293754-55-9 | T0901317

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$23.00	$17.00
5mg	95%	in stock	$44.00	$31.00
10mg	95%	in stock	$52.00	$36.00
25mg	95%	in stock	$110.00	$77.00
50mg	95%	in stock	$149.00	$104.00
100mg	95%	in stock	$223.00	$156.00
250mg	95%	in stock	$311.00	$218.00
1g	95%	in stock	$840.00	$588.00

Description

• Catalog Number: AB37458
• Chemical Name: T0901317
• CAS Number: 293754-55-9
• Molecular Formula: C17H12F9NO3S
• Molecular Weight: 481.3327
• MDL Number: MFCD03412028
• SMILES: FC(CN(S(=O)(=O)c1ccccc1)c1ccc(cc1)C(C(F)(F)F)(C(F)(F)F)O)(F)F

Computed Properties

• Complexity: 684
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 13
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 4.9

Literature

• Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies.

  Archives of toxicology 20180713

• Oxyresveratrol ameliorates nonalcoholic fatty liver disease by regulating hepatic lipogenesis and fatty acid oxidation through liver kinase B1 and AMP-activated protein kinase.

  Chemico-biological interactions 20180601

• Sedaxane-Use of Nuclear Receptor Transactivation Assays, Toxicogenomics, and Toxicokinetics as Part of a Mode of Action Framework for Rodent Liver Tumors.

  Toxicological sciences : an official journal of the Society of Toxicology 20180401

• Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles.

  Archives of toxicology 20180401

• Activation of liver X receptors inhibit LPS-induced inflammatory response in primary bovine mammary epithelial cells.

  Veterinary immunology and immunopathology 20180301

• Liver X Receptor Agonist Therapy Prevents Diffuse Alveolar Hemorrhage in Murine Lupus by Repolarizing Macrophages.

  Frontiers in immunology 20180101

• Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis.

  Toxicological sciences : an official journal of the Society of Toxicology 20170901

• B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.

  Toxicology 20170701

• Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor.

  Archives of toxicology 20170601

• Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics.

  Molecular pharmacology 20170401

• Ozone-derived Oxysterols Affect Liver X Receptor (LXR) Signaling: A POTENTIAL ROLE FOR LIPID-PROTEIN ADDUCTS.

  The Journal of biological chemistry 20161125

• Activation of the Constitutive Androstane Receptor by Monophthalates.

  Chemical research in toxicology 20161017

• Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages.

  The Journal of biological chemistry 20160520

• Emodin isolated from Polygoni Multiflori Ramulus inhibits melanogenesis through the liver X receptor-mediated pathway.

  Chemico-biological interactions 20160425

• Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders.

  Toxicology and applied pharmacology 20160401

• Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators.

  ACS medicinal chemistry letters 20150813

• Activation of liver X receptors inhibits cadmium-induced apoptosis of human renal proximal tubular cells.

  Toxicology letters 20150805

• Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells.

  Chemical research in toxicology 20150615

• Isoflavones enhance interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.

  Toxicology 20150302

• Effects of toxicologically relevant xenobiotics and the lipid-derived electrophile 4-hydroxynonenal on macrophage cholesterol efflux: silencing carboxylesterase 1 has paradoxical effects on cholesterol uptake and efflux.

  Chemical research in toxicology 20141020

• Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture.

  Toxicological sciences : an official journal of the Society of Toxicology 20140801

• Protective effect of resveratrol derivatives on high-fat diet induced fatty liver by activating AMP-activated protein kinase.

  Archives of pharmacal research 20140101

• Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors.

  Toxicology in vitro : an international journal published in association with BIBRA 20131001

• Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction.

  Toxicology and applied pharmacology 20130815

• Dual roles of nuclear receptor liver X receptor α (LXRα) in the CYP3A4 expression in human hepatocytes as a positive and negative regulator.

  Biochemical pharmacology 20130801

• Resveratrol suppresses T0901317-induced hepatic fat accumulation in mice.

  The AAPS journal 20130701

• Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

  Journal of hepatology 20130501

• Liver X receptor alpha mediated genistein induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1) in Hep G2 cells.

  Toxicology and applied pharmacology 20130415

• Mechanisms of action of hormone-sensitive lipase in mouse Leydig cells: its role in the regulation of the steroidogenic acute regulatory protein.

  The Journal of biological chemistry 20130322

• A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα.

  Biochimie 20130301

• Resveratrol administration or SIRT1 overexpression does not increase LXR signaling and macrophage-to-feces reverse cholesterol transport in vivo.

