301836-43-1 | D4476

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$12.00	$9.00
5mg	99%	in stock	$28.00	$19.00
50mg	99%	in stock	$113.00	$79.00

Description

• Catalog Number: AF31529
• Chemical Name: D4476
• CAS Number: 301836-43-1
• Molecular Formula: C23H18N4O3
• Molecular Weight: 398.414
• MDL Number: MFCD09037526
• SMILES: NC(=O)c1ccc(cc1)c1nc(c([nH]1)c1ccccn1)c1ccc2c(c1)OCCO2

Computed Properties

• Complexity: 597
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 2.6

Upstream Synthesis Route

D4476 is a potent and selective inhibitor of casein kinase 1 (CK1), a key enzyme involved in various cellular processes. In chemical synthesis, D4476 has been widely utilized as a valuable tool for modulating CK1 activity. This compound's ability to target CK1 makes it a versatile option for studying and manipulating biological pathways, protein functions, and gene expression. Researchers and chemists have successfully employed D4476 in the development of novel drugs, understanding circadian rhythms, and investigating cell proliferation mechanisms. Its precise targeting and high selectivity for CK1 make it a crucial component in the realm of chemical synthesis, enabling precise control over various biological processes and paving the way for innovative research in biochemistry and pharmacology.

Literature

• Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.

  Molecular pain 20140101

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

  The Biochemical journal 20130415

• Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.

  European journal of medicinal chemistry 20121001

• Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies.

  Neurobiology of disease 20120301

• Protein kinase CK1α regulates erythrocyte survival.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• The interplay of the aryl hydrocarbon receptor and β-catenin alters both AhR-dependent transcription and Wnt/β-catenin signaling in liver progenitors.

  Toxicological sciences : an official journal of the Society of Toxicology 20110801

• Opposing action of casein kinase 1 and calcineurin in nucleo-cytoplasmic shuttling of mammalian translation initiation factor eIF6.

  The Journal of biological chemistry 20110128

• 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta.

  Journal of medicinal chemistry 20091210

• CK1alpha plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability.

  The Journal of biological chemistry 20091120

• Identification of novel protein kinase CK1 delta (CK1delta) inhibitors through structure-based virtual screening.

  Bioorganic & medicinal chemistry letters 20081015

• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

  Proceedings of the National Academy of Sciences of the United States of America 20071218

• The selectivity of protein kinase inhibitors: a further update.

  The Biochemical journal 20071215

• D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a.

  EMBO reports 20040101