol-dorzolamide combination in patients with open-angle glaucoma or ocular hypertension].

  Journal francais d'ophtalmologie 20020601

• Acute atrial fibrillation.

  Clinical evidence 20020601

• Comparison of travoprost 0.0015% and 0.004% with timolol 0.5% in patients with elevated intraocular pressure: a 6-month, masked, multicenter trial.

  Ophthalmology 20020501

• Travoprost compared with latanoprost and timolol in patients with open-angle glaucoma or ocular hypertension.

  American journal of ophthalmology 20020501

• [Physiologic significance of the interaction between timolol and free amino acids in eye structures].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20020501

• The safety and efficacy of timolol 0.5% in xanthan gum versus timolol gel forming solution 0.5%.

  Current eye research 20020501

• Simultaneous determination of dorzolamide HCL and timolol maleate in eye drops by two different spectroscopic methods.

  Journal of pharmaceutical and biomedical analysis 20020415

• Attenuation of aortic banding-induced cardiac hypertrophy by propranolol is independent of beta-adrenoceptor blockade.

  Journal of hypertension 20020401

• Timolol concentrations in rat ocular tissues and plasma after topical and intraperitoneal dosing.

  Journal of glaucoma 20020401

• Bimatoprost vs. timolol.

  Ophthalmology 20020401

• Symptomatic bradycardia secondary to interaction between topical timolol maleate, verapamil, and flecainide: a case report.

  The Journal of emergency medicine 20020401

• [Study on hypotensive effect of latanoprost vs timolol-dorzolamide association].

  Archivos de la Sociedad Espanola de Oftalmologia 20020401

• A comparison of the efficacy and tolerability of 0.5% timolol maleate ophthalmic gel-forming solution QD and 0.5% levobunolol hydrochloride BID in patients with ocular hypertension or open-angle glaucoma.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020401

• Bioavailability in the human eye of a fixed combination of latanoprost and timolol compared to monotherapy.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20020401

• Effect of Xalatan(R) and Cosopt(R) on the vascular tone of quiescent isolated pig ciliary arteries.

  Klinische Monatsblatter fur Augenheilkunde 20020401

• Quantitative determination of oxprenolol and timolol in urine by capillary zone electrophoresis.

  Journal of chromatography. A 20020308

• Interventions to retard myopia progression in children: an evidence-based update.

  Ophthalmology 20020301

• Direct enantiomeric resolution of some cardiovascular agents using synthetic polymers imprinted with (-)-S-timolol as chiral stationary phase by thin layer chromatography.

  Die Pharmazie 20020301

• Timolol maleate 0.5% versus timolol maleate in gel forming solution 0.5% (Timolol GFS) in open angle glaucoma in India. Preliminary safety and efficacy study.

  Indian journal of ophthalmology 20020301

• Beta-adrenoceptors mediate inhibition of lipolysis in adipocytes of tilapia (Oreochromis mossambicus).

  American journal of physiology. Endocrinology and metabolism 20020201

• Application of TLC-densitometry, first-derivative UV-spectrophotometry and ratio derivative spectrophotometry for the determination of dorzolamide hydrochloride and timolol maleate.

  Journal of pharmaceutical and biomedical analysis 20020201

• A double-masked randomized comparison of the efficacy and safety of unoprostone with timolol and betaxolol in patients with primary open-angle glaucoma including pseudoexfoliation glaucoma or ocular hypertension. 6 month data.

  American journal of ophthalmology 20020101

• Efficacy and safety of immediate anterior chamber paracentesis in the treatment of acute primary angle-closure glaucoma: a pilot study.

  Ophthalmology 20020101

• A short term study of the additive effect of timolol and brimonidine on intraocular pressure.

  Eye (London, England) 20020101

• Effects of timolol and dorzolamide on retrobulbar hemodynamics in patients with newly diagnosed primary open-angle glaucoma.

