-
4,5-Dihydro-1H-pyrazolo[3,4-d]pyrimidine containing phenothiazines as antitubercular agents.
Bioorganic & medicinal chemistry letters 20140315
-
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Bioorganic & medicinal chemistry letters 20121201
-
Synthesis and antioxidant evaluation of some new pyrazolopyridine derivatives.
Archiv der Pharmazie 20120201
-
Synthesis of 2- and 2,3-substituted pyrazolo[1,5-a]pyridines: scope and mechanistic considerations of a domino direct alkynylation and cyclization of N-iminopyridinium ylides using alkenyl bromides, alkenyl iodides, and alkynes.
The Journal of organic chemistry 20111021
-
Pyrazolopyridine inhibitors of B-RafV600E. Part 2: structure-activity relationships.
Bioorganic & medicinal chemistry letters 20110915
-
Phosphodiesterase inhibitors. Part 1: Synthesis and structure-activity relationships of pyrazolopyridine-pyridazinone PDE inhibitors developed from ibudilast.
Bioorganic & medicinal chemistry letters 20110601
-
Synthesis, structure, photophysical and electrochemiluminescence properties of Re(I) tricarbonyl complexes incorporating pyrazolyl-pyridyl-based ligands.
Dalton transactions (Cambridge, England : 2003) 20110514
-
Acylation of heteroaromatic amines: facile and efficient synthesis of a new class of 1,2,3-triazolo[4,5-b]pyridine and pyrazolo[4,3-b]pyridine derivatives.
Molecules (Basel, Switzerland) 20110504
-
Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions.
Journal of medicinal chemistry 20110414
-
Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties.
Bioorganic & medicinal chemistry letters 20101215
-
Design, synthesis and bioevaluation of dihydropyrazolo[3,4-b]pyridine and benzo[4,5]imidazo[1,2-a]pyrimidine compounds as dual KSP and Aurora-A kinase inhibitors for anti-cancer agents.
Bioorganic & medicinal chemistry 20101115
-
A myosin V inhibitor based on privileged chemical scaffolds.
Angewandte Chemie (International ed. in English) 20101102
-
Pyrazolo[1,5-a]pyrimidine acetamides: 4-Phenyl alkyl ether derivatives as potent ligands for the 18 kDa translocator protein (TSPO).
Bioorganic & medicinal chemistry letters 20101001
-
Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain.
Bioorganic & medicinal chemistry letters 20100801
-
Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif.
Bioorganic & medicinal chemistry letters 20100801
-
Antiplatelet activity and structure-activity relationship study of Pyrazolopyridine Derivatives as potential series for treating thrombotic diseases.
Journal of atherosclerosis and thrombosis 20100730
-
Recent advances in the development of selective, ATP-competitive inhibitors of mTOR.
Current opinion in drug discovery & development 20100701
-
Synthesis, structural characterisation and quadruplex DNA binding studies of a new gold(III) pyrazolylpyridine complex.
Chemistry (Weinheim an der Bergstrasse, Germany) 20100322
-
Pyrazolopyrimidines as highly potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR): optimization of the 1-substituent.
Bioorganic & medicinal chemistry letters 20100215
-
Synthesis of the highly selective p38 MAPK inhibitor UR-13756 for possible therapeutic use in Werner syndrome.
Future medicinal chemistry 20100201
-
Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).
Bioorganic & medicinal chemistry letters 20100115
-
Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-alpha: Hit to lead studies.
Bioorganic & medicinal chemistry letters 20100115
-
Assessment of the putative binding conformation of a pyrazolopyridine class of inhibitors of MAPKAPK2 using computational studies.
European journal of medicinal chemistry 20100101
-
Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors.
Bioorganic & medicinal chemistry letters 20091101
-
Expedient synthesis of 3-alkoxymethyl- and 3-aminomethyl-pyrazolo[3,4-b]pyridines.
The Journal of organic chemistry 20090116
-
Regio- and chemoselective metalation of chloropyrimidine derivatives with TMPMgCl x LiCl and TMP(2)Zn x 2 MgCl(2) x 2 LiCl.
Chemistry (Weinheim an der Bergstrasse, Germany) 20090101
-
Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Bioorganic & medicinal chemistry letters 20081015
-
Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors.
Bioorganic & medicinal chemistry letters 20080715
-
Synthesis and antiviral activity evaluation of some novel acyclic C-nucleosides.
Chemical & pharmaceutical bulletin 20080601
-
Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents.
Bioorganic & medicinal chemistry letters 20080315
-
Pyrazolopyridines with potent activity against herpesviruses: effects of C5 substituents on antiviral activity.
Bioorganic & medicinal chemistry letters 20080201
-
Synthesis of benzo[1,2-d;3,4-d']diimidazole and 1H-pyrazolo[4,3-b]pyridine as putative A2A receptor antagonists.
Organic & biomolecular chemistry 20070821
-
Design and synthesis of pyridine-pyrazolopyridine-based inhibitors of protein kinase B/Akt.
Bioorganic & medicinal chemistry 20070315
-
3D-QSAR and molecular docking studies on pyrazolopyrimidine derivatives as glycogen synthase kinase-3beta inhibitors.
Journal of molecular graphics & modelling 20070301
-
Modelling of UV-molecular spectra of several bis-pyrazolopyridines derivatives.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20061101
-
Synthesis and structure of a sodium complex of an aromatic beta-diketone and pyrazolylpyridine.
Molecules (Basel, Switzerland) 20060717
-
Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses.
Bioorganic & medicinal chemistry 20060215
-
Development of ligands for the peripheral benzodiazepine receptor.
Current medicinal chemistry 20060101
-
Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses.
Bioorganic & medicinal chemistry 20050915
-
New orally active PDE4 inhibitors with therapeutic potential.
Bioorganic & medicinal chemistry 20040801
-
Synthesis of some new annulated pyrazolo-pyrido (or pyrano) pyrimidine, pyrazolopyridine and pyranopyrazole derivatives.
Acta pharmaceutica (Zagreb, Croatia) 20040601
-
The synthesis of 4-deazaformycin A.
The Journal of organic chemistry 20030808
-
Inhibition of tyrosine kinase Src suppresses pancreatic cancer invasiveness.
Surgery 20030801
-
Non-imidazole heterocyclic histamine H3 receptor antagonists.
Bioorganic & medicinal chemistry letters 20030519
-
Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist.
Biochemical and biophysical research communications 20021206
-
Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.
Bioorganic & medicinal chemistry 20020601
-
Implication of Galpha i proteins and Src tyrosine kinases in endotoxin-induced signal transduction events and mediator production.
Journal of endotoxin research 20020101
-
NO-independent regulatory site on soluble guanylate cyclase.
Nature 20010308
