274-79-3 | Imidazo[1,2-a]pyrazine

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$15.00	$10.00
250mg	97%	in stock	$18.00	$12.00
1g	97%	in stock	$22.00	$15.00
5g	97%	in stock	$32.00	$22.00
10g	97%	in stock	$60.00	$42.00
25g	97%	in stock	$145.00	$101.00

Description

• Catalog Number: AB74738
• Chemical Name: Imidazo[1,2-a]pyrazine
• CAS Number: 274-79-3
• Molecular Formula: C6H5N3
• Molecular Weight: 119.124
• MDL Number: MFCD06245371
• SMILES: n1ccn2c(c1)ncc2

Computed Properties

• Complexity: 105
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 0.7

Literature

• Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity.

  Bioorganic & medicinal chemistry letters 20120515

• Imidazo[1,2-a]pyrazines as novel PI3K inhibitors.

  Bioorganic & medicinal chemistry letters 20120301

• Aurora kinase inhibitors based on the imidazo[1,2-a]pyrazine core: fluorine and deuterium incorporation improve oral absorption and exposure.

  Journal of medicinal chemistry 20110113

• Bioisosteric approach to the discovery of imidazo[1,2-a]pyrazines as potent Aurora kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20110101

• Combined 3D-QSAR modeling and molecular docking studies on pyrrole-indolin-2-ones as Aurora A kinase inhibitors.

  International journal of molecular sciences 20110101

• Discovery of orally bioavailable imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20101115

• Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines.

  European journal of medicinal chemistry 20101101

• Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells.

  Bioorganic & medicinal chemistry letters 20101015

• Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20100901

• 2-Oxo-2,3-dihydro-1H-imidazo[1,2-a]pyridinium iodide.

  Acta crystallographica. Section E, Structure reports online 20100301

• Novel imidazo[1,2-a]pyrazine derivatives as potent reversible inhibitors of the gastric H+/K+-ATPase.

  Bioorganic & medicinal chemistry 20080101

• Imidazo[1,2-a]quinoxalines: synthesis and cyclic nucleotide phosphodiesterase inhibitory activity.

  European journal of medicinal chemistry 20010301