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20020101

• Topical bimatoprost: a review of its use in open-angle glaucoma and ocular hypertension.

  Drugs & aging 20020101

• Ocular surface changes induced by topical antiglaucoma monotherapy.

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20020101

• Effects of L-NAME and timolol on aqueous IL-1beta, IL-6, IL-8, TNF-alpha and NO levels after Nd:YAG laser iridotomy in rabbits.

  European journal of ophthalmology 20020101

• Comparison of latanoprost, brimonidine and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with primary open-angle glaucoma and ocular hypertension.

  Acta ophthalmologica Scandinavica. Supplement 20020101

• The pulsatile ocular blood flow behaviour in open angle glaucoma patients after replacing timolol therapy with timolol and dorzolamide fixed combination: preliminary study.

  Acta ophthalmologica Scandinavica. Supplement 20020101

• Projected impact of travoprost versus both timolol and latanoprost on visual field deficit progression and costs among black glaucoma subjects.

  Transactions of the American Ophthalmological Society 20020101

• [Therapeutical difficulties in a patient with TB panuveitis and open angle glaucoma].

  Oftalmologia (Bucharest, Romania : 1990) 20020101

• Evaluation of travoprost as adjunctive therapy in patients with uncontrolled intraocular pressure while using timolol 0.5%.

  American journal of ophthalmology 20011201

• Corneal effects of latanoprost and timolol.

  Ophthalmology 20011201

• Contact dermatitis to topical drugs for glaucoma.

  American journal of contact dermatitis : official journal of the American Contact Dermatitis Society 20011201

• Ocular and retrobulbar blood flow in ocular hypertensives treated with topical timolol, betaxolol and carteolol.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20011201

• Long-term management of a glaucomatous eye in a dog treated with medical therapy alone.

  The Journal of veterinary medical science 20011201

• Effect of fenoterol-induced constitutive beta(2)-adrenoceptor activity on contractile receptor function in airway smooth muscle.

  European journal of pharmacology 20011123

• Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension.

  Investigative ophthalmology & visual science 20011101

• Comparison of aqueous and gellan ophthalmic timolol with placebo on the 24-hour heart rate response in patients on treatment for glaucoma.

  American journal of ophthalmology 20011101

• Ocular surface changes induced by topical application of latanoprost and timolol: a short-term study in glaucomatous patients with and without allergic conjunctivitis.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20011101

• Effect of adrenergic blockade on lymphocyte cytokine production at rest and during exercise.

  American journal of physiology. Cell physiology 20011001

• Mitochondrial activity and glutathione injury in apoptosis induced by unpreserved and preserved beta-blockers on Chang conjunctival cells.

  Investigative ophthalmology & visual science 20011001

• Juvenile xanthogranuloma: concurrent involvement of skin and eye.

  Cornea 20011001

• Travoprost compared with latanoprost and timolol in patients with open-angle glaucoma or ocular hypertension.

  American journal of ophthalmology 20011001

• Effect of dorzolamide timolol combination versus timolol 0.5% on ocular bloodflow in patients with primary open-angle glaucoma.

  American journal of ophthalmology 20011001

• Timolol increased retrobulbar flow velocities in untreated glaucoma eyes but not in ocular hypertension.

  Acta ophthalmologica Scandinavica 20011001

• [Innovative glaucoma therapy. Glaucoma therapy with topical carbonic anhydrase inhibitors].

  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20011001

• [Prevention of early postoperative increase in intraocular pressure after phacoemulsification. Comparison of different antiglaucoma drugs].

  Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 20011001

• Comparison of topical travoprost eye drops given once daily and timolol 0.5% given twice daily in patients with open-angle glaucoma or ocular hypertension.

  Journal of glaucoma 20011001

• Short-term effect of beta-adrenoreceptor blocking agents on ocular blood flow.

  Current eye research 20011001

• Timolol may inhibit aqueous humor secretion by cAMP-independent action on ciliary epithelial cells.

