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Cadmium-induced heme-oxygenase-1 expression plays dual roles in autophagy and apoptosis and is regulated by both PKC-δ and PKB/Akt activation in NRK52E kidney cells.
Toxicology 20160831
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Effects of Chrysotile Exposure in Human Bronchial Epithelial Cells: Insights into the Pathogenic Mechanisms of Asbestos-Related Diseases.
Environmental health perspectives 20160601
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Enhancing Beta-Catenin Activity via GSK3beta Inhibition Protects PC12 Cells against Rotenone Toxicity through Nurr1 Induction.
PloS one 20160101
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Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.
The Journal of biological chemistry 20150529
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Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells.
Cell death & disease 20140801
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Cell-based assays for Parkinson's disease using differentiated human LUHMES cells.
Acta pharmacologica Sinica 20140701
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Activation of β-catenin by inhibitors of glycogen synthase kinase-3 ameliorates cisplatin-induced cytotoxicity and pro-inflammatory cytokine expression in HEI-OC1 cells.
Toxicology 20140605
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Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells.
The Journal of biological chemistry 20140418
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Resveratrol protects astrocytes against traumatic brain injury through inhibiting apoptotic and autophagic cell death.
Cell death & disease 20140301
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PI3K signaling mediates diverse regulation of ATF4 expression for the survival of HK-2 cells exposed to cadmium.
Archives of toxicology 20140201
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3,5,4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.
Toxicology and applied pharmacology 20131101
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The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells.
Toxicology letters 20130412
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A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors.
PloS one 20130101
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Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimer's disease: design, synthesis, and characterization of pyrazines.
Journal of medicinal chemistry 20121108
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IL-6 augmented motility of airway epithelial cell BEAS-2B via Akt/GSK-3β signaling pathway.
Journal of cellular biochemistry 20121101
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WNT/β-catenin-signaling pathway stimulates the proliferation of cultured adult human Sertoli cells via upregulation of C-myc expression.
Reproductive sciences (Thousand Oaks, Calif.) 20121101
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Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains.
FEBS letters 20121019
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Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling.
Toxicology and applied pharmacology 20121015
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Pharmacological inhibition of GSK-3β produces late phase of cardioprotection in hyperlipidemic rat: possible involvement of HSP 72.
Molecular and cellular biochemistry 20121001
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Glycogen synthase kinase-3β activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization.
Biochemical and biophysical research communications 20120914
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Roles of glycogen synthase kinase 3 in Alzheimer's disease.
Current Alzheimer research 20120901
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Activation of Akt/protein kinase B mediates the protective effects of mechanical stretching against myocardial ischemia-reperfusion injury.
Journal of veterinary science 20120901
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Ischemic postconditioning mediates cardioprotection via PI3K/GSK-3β/β-catenin signaling pathway in ischemic rat myocardium.
Shock (Augusta, Ga.) 20120801
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Wnt3a upregulates prostaglandin F2α-stimulated vascular endothelial growth factor synthesis in osteoblasts.
Molecular medicine reports 20120801
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GSK-3 promotes cell survival, growth, and PAX3 levels in human melanoma cells.
Molecular cancer research : MCR 20120801
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Glycogen synthase kinase 3β (GSK3β) modulates antiviral activity of zinc-finger antiviral protein (ZAP).
The Journal of biological chemistry 20120629
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Acute inhibition of GSK causes mitochondrial remodeling.
American journal of physiology. Heart and circulatory physiology 20120601
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Inhibition of GSK-3beta ameliorates hepatic ischemia-reperfusion injury through GSK-3beta/beta-catenin signaling pathway in mice.
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Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523
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Inhibition of GSK3 attenuates amphetamine-induced hyperactivity and sensitization in the mouse.
Behavioural brain research 20120516
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Apoptosis induced by SRC-family tyrosine kinase inhibitors in cultured rat cortical cells.
Neurotoxicity research 20120401
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Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine.
