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Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors.
Expert opinion on therapeutic patents 20171201
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Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.
Bioorganic & medicinal chemistry 20121115
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Identification and synthesis of substituted pyrrolo[2,3-d]pyrimidines as novel firefly luciferase inhibitors.
Bioorganic & medicinal chemistry 20120915
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Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines.
Organic & biomolecular chemistry 20120607
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N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
Bioorganic & medicinal chemistry 20120401
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First total synthesis of a naturally occurring iodinated 5'-deoxyxylofuranosyl marine nucleoside.
Marine drugs 20120401
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Pyrrolo[3,2-d]pyrimidine derivatives as type II kinase insert domain receptor (KDR) inhibitors: CoMFA and CoMSIA studies.
International journal of molecular sciences 20120101
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Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17.
PloS one 20120101
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Synthesis of new pyrroles of potential anti-inflammatory activity.
Archiv der Pharmazie 20111201
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Synthesis and anti-HIV-1 activity of 4-substituted-7-(2'-deoxy-2'-fluoro-4'-azido-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine analogues.
Bioorganic & medicinal chemistry letters 20111115
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2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance.
Bioorganic & medicinal chemistry 20110715
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New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies.
European journal of medicinal chemistry 20110701
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Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometrioid and serous papillary endometrial cancer cell lines.
Gynecologic oncology 20110501
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Discovery of pyrrolo[2,3-d]pyrimidin-4-ones as corticotropin-releasing factor 1 receptor antagonists with a carbonyl-based hydrogen bonding acceptor.
Bioorganic & medicinal chemistry letters 20110415
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Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.
Journal of medicinal chemistry 20101125
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Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives as antibacterial and antifungal agents.
European journal of medicinal chemistry 20101101
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Synthesis of novel pyrrole and pyrrolo[2,3-d]pyrimidine derivatives bearing sulfonamide moiety for evaluation as anticancer and radiosensitizing agents.
Bioorganic & medicinal chemistry letters 20101101
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Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors.
Molecular pharmacology 20101001
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Toward pyrrolo[2,3-d]pyrimidine scaffolds.
The Journal of organic chemistry 20100806
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Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities.
European journal of medicinal chemistry 20100701
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7-(5-Methyl-sulfanyl-β-d-erythrofuran-osyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-amine monohydrate (MT-tubercidin·H(2)O).
Acta crystallographica. Section E, Structure reports online 20100701
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Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives and evaluation of their activities against human colon cancer cell lines.
European journal of medicinal chemistry 20100401
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5-Chloro-N-[2-(1H-imidazol-4-yl)eth-yl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine.
Acta crystallographica. Section E, Structure reports online 20100101
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Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line.
Bioorganic & medicinal chemistry letters 20091201
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Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors.
Bioorganic & medicinal chemistry 20091001
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Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases.
Bioorganic & medicinal chemistry 20090701
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Synthesis and antiviral evaluation of 2'-C-methyl analogues of 5-alkynyl- and 6-alkylfurano- and pyrrolo[2,3-d]pyrimidine ribonucleosides.
Nucleosides, nucleotides & nucleic acids 20090501
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8-Aza-7-deazaguanine nucleosides and oligonucleotides with octadiynyl side chains: synthesis, functionalization by the azide-alkyne 'click' reaction and nucleobase specific fluorescence quenching of coumarin dye conjugates.
Organic & biomolecular chemistry 20090407
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Electronic and steric effects on the mechanism of the inverse electron demand Diels-Alder reaction of 2-aminopyrroles with 1,3,5-triazines: identification of five intermediates by 1H, 13C, 15N, and 19F NMR spectroscopy.
The Journal of organic chemistry 20090102
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Novel antitumor acetamide, pyrrole, pyrrolopyrimidine, thiocyanate, hydrazone, pyrazole, isothiocyanate and thiophene derivatives containing a biologically active pyrazole moiety.
Arzneimittel-Forschung 20090101
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Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity.
Journal of medicinal chemistry 20080828
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The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents.
Journal of medicinal chemistry 20080814
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Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors.
European journal of medicinal chemistry 20080601
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Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.
Bioorganic & medicinal chemistry 20080515
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The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells.
British journal of haematology 20080501
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A CoMSIA study on the adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues.
Bioorganic & medicinal chemistry 20080501
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Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines.
Bioorganic & medicinal chemistry letters 20080501
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Molecular modeling study and synthesis of novel pyrrolo[2,3-d]pyrimidines and pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities.
