2799-07-7 | S-Trityl-L-cysteine

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$6.00	$4.00
5g	95%	in stock	$8.00	$6.00
10g	95%	in stock	$11.00	$8.00
25g	95%	in stock	$26.00	$18.00
100g	95%	in stock	$100.00	$70.00
500g	95%	in stock	$436.00	$306.00

Description

• Catalog Number: AI46430
• Chemical Name: S-Trityl-L-cysteine
• CAS Number: 2799-07-7
• Molecular Formula: C22H21NO2S
• Molecular Weight: 363.4726
• MDL Number: MFCD00002611
• SMILES: NC(C(=O)O)CSC(c1ccccc1)(c1ccccc1)c1ccccc1

Computed Properties

• Complexity: 392
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 7
• XLogP3: 2

Literature

• Doing the methylene shuffle--further insights into the inhibition of mitotic kinesin Eg5 with S-trityl L-cysteine.

  European journal of medicinal chemistry 20120801

• Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives.

  European journal of medicinal chemistry 20120301

• Triphenylbutanamines: kinesin spindle protein inhibitors with in vivo antitumor activity.

  Journal of medicinal chemistry 20120223

• Synthesis and characterization of tritylthioethanamine derivatives with potent KSP inhibitory activity.

  Bioorganic & medicinal chemistry 20110915

• Isobaric peptide termini labeling utilizing site-specific N-terminal succinylation.

  Analytical chemistry 20110615

• Structure-activity relationship and multidrug resistance study of new S-trityl-L-cysteine derivatives as inhibitors of Eg5.

  Journal of medicinal chemistry 20110324

• Loop 5-directed compounds inhibit chimeric kinesin-5 motors: implications for conserved allosteric mechanisms.

  The Journal of biological chemistry 20110225

• S-trityl-L-cysteine derivative induces caspase-independent cell death in K562 human chronic myeloid leukemia cell line.

  Cancer letters 20101201

• Proteomic analysis of annexin A2 phosphorylation induced by microtubule interfering agents and kinesin spindle protein inhibitors.

  Journal of proteome research 20100903

• Chiral ligand-exchange separation and resolution of extremely rigid glutamate analogs: 1-aminospiro[2.2]pentyl-1,4-dicarboxylic acids.

  Analytical and bioanalytical chemistry 20100701

• The conserved L5 loop establishes the pre-powerstroke conformation of the Kinesin-5 motor, eg5.

  Biophysical journal 20100602

• Docetaxel-resistant prostate cancer cells remain sensitive to S-trityl-L-cysteine-mediated Eg5 inhibition.

  Molecular cancer therapeutics 20100601

• Tiam1-Rac signaling counteracts Eg5 during bipolar spindle assembly to facilitate chromosome congression.

  Current biology : CB 20100413

• Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry.

  PLoS biology 20100401

• Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines.

  Biochemical pharmacology 20100315

• Biochemical analysis of cellular target of S-trityl-L-cysteine derivatives using affinity matrix.

  Bioorganic & medicinal chemistry letters 20100301

• Glyfoline induces mitotic catastrophe and apoptosis in cancer cells.

  International journal of cancer 20100215

• Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition.

  Molecular & cellular proteomics : MCP 20100201

• Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest.

  PloS one 20100101

• An allosteric transition trapped in an intermediate state of a new kinesin-inhibitor complex.

  The Biochemical journal 20091214

• Effects of chemical manipulation of mitotic arrest and slippage on cancer cell survival and proliferation.

  Cell cycle (Georgetown, Tex.) 20090915

• Isobaric peptide termini labeling for MS/MS-based quantitative proteomics.

  Journal of proteome research 20090901

• Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells.

  PLoS biology 20090501

• The effect of the copper(II) salt anion in the Chiral Ligand-Exchange Chromatography of amino acids.

  Analytica chimica acta 20090413

• Microtubule interfering agents and KSP inhibitors induce the phosphorylation of the nuclear protein p54(nrb), an event linked to G2/M arrest.

  Journal of proteomics 20090130

• Polo-like kinase-1 controls Aurora A destruction by activating APC/C-Cdh1.

  PloS one 20090101

• Localization and function of Kinesin-5-like proteins during assembly and maintenance of mitotic spindles in Silvetia compressa.

  BMC research notes 20090101

• KIF11 inhibition for glioblastoma treatment: reason to hope or a struggle with the brain?

  BMC cancer 20090101

• Cysteine-based chiral selectors for the ligand-exchange separation of amino acids.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081101

• Descriptive structure-separation relationship studies in chiral ligand-exchange chromatography.

  Journal of separation science 20080701

• Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.

  Journal of medicinal chemistry 20080313

• S-trityl-(R)-cysteine, a powerful chiral selector for the analytical and preparative ligand-exchange chromatography of amino acids.

  Journal of separation science 20080301

• Cysteine-S-trityl a key derivative to prepare N-methyl cysteines.

  Journal of combinatorial chemistry 20080101

• Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.

  Proteomics 20080101

• ATP-competitive inhibitors of the mitotic kinesin KSP that function via an allosteric mechanism.

  Nature chemical biology 20071101

• Docking studies on kinesin spindle protein inhibitors: an important cooperative 'minor binding pocket' which increases the binding affinity significantly.

  Journal of molecular modeling 20070901

• Estrogen-dependent regulation of Eg5 in breast cancer cells.

  Anti-cancer drugs 20070801

• Inhibition of cell growth and induction of apoptosis via inactivation of NF-kappaB by a sulfurcompound isolated from garlic in human colon cancer cells.

  Journal of pharmacological sciences 20070801

• Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors.

  Bioorganic & medicinal chemistry letters 20070715

• Inhibitors of kinesin Eg5: antiproliferative activity of monastrol analogues against human glioblastoma cells.

  Cancer chemotherapy and pharmacology 20070201

• Regulation and targeting of Eg5, a mitotic motor protein in blast crisis CML: overcoming imatinib resistance.

  Cell cycle (Georgetown, Tex.) 20061001

• Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents.

  Journal of molecular biology 20060707

• S-trityl-L-cysteine is a reversible, tight binding inhibitor of the human kinesin Eg5 that specifically blocks mitotic progression.

  The Journal of biological chemistry 20060630

• Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol.

  BMC chemical biology 20060101

• Kinesin-5 motors are required for organization of spindle microtubules in Silvetia compressa zygotes.

  BMC plant biology 20060101

• Effects of a series of organosulfur compounds on mitotic arrest and induction of apoptosis in colon cancer cells.

  Molecular cancer therapeutics 20050901

• Identification of the protein binding region of S-trityl-L-cysteine, a new potent inhibitor of the mitotic kinesin Eg5.

  Biochemistry 20041019

• In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities.

  Molecular cancer therapeutics 20040901

• Enhanced antitumor activity of irofulven in combination with antimitotic agents.

  Investigational new drugs 20020801

• seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties.

  Journal of medicinal chemistry 20010215