  Translational research : the journal of laboratory and clinical medicine 20130201

• TO901317, a potent LXR agonist, is an inverse agonist of CAR.

  The Journal of toxicological sciences 20130101

• Activation of liver X receptor induces macrophage interleukin-5 expression.

  The Journal of biological chemistry 20121221

• A role for protein inhibitor of activated STAT1 (PIAS1) in lipogenic regulation through SUMOylation-independent suppression of liver X receptors.

  The Journal of biological chemistry 20121102

• Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice.

  The Journal of steroid biochemistry and molecular biology 20121101

• Activation of liver X receptor inhibits osteopontin and ameliorates diabetic nephropathy.

  Journal of the American Society of Nephrology : JASN 20121101

• Unsaturated fatty acids repress expression of ATP binding cassette transporter A1 and G1 in RAW 264.7 macrophages.

  The Journal of nutritional biochemistry 20121001

• Regulation of sphingomyelin phosphodiesterase acid-like 3A gene (SMPDL3A) by liver X receptors.

  Molecular pharmacology 20121001

• Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton.

  Journal of medicinal chemistry 20120913

• Lycopene and the LXRα agonist T0901317 synergistically inhibit the proliferation of androgen-independent prostate cancer cells via the PPARγ-LXRα-ABCA1 pathway.

  The Journal of nutritional biochemistry 20120901

• Liver X receptors agonists impede hepatitis C virus infection in an Idol-dependent manner.

  Antiviral research 20120901

• Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.

  Arteriosclerosis, thrombosis, and vascular biology 20120901

• Liver X receptor agonist alleviated high glucose-induced endothelial progenitor cell dysfunction via inhibition of reactive oxygen species and activation of AMP-activated protein kinase.

  Microcirculation (New York, N.Y. : 1994) 20120801

• Highly potent binding and inverse agonist activity of bisphenol A derivatives for retinoid-related orphan nuclear receptor RORγ.

  Toxicology letters 20120720

• LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis.

  Anticancer research 20120701

• Ethyl 2,4,6-trihydroxybenzoate is an agonistic ligand for liver X receptor that induces cholesterol efflux from macrophages without affecting lipid accumulation in HepG2 cells.

  Bioorganic & medicinal chemistry letters 20120615

• Aberrant activation of liver X receptors impairs pancreatic beta cell function through upregulation of sterol regulatory element-binding protein 1c in mouse islets and rodent cell lines.

  Diabetologia 20120601

• Pharmacological LXR activation reduces presence of SR-B1 in liver membranes contributing to LXR-mediated induction of HDL-cholesterol.

  Atherosclerosis 20120601

• Lipopolysaccharide represses the expression of ATP-binding cassette transporter G1 and scavenger receptor class B, type I in murine macrophages.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120501

• Liver X receptor α is involved in the transcriptional regulation of the 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene.

  Diabetes 20120501

• Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice.

  The Journal of clinical investigation 20120501

• ABCA1 upregulating apolipoproein M expression mediates via the RXR/LXR pathway in HepG2 cells.

  Biochemical and biophysical research communications 20120427

• HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux.

  Journal of lipid research 20120401

• Discovery of a new binding mode for a series of liver X receptor agonists.

  Bioorganic & medicinal chemistry letters 20120401

• Inhibitory effects of azole-type fungicides on interleukin-17 gene expression via retinoic acid receptor-related orphan receptors α and γ.

  Toxicology and applied pharmacology 20120315

• Liver X receptor activation enhances blood-brain barrier integrity in the ischemic brain and increases the abundance of ATP-binding cassette transporters ABCB1 and ABCC1 on brain capillary cells.

  Brain pathology (Zurich, Switzerland) 20120301

• Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells.

  Biology of reproduction 20120301

• Effect of simvastatin on the expression and regulation mechanism of apolipoprotein M.

  International journal of molecular medicine 20120301

• Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule.

  American journal of physiology. Renal physiology 20120301

• Activation of liver X receptors attenuates endotoxin-induced liver injury in mice with nonalcoholic fatty liver disease.

  Digestive diseases and sciences 20120201

• Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line.

  Biochemical pharmacology 20120115

• Liver X receptors regulate cholesterol homeostasis in oligodendrocytes.

  Journal of neuroscience research 20120101

• Retinoic acid and liver X receptor agonist synergistically inhibit HIV infection in CD4+ T cells by up-regulating ABCA1-mediated cholesterol efflux.

