-
Disrupted intracellular redox balance of the diplomonad fish parasite Spironucleus vortens by 5-nitroimidazoles and garlic-derived compounds.
Veterinary parasitology 20121123
-
Simultaneous determination of morinidazole, its N-oxide, sulfate, and diastereoisomeric N(+)-glucuronides in human plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121101
-
Genotoxicity profile of fexinidazole--a drug candidate in clinical development for human African trypanomiasis (sleeping sickness).
Mutagenesis 20120901
-
Validation of a modified fluorimetric assay for the screening of trichomonacidal drugs.
Memorias do Instituto Oswaldo Cruz 20120801
-
Development of metronidazole-resistant lines of Blastocystis sp.
Parasitology research 20120701
-
Synthesis, in vitro and in vivo characterization of novel 99mTc-'4+1'-labeled 5-nitroimidazole derivatives as potential agents for imaging hypoxia.
Nuclear medicine and biology 20120701
-
Influence of ligand denticity on the properties of novel ⁹⁹mTc(I)-carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic tissue.
Bioorganic & medicinal chemistry 20120701
-
First report of anti-Trichomonas vaginalis activity of the medicinal plant Polygala decumbens from the Brazilian semi-arid region, Caatinga.
Parasitology research 20120601
-
Anti-Trichomonas vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species.
Parasitology research 20120601
-
Down-regulation of flavin reductase and alcohol dehydrogenase-1 (ADH1) in metronidazole-resistant isolates of Trichomonas vaginalis.
Molecular and biochemical parasitology 20120601
-
Trichomonas vaginalis antimicrobial drug resistance in 6 US cities, STD Surveillance Network, 2009-2010.
Emerging infectious diseases 20120601
-
[Far-IR and THz absorption spectra studies of metronidazole, tinidazole and ornidazole].
Guang pu xue yu guang pu fen xi = Guang pu 20120401
-
Mucosal fixed drug eruption in a patient treated with ornidazole.
Journal of dermatological case reports 20120327
-
Metabolism and pharmacokinetics of morinidazole in humans: identification of diastereoisomeric morpholine N+-glucuronides catalyzed by UDP glucuronosyltransferase 1A9.
Drug metabolism and disposition: the biological fate of chemicals 20120301
-
Extensive genetic diversity, unique population structure and evidence of genetic exchange in the sexually transmitted parasite Trichomonas vaginalis.
PLoS neglected tropical diseases 20120301
-
The anti-trypanosome drug fexinidazole shows potential for treating visceral leishmaniasis.
Science translational medicine 20120201
-
Evolutionary, ecological and biotechnological perspectives on plasmids resident in the human gut mobile metagenome.
Bioengineered bugs 20120101
-
Effect of a second nitroimidazole redox centre on the accumulation of a hypoxia marker: synthesis and in vitro evaluation of 99mTc-labeled bisnitroimidazole propylene amine oxime complexes.
Bioorganic & medicinal chemistry letters 20120101
-
Virtual screening, identification and in vitro testing of novel inhibitors of O-acetyl-L-serine sulfhydrylase of Entamoeba histolytica.
PloS one 20120101
-
Simultaneous determination of some antiprotozoal drugs in different combined dosage forms by mean centering of ratio spectra and multivariate calibration with model updating methods.
Chemistry Central journal 20120101
-
A comparative study of oral single dose of metronidazole, tinidazole, secnidazole and ornidazole in bacterial vaginosis.
Indian journal of pharmacology 20120101
-
Application of 2-trichloromethylbenzimidazole in analytical chemistry: a highly selective chromogenic reagent for thin-layer chromatography and some other analytical uses.
Journal of analytical methods in chemistry 20120101
-
Computational study of proton and methyl cation affinities of imidazole-based highly energetic ionic liquids.
Journal of molecular modeling 20111001
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New approaches to the treatment of giardiasis.
Current opinion in infectious diseases 20111001
-
High functionalization of 5-nitro-1H-imidazole derivatives: the TDAE approach.
Molecules (Basel, Switzerland) 20110812
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Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia.
The Journal of antimicrobial chemotherapy 20110801
-
The progress made in determining the Mycobacterium tuberculosis structural proteome.
Proteomics 20110801
-
Genetically different clonal isolates of Trichomonas gallinae, obtained from the same bird, can vary in their drug susceptibility, an in vitro evidence.
Parasitology international 20110601
-
Metronidazole-induced encephalopathy in a patient with liver cirrhosis.
The Korean journal of hepatology 20110601
-
Antimicrobial resistance and prevalence of resistance genes in intestinal Bacteroidales strains.