  American journal of physiology. Cell physiology 20010901

• Effects of nipradilol, a nitric oxide-releasing beta-adrenoceptor blocking agent, on phosphoenolpyruvate carboxykinase gene transcription in a rat hepatoma cell line.

  Japanese journal of pharmacology 20010901

• [The pH reaction in aqueous humor to antiglaucoma agents of various concentrations and pH levels].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20010901

• [Effect of pH on the permeability of timolol maleate across isolated rabbit cornea].

  Yao xue xue bao = Acta pharmaceutica Sinica 20010901

• A 7 year prospective comparative study of three topical beta blockers in the management of primary open angle glaucoma.

  The British journal of ophthalmology 20010801

• Meta-analysis of randomised controlled trials comparing latanoprost with timolol in the treatment of patients with open angle glaucoma or ocular hypertension.

  The British journal of ophthalmology 20010801

• Systemic beta-blocker therapy and brimonidine and timolol.

  Ophthalmology 20010801

• Intraocular pressure over 24 hours after repeated administration of latanoprost 0.005% or timolol gel-forming solution 0.5% in patients with ocular hypertension.

  Ophthalmology 20010801

• Comparison of topical brinzolamide 1% and dorzolamide 2% eye drops given twice daily in addition to timolol 0.5% in patients with primary open-angle glaucoma or ocular hypertension.

  American journal of ophthalmology 20010801

• Comparison of the additive intraocular pressure-lowering effect of latanoprost and dorzolamide when added to timolol in patients with open-angle glaucoma or ocular hypertension: a randomized, open-label, multicenter study in Greece.

  Journal of glaucoma 20010801

• The effect of topical CS-088, an angiotensin AT1 receptor antagonist, on intraocular pressure and aqueous humor dynamics in rabbits.

  Current eye research 20010801

• Reliable measurement of mouse intraocular pressure by a servo-null micropipette system.

  Investigative ophthalmology & visual science 20010701

• Comparison of the ocular hypotensive lipid AGN 192024 with timolol: dosing, efficacy, and safety evaluation of a novel compound for glaucoma management.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20010701

• Treatment of intraocular pressure elevation after photorefractive keratectomy.

  Journal of cataract and refractive surgery 20010701

• [Change in the pH of aqueous humor after administration of anti-glaucoma agents in rabbits in vivo].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20010701

• [Additive effects of topical carbonic anhydrase inhibitors].

  Ceska a slovenska oftalmologie : casopis Ceske oftalmologicke spolecnosti a Slovenske oftalmologicke spolecnosti 20010701

• Plasma timolol concentrations of timolol maleate: timolol gel-forming solution (TIMOPTIC-XE) once daily versus timolol maleate ophthalmic solution twice daily.

  Documenta ophthalmologica. Advances in ophthalmology 20010701

• Comparison of once- or twice-daily bimatoprost with twice-daily timolol in patients with elevated IOP : a 3-month clinical trial.

  Ophthalmology 20010601

• Brimonidine 0.2% given two or three times daily versus timolol maleate 0.5% in primary open-angle glaucoma.

  American journal of ophthalmology 20010601

• Additive IOP-reducing effect of latanoprost in patients insufficiently controlled on timolol.

  Acta ophthalmologica Scandinavica 20010601

• Assessment of systemic adverse reactions induced by ophthalmic beta-adrenergic receptor antagonists.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010601

• Effect of timolol 0.5% gel and solution on pulmonary function in older glaucoma patients.

  Journal of glaucoma 20010601

• Quantitation of mitomycin C in human ocular tissues by high-performance liquid chromatography-photo-diode array detection.

  Journal of chromatography. B, Biomedical sciences and applications 20010505

• Effect of topical administration of 2% dorzlamide hydrochloride or 2% dorzlamide hydrochloride-0.5% timolol maleate on intraocular pressure in clinically normal horses.

