28230-32-2 | 3-Hydroxy-1,2,3-ben zotriazin-4(3H)-one

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$96.00	$67.00
5g	98%	in stock	$126.00	$88.00
25g	95	in stock	$142.00	$99.00
100g	95	in stock	$327.00	$229.00

Description

• Catalog Number: AB51227
• Chemical Name: 3-Hydroxy-1,2,3-ben zotriazin-4(3H)-one
• CAS Number: 28230-32-2
• Molecular Formula: C7H5N3O2
• Molecular Weight: 163.1335
• MDL Number: MFCD00042803
• SMILES: On1nnc2c(c1=O)cccc2
• NSC Number: 279266

Computed Properties

• Complexity: 229
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• XLogP3: 0.3

Upstream Synthesis Route

3-Hydroxy-1,2,3-benzotriazin-4(3H)-one, also known as hydroxybenzotriazole (HOBt), is a versatile and widely used reagent in chemical synthesis. It is commonly employed as a coupling agent in peptide synthesis to enhance the efficiency and yield of amide bond formation. HOBt functions as a catalyst in these reactions, promoting the formation of peptide bonds between amino acids with minimal racemization. Additionally, HOBt is utilized in the synthesis of esters and other organic compounds due to its ability to improve reaction selectivity and purity. Its compatibility with a variety of functional groups and relatively mild reaction conditions make it a valuable tool in modern organic chemistry.

Literature

• Effect of Steric Constraint at the γ-Backbone Position on the Conformations and Hybridization Properties of PNAs.

  Journal of nucleic acids 20110101

• Dual-cloud point extraction and tertiary amine labeling for selective and sensitive capillary electrophoresis-electrochemiluminescent detection of auxins.

  Journal of chromatography. A 20100219

• Delay of coupling caused by excess additives.

  Journal of peptide science : an official publication of the European Peptide Society 20060201

• Studies on mediators of manganese peroxidase for bleaching of wood pulps.

  Bioresource technology 20021201

• Synthesis of a membrane protein with two transmembrane regions.

  Journal of peptide science : an official publication of the European Peptide Society 20020401

• Electrogenerated chemiluminescence derivatization reagents for carboxylic acids and amines in high-performance liquid chromatography using tris(2,2'-bipyridine)ruthenium(II).

  Analytical chemistry 20020401

• An alternative solid phase peptide fragment condensation protocol with improved efficiency.

  Journal of peptide science : an official publication of the European Peptide Society 20011001