290297-26-6 | Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-

Packsize	Purity	Availability	Price	Discounted Price
5mg	99%	in stock	$15.00	$10.00
250mg	99%	in stock	$45.00	$31.00
1g	99%	in stock	$80.00	$56.00
5g	99%	in stock	$279.00	$195.00
25g	99%	in stock	$975.00	$682.00

Description

• Catalog Number: AB33624
• Chemical Name: Benzeneacetamide, N,α,α-trimethyl-N-[4-(2-methylphenyl)-6-(4-methyl-1-piperazinyl)-3-pyridinyl]-3,5-bis(trifluoromethyl)-
• CAS Number: 290297-26-6
• Molecular Formula: C30H32F6N4O
• Molecular Weight: 578.5917
• MDL Number: MFCD02684471
• SMILES: CN1CCN(CC1)c1ncc(c(c1)c1ccccc1C)N(C(=O)C(c1cc(cc(c1)C(F)(F)F)C(F)(F)F)(C)C)C

Computed Properties

• Complexity: 865
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 41
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 5
• XLogP3: 6.8

Literature

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  Pharmacology, biochemistry, and behavior 20150401

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  Annals of oncology : official journal of the European Society for Medical Oncology 20140701

• Activation of neurokinin-1 receptors increases the excitability of guinea pig dorsal root ganglion cells.

  The Journal of pharmacology and experimental therapeutics 20121001

• In vitro and in vivo pharmacological characterization of the novel NK₁ receptor selective antagonist Netupitant.

  Peptides 20120901

• Inhibition of substance P-mediated responses in NG108-15 cells by netupitant and palonosetron exhibit synergistic effects.

  European journal of pharmacology 20120815

• Novel neurokinin-1 antagonists as antiemetics for the treatment of chemotherapy-induced emesis.

  Supportive cancer therapy 20060401

• Efficient synthesis of novel NK1 receptor antagonists: selective 1,4-addition of grignard reagents to 6-chloronicotinic acid derivatives.

  The Journal of organic chemistry 20060303

• Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists.

  Bioorganic & medicinal chemistry letters 20060301