  Lipids in health and disease 20120101

• Myelin-derived lipids modulate macrophage activity by liver X receptor activation.

  PloS one 20120101

• Synthetic LXR agonist inhibits the development of atherosclerosis in New Zealand White rabbits.

  Biochimica et biophysica acta 20111201

• Synthetic LXR agonist T0901317 attenuates lipopolysaccharide-induced acute lung injury in rats.

  International immunopharmacology 20111201

• Effect of synthetic ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the fatty acid composition of phospholipids in mice.

  Lipids 20111101

• Rimonabant, a cannabinoid receptor type 1 inverse agonist, inhibits hepatocyte lipogenesis by activating liver kinase B1 and AMP-activated protein kinase axis downstream of Gα i/o inhibition.

  Molecular pharmacology 20111101

• T0901317 inhibits cisplatin-induced apoptosis in ovarian cancer cells [corrected].

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20111101

• Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding.

  Antioxidants & redox signaling 20111015

• Activation of liver X receptor decreases BACE1 expression and activity by reducing membrane cholesterol levels.

  Neurochemical research 20111001

• Modified low density lipoproteins decrease the activity and expression of lysosomal acid lipase in human endothelial and smooth muscle cells.

  Cell biochemistry and biophysics 20110901

• n-3 fatty acids ameliorate hepatic steatosis and dysfunction after LXR agonist ingestion in mice.

  Biochimica et biophysica acta 20110901

• Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

  Environmental health perspectives 20110801

• PPARα-LXR as a novel metabolostatic signalling axis in skeletal muscle that acts to optimize substrate selection in response to nutrient status.

  The Biochemical journal 20110801

• Liver X receptor activation restores memory in aged AD mice without reducing amyloid.

  Neurobiology of aging 20110701

• The effect of diet on the response of low-density lipoprotein receptor knockout mice to the liver X receptor agonist T1317.

  Journal of cardiovascular pharmacology 20110701

• LXR as a novel antithrombotic target.

  Blood 20110526

• Critical role of astroglial apolipoprotein E and liver X receptor-α expression for microglial Aβ phagocytosis.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20110511

• Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4.

  Journal of immunology (Baltimore, Md. : 1950) 20110415

• Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor κB pathway.

  Shock (Augusta, Ga.) 20110401

• Selective phthalate activation of naturally occurring human constitutive androstane receptor splice variants and the pregnane X receptor.

  Toxicological sciences : an official journal of the Society of Toxicology 20110401

• Inhibition of LXRα-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation.

  Antioxidants & redox signaling 20110301

• Biliary sterol secretion is required for functional in vivo reverse cholesterol transport in mice.

  Gastroenterology 20110301

• Stimulation of lipogenesis as well as fatty acid oxidation protects against palmitate-induced INS-1 beta-cell death.

  Endocrinology 20110301

• Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.

  Journal of medicinal chemistry 20110210

• Regulation of bile acid, cholesterol, and fatty acid synthesis in chicken primary hepatocytes by different concentrations of T0901317, an agonist of liver X receptors.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20110201

• Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signaling pathway in human aortic endothelial cells.

  Atherosclerosis 20110201

• Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors.

  Placenta 20110201

• Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs.

  Journal of cellular biochemistry 20110201

• Evaluation of anti-atherosclerotic activities of PPAR-α, PPAR-γ, and LXR agonists in hyperlipidemic atherosclerosis-susceptible F(1)B hamsters.

  Atherosclerosis 20110101

• The evolution of farnesoid X, vitamin D, and pregnane X receptors: insights from the green-spotted pufferfish (Tetraodon nigriviridis) and other non-mammalian species.

  BMC biochemistry 20110101

• Human cytochrome P450 1A1 is a novel target gene of liver X receptor α.

  Drug metabolism and pharmacokinetics 20110101

• Mechanism of AMPK suppression of LXR-dependent Srebp-1c transcription.

  International journal of biological sciences 20110101

• Palmitic acid-induced apoptosis in pancreatic β-cells is increased by liver X receptor agonist and attenuated by eicosapentaenoate.

  In vivo (Athens, Greece) 20110101

• LXR agonist increases apoE secretion from HepG2 spheroid, together with an increased production of VLDL and apoE-rich large HDL.

  Lipids in health and disease 20110101

• A systems biology strategy for predicting similarities and differences of drug effects: evidence for drug-specific modulation of inflammation in atherosclerosis.

  BMC systems biology 20110101

• Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux.

