274-56-6 | Pyrazolo[1,5-a]pyridine

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$12.00	$9.00
1g	97%	in stock	$30.00	$21.00
5g	97%	in stock	$133.00	$93.00

Description

• Catalog Number: AB50281
• Chemical Name: Pyrazolo[1,5-a]pyridine
• CAS Number: 274-56-6
• Molecular Formula: C7H6N2
• Molecular Weight: 118.1359
• MDL Number: MFCD08752622
• SMILES: c1ccc2n(c1)ncc2

Computed Properties

• Complexity: 103
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 1
• XLogP3: 1.1

Literature

• Phosphodiesterase inhibitors. Part 4: design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-4,4-dimethylpyrazolones.

  Bioorganic & medicinal chemistry letters 20120915

• Au(I)-catalyzed and iodine-mediated cyclization of enynylpyrazoles to provide pyrazolo[1,5-a]pyridines.

  Organic & biomolecular chemistry 20120907

• Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor.

  Journal of medicinal chemistry 20120614

• Phosphodiesterase inhibitors. Part 3: Design, synthesis and structure-activity relationships of dual PDE3/4-inhibitory fused bicyclic heteroaromatic-dihydropyridazinones with anti-inflammatory and bronchodilatory activity.

  Bioorganic & medicinal chemistry 20120301

• Ultrasound assisted one-pot, three-components synthesis of pyrimido[1,2-a]benzimidazoles and pyrazolo[3,4-b]pyridines: A new access via phenylsulfone synthon.

  Ultrasonics sonochemistry 20120101

• Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors.

  Bioorganic & medicinal chemistry 20120101

• Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR.

  Bioorganic & medicinal chemistry 20120101

• Synthesis, X-ray crystal structure and fluorescent spectra of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111015

• Phosphodiesterase inhibitors. Part 2: design, synthesis, and structure-activity relationships of dual PDE3/4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory and bronchodilatory activity.

  Bioorganic & medicinal chemistry letters 20110915

• A copper-mediated cyclization reaction of hydrazine with enediynones providing pyrazolo[1,5-a]pyridines.

  Organic & biomolecular chemistry 20110207

• One-step synthesis of diarylpyrazolo[3,4-b]pyridines from isoflavones.

  Journal of combinatorial chemistry 20100712

• Ethyl 3-{5-[(diethyl-amino)meth-yl]isoxazol-3-yl}-2-phenyl-pyrazolo[1,5-a]pyridine-5-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20100401

• Assessment of the putative binding conformation of a pyrazolopyridine class of inhibitors of MAPKAPK2 using computational studies.

  European journal of medicinal chemistry 20100101

• The first examples of chemical modification of oligomycin A.

  The Journal of antibiotics 20100101

• Novel pyrazolopyrimidines as highly potent B-Raf inhibitors.

  Bioorganic & medicinal chemistry letters 20091215

• An efficient one-step synthesis of heterobiaryl pyrazolo[3,4-b]pyridines via indole ring opening.

  Organic letters 20091119

• Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20091101

• Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.

  Journal of medicinal chemistry 20090326

• The identification of pyrazolo[1,5-a]pyridines as potent p38 kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20081015

• Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.

  Bioorganic & medicinal chemistry letters 20080801

• Substituted pyrazolo[3,4-b]pyridines as potent A1 adenosine antagonists: synthesis, biological evaluation, and development of an A1 bovine receptor model.

  ChemMedChem 20080601

• Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems.

  Journal of medicinal chemistry 20080410

• Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET.

  Journal of medicinal chemistry 20080327

• Concise routes to pyrazolo[1,5-a]pyridin-3-yl pyridazin-3-ones.

  Organic & biomolecular chemistry 20080107

• Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2.

  Bioorganic & medicinal chemistry letters 20071115

• Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists.

  Bioorganic & medicinal chemistry letters 20070801

• Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.

  Bioorganic & medicinal chemistry letters 20070801

• Pyrazolo[1,5-a]pyridine antiherpetics: effects of the C3 substituent on antiviral activity.

  Bioorganic & medicinal chemistry letters 20070515

• Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses.

  Bioorganic & medicinal chemistry 20060215

• Pyrazoloheteroaryls: novel p38alpha MAP kinase inhibiting scaffolds with oral activity.

  Bioorganic & medicinal chemistry letters 20060115

• Tissue distribution of radioiodinated FAUC113: assessment of a pyrazolo(1,5-a) pyridine based dopamine D4 receptor radioligand candidate.

  Nuklearmedizin. Nuclear medicine 20060101

• Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses.

  Bioorganic & medicinal chemistry 20050915

• New pyrazolo[3,4-b]pyridones as selective A(1) adenosine receptor antagonists: synthesis, biological evaluation and molecular modelling studies.

  Organic & biomolecular chemistry 20050621

• Pyrazolopyridine antiherpetics: SAR of C2' and C7 amine substituents.

  Bioorganic & medicinal chemistry 20050401

• Synthesis and biological evaluation of some acyclic 4,6-disubstituted 1H-pyrazolo[3,4-d]pyrimidine nucleosides.

  Nucleosides, nucleotides & nucleic acids 20030101

• Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy.

  Bioorganic & medicinal chemistry letters 20020225