  American journal of veterinary research 20010501

• Case reports and small case series: LASIK-associated visual field loss in a glaucoma suspect.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20010501

• [Glaucoma related with photoreceptor outer segments in aqueous humor. Schwartz-Matsuo syndrome].

  Archivos de la Sociedad Espanola de Oftalmologia 20010501

• Intraindividual comparison of the effects of a fixed dorzolamide-timolol combination and latanoprost on intraocular pressure after small incision cataract surgery.

  Journal of cataract and refractive surgery 20010501

• Topical ocular instillation of nitric oxide synthase inhibitors and intraocular pressure in rabbits.

  Klinische Monatsblatter fur Augenheilkunde 20010501

• Six-month comparison of bimatoprost once-daily and twice-daily with timolol twice-daily in patients with elevated intraocular pressure.

  Survey of ophthalmology 20010501

• Bimatoprost: a member of a new class of agents, the prostamides, for glaucoma management.

  Expert opinion on investigational drugs 20010401

• The effect on diurnal intraocular pressure of the fixed combination of latanoprost 0.005% and timolol 0.5% in patients with ocular hypertension.

  Acta ophthalmologica Scandinavica 20010401

• Aqueous humor flow in normal human eyes treated with brimonidine and timolol, alone and in combination.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20010401

• Equivalence of generic and brand-name ophthalmic products.

  American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20010401

• Effect on intraocular pressure during 24 hours after repeated administration of the fixed combination of latanoprost 0.005% and timolol 0.5% in patients with ocular hypertension.

  Journal of glaucoma 20010401

• Immediate diode laser peripheral iridoplasty as treatment of acute attack of primary angle closure glaucoma: a preliminary study.

  Journal of glaucoma 20010401

• In vitro transdermal iontophoretic transport of timolol maleate: effect of age and species.

  Journal of controlled release : official journal of the Controlled Release Society 20010312

• Effect of latanoprost and timolol on the histopathology of the rabbit conjunctiva.

  Investigative ophthalmology & visual science 20010301

• Neuroprotective effect and intraocular penetration of nipradilol, a beta-blocker with nitric oxide donative action.

  Investigative ophthalmology & visual science 20010301

• Enhanced disruption of the blood-aqueous barrier and the incidence of angiographic cystoid macular edema by topical timolol and its preservative in early postoperative pseudophakia.

  Archives of ophthalmology (Chicago, Ill. : 1960) 20010301

• [A case of suspected drug-induced ocular pemphigoid].

  Nippon Ganka Gakkai zasshi 20010301

• Efficacy and tolerability of timolol maleate ophthalmic gel-forming solution versus timolol ophthalmic solution in adults with open-angle glaucoma or ocular hypertension: a six-month, double-masked, multicenter study.

  Clinical therapeutics 20010301

• Comparison of the corneal effects of latanoprost, fixed combination latanoprost-timolol, and timolol: A double-masked, randomized, one-year study.

  Ophthalmology 20010201

• Latanoprost versus combined therapy with timolol plus dorzolamide: IOP-lowering effect in open-angle glaucoma.

  Acta ophthalmologica Scandinavica 20010201

• Effect of timolol on anterior optic nerve blood flow in patients with primary open-angle glaucoma as assessed by the Heidelberg retina flowmeter.

  Journal of glaucoma 20010201

• Atopic dermatitis: a case report and current clinical review of systemic and ocular manifestations.

  Optometry (St. Louis, Mo.) 20010201

• Enhanced ocular hypotensive response to timolol in rabbits with prior dexamethasone treatment.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010201

• Respiratory and cardiovascular effects of WP-934 in guinea pigs.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20010201

• Development of glaucoma after phacoemulsification for removal of cataracts in dogs: 22 cases (1987-1997).

  Journal of the American Veterinary Medical Association 20010101

• [A comparative study of the ocular tolerance of 3 timolol-based preparations: the influence of preservatives on ocular tolerance].