  PloS one 20110101

• TO901317 regulating apolipoprotein M expression mediates via the farnesoid X receptor pathway in Caco-2 cells.

  Lipids in health and disease 20110101

• Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity.

  Journal of lipid research 20101201

• hCG-induced down-regulation of PPARγ and liver X receptors promotes periovulatory progesterone synthesis by macaque granulosa cells.

  Endocrinology 20101201

• Regulation of ABCG1 expression in human keratinocytes and murine epidermis.

  Journal of lipid research 20101101

• Activation of liver X receptors with T0901317 attenuates cardiac hypertrophy in vivo.

  European journal of heart failure 20101001

• The liver X receptor (LXR) and its target gene ABCA1 are regulated upon low oxygen in human trophoblast cells: a reason for alterations in preeclampsia?

  Placenta 20101001

• Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages.

  Arteriosclerosis, thrombosis, and vascular biology 20101001

• LXRalpha regulates human CETP expression in vitro and in transgenic mice.

  Atherosclerosis 20100901

• Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines.

  Anticancer research 20100901

• Activation of LXRα induces lipogenesis in HaCaT cells.

  Archives of pharmacal research 20100901

• An agonist of liver X receptor slows valvular disease in a hypercholesterolemia mouse model.

  The Journal of heart valve disease 20100901

• Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes.

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20100801

• Metabolic switching of human myotubes is improved by n-3 fatty acids.

  Journal of lipid research 20100801

• Stimulation of the liver X receptor pathway inhibits HIV-1 replication via induction of ATP-binding cassette transporter A1.

  Molecular pharmacology 20100801

• Recent progress in liver X receptor-selective modulators.

  Current opinion in drug discovery & development 20100701

• The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

  The Journal of biological chemistry 20100625

• Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI.

  Cardiovascular research 20100601

• Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.

  Oncogene 20100506

• Synthesis of 4-(3-biaryl)quinoline sulfones as potent liver X receptor agonists.

  Bioorganic & medicinal chemistry letters 20100501

• Discovery of tertiary sulfonamides as potent liver X receptor antagonists.

  Journal of medicinal chemistry 20100422

• Identification of phenylsulfone-substituted quinoxaline (WYE-672) as a tissue selective liver X-receptor (LXR) agonist.

  Journal of medicinal chemistry 20100422

• FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.

  Circulation research 20100305

• Impacts of different promoters on the mammalian one-hybrid assay for detecting nuclear receptor agonists.

  Analytical and bioanalytical chemistry 20100301

• Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.

  The Journal of biological chemistry 20100219

• Inhibition of SREBP-1c-mediated hepatic steatosis and oxidative stress by sauchinone, an AMPK-activating lignan in Saururus chinensis.

  Free radical biology & medicine 20100215

• Modulation of paraoxonase 1 and protein N-homocysteinylation by leptin and the synthetic liver X receptor agonist T0901317 in the rat.

  The Journal of endocrinology 20100201

• Liver X receptor agonist treatment regulates inflammatory response after spinal cord trauma.

  Journal of neurochemistry 20100201

• Liver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury.

  Journal of leukocyte biology 20100201

• Quinoline-3-carboxamide containing sulfones as liver X receptor (LXR) agonists with binding selectivity for LXRbeta and low blood-brain penetration.

  Bioorganic & medicinal chemistry letters 20100115

• 3-(3-Aryloxyaryl)imidazo[1,2-a]pyridine sulfones as liver X receptor agonists.

  Bioorganic & medicinal chemistry letters 20100115

• The human ADFP gene is a direct liver-X-receptor (LXR) target gene and differentially regulated by synthetic LXR ligands.

  Molecular pharmacology 20100101

• Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein.

  Gynecologic oncology 20100101

• 4-(3-Aryloxyaryl)quinoline sulfones are potent liver X receptor agonists.

  Bioorganic & medicinal chemistry letters 20100101

• Effects of Liver x receptor agonist treatment on signal transduction pathways in acute lung inflammation.

  Respiratory research 20100101

• Liver X receptor agonist methyl-3β-hydroxy-5α,6α-epoxycholanate attenuates atherosclerosis in apolipoprotein E knockout mice without increasing plasma triglyceride.

  Pharmacology 20100101

• Role of the nuclear receptors HNF4 alpha, PPAR alpha, and LXRs in the TNF alpha-mediated inhibition of human apolipoprotein A-I gene expression in HepG2 cells.

  Biochemistry 20091222

• Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling.

  Neuroscience 20091201

• 4-(3-aryloxyaryl)quinoline alcohols are liver X receptor agonists.

