271-47-6 | 1H-Pyrazolo[3,4-c]pyridine

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$15.00	$10.00
5g	98%	in stock	$49.00	$35.00
10g	98%	in stock	$90.00	$63.00
25g	98%	in stock	$196.00	$138.00

Description

• Catalog Number: AB43367
• Chemical Name: 1H-Pyrazolo[3,4-c]pyridine
• CAS Number: 271-47-6
• Molecular Formula: C6H5N3
• Molecular Weight: 119.124
• MDL Number: MFCD00661308
• SMILES: c1ncc2c(c1)cn[nH]2

Computed Properties

• Complexity: 105
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 0.5

Literature

• Au(I)-catalyzed and iodine-mediated cyclization of enynylpyrazoles to provide pyrazolo[1,5-a]pyridines.

  Organic & biomolecular chemistry 20120907

• Ultrasound assisted one-pot, three-components synthesis of pyrimido[1,2-a]benzimidazoles and pyrazolo[3,4-b]pyridines: A new access via phenylsulfone synthon.

  Ultrasonics sonochemistry 20120101

• Synthesis, X-ray crystal structure and fluorescent spectra of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111015

• Phosphodiesterase inhibitors. Part 2: design, synthesis, and structure-activity relationships of dual PDE3/4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory and bronchodilatory activity.

  Bioorganic & medicinal chemistry letters 20110915

• A copper-mediated cyclization reaction of hydrazine with enediynones providing pyrazolo[1,5-a]pyridines.

  Organic & biomolecular chemistry 20110207

• One-step synthesis of diarylpyrazolo[3,4-b]pyridines from isoflavones.

  Journal of combinatorial chemistry 20100712

• Novel pyrazolopyrimidines as highly potent B-Raf inhibitors.

  Bioorganic & medicinal chemistry letters 20091215

• An efficient one-step synthesis of heterobiaryl pyrazolo[3,4-b]pyridines via indole ring opening.

  Organic letters 20091119

• Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.

  Journal of medicinal chemistry 20090326

• Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model.

  ChemMedChem 20080601

• Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides.

  Chemical & pharmaceutical bulletin 20080601

• Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems.

  Journal of medicinal chemistry 20080410

• Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.

  Journal of medicinal chemistry 20080327

• Concise routes to pyrazolo[1,5-a]pyridin-3-yl pyridazin-3-ones.

  Organic & biomolecular chemistry 20080107

• Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2.

  Bioorganic & medicinal chemistry letters 20071115

• Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists.

  Bioorganic & medicinal chemistry letters 20070801

• Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.

  Bioorganic & medicinal chemistry letters 20070801

• Pyrazolo[1,5-a]pyridine antiherpetics: effects of the C3 substituent on antiviral activity.

  Bioorganic & medicinal chemistry letters 20070515

• Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.

  Bioorganic & medicinal chemistry letters 20060115

• New pyrazolo[3,4-b]pyridones as selective A(1) adenosine receptor antagonists: synthesis, biological evaluation and molecular modelling studies.

  Organic & biomolecular chemistry 20050621

• Design, synthesis, and pharmacological profile of novel fused pyrazolo[4,3-d]pyridine and pyrazolo[3,4-b][1,8]naphthyridine isosteres: a new class of potent and selective acetylcholinesterase inhibitors.

  Journal of medicinal chemistry 20030327

• Synthesis and biological evaluation of some acyclic 4,6-disubstituted 1H-pyrazolo[3,4-d]pyrimidine nucleosides.

  Nucleosides, nucleotides & nucleic acids 20030101