  Journal francais d'ophtalmologie 20010101

• Management of glaucoma in pregnancy and lactation.

  Survey of ophthalmology 20010101

• A reverse microemulsion polymerization method for preparation of bioadhesive polyacrylic acid nanoparticles for mucosal drug delivery: loading and release of timolol maleate.

  Artificial cells, blood substitutes, and immobilization biotechnology 20010101

• The effects of beta-blockers on ocular blood flow in patients with primary open angle glaucoma: a color Doppler imaging study.

  European journal of ophthalmology 20010101

• Brimonidine (Alphagan): a clinical profile four years after launch.

  European journal of ophthalmology 20010101

• [Clinical evaluation of isopropyl unoprostone (Rescula), in the adjunctive treatment of primary open angle glaucoma].

  Klinika oczna 20010101

• Third degree AC block due to ophthalmic timilol solution.

  International journal of cardiology 20010101

• Color Doppler imaging study in patients with primary open-angle glaucoma treated with timolol 0.5% and carteolol 2%.

  European journal of ophthalmology 20010101

• Beta-adrenergic blockade in the dentate gyrus in vivo prevents high frequency-induced long-term potentiation of EPSP slope, but not long-term potentiation of population spike amplitude.

  Hippocampus 20010101

• Cardiovascular considerations in using topical, oral, and intravenous drugs for the treatment of glaucoma and ocular hypertension: focus on beta-adrenergic blockade.

  Heart disease (Hagerstown, Md.) 20010101

• Does glaucoma medication influence the diameter of the retinal arteriole in the human eye? (A pilot study using the retinal vessel analyser).

  Acta physiologica Hungarica 20010101

• Nightmares with topical beta-blocker.

  Eye (London, England) 20001001

• A randomized, comparative open-label study on the efficacy of latanoprost and timolol in steroid induced ocular hypertension after photorefractive keratectomy.

  European journal of ophthalmology 20000101

• Beta-blocker eyedrops and nocturnal arterial hypotension.

  American journal of ophthalmology 19990901

• [Atrioventricular block secondary to topical ophthalmic beta blockers].

  Revista espanola de cardiologia 19990701

• Topical timolol therapy in pregnancy: is it safe for the fetus?

  Teratology 19981201

• Timolol, carotid sinus hypersensitivity, and elderly patients.

  Lancet (London, England) 19981003

• Comparison of the effect of latanoprost 0.005% and timolol 0.5% on the calculated ocular perfusion pressure in patients with normal-tension glaucoma.

  American journal of ophthalmology 19980501

• Cardiovascular effects of topical carteolol hydrochloride and timolol maleate in patients with ocular hypertension and primary open-angle glaucoma. Night Study Group.

  American journal of ophthalmology 19970401

• A prospective study of the effects of prolonged timolol therapy on alpha- and beta-adrenoceptor and angiotensin II receptor mediated responses in normal subjects.

  British journal of clinical pharmacology 19970301

• Clinical experience with brimonidine 0.2% and timolol 0.5% in glaucoma and ocular hypertension.

  Survey of ophthalmology 19961101

• A comparison of latanoprost and timolol in primary open-angle glaucoma and ocular hypertension. A 12-week study.

  Archives of ophthalmology (Chicago, Ill. : 1960) 19960801

• Cardiac failure aggravated by timolol eye drops: preoperative improvement by changing to pilocarpine.

  Acta anaesthesiologica Scandinavica 19960301

• Comparison of latanoprost and timolol in patients with ocular hypertension and glaucoma: a six-month masked, multicenter trial in the United States. The United States Latanoprost Study Group.

  Ophthalmology 19960101

• [Bradycardia of an elderly patient caused by Timolol therapy in ocular hypertension].

  Duodecim; laaketieteellinen aikakauskirja 19960101

• Additive effect of latanoprost, a prostaglandin F2 alpha analogue, and timolol in patients with elevated intraocular pressure.