Clinics (Sao Paulo, Brazil) 20110401
-
5-Nitroimidazole-based 1,3,4-thiadiazoles: heterocyclic analogs of metronidazole as anti-Helicobacter pylori agents.
Archiv der Pharmazie 20110301
-
2-Chloro-N-[(4-chloro-phen-yl)(phen-yl)meth-yl]-N-[2-(4-nitro-1H-imidazol-1-yl)eth-yl]ethanamine.
Acta crystallographica. Section E, Structure reports online 20110201
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Synthesis and biological characterisation of novel dithiocarbamate containing 5-nitroimidazole (99m)Tc-complexes as potential agents for targeting hypoxia.
Bioorganic & medicinal chemistry letters 20110101
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The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes.
PloS one 20110101
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[Development and use of test systems for the evaluation of sensitivity of Trichomonas vaginalisto preparations of the 5-nitroimidazole and 5-nitrofuran groups].
Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20110101
-
[Short - term combined 5-nitroimidazole treatment in vaginal dysbacteriosis with dominant anaerobic species].
Akusherstvo i ginekologiia 20110101
-
Molecularly imprinted polymers: present and future prospective.
International journal of molecular sciences 20110101
-
Clinical, neuroimaging and pathological features of 5-nitroimidazole-induced encephalo-neuropathy in two patients: Insights into possible pathogenesis.
Neurology India 20110101
-
Mebendazole compared with secnidazole in the treatment of adult giardiasis: a randomised, no-inferiority, open clinical trial.
Journal of parasitology research 20110101
-
Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness.
PLoS neglected tropical diseases 20101201
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Study on ITS1 Gene of Iranian Trichomonas vaginalis by Molecular Methods.
Iranian journal of parasitology 20101201
-
Susceptibility in vitro of clinically metronidazole-resistant Trichomonas vaginalis to nitazoxanide, toyocamycin, and 2-fluoro-2'-deoxyadenosine.
Parasitology research 20100901
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Giardiasis in the post genomic era: treatment, drug resistance and novel therapeutic perspectives.
Infectious disorders drug targets 20100801
-
A new-generation 5-nitroimidazole can induce highly metronidazole-resistant Giardia lamblia in vitro.
International journal of antimicrobial agents 20100701
-
2-Chloro-4-nitro-1H-imidazole.
Acta crystallographica. Section E, Structure reports online 20100701
-
Cationic nucleoside lipids derived from universal bases: A rational approach for siRNA transfection.
Bioconjugate chemistry 20100616
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Bacteroides fragilis RecA protein overexpression causes resistance to metronidazole.
Research in microbiology 20100601
-
The flavin inhibitor diphenyleneiodonium renders Trichomonas vaginalis resistant to metronidazole, inhibits thioredoxin reductase and flavin reductase, and shuts off hydrogenosomal enzymatic pathways.
Molecular and biochemical parasitology 20100501
-
Biophysical characterization and mutational analysis of the antibiotic resistance protein NimA from Deinococcus radiodurans.
Biochimica et biophysica acta 20100401
-
Selectivity of Enzymatic Conversion of Oligonucleotide Probes during Nucleotide Polymorphism Analysis of DNA.
Acta naturae 20100401
-
Ronidazole toxicosis in 3 society finches (Lonchura striata).
Veterinary pathology 20100301
-
[Tetracyclines, sulfonamides, and metronidazole].
Enfermedades infecciosas y microbiologia clinica 20100201
-
The tropical brown alga Lobophora variegata: a source of antiprotozoal compounds.
Marine drugs 20100101
-
Documentation of in vivo and in vitro aerobic resistance of feline Tritrichomonas foetus isolates to ronidazole.
Journal of veterinary internal medicine 20100101
-
Treatment of bacterial vaginosis: a multicenter, double-blind, double-dummy, randomised phase III study comparing secnidazole and metronidazole.
Infectious diseases in obstetrics and gynecology 20100101
-
New 4-thiazolidinones of nicotinic acid with 2-Amino-6-methylbenzothiazole and their biological activity.
Scientia pharmaceutica 20100101
-
Simultaneous Determination of Ofloxacin and Ornidazole in Solid Dosage Form by RP-HPLC and HPTLC Techniques.
Indian journal of pharmaceutical sciences 20100101
-
Synthesis and cloxacillin antimicrobial enhancement of 2-methylsulfonylimidazolyl-1,4-dihydropyridine derivatives.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20100101
-
In vitro resistance to 5-nitroimidazoles and benzimidazoles in Giardia duodenalis: variability and variation in gene expression.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20091201
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Overexpression of the rhamnose catabolism regulatory protein, RhaR: a novel mechanism for metronidazole resistance in Bacteroides thetaiotaomicron.