  Bioorganic & medicinal chemistry 20091201

• LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.

  Atherosclerosis 20091101

• Fetal liver X receptor activation acutely induces lipogenesis but does not affect plasma lipid response to a high-fat diet in adult mice.

  American journal of physiology. Endocrinology and metabolism 20091101

• Liver X receptor regulates expression of MRP2 but not that of MDR1 and BCRP in the liver.

  Biochimica et biophysica acta 20091101

• Effect of 27-hydroxycholesterol on survival and death of human macrophages and vascular smooth muscle cells.

  Free radical research 20091001

• An induction in hepatic HDL secretion associated with reduced ATPase expression.

  The American journal of pathology 20091001

• Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet.

  Atherosclerosis 20090901

• On the mechanism for PPAR agonists to enhance ABCA1 gene expression.

  Atherosclerosis 20090801

• LXRalpha activation perturbs hepatic insulin signaling and stimulates production of apolipoprotein B-containing lipoproteins.

  American journal of physiology. Gastrointestinal and liver physiology 20090801

• Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis.

  American journal of physiology. Endocrinology and metabolism 20090801

• Activation of the liver X receptor stimulates trans-intestinal excretion of plasma cholesterol.

  The Journal of biological chemistry 20090717

• Reduced insulin-mediated inhibition of VLDL secretion upon pharmacological activation of the liver X receptor in mice.

  Journal of lipid research 20090701

• Absence of nuclear receptors for oxysterols liver X receptor induces ovarian hyperstimulation syndrome in mice.

  Endocrinology 20090701

• eNOS mediates TO90317 treatment-induced angiogenesis and functional outcome after stroke in mice.

  Stroke 20090701

• Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells.

  Molecular cancer therapeutics 20090701

• Compound reduces viral cholesterol and inhibits HIV-1.

  AIDS patient care and STDs 20090701

• Elevated insulin secretion from liver X receptor-activated pancreatic beta-cells involves increased de novo lipid synthesis and triacylglyceride turnover.

  Endocrinology 20090601

• Discovery and SAR of cinnolines/quinolines as liver X receptor (LXR) agonists with binding selectivity for LXRbeta.

  Bioorganic & medicinal chemistry 20090515

• 25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.

  Journal of neurochemistry 20090501

• Fenofibrate ameliorates diabetic and dyslipidemic profiles in KKAy mice partly via down-regulation of 11beta-HSD1, PEPCK and DGAT2. Comparison of PPARalpha, PPARgamma, and liver x receptor agonists.

  European journal of pharmacology 20090401

• Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator.

  Bioorganic & medicinal chemistry letters 20090315

• LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms.

  Journal of lipid research 20090201

• Regulation of hepatic fatty acid elongase 5 by LXRalpha-SREBP-1c.

  Biochimica et biophysica acta 20090201

• Suppression of beta-catenin signaling by liver X receptor ligands.

  Biochemical pharmacology 20090115

• Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells.

  Molecular pharmaceutics 20090101

• Comprehensive mRNA profiling of lipid-related genes in microglia and macrophages using taqman arrays.

  Methods in molecular biology (Clifton, N.J.) 20090101

• Lipogenesis in arterial wall and vascular smooth muscular cells: regulation and abnormalities in insulin-resistance.

  Cardiovascular diabetology 20090101

• Characterization of placental cholesterol transport: ABCA1 is a potential target for in utero therapy of Smith-Lemli-Opitz syndrome.

  Human molecular genetics 20081201

• Liver X receptor activation induces the uptake of cholesteryl esters from high density lipoproteins in primary human macrophages.

  Arteriosclerosis, thrombosis, and vascular biology 20081201

• Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism.

  American journal of physiology. Endocrinology and metabolism 20081201

• LXR-agonists regulate ApoM expression differentially in liver and intestine.

  Current pharmaceutical biotechnology 20081201

• Beneficial effect of 3,4,5,6-tetrahydroxyxanthone on dyslipidemia in apolipoprotein E-deficient mice.

  Canadian journal of physiology and pharmacology 20081201

• Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic triglyceride synthesis.

  Journal of medicinal chemistry 20081127

• Regulation of alpha-synuclein expression by liver X receptor ligands in vitro.

  Neuroreport 20081119

• Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20081105

• Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice.

  The Journal of pharmacology and experimental therapeutics 20081101

• Intestine-specific regulation of PPARalpha gene transcription by liver X receptors.

  Endocrinology 20081001

• Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.