  The British journal of ophthalmology 19941201

• The effect of wrist rest, caffeine, and oral timolol on the hand steadiness of ophthalmologists.

  Annals of ophthalmology 19930701

• A comparison of the ocular tolerability of a single dose of timolol and levobunolol in healthy normotensive volunteers.

  Annals of ophthalmology 19930401

• Major depressive episode secondary to antiglaucoma drugs.

  The American journal of psychiatry 19930301

• [Severe anaphylactic shock with heart arrest caused by coffee and gum arabic, potentiated by beta-blocking eyedrops].

  La Revue de medecine interne 19930201

• Changes in depressive status associated with topical beta-blockers.

  International ophthalmology 19920901

• [Bradyarrhythmias secondary to the use of ophthalmic timolol. A report of 3 cases].

  Revista espanola de cardiologia 19920101

• Complete heart block after topical timolol.

  The Journal of the Association of Physicians of India 19900801

• Apraclonidine hydrochloride: an evaluation of plasma concentrations, and a comparison of its intraocular pressure lowering and cardiovascular effects to timolol maleate.

  Transactions of the American Ophthalmological Society 19900101

• [Raynaud syndrome following timolol-containing eyedrops].

  Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 19900101

• [Timolol: adverse cardiorespiratory effects].

  Atencion primaria 19890501

• [Timolol ophthalmic solution and atrio-ventricular block syncope].

  Anales de medicina interna (Madrid, Spain : 1984) 19890101

• Topical beta-blocker therapy and central nervous system side effects. A preliminary study comparing betaxolol and timolol.

  Archives of ophthalmology (Chicago, Ill. : 1960) 19880701

• [Rare general side-effects after timolol eyedrops in glaucoma].

  Harefuah 19871115

• Timolol/pilocarpine combination eye drops in open angle glaucoma and in ocular hypertension. A controlled randomized study.

  Acta ophthalmologica 19871001

• Psychiatric side effects from topical ocular timolol, a beta-adrenergic blocker.

  Journal of clinical psychopharmacology 19870801

• Severe bradycardia due to interaction of timolol eye drops and verapamil.

  British medical journal (Clinical research ed.) 19870117

• Increased occurrence of left ventricular thrombi during early treatment with timolol in patients with acute myocardial infarction.

  Circulation 19870101

• Adverse respiratory and cardiovascular events attributed to timolol ophthalmic solution, 1978-1985.

  American journal of ophthalmology 19861115

• Sinus arrest due to timolol eye drops.

  The British journal of clinical practice 19860601

• Epinephrine-induced hypokalemia: the role of beta adrenoceptors.

  The American journal of cardiology 19860425

• Acute electrophysiologic, hemodynamic and left ventricular effects of nifedipine and beta-blocker interactions. Maintenance of global and regional left ventricular wall motion.

  The American journal of cardiology 19850517

• Systemic side effects associated with the ophthalmic administration of timolol.

  Drug intelligence & clinical pharmacy 19850201

• Postmarketing study of timolol-hydrochlorothiazide antihypertensive therapy.

  Clinical therapeutics 19850101

• Transient ischemic attacks and amaurosis fugax from timolol.

  Annals of ophthalmology 19850101

• [Evaluation of the systemic effects of timolol maleate in eye drops].

  Journal francais d'ophtalmologie 19850101

• Reduction of increased levels of blood glycerol and ketone bodies by propranolol in human hyperthyroidism: role of the fall of the triiodothyronine level.

  Metabolism: clinical and experimental 19841201

• Effect of timolol maleate on pacing induced myocardial ischaemia.

  British heart journal 19841201

• Role of vagus in the antagonism of ouabain induced arrhythmias in dogs by beta-adrenoceptor antagonists and related drugs.

  The Journal of pharmacy and pharmacology 19841001

• Changes in heart size during long-term timolol treatment after myocardial infarction.

  Acta medica Scandinavica 19840101

• Intraoperative bradycardia and hypotension associated with timolol and pilocarpine eye drops.