The Journal of antimicrobial chemotherapy 20090801
-
New synthesis and antiparasitic activity of model 5-aryl-1-methyl-4-nitroimidazoles.
Molecules (Basel, Switzerland) 20090727
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Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia.
Journal of medicinal chemistry 20090709
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[Tinidazole: a classical anaerobical drug with multiple potential uses nowadays].
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20090601
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Diffuse alveolar haemorrhage due to 5-nitroimidazole treatment.
Respirology (Carlton, Vic.) 20090501
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Trichomonas vaginalis: metronidazole and other nitroimidazole drugs are reduced by the flavin enzyme thioredoxin reductase and disrupt the cellular redox system. Implications for nitroimidazole toxicity and resistance.
Molecular microbiology 20090401
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Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles.
Journal of medicinal chemistry 20090312
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Synthesis, reduction potentials, and antitubercular activity of ring A/B analogues of the bioreductive drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824).
Journal of medicinal chemistry 20090212
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Synthesis of some N-substituted nitroimidazole derivatives as potential antioxidant and antifungal agents.
European journal of medicinal chemistry 20090201
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Validation of a liquid chromatography-tandem mass spectrometry method for the identification and quantification of 5-nitroimidazole drugs and their corresponding hydroxy metabolites in lyophilised pork meat.
Journal of chromatography. A 20090109
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Guidelines for the treatment of bacterial vaginosis: focus on tinidazole.
Therapeutics and clinical risk management 20090101
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The old and new therapeutic approaches to the treatment of giardiasis: where are we?
Biologics : targets & therapy 20090101
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In vitro activity of Arbutus unedo leaf extracts against Trichomonas vaginalis trophozoites.
Turkiye parazitolojii dergisi 20090101
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Genotoxicity revaluation of three commercial nitroheterocyclic drugs: nifurtimox, benznidazole, and metronidazole.
Journal of parasitology research 20090101
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On the isolation and evaluation of a novel unsubstituted 5-nitroimidazole derivative as an agent to target tumor hypoxia.
Bioorganic & medicinal chemistry letters 20081001
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Toxicology.
Indian journal of pharmacology 20081001
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[Efficacy of 5-nitroimidazole derivatives in treatment of bacterial vaginosis].
Zhonghua yi xue za zhi 20080812
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Genotoxicity and cell death induced by tinidazole (TNZ).
Toxicology letters 20080730
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Intermediates in the reduction of the antituberculosis drug PA-824, (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine, in aqueous solution.
Organic & biomolecular chemistry 20080607
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A comparison of metronidazole and single-dose ornidazole for the treatment of dientamoebiasis.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20080601
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High-resolution structure of the antibiotic resistance protein NimA from Deinococcus radiodurans.
Acta crystallographica. Section F, Structural biology and crystallization communications 20080601
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Use of molecularly imprinted solid-phase extraction sorbent for the determination of four 5-nitroimidazoles and three of their metabolites from egg-based samples before tandem LC-ESIMS/MS analysis.
Journal of agricultural and food chemistry 20080528
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The treatment of giardiasis in children: single-dose tinidazole compared with 3 days of nitazoxanide.
Annals of tropical medicine and parasitology 20080401
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NLNQ-1, a 2-[3-(2-nitro-1-imidazolyl) propylamino]-3-chloro-1,4-naphthoquinone, as a hypoxia-selective cytotoxin and radiosensitizer.
In vivo (Athens, Greece) 20080101
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Characterization of a Giardia lamblia WB C6 clone resistant to the isoflavone formononetin.
Microbiology (Reading, England) 20071201
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Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2H)-benzofuranone derivatives.
Bioorganic & medicinal chemistry letters 20071115
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Sequential regimens for Helicobacter pylori eradication.
Lancet (London, England) 20070922
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Crystal packing of two 5-substituted 2-methyl-4-nitro-1H-imidazoles.
Acta crystallographica. Section C, Crystal structure communications 20070801
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Two different modes of halogen bonding in two 4-nitroimidazole derivatives.
Acta crystallographica. Section C, Crystal structure communications 20070801
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Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase.
PLoS biology 20070801
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A randomized, controlled, open-label trial of a single day of mebendazole versus a single dose of tinidazole in the treatment of giardiasis in children.
Current medical research and opinion 20061101
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Dissolution and vaginal absorption characteristics of metronidazole and ornidazole.
Die Pharmazie 20061001
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High throughput screening identified a substituted imidazole as a novel RANK pathway-selective osteoclastogenesis inhibitor.
Assay and drug development technologies 20060801
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Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Nitroimidazoles, part 2: Synthesis, antiviral and antitumor activity of new 4-nitroimidazoles.