Schizophrenia research 20120401
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Targeting of GSK3β promotes imatinib-mediated apoptosis in quiescent CD34+ chronic myeloid leukemia progenitors, preserving normal stem cells.
Blood 20120308
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Inhibition of glycogen synthase kinase-3 activity triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms.
Carcinogenesis 20120301
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Sex differences in the GSK3β-mediated survival of adherent leukemic progenitors.
Oncogene 20120209
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Phosphorylation of Akt/GSK-3β/eNOS amplifies 5-HT2B receptor blockade mediated anti-hypertrophic effect in rats.
FEBS letters 20120120
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A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells.
Toxicology and applied pharmacology 20120115
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Muscle FBPase binds to cardiomyocyte mitochondria under glycogen synthase kinase-3 inhibition or elevation of cellular Ca2+ level.
FEBS letters 20120102
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Ursolic acid from Oldenlandia diffusa induces apoptosis via activation of caspases and phosphorylation of glycogen synthase kinase 3 beta in SK-OV-3 ovarian cancer cells.
Biological & pharmaceutical bulletin 20120101
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Wnt activation by wild type and mutant myocilin in cultured human trabecular meshwork cells.
PloS one 20120101
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Inhibition of glycogen synthase kinase 3β ameliorates D-GalN/LPS-induced liver injury by reducing endoplasmic reticulum stress-triggered apoptosis.
PloS one 20120101
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Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania.
The international journal of neuropsychopharmacology 20110901
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Glycogen synthase kinase-3β regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src.
The Biochemical journal 20110715
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Glycogen synthase kinase 3β in the basolateral amygdala is critical for the reconsolidation of cocaine reward memory.
Journal of neurochemistry 20110701
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Glycogen synthase kinase-3β is a crucial mediator of signal-induced RelB degradation.
Oncogene 20110526
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GSK3β inactivation in podocytes results in decreased phosphorylation of p70S6K accompanied by cytoskeletal rearrangements and inhibited motility.
American journal of physiology. Renal physiology 20110501
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Tumor necrosis factor-α induces increased lung vascular permeability: a role for GSK3α/β.
European journal of pharmacology 20110425
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The regulatory mechanism of melanogenesis by FTY720, a sphingolipid analogue.
Experimental dermatology 20110301
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Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production.
Journal of neurochemistry 20110301
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Behavioral phenotyping of v-akt murine thymoma viral oncogene homolog 1-deficient mice reveals a sex-specific prepulse inhibition deficit in females that can be partially alleviated by glycogen synthase kinase-3 inhibitors but not by antipsychotics.
Neuroscience 20110203
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The first synthesis of [(11)C]SB-216763, a new potential PET agent for imaging of glycogen synthase kinase-3 (GSK-3).
Bioorganic & medicinal chemistry letters 20110101
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RNAi-based screening identifies kinases interfering with dioxin-mediated up-regulation of CYP1A1 activity.
PloS one 20110101
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Dendritic cell maturation occurs through the inhibition of GSK-3β.
Cellular immunology 20110101
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AP-1 is a component of the transcriptional network regulated by GSK-3 in quiescent cells.
PloS one 20110101
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Lithium promotes neural precursor cell proliferation: evidence for the involvement of the non-canonical GSK-3β-NF-AT signaling.
Cell & bioscience 20110101
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Lithium suppresses astrogliogenesis by neural stem and progenitor cells by inhibiting STAT3 pathway independently of glycogen synthase kinase 3 beta.
PloS one 20110101
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Involvement of the glycogen synthase kinase-3 signaling pathway in TBI pathology and neurocognitive outcome.
PloS one 20110101
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Inhibition of glycogen synthase kinase-3β counteracts ligand-independent activity of the androgen receptor in castration resistant prostate cancer.
PloS one 20110101
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Glycogen synthase kinase-3 and p38 MAPK are required for opioid-induced microglia apoptosis.
Neuropharmacology 20101101
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Phosphorylation-dependent regulation of PSF by GSK3 controls CD45 alternative splicing.