  Journal of medicinal chemistry 20080925

• Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity.

  American journal of physiology. Endocrinology and metabolism 20080801

• PPARalpha gene expression is up-regulated by LXR and PXR activators in the small intestine.

  Biochemical and biophysical research communications 20080711

• Hyperinsulinemia induces insulin resistance on glucose and lipid metabolism in a human adipocytic cell line: paracrine interaction with myocytes.

  The Journal of clinical endocrinology and metabolism 20080701

• Liver X receptor agonist downregulates hepatic apoM expression in vivo and in vitro.

  Biochemical and biophysical research communications 20080620

• Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice.

  Gastroenterology 20080601

• Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus.

  Circulation 20080527

• LXRalpha enhances lipid synthesis in SZ95 sebocytes.

  The Journal of investigative dermatology 20080501

• The LXR agonist T0901317 promotes the reverse cholesterol transport from macrophages by increasing plasma efflux potential.

  Journal of lipid research 20080501

• Ligand specificity and evolution of liver X receptors.

  The Journal of steroid biochemistry and molecular biology 20080501

• The effect of T0901317 on ATP-binding cassette transporter A1 and Niemann-Pick type C1 in apoE-/- mice.

  Journal of cardiovascular pharmacology 20080501

• Liver X receptor agonist T0901317 reduces atherosclerotic lesions in apoE-/- mice by up-regulating NPC1 expression.

  Science in China. Series C, Life sciences 20080501

• Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.

  Bioorganic & medicinal chemistry 20080415

• Dual mechanisms for the fibrate-mediated repression of proprotein convertase subtilisin/kexin type 9.

  The Journal of biological chemistry 20080411

• Combination of virtual screening and high throughput gene profiling for identification of novel liver X receptor modulators.

  Journal of medicinal chemistry 20080410

• Dietary soy protein inhibits DNA damage and cell survival of colon epithelial cells through attenuated expression of fatty acid synthase.

  American journal of physiology. Gastrointestinal and liver physiology 20080401

• Effects of the synthetic liver X receptor agonist T0901317 on the growth hormone and thyroid hormone axes in male rats.

  Endocrine 20080401

• [Activation of liver X receptor regulates fatty acid synthase expression in diabetic liver].

  Zhonghua yi xue za zhi 20080325

• Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.

  Journal of immunology (Baltimore, Md. : 1950) 20080301

• Synthetic liver X receptor agonist T0901317 inhibits semicarbazide-sensitive amine oxidase gene expression and activity in apolipoprotein E knockout mice.

  Acta biochimica et biophysica Sinica 20080301

• LXR agonist increases the lymph HDL transport in rats by promoting reciprocally intestinal ABCA1 and apo A-I mRNA levels.

  Lipids 20080201

• OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages.

  The Journal of biological chemistry 20080104

• The effect of statins on ABCA1 and ABCG1 expression in human macrophages is influenced by cellular cholesterol levels and extent of differentiation.

  Atherosclerosis 20080101

• Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.

  Bioorganic & medicinal chemistry letters 20080101

• Liver X receptors (LXR) as therapeutic targets in dyslipidemia.

  Cardiovascular therapeutics 20080101

• Chenodeoxycholic acid suppresses the activation of acetyl-coenzyme A carboxylase-alpha gene transcription by the liver X receptor agonist T0-901317.

  Journal of lipid research 20071201

• Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists.

  Biochemical pharmacology 20071115

• Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL.

  Journal of lipid research 20071101

• SIRT1 deacetylates and positively regulates the nuclear receptor LXR.

  Molecular cell 20071012

• Regulation of 17beta-hydroxysteroid dehydrogenase type 2, type 4 and type 5 by calcitriol, LXR agonist and 5alpha-dihydrotestosterone in human prostate cancer cells.

  The Journal of steroid biochemistry and molecular biology 20071001

• Conversion of the LXR-agonist TO-901317--from inverse to normal modulation of gamma-secretase by addition of a carboxylic acid and a lipophilic anchor.

  Bioorganic & medicinal chemistry letters 20071001

• N-Acylthiadiazolines, a new class of liver X receptor agonists with selectivity for LXRbeta.

  Journal of medicinal chemistry 20070823

• 2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists.

  Bioorganic & medicinal chemistry letters 20070815

• Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells.

  Molecular and cellular biochemistry 20070801

• Effect of T0901317 on hepatic proinflammatory gene expression in apoE-/- mice fed a high-fat/high-cholesterol diet.

  Inflammation 20070801

• Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status.