Bioorganic & medicinal chemistry 20080301
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Biochemical and biological properties of 5-bromotubercidin: differential effects on cellular DNA-directed and viral RNA-directed RNA synthesis.
Bioorganic & medicinal chemistry 20080201
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[New furano- and pyrrolo[2,3-d]pyrimidine nucleosides and their 5'-triphosphates: synthesis and biological properties].
Bioorganicheskaia khimiia 20080101
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Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice.
Neoplasia (New York, N.Y.) 20071201
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Role of focal adhesion kinase in human cancer: a potential target for drug discovery.
Anti-cancer agents in medicinal chemistry 20071101
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Classical anticytokinins do not interact with cytokinin receptors but inhibit cyclin-dependent kinases.
The Journal of biological chemistry 20070511
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Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents.
Bioorganic chemistry 20070201
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Furano- and pyrrolo [2,3-d] pyrimidine nucleosides and their 5'-O-triphospates: synthesis and enzymatic activity.
Nucleosides, nucleotides & nucleic acids 20070101
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The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine.
Nucleosides, nucleotides & nucleic acids 20070101
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The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine.
Organic & biomolecular chemistry 20060507
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Cell cycle arrest and apoptotic induction in LNCaP cells by MCS-C2, novel cyclin-dependent kinase inhibitor, through p53/p21WAF1/CIP1 pathway.
Cancer science 20060501
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Progress in 7-deazapurine - pyrrolo[2,3-d]pyrimidine - ribonucleoside synthesis.
Current topics in medicinal chemistry 20060101
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Novel antitumor and radioprotective sulfonamides containing pyrrolo [2,3-d]pyrimidines.
Arzneimittel-Forschung 20060101
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Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents.
Journal of medicinal chemistry 20051117
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Synthesis and antimicrobial screening of some fused heterocyclic pyrroles.
Acta pharmaceutica (Zagreb, Croatia) 20050901
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Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides.
Journal of medicinal chemistry 20050714
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Synthesis and properties of 7-substituted 7-deazapurine (pyrrolo[2,3-d]pyrimidine) 2'-deoxyribonucleosides.
Current protocols in nucleic acid chemistry 20050701
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Role of insulin-like growth factor 1 receptor signalling in cancer.
British journal of cancer 20050620
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Induction of apoptosis in human leukemia cells by MCS-C2 via caspase-dependent Bid cleavage and cytochrome c release.
Cancer letters 20050608
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Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates.
Journal of medicinal chemistry 20041230
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Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase.
Bioorganic & medicinal chemistry letters 20041101
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AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity.
Cancer research 20040715
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A TOPS-MODE approach to predict adenosine kinase inhibition.
Bioorganic & medicinal chemistry letters 20040621
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In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase.
Cancer cell 20040301
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A new and efficient synthesis of pyrrolo[2,3-d]pyrimidine anticancer agents: Alimta (LY231514, MTA), homo-Alimta, TNP-351, and some aryl 5-substituted pyrrolo[2,3-d]pyrimidines.
The Journal of organic chemistry 20031226
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Synthesis and evaluation of optically pure dioxolanes as inhibitors of hepatitis C virus RNA replication.
Bioorganic & medicinal chemistry letters 20031215
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Novel synthesis and antifungal activity of pyrrole and pyrrolo[2,3-d]pyrimidine derivatives containing sulfonamido moieties.
Farmaco (Societa chimica italiana : 1989) 20020801
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N(7)-substituted-5-aryl-pyrrolo[2,3-d]pyrimidines represent a versatile class of potent inhibitors of the tyrosine kinase c-Src.
Mini reviews in medicinal chemistry 20020601
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QSAR study on adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues using the hansch approach.
Bioorganic & medicinal chemistry letters 20020325
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Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
Journal of molecular biology 20011102
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Tyrosine kinase inhibitors: from rational design to clinical trials.
Medicinal research reviews 20011101
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Pyrrolo[2,3-d]pyrimidine thymidylate synthase inhibitors: design and synthesis of one-carbon bridge derivatives.
Chemical & pharmaceutical bulletin 20011001
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Chemical modification of aryl-1,2,3,6-tetrahydropyridinopyrimidine derivative to discover corticotropin-releasing factor(1) receptor antagonists: aryl-1,2,3,6-tetrahydropyridino-purine, -3H-1,2,3-triazolo[4,5-d)pyrimidine, -purin-8-one, and -7H-pyrrolo[2,3-d]pyrimidine derivatives.
Bioorganic & medicinal chemistry 20010501