Chemistry & biodiversity 20060501
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Analysis of four 5-nitroimidazoles and their corresponding hydroxylated metabolites in egg, processed egg, and chicken meat by isotope dilution liquid chromatography tandem mass spectrometry.
Journal of agricultural and food chemistry 20060322
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In vitro activities of tinidazole and metronidazole against Clostridium difficile, Prevotella bivia and Bacteroides fragilis.
Anaerobe 20051201
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Radiosynthesis and evaluation of two novel 123I-labeled 2-methyl-4-nitroimidazole derivatives as potential infection imaging agents.
Nuclear medicine and biology 20050501
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[Two cases of metronidazole-induced encephalopathy].
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20050301
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Probing NMR parameters, structure and dynamics of 5-nitroimidazole derivatives. Density functional study of prototypical radiosensitizers.
Magnetic resonance in chemistry : MRC 20050201
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Structural basis of 5-nitroimidazole antibiotic resistance: the crystal structure of NimA from Deinococcus radiodurans.
The Journal of biological chemistry 20041231
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Variability and variation in drug susceptibility among Giardia duodenalis isolates and clones exposed to 5-nitroimidazoles and benzimidazoles in vitro.
The Journal of antimicrobial chemotherapy 20041001
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Synthesis and anti-tuberculosis activity of N-aryl-C-nitroazoles.
European journal of medicinal chemistry 20041001
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Stereoselective synthesis of cis-1,3-disubstituted cyclobutyl kinase inhibitors.
Organic letters 20040527
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Inhibition of adenosine deaminase by novel 5:7 fused heterocycles containing the imidazo[4,5-e][1,2,4]triazepine ring system: a structure-activity relationship study.
Journal of medicinal chemistry 20040212
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Synthesis and biological results of the technetium-99m-labeled 4-nitroimidazole for imaging tumor hypoxia.
Bioorganic & medicinal chemistry letters 20040209
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In vitro activity of antiamoebic drugs against clinical isolates of Entamoeba histolytica and Entamoeba dispar.
Annals of clinical microbiology and antimicrobials 20040101
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[Tetracyclines, sulfonamides and metronidazole].
Enfermedades infecciosas y microbiologia clinica 20031101
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Drug resistance in the sexually transmitted protozoan Trichomonas vaginalis.
Cell research 20030801
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Two stability-indicating UV spectrophotometric methods for the analysis of hydrolyzed tinidazole.
Journal of pharmaceutical and biomedical analysis 20030310
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[Therapeutic aspects of trichomoniasis].
Srpski arhiv za celokupno lekarstvo 20030101
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Pathways of reductive fragmentation of heterocyclic nitroarylmethyl quaternary ammonium prodrugs of mechlorethamine.
Radiation research 20021201
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'In vitro' study of chemotherapeutic activity of sulphimidazole on some sensitive and metronidazole-resistant Trichomonas vaginalis strains.
Pharmacological research 20021101
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[Prospects for development of new antituberculous drugs].
Kekkaku : [Tuberculosis] 20020801
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New findings in beta-lactam and metronidazole resistant Bacteroides fragilis group.
International journal of antimicrobial agents 20020501
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Current trends in research into the waterborne parasite Giardia.
Critical reviews in microbiology 20020101
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Synthesis and calcium channel antagonist activity of 1,4-dihydropyridine derivatives containing 4-nitroimidazolyl substituents.
Arzneimittel-Forschung 20020101
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Effect of metronidazole on spermatogenesis and FSH, LH and testosterone levels of pre-pubertal rats.
Indian journal of experimental biology 20011101
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Investigation of 5-nitrofuran derivatives: synthesis, antibacterial activity, and quantitative structure-activity relationships.
Journal of medicinal chemistry 20011025
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Prevalence of 5-nitroimidazole-resistant trichomonas vaginalis in Oviedo, Spain.
Sexually transmitted diseases 20010201
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Prevalence and characteristics of nim genes encoding 5-nitroimidazole resistance among Bacteroides strains isolated in Morocco.
Microbial drug resistance (Larchmont, N.Y.) 20010101
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5-Nitroimidazole derivatives as possible antibacterial and antifungal agents.
Farmaco (Societa chimica italiana : 1989) 19990101
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Antituberculosis activity of certain antifungal and antihelmintic drugs.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 19990101
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In-vitro studies of two 5-nitroimidazole derivatives.
The Journal of antimicrobial chemotherapy 19970701
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Efficacy of 101 antimicrobials and other agents on the development of Cryptosporidium parvum in vitro.
Annals of tropical medicine and parasitology 19961201