  The Journal of biological chemistry 20070720

• A novel pathway to enhance adipocyte differentiation of 3T3-L1 cells by up-regulation of lipocalin-type prostaglandin D synthase mediated by liver X receptor-activated sterol regulatory element-binding protein-1c.

  The Journal of biological chemistry 20070622

• Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists.

  Bioorganic & medicinal chemistry letters 20070615

• Liver-X-receptor activator prevents homocysteine-induced production of IgG antibodies from murine B lymphocytes via the ROS-NF-kappaB pathway.

  Biochemical and biophysical research communications 20070608

• The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells.

  Biochemical and biophysical research communications 20070601

• Inhibition of progesterone production in human luteinized granulosa cells treated with LXR agonists.

  Molecular human reproduction 20070601

• Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin.

  Blood 20070515

• T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR.

  FEBS letters 20070501

• Activation of liver X receptors and retinoid X receptors induces growth arrest and apoptosis in insulin-secreting cells.

  Endocrinology 20070401

• The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

  Molecular and cellular neurosciences 20070401

• Immunomodulatory properties of increased levels of liver X receptor beta in peripheral blood mononuclear cells from multiple sclerosis patients.

  Experimental neurology 20070401

• Crystal structure of the PXR-T1317 complex provides a scaffold to examine the potential for receptor antagonism.

  Bioorganic & medicinal chemistry 20070301

• PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.

  Journal of lipid research 20070201

• 24S-hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression.

  Journal of neurochemistry 20070201

• Activation of LXRs prevents bile acid toxicity and cholestasis in female mice.

  Hepatology (Baltimore, Md.) 20070201

• Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole.

  Oncogene 20070111

• The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR.

  The Journal of biological chemistry 20070105

• Liver X receptor inhibits the synthesis and secretion of apolipoprotein A1 by human liver-derived cells.

  Biochemistry 20061219

• 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes.

  Biochimica et biophysica acta 20061201

• Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice.

  Endocrinology 20061101

• The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands.

  Biochemical and biophysical research communications 20061020

• Discovery of phenyl acetic acid substituted quinolines as novel liver X receptor agonists for the treatment of atherosclerosis.

  Journal of medicinal chemistry 20061019

• Insulin induction of glucokinase and fatty acid synthase in hepatocytes: analysis of the roles of sterol-regulatory-element-binding protein-1c and liver X receptor.

  The Biochemical journal 20061015

• Synthesis and evaluation of anilinohexafluoroisopropanols as activators/modulators of LXRalpha and beta.

  Bioorganic & medicinal chemistry letters 20061001

• Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.

  Journal of lipid research 20060901

• The chicken ovalbumin upstream promoter-transcription factors modulate genes and pathways involved in skeletal muscle cell metabolism.

  The Journal of biological chemistry 20060825

• Identification of a lead pharmacophore for the development of potent nuclear receptor modulators as anticancer and X syndrome disease therapeutic agents.

  Bioorganic & medicinal chemistry letters 20060815

• Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels.

  Endocrinology 20060801

• Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha.

  Toxicological sciences : an official journal of the Society of Toxicology 20060801

• The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.

  Journal of neurochemistry 20060801

• The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice.

  Hepatology (Baltimore, Md.) 20060801

• Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages.

  Shock (Augusta, Ga.) 20060801

• Regulation of retinal dehydrogenases and retinoic acid synthesis by cholesterol metabolites.

  The EMBO journal 20060712

• Glucose regulates LXRalpha subcellular localization and function in rat pancreatic beta-cells.

  Cell research 20060701

• Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist.

  Cancer research 20060701

• [Liver X receptors mediate cholesterol efflux in mouse glomerular mesangial cells].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20060618

• ABCA1-dependent but apoA-I-independent cholesterol efflux mediated by fatty acid-bile acid conjugates (FABACs).

  The Biochemical journal 20060615

• Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study.

  Journal of lipid research 20060601

• Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule.

  American journal of physiology. Renal physiology 20060501

• PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver.

  Journal of lipid research 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Discovery and optimization of a novel series of liver X receptor-alpha agonists.

  Bioorganic & medicinal chemistry letters 20060315

• Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c.

  The Journal of biological chemistry 20060310

• Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor.

  Neuroreport 20060206

• Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells.

  The international journal of biochemistry & cell biology 20060101

• Non-steroidal LXR agonists; an emerging therapeutic strategy for the treatment of atherosclerosis.

  Recent patents on cardiovascular drug discovery 20060101

• Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line.

