300657-03-8 | 2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid

Packsize	Purity	Availability	Price	Discounted Price
1mg	96%	in stock	$57.00	$40.00
5mg	96%	in stock	$112.00	$79.00
10mg	96%	in stock	$195.00	$136.00
25mg	96%	in stock	$289.00	$202.00
50mg	96%	in stock	$419.00	$293.00
100mg	96%	in stock	$463.00	$324.00
250mg	96%	in stock	$892.00	$624.00

Description

• Catalog Number: AD51789
• Chemical Name: 2-((2'-(5-Ethyl-3,4-diphenyl-1H-pyrazol-1-yl)-[1,1'-biphenyl]-3-yl)oxy)acetic acid
• CAS Number: 300657-03-8
• Molecular Formula: C31H26N2O3
• Molecular Weight: 474.5497
• MDL Number: MFCD09991687
• SMILES: CCc1c(c2ccccc2)c(nn1c1ccccc1c1cccc(c1)OCC(=O)O)c1ccccc1

Computed Properties

• Complexity: 689
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 36
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 8
• XLogP3: 7.2

Literature

• Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes.

  European journal of medicinal chemistry 20120601

• Synthesis of BMS-309403-related compounds, including [¹⁴C]BMS-309403, a radioligand for adipocyte fatty acid binding protein.

  Chemical & pharmaceutical bulletin 20120101

• BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinase.

  PloS one 20120101

• BMS309403 directly suppresses cardiac contractile function.

  Naunyn-Schmiedeberg's archives of pharmacology 20110901

• Fatty acid binding protein 4 regulates intracellular lipid accumulation in human trophoblasts.

  The Journal of clinical endocrinology and metabolism 20110701

• Expression and function of fatty acid-binding protein 4 during mouse decidualization.

  Fertility and sterility 20110630

• Identification of a potential biomarker for FABP4 inhibition: the power of lipidomics in preclinical drug testing.

  Journal of biomolecular screening 20110601

• New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein.

  Bioorganic & medicinal chemistry letters 20110515

• Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells.

  British journal of pharmacology 20110401

• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

  Nature 20070621

• Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP).

  Bioorganic & medicinal chemistry letters 20070615

• Urea metabolism in the llama.

  Comparative biochemistry and physiology. A, Comparative physiology 19751201