301836-41-9 | 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide

Packsize	Purity	Availability	Price	Discounted Price
10mg	99%	in stock	$66.00	$46.00
50mg	99%	in stock	$173.00	$121.00
100mg	99%	in stock	$282.00	$197.00
250mg	99%	in stock	$410.00	$287.00
1g	99%	in stock	$1,039.00	$727.00

Description

• Catalog Number: AB49728
• Chemical Name: 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide
• CAS Number: 301836-41-9
• Molecular Formula: C22H16N4O3
• Molecular Weight: 384.3874
• MDL Number: MFCD05865244
• SMILES: NC(=O)c1ccc(cc1)c1[nH]c(c(n1)c1ccc2c(c1)OCO2)c1ccccn1

Computed Properties

• Complexity: 582
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 2.7

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• ALK5 and Smad4 are involved in TGF-beta1-induced pulmonary endothelial permeability.

  FEBS letters 20050718

• SB-431542 inhibits TGF-beta-induced contraction of collagen gel by normal and keloid fibroblasts.

  Journal of dermatological science 20050701

• Smad7 abrogates transforming growth factor-beta1-mediated growth inhibition in COLO-357 cells through functional inactivation of the retinoblastoma protein.

  The Journal of biological chemistry 20050610

• A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers.

  Neoplasia (New York, N.Y.) 20050501

• Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production.

  Brain research 20050321

• TGFbeta/activin/nodal signaling is necessary for the maintenance of pluripotency in human embryonic stem cells.

  Development (Cambridge, England) 20050301

• Selective inhibition of activin receptor-like kinase 5 signaling blocks profibrotic transforming growth factor beta responses in skin fibroblasts.

  Arthritis and rheumatism 20041201

• A role for Id in the regulation of TGF-beta-induced epithelial-mesenchymal transdifferentiation.

  Cell death and differentiation 20041001

• SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility.

  Molecular cancer therapeutics 20040601

• SB-505124 is a selective inhibitor of transforming growth factor-beta type I receptors ALK4, ALK5, and ALK7.

  Molecular pharmacology 20040301

• Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells.

  The EMBO journal 20040211

• SB-431542 and Gleevec inhibit transforming growth factor-beta-induced proliferation of human osteosarcoma cells.

  Cancer research 20031115

• Effects of high glucose and TGF-beta1 on the expression of collagen IV and vascular endothelial growth factor in mouse podocytes.

  Kidney international 20020901

• Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542.

  Molecular pharmacology 20020701

• SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.

  Molecular pharmacology 20020701

• Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).

  Journal of medicinal chemistry 20020227

• MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4.

  Molecular endocrinology (Baltimore, Md.)