29608-49-9 | 6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-N,4-N-bis(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine; bis(methanesulfonic acid)

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$8.00	$6.00
1g	97%	in stock	$12.00	$9.00
5g	97%	in stock	$35.00	$25.00
10g	97%	in stock	$59.00	$41.00
25g	97%	in stock	$119.00	$84.00

Description

• Catalog Number: AI46701
• Chemical Name: 6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-N,4-N-bis(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine; bis(methanesulfonic acid)
• CAS Number: 29608-49-9
• Molecular Formula: C28H37F2N7O6S2
• Molecular Weight: 669.7635
• MDL Number: MFCD01679060
• SMILES: CS(=O)(=O)O.CS(=O)(=O)O.C=CCNc1nc(nc(n1)NCC=C)N1CCN(CC1)C(c1ccc(cc1)F)c1ccc(cc1)F

Computed Properties

• Complexity: 694
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 45
• Hydrogen Bond Acceptor Count: 15
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 10

Literature

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  Anesthesiology 20110801

• Almitrine-Raubasine combination for dementia.

  The Cochrane database of systematic reviews 20110316

• Stability-indicating methods for the determination of a mixture of almitrine and raubasine by derivative spectrophotometry.

  Drug testing and analysis 20090601

• [Combination of thiotropium bromide with almitrine and pulmonary rehabilitation in the treatment of patients with chronic obstructive pulmonary disease].

  Terapevticheskii arkhiv 20080101

• Low-tidal-volume ventilation.

  The New England journal of medicine 20071213

• [Clinical research of effect of Yishen Yangnao capsule on vascular dementia].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070401

• Low- vs high-dose almitrine combined with nitric oxide to prevent hypoxia during open-chest one-lung ventilation.

  British journal of anaesthesia 20050901

• Treatment of hypoxemia during one-lung ventilation using intravenous almitrine.

  Anesthesia and analgesia 20040301

• Assessment of the therapeutic activity of a combination of almitrine and raubasine on functional rehabilitation following ischaemic stroke.

  Current medical research and opinion 20040301

• Orthodeoxia--an uncommon presentation following bilateral thoracic sympathectomy.

  Anaesthesia and intensive care 20031001

• Long-term effects of almitrine bismesylate in COPD patients with chronic hypoxaemia.

  Respiratory medicine 20030601

• Selective pulmonary vasodilation in acute respiratory distress syndrome.

  Critical care medicine 20030401

• Effects of almitrine bismesylate on arterial blood gases in patients with chronic obstructive pulmonary disease and moderate hypoxaemia: a multicentre, randomised, double-blind, placebo-controlled study.

  Respiration; international review of thoracic diseases 20030101

• pO2 - Do we treat the right thing?

  Respiration; international review of thoracic diseases 20030101

• Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury.

  Journal of applied physiology (Bethesda, Md. : 1985) 20021201

• Primary alveolar hypoventilation and response to the respiratory stimulant almitrine.

  Internal medicine journal 20021201

• Treatment of hypoxaemia during one-lung ventilation with almitrine.

  Lancet (London, England) 20020413

• The effects of intravenous almitrine on oxygenation and hemodynamics during one-lung ventilation.

  Anesthesia and analgesia 20020401

• [Effect of almitrine/raubasine on cerebral metabolism in the elderly].

  Presse medicale (Paris, France : 1983) 20020330

• Effects of almitrine on diaphragm contractile properties in young and old rats.

  Respiration; international review of thoracic diseases 20020101

• An investigation into the mechanism of action of almitrine on isolated rat diaphragm muscle fatigue.

  Respiration; international review of thoracic diseases 20020101

• High or low doses of almitrine bismesylate in ARDS patients responding to inhaled NO and receiving norepinephrine?

  Intensive care medicine 20011101

• [Comparative changes in PaO2 in moderately hypoxemic COPD patients treated with almitrine versus placebo for one year].

  Revue des maladies respiratoires 20010901

• Association of oral almitrine and medroxyprogesterone acetate: effect on arterial blood gases in chronic obstructive pulmonary disease.

  Respiratory medicine 20010701

• Effects of combined high-dose partial liquid ventilation and almitrine on pulmonary gas exchange and hemodynamics in an animal model of acute lung injury.

  Intensive care medicine 20010301

• Effect of inhaled prostacyclin in combination with almitrine on ventilation-perfusion distributions in experimental lung injury.

  Anesthesiology 20010301

• Effect of almitrine on upper airway muscle contraction in young and old rats.

  European journal of pharmacology 20010126

• Right ventricular response to high-dose almitrine infusion in patients with severe hypoxemia related to acute respiratory distress syndrome.

  Critical care medicine 20010101

• Peripheral neuropathy in patients treated with almitrine dimesylate.

  Lancet (London, England) 19850601

• [Competitive study of the effects of naloxone and of almitrine on fentanyl analgesia in the anesthetized dog: effects on the muzzle opening reflex and blood gases].

  Annales de l'anesthesiologie francaise 19800101