305-01-1 | Esculetin

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$6.00	$4.00
1g	98%	in stock	$20.00	$14.00
5g	98%	in stock	$25.00	$17.00
10g	98%	in stock	$42.00	$30.00
25g	98%	in stock	$104.00	$73.00
100g	98%	in stock	$360.00	$252.00

Description

• Catalog Number: AB40272
• Chemical Name: Esculetin
• CAS Number: 305-01-1
• Molecular Formula: C9H6O4
• Molecular Weight: 178.1415
• MDL Number: MFCD00006874
• SMILES: O=c1ccc2c(o1)cc(c(c2)O)O
• NSC Number: 26428

Computed Properties

• Complexity: 248
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• XLogP3: 1.2

Literature

• Esculetin ameliorates vascular perturbation by intervening in the occupancy of H2BK120Ub at At1, At2, Tgfβ1 and Mcp1 promoter gene in thoracic aorta of IR and T2D rats.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20171101

• Esculetin prevents non-alcoholic fatty liver in diabetic mice fed high-fat diet.

  Chemico-biological interactions 20161225

• Esculetin induces apoptosis in human gastric cancer cells through a cyclophilin D-mediated mitochondrial permeability transition pore associated with ROS.

  Chemico-biological interactions 20151205

• Human acute promyelocytic leukemia NB4 cells are sensitive to esculetin through induction of an apoptotic mechanism.

  Chemico-biological interactions 20140905

• Simultaneous determination of esculin and its metabolite esculetin in rat plasma by LC-ESI-MS/MS and its application in pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121015

• Determination of the esculetin contents of medicinal plants by liquid chromatography-tandem mass spectrometry.

  Biomedical chromatography : BMC 20121001

• Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action.

  Bioorganic & medicinal chemistry 20120915

• Esculetin promotes type I procollagen expression in human dermal fibroblasts through MAPK and PI3K/Akt pathways.

  Molecular and cellular biochemistry 20120901

• Influence of formulation factors on the preparation of zein nanoparticles.

  AAPS PharmSciTech 20120901

• Drought stress has contrasting effects on antioxidant enzymes activity and phenylpropanoid biosynthesis in Fraxinus ornus leaves: an excess light stress affair?

  Journal of plant physiology 20120701

• A natural coumarin derivative esculetin offers neuroprotection on cerebral ischemia/reperfusion injury in mice.

  Journal of neurochemistry 20120601

• Inhibitory activity of coumarins from Artemisia capillaris against advanced glycation endproduct formation.

  Archives of pharmacal research 20120601

• [Chemical constituents from Gueldenstaedtia stenophylla].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

• New biological activities of Casimiroa edulis leaf extract and isolated compounds.

  Phytotherapy research : PTR 20120301

• Formation of biopolymers owing to the oxidation of esculetine by Cu(II) ions in a Ca-polygalacturonate network.

  Journal of inorganic biochemistry 20120301

• Hepatoprotective activity of Cyperus alternifolius on carbon tetrachloride-induced hepatotoxicity in rats.

  Pharmaceutical biology 20120201

• Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.

  Bioorganic & medicinal chemistry 20120115

• Retracted: Modulation of p53 /Akt / phosphatase and tensin homolog expression by esculetin potentiates the anticancer activity of cisplatin and prevents its nephrotoxicity.

  Cancer science 20120101

• Properties of lewis lung carcinoma cells surviving curcumin toxicity.

  Journal of Cancer 20120101

• Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Anti-Inflammatory Activities of Cinnamomum cassia Constituents In Vitro and In Vivo.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Application of ionic liquids in the microwave-assisted extraction of proanthocyanidins from Larix gmelini bark.

  International journal of molecular sciences 20120101

• Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma.

  PloS one 20120101

• Biosynthesis of coumarin glycosides by transgenic hairy roots of Polygonum multiflorum.

  Bioscience, biotechnology, and biochemistry 20120101

• [Antioxidant activity of hydroxy derivatives of coumarin].

  Prikladnaia biokhimiia i mikrobiologiia 20120101

• Evaluation of the antioxidant capacity of synthesized coumarins.

  International journal of molecular sciences 20120101

• The hepatoprotective effect of coumarin and coumarin derivates on carbon tetrachloride-induced hepatic injury by antioxidative activities in rats.

  Journal of physiology and biochemistry 20111201

• A TD-DFT study on the hydrogen bonding of three esculetin complexes in electronically excited states: strengthening and weakening.

  Journal of computational chemistry 20111201

• Seaweed polysaccharides and derived oligosaccharides stimulate defense responses and protection against pathogens in plants.

  Marine drugs 20111201

• Sensitive detection of esculetin based on a CdSe nanoparticles-decorated poly(diallyldimethylammonium chloride)-functionalized graphene nanocomposite film.

