30459-17-7 | 1-(4-Trifluoromethylphenyl)piperazine

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$19.00	$13.00
5g	95%	in stock	$42.00	$30.00
25g	95%	in stock	$148.00	$104.00
100g	95%	in stock	$492.00	$345.00

Description

• Catalog Number: AB40015
• Chemical Name: 1-(4-Trifluoromethylphenyl)piperazine
• CAS Number: 30459-17-7
• Molecular Formula: C11H13F3N2
• Molecular Weight: 230.2295
• MDL Number: MFCD00040765
• SMILES: FC(c1ccc(cc1)N1CCNCC1)(F)F

Computed Properties

• Complexity: 216
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 2

Upstream Synthesis Route

1-(4-Trifluoromethylphenyl)piperazine is a valuable chemical compound frequently employed in organic synthesis due to its versatile reactivity and unique properties. Within chemical synthesis, this compound serves as a key building block for the creation of various pharmaceuticals, agrochemicals, and advanced materials. By undergoing selective functionalization reactions, 1-(4-Trifluoromethylphenyl)piperazine can be transformed into a diverse array of derivatives with enhanced biological activities or specific functionalities. Its trifluoromethylphenyl group confers distinct physicochemical characteristics, making it an essential component in the development of novel compounds with improved properties. Whether utilized as a pharmacophore or as a structural moiety, the incorporation of 1-(4-Trifluoromethylphenyl)piperazine enables chemists to access a wide range of molecular designs, paving the way for innovative advancements in chemical synthesis.

Literature

• Synthesis of novel 6-(4-substituted piperazine-1-yl)-9-(β-D-ribofuranosyl)purine derivatives, which lead to senescence-induced cell death in liver cancer cells.

  Journal of medicinal chemistry 20120412