Molecular cell 20101008
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Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells.
Bioorganic & medicinal chemistry 20100915
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Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.
Cellular and molecular neurobiology 20100801
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{beta}-Catenin regulates airway smooth muscle contraction.
American journal of physiology. Lung cellular and molecular physiology 20100801
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Inhibition of glycogen synthase kinase 3beta prevents peroxide-induced collapse of mitochondrial membrane potential in rat ventricular myocytes.
Clinical and experimental pharmacology & physiology 20100701
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Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100630
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4-Aminoethylamino-emodin--a novel potent inhibitor of GSK-3beta--acts as an insulin-sensitizer avoiding downstream effects of activated beta-catenin.
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Cardioprotection by GSK-3 inhibition: role of enhanced glycogen synthesis and attenuation of calcium overload.
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Pulmonary artery smooth muscle hypertrophy: roles of glycogen synthase kinase-3beta and p70 ribosomal S6 kinase.
American journal of physiology. Lung cellular and molecular physiology 20100601
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Effects of areca nut extract on the apoptosis pathways in human neutrophils.
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Neurites regrowth of cortical neurons by GSK3beta inhibition independently of Nogo receptor 1.
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Inhibition of GSK3 attenuates dopamine D1 receptor agonist-induced hyperactivity in mice.
Brain research bulletin 20100531
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GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100421
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Chelation of extracellular calcium-induced cell death was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.
Cellular and molecular neurobiology 20100301
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3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763), a glycogen synthase kinase-3 inhibitor, displays therapeutic properties in a mouse model of pulmonary inflammation and fibrosis.
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A new class of molecular targeted radioprotectors: GSK-3beta inhibitors.
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Modulation of Akt and ERK1/2 pathways by resveratrol in chronic myelogenous leukemia (CML) cells results in the downregulation of Hsp70.
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Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice.
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Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/beta-catenin pathway.
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Regulation of serotonin 1B receptor by glycogen synthase kinase-3.
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Glycogen synthase kinase 3beta in the nucleus accumbens core mediates cocaine-induced behavioral sensitization.
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Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway.
Molecular pharmacology 20091001
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nature chemical biology 20091001
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Chronic lithium treatment up-regulates cell surface Na(V)1.7 sodium channels via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells: enhancement of Na(+) influx, Ca(2+) influx and catecholamine secretion after lithium withdrawal.
Neuropharmacology 20090901
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Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models.
European journal of medicinal chemistry 20090601
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Bimodal modulation of tau protein phosphorylation and conformation by extracellular Zn2+ in human-tau transfected cells.
Biochimica et biophysica acta 20090601
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The ceiling effect of pharmacological postconditioning with the phytoestrogen genistein is reversed by the GSK3beta inhibitor SB 216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione] through mitochondrial ATP-dependent potassium channel opening.
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TNF-induced activation of pulmonary microvessel endothelial cells: a role for GSK3beta.
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Cadmium toxicity toward autophagy through ROS-activated GSK-3beta in mesangial cells.
Toxicological sciences : an official journal of the Society of Toxicology 20090301
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Knockin of mutant PIK3CA activates multiple oncogenic pathways.
Proceedings of the National Academy of Sciences of the United States of America 20090224
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Neuropharmacology 20090201
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GSK3beta regulates differentiation and growth arrest in glioblastoma.
PloS one 20090101
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Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation.
Circulation research 20081024
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A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression.
American journal of physiology. Cell physiology 20080901
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Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition.
Anesthesia and analgesia 20080901
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Cardioprotective effect of morphine and a blocker of glycogen synthase kinase 3 beta, SB216763 [3-(2,4-dichlorophenyl)-4(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione], via inhibition of the mitochondrial permeability transition pore.
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Inhibition of glycogen synthase kinase-3 in androgen-responsive prostate cancer cell lines: are GSK inhibitors therapeutically useful?