  The Analyst 20111107

• Metabolism of ethanol to acetaldehyde by rat uterine horn subcellular fractions.

  Human & experimental toxicology 20111101

• Cardiovascular and vasoconstrictive actions of skate bradykinin in the little skate, Leucoraja erinacea (Elasmobranchii).

  General and comparative endocrinology 20111101

• p38 MAPK activation is required for esculetin-induced inhibition of vascular smooth muscle cells proliferation.

  Toxicology in vitro : an international journal published in association with BIBRA 20111001

• Differential effects of esculetin and daphnetin on in vitro cell proliferation and in vivo estrogenicity.

  European journal of pharmacology 20111001

• Structure elucidation of two new unusual monoterpene glycosides from Euphorbia decipiens, by 1D and 2D NMR experiments.

  Magnetic resonance in chemistry : MRC 20111001

• [Study on antibacterial active components from Viola yedoensis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111001

• Inhibitory effects of constituents from Euphorbia lunulata on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells.

  Molecules (Basel, Switzerland) 20110929

• Protective effects of cortex fraxini coumarines against oxonate-induced hyperuricemia and renal dysfunction in mice.

  European journal of pharmacology 20110901

• Inhibition of 5-lipoxygenase and skin inflammation by the aerial parts of Artemisia capillaris and its constituents.

  Archives of pharmacal research 20110901

• Esculetin inhibits N-methyl-D-aspartate neurotoxicity via glutathione preservation in primary cortical cultures.

  Laboratory animal research 20110901

• Chemical constituents of Cichorium intybus and their inhibitory effects against urease and alpha-chymotrypsin enzymes.

  Natural product communications 20110801

• Study of polyethylene glycol as a green solvent in the microwave-assisted extraction of flavone and coumarin compounds from medicinal plants.

  Journal of chromatography. A 20110610

• Excited-state hydrogen bonding and deprotonation of esculetin in solution: a DFT/TDDFT study.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110601

• Esculetin induced changes in Mmp13 and Bmp6 gene expression and histone H3 modifications attenuate development of glomerulosclerosis in diabetic rats.

  Journal of molecular endocrinology 20110601

• Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet.

  Nutrition research and practice 20110601

• Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20110501

• Evaluation of the interaction of coumarins with biomembrane models studied by differential scanning calorimetry and Langmuir-Blodgett techniques.

  Journal of natural products 20110425

• The influence of chronic eicosanoid biosynthesis inhibition on life history of the greater waxmoth, Galleria mellonella and its ectoparasitoid, Bracon hebetor.

  Journal of insect physiology 20110401

• Extraction and identification of three major aldose reductase inhibitors from Artemisia montana.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110201

• Esculetin-induced protection of human hepatoma HepG2 cells against hydrogen peroxide is associated with the Nrf2-dependent induction of the NAD(P)H: Quinone oxidoreductase 1 gene.

  Toxicology and applied pharmacology 20110115

• Esculetin inhibits cell proliferation through the Ras/ERK1/2 pathway in human colon cancer cells.

  Oncology reports 20110101

• The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• The effect of handwashing with water or soap on bacterial contamination of hands.

  International journal of environmental research and public health 20110101

• The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

  International journal of molecular sciences 20110101

• Inhibitory effect of esculetin on migration, invasion and matrix metalloproteinase-9 expression in TNF-α-induced vascular smooth muscle cells.

  Molecular medicine reports 20110101

• What is new for an old molecule? Systematic review and recommendations on the use of resveratrol.

  PloS one 20110101

• Hepatoprotective effect of feeding celery leaves mixed with chicory leaves and barley grains to hypercholesterolemic rats.

  Pharmacognosy magazine 20110101

• Esculetin ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats.

  International journal of molecular sciences 20110101

• Ralstonia syzygii, the Blood Disease Bacterium and some Asian R. solanacearum strains form a single genomic species despite divergent lifestyles.

  PloS one 20110101

• Role of phenolic compounds in peptic ulcer: An overview.

  Journal of pharmacy & bioallied sciences 20110101

• Hyperforin inhibits Akt1 kinase activity and promotes caspase-mediated apoptosis involving Bad and Noxa activation in human myeloid tumor cells.

  PloS one 20110101

• Modeling natural anti-inflammatory compounds by molecular topology.

  International journal of molecular sciences 20110101

• Prostaglandins and their receptors in insect biology.

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  Phytochemistry 20101201

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• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Molecular cloning and characterization of a novel tomato xylosyltransferase specific for gentisic acid.

  Journal of experimental botany 20101001

• 6,7-Dihydroxy-4-phenylcoumarin as inhibitor of aldose reductase 2.

  Bioorganic & medicinal chemistry letters 20101001

• Two new flavones from Tridax procumbens Linn.

