288150-92-5 | SB-408124

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$17.00	$12.00
5mg	98%	in stock	$53.00	$37.00
100mg	98	in stock	$965.00	$676.00

Description

• Catalog Number: AB35366
• Chemical Name: SB-408124
• CAS Number: 288150-92-5
• Molecular Formula: C19H18F2N4O
• Molecular Weight: 356.3692
• MDL Number: MFCD06411575
• SMILES: O=C(Nc1cc(C)nc2c1cc(F)cc2F)Nc1ccc(cc1)N(C)C

Computed Properties

• Complexity: 484
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 3.5

Literature

• Selective orexin receptor antagonists.

  Bioorganic & medicinal chemistry letters 20130901

• Neuroendocrine regulatory peptide-1 and neuroendocrine regulatory peptide-2 influence differentially feeding and penile erection in male rats: sites of action in the brain.

  Regulatory peptides 20120820

• The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats.

  Pflugers Archiv : European journal of physiology 20120401

• Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone.

  PloS one 20120101

• Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.

  British journal of pharmacology 20110301

• Activation of orexin/hypocretin type 1 receptors stimulates cAMP synthesis in primary cultures of rat astrocytes.

  Pharmacological reports : PR 20110101

• [Cardiovascular effect of intracerebroventricular injection of orexin-1 receptor antagonist in rats].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20100801

• Modulation of respiratory activity by hypocretin-1 (orexin A) in situ and in vitro.

  Advances in experimental medicine and biology 20100101

• Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.

  The Journal of pharmacology and experimental therapeutics 20090701

• Reinstatement of cocaine seeking by hypocretin (orexin) in the ventral tegmental area: independence from the local corticotropin-releasing factor network.

  Biological psychiatry 20090515