  Placenta 20051101

• The human ABCG1 gene: identification of LXR response elements that modulate expression in macrophages and liver.

  Journal of lipid research 20051001

• Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells.

  International journal of molecular medicine 20051001

• Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.

  Journal of medicinal chemistry 20050825

• Diet-dependent cardiovascular lipid metabolism controlled by hepatic LXRalpha.

  Cell metabolism 20050501

• Pharmacological regulation of cholesterol efflux in human monocyte-derived macrophages in the absence of exogenous cholesterol acceptors.

  Atherosclerosis 20050401

• Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathway.

  Diabetes 20050401

• Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells.

  The Journal of biological chemistry 20050204

• Macrophage liver X receptor is required for antiatherogenic activity of LXR agonists.

  Arteriosclerosis, thrombosis, and vascular biology 20050101

• Liver X receptor agonists suppress vascular smooth muscle cell proliferation and inhibit neointima formation in balloon-injured rat carotid arteries.

  Circulation research 20041210

• LXR activation and cholesterol efflux from a lipoprotein depot in vivo.

  Biochimica et biophysica acta 20041108

• Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.

  The Journal of biological chemistry 20041029

• Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions.

  Journal of molecular endocrinology 20041001

• Post-transcriptional regulation of sterol regulatory element-binding protein-1 by ethanol induces class I alcohol dehydrogenase in rat liver.

  The Journal of biological chemistry 20040702

• Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivo.

  The Journal of pharmacology and experimental therapeutics 20040601

• A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes.

  Journal of neurochemistry 20040201

• Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor.

  Gastroenterology 20040101

• CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor.

  Drug metabolism and disposition: the biological fate of chemicals 20040101

• T0901317 is a dual LXR/FXR agonist.

  Molecular genetics and metabolism 20040101

• Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist.

  Journal of molecular biology 20031212

• The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse.

  Journal of lipid research 20031101

• Molecular determinants of LXRalpha agonism.

  Journal of molecular graphics & modelling 20031101

• Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist.

  The Journal of biological chemistry 20030919

• Crystal structure of the heterodimeric complex of LXRalpha and RXRbeta ligand-binding domains in a fully agonistic conformation.

  The EMBO journal 20030915

• X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.

  The Journal of biological chemistry 20030718

• Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. I. PPARs suppress sterol regulatory element binding protein-1c promoter through inhibition of LXR signaling.

  Molecular endocrinology (Baltimore, Md.) 20030701

• Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.

  Molecular endocrinology (Baltimore, Md.) 20030701

• Angiopoietin-like protein 3 mediates hypertriglyceridemia induced by the liver X receptor.

  The Journal of biological chemistry 20030613

• Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice.

  Journal of hepatology 20030601

• Stimulation of cholesterol excretion by the liver X receptor agonist requires ATP-binding cassette transporters G5 and G8.

  The Journal of biological chemistry 20030502

• Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha.

  Molecular endocrinology (Baltimore, Md.) 20030301

• Pharmacological evidence for a role of liver X receptors in atheroprotection.

  FEBS letters 20030211

• T-0901317, a synthetic liver X receptor ligand, inhibits development of atherosclerosis in LDL receptor-deficient mice.

  FEBS letters 20030211

• On the role of liver X receptors in lipid accumulation in adipocytes.

  Molecular endocrinology (Baltimore, Md.) 20030201

• A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.

  The Journal of biological chemistry 20030124

• Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

  The Journal of biological chemistry 20030110

• Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport.

  The Biochemical journal 20021215

• Phospholipid transfer protein is regulated by liver X receptors in vivo.

  The Journal of biological chemistry 20021018

• Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles.

  The Journal of biological chemistry 20020913

• Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1.

  The Journal of biological chemistry 20020913

• LXR/RXR activation enhances basolateral efflux of cholesterol in CaCo-2 cells.

  Journal of lipid research 20020701

• Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines.

  Journal of medicinal chemistry 20020509

• Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c.

  The Journal of biological chemistry 20020315

• Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism.

  Molecular endocrinology (Baltimore, Md.) 20020301

• Hypolipidemic effects of selective liver X receptor alpha agonists.

  Steroids 20010901

• Role of LXRs in control of lipogenesis.

  Genes & development 20001115

• Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.

  The Journal of biological chemistry 20000519

• Liver X receptor-alpha regulates proopiomelanocortin (POMC) gene transcription in the pituitary.

  Molecular endocrinology (Baltimore, Md.)

• Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation.

  Molecular endocrinology (Baltimore, Md.)