  British journal of anaesthesia 19830901

• Experience with dipivalyl epinephrine. Its effectiveness, alone or in combination, and its side effects.

  Australian journal of ophthalmology 19830801

• The effects of cardioselective and non-selective beta-adrenoceptor blockade on the hypokalaemic and cardiovascular responses to adrenomedullary hormones in man.

  Clinical science (London, England : 1979) 19830801

• [Increase in visual field defects under long-term timolol treatment in patients with open-angle glaucoma - observations from an ophthalmology practice].

  Klinische Monatsblatter fur Augenheilkunde 19830701

• The Timolol Myocardial Infarction Study: an evaluation of selected variables.

  Circulation 19830601

• Cardiorespiratory reaction to timolol maleate in a pediatric patient: a case report.

  Annals of ophthalmology 19821001

• Does prostacyclin mediate alpha-adrenergic induced hypotension?

  Documenta ophthalmologica. Advances in ophthalmology 19820930

• Clinical implications of reported timolol-induced side effects.

  American journal of optometry and physiological optics 19820601

• Acute suicidal depression associated with use of timolol.

  JAMA 19820319

• A comparative trial of timolol and flutonidin as antihypertensive agents.

  International journal of clinical pharmacology, therapy, and toxicology 19820201

• [Blood pressure profile after exertion in borderline arterial hypertension before and after timolol. Predictive importance of the trinitrin test].

  Annales de cardiologie et d'angeiologie 19820101

• Timolol-induced bronchospasm.

  American family physician 19810901

• [Monotherapy of hypertension with a beta-blocker in a single daily dose (author's transl)].

  La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris 19810501

• Bradycardia and congestive heart failure associated with ocular timolol maleate.

  American journal of hospital pharmacy 19810501

• Timolol and glaucoma.

  Archives of ophthalmology (Chicago, Ill. : 1960) 19810401

• [Life-threatening status asthmaticus following use of timolol-containing eye drops (Timoptol)].

  Nederlands tijdschrift voor geneeskunde 19810314

• Effect of timolol on late ventricular arrhythmias after acute myocardial infarction.

  Acta medica Scandinavica. Supplementum 19810101

• Timolol-induced congestive heart failure.

  Southern medical journal 19810101

• Syncope and visual hallucinations, apparently from timolol.

  JAMA 19800801

• Adverse reactions from timolol administration.

  Ophthalmology 19800501

• The place of timolol in the practice of ophthalmology.

  Ophthalmology 19800501

• Timolol-induced bradycardia.

  Anesthesia and analgesia 19800401

• Inefficacy of digitalis in the control of heart rate in patients with chronic atrial fibrillation: beneficial effect of an added beta adrenergic blocking agent.

  The American journal of cardiology 19791201

• Cardiopulmonary effects of timolol eyedrops.

  Lancet (London, England) 19791110

• Timolol and myasthenia gravis.

  JAMA 19791012

• Adverse effects experienced by patients taking timolol.

  American journal of ophthalmology 19791001

• Apneic spells associated with timolol therapy in a neonate.

  American journal of ophthalmology 19790701

• Randomised study of six beta-blockers and a thiazide diuretic in essential hypertension.

  British medical journal 19780805

• [The effect of timolol eye drops on the intraocular pressure in simple glaucoma (author's transl)].

  Klinische Monatsblatter fur Augenheilkunde 19780501

• Long-term experience with timolol ophthalmic solution in patients with open-angle glaucoma.

  Ophthalmology 19780301

• Timolol. Hypotensive effect, used alone and in combination for treatment of increased intraocular pressure.

  Acta ophthalmologica 19780101

• Amelioration of bendrofluazide-induced hypokalemia by timolol.

  Clinical pharmacology and therapeutics 19770701

• Haemodynamic effects of prazosin.

  Archives internationales de pharmacodynamie et de therapie 19761201