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Regulation of Akt mRNA and protein levels by glycogen synthase kinase-3beta in adrenal chromaffin cells: effects of LiCl and SB216763.
European journal of pharmacology 20080531
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Inhibition of GSK3beta by postconditioning is required to prevent opening of the mitochondrial permeability transition pore during reperfusion.
Circulation 20080527
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GSK3 promotes arsenite-induced apoptosis via facilitation of mitochondria disruption.
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Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore.
American journal of hypertension 20080501
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Delayed cardioprotection afforded by the glycogen synthase kinase 3 inhibitor SB-216763 occurs via a KATP- and MPTP-dependent mechanism at reperfusion.
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Inhibitors of GSK-3 prevent corticosterone from inducing COX-1 expression in cardiomyocytes.
Cardiovascular toxicology 20080101
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The selectivity of protein kinase inhibitors: a further update.
The Biochemical journal 20071215
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Inhibition of GSK-3beta decreases NF-kappaB-dependent gene expression and impairs the rat liver regeneration.
Journal of cellular biochemistry 20071201
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MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.
The Journal of biological chemistry 20071019
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Media conditioned by retinal pigment epithelial cells suppress the canonical Wnt pathway.
Neuroscience letters 20070913
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Cyclosporine A- and FK506-induced apoptosis in PC12 cells.
Cell biology and toxicology 20070901
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Calmodulin inhibitor-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.
Cellular and molecular neurobiology 20070901
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GSK3beta inhibition and K(ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion.
Basic research in cardiology 20070701
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Celecoxib induces apoptosis in COX-2 deficient human gastric cancer cells through Akt/GSK3beta/NAG-1 pathway.
Cancer letters 20070628
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Structure based de novo design of novel glycogen synthase kinase 3 inhibitors.
Bioorganic & medicinal chemistry 20070601
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Erythropoietin protects cardiac myocytes against anthracycline-induced apoptosis.
Biochemical and biophysical research communications 20070309
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Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates.
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An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells.
Cancer research 20070101
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Inhibiting glycogen synthase kinase 3beta in sepsis.
Novartis Foundation symposium 20070101
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Involvement of glycogen synthase kinase-3beta in palmitate-induced human umbilical vein endothelial cell apoptosis.
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Thapsigargin-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells.
Neuroscience letters 20061113
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The Journal of pharmacology and experimental therapeutics 20061101
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Journal of agricultural and food chemistry 20060920
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Journal of agricultural and food chemistry 20060920
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Brain research 20060919
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A cellular assay for measuring the inhibition of glycogen synthase kinase-3 via the accumulation of beta-catenin in Chinese hamster ovary clone K1 cells.
Assay and drug development technologies 20060801
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Neuroscience letters 20060529
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Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Glycogen synthase kinase-3beta inhibitors protect against the organ injury and dysfunction caused by hemorrhage and resuscitation.
Shock (Augusta, Ga.) 20060501
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The Journal of biological chemistry 20060224
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Oncogene 20060105
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Journal of molecular and cellular cardiology 20060101
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IDrugs : the investigational drugs journal 20060101
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Developmental biology 20050915
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Critical care medicine 20050901
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Molecular cancer therapeutics 20050901
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Cancer research 20050715
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Clinical cancer research : an official journal of the American Association for Cancer Research 20050615
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Neuroscience 20050101
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The Journal of biological chemistry 20041210
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Oncogene 20041014
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European journal of pharmacology 20040924
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European journal of pharmacology 20040714
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Circulation research 20040416
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Oncogene 20040401
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Biochemical and biophysical research communications 20040319
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Bioorganic & medicinal chemistry letters 20030915
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Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin.
The Biochemical journal 20021015
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Circulation research 20020308
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FEBS letters 20011102
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Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.
Chemistry & biology 20001001
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Diabetes 20000201
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Diabetes 19990801
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Proceedings of the National Academy of Sciences of the United States of America 19930815
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Molecular endocrinology (Baltimore, Md.)