  Molecules (Basel, Switzerland) 20100909

• Structure-activity relationship of dihydroxy-4-methylcoumarins as powerful antioxidants: correlation between experimental & theoretical data and synergistic effect.

  Biochimie 20100901

• [Study on the chemical constituents from fresh roots of Euphorbia fischeriana].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100901

• Functional differentiation of the glycosyltransferases that contribute to the chemical diversity of bioactive flavonol glycosides in grapevines (Vitis vinifera).

  The Plant cell 20100801

• [Isolation and purification of esculetin from the seeds of Euphorbia lathyris L. using high-speed counter-current chromatography].

  Se pu = Chinese journal of chromatography 20100801

• Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis.

  Chemico-biological interactions 20100730

• Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20100601

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  Applied microbiology and biotechnology 20100601

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  Phytochemistry 20100401

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  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100401

• Phospholipid-esterified eicosanoids are generated in agonist-activated human platelets and enhance tissue factor-dependent thrombin generation.

  The Journal of biological chemistry 20100305

• Induction of apoptosis by esculetin in human leukemia U937 cells: roles of Bcl-2 and extracellular-regulated kinase signaling.

  Toxicology in vitro : an international journal published in association with BIBRA 20100301

• Metabolic networking in Brunfelsia calycina petals after flower opening.

  Journal of experimental botany 20100301

• Aesculetin-induced apoptosis through a ROS-mediated mitochondrial dysfunction pathway in human cervical cancer cells.

  Journal of Asian natural products research 20100301

• Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1.

  Journal of ethnopharmacology 20100217

• Antioxidant activities of coumarins from Korean medicinal plants and their structure-activity relationships.

  Phytotherapy research : PTR 20100101

• ABL-N-induced apoptosis in human breast cancer cells is partially mediated by c-Jun NH2-terminal kinase activation.

  Breast cancer research : BCR 20100101

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  Chinese medicine 20100101

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  Journal of translational medicine 20100101

• Chemical modulators of the innate immune response alter gypsy moth larval susceptibility to Bacillus thuringiensis.

  BMC microbiology 20100101

• Inhibitory effects of coumarins from the stem barks of Fraxinus rhynchophylla on adipocyte differentiation in 3T3-L1 cells.

  Biological & pharmaceutical bulletin 20100101

• Esculetin enhances TRAIL-induced apoptosis through DR5 upregulation in human oral cancer SAS cells.

  Oral oncology 20091201

• [Chemical constituents from stems of Lonicera japonica].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201

• Eicosanoids influence insect susceptibility to nucleopolyhedroviruses.

  Journal of invertebrate pathology 20091101

• Formation of coumarines during the degradation of alkyl substituted aromatic oil components by the yeast Trichosporon asahii.

  Applied microbiology and biotechnology 20091001

• Carbon nanotube/poly(ethylene-co-vinyl acetate) composite electrode for capillary electrophoretic determination of esculin and esculetin in Cortex Fraxini.

  Electrophoresis 20091001

• Dual anti-oxidative effects of fraxetin isolated from Fraxinus rhinchophylla.

  Biological & pharmaceutical bulletin 20090901

• Variations in IC(50) values with purity of mushroom tyrosinase.

  International journal of molecular sciences 20090901

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• [Studies on the chemical constituents of Chaenomeles speciosa].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090901

• Esculetin restores mitochondrial dysfunction and reduces allergic asthma features in experimental murine model.

  Journal of immunology (Baltimore, Md. : 1950) 20090801

• Investigation of the antioxidant properties of some new 4-hydroxycoumarin derivatives.

  European journal of medicinal chemistry 20090701

• A new dicoumarin and anticoagulant activity from Viola yedoensis Makino.

  Fitoterapia 20090701

• Pulsatilla decoction and its active ingredients inhibit secretion of NO, ET-1, TNF-alpha, and IL-1 alpha in LPS-induced rat intestinal microvascular endothelial cells.

  Cell biochemistry and function 20090701

• Enhancement of esculetin on arsenic trioxide-provoked apoptosis in human leukemia U937 cells.

  Chemico-biological interactions 20090615

• 7-O-methylkaempferol and -quercetin glycosides from the whole plant of Nervilia fordii.

  Journal of natural products 20090601

• An updated review of tyrosinase inhibitors.

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• An in vitro screening cascade to identify neuroprotective antioxidants in ALS.

  Free radical biology & medicine 20090415

• Biotransformation of aesculin by human gut bacteria and identification of its metabolites in rat urine.

  World journal of gastroenterology 20090328

• Eicosanoids mediate nodulation reactions to a mollicute bacterium in larvae of the blowfly, Chrysomya megacephala.

  Journal of insect physiology 20090301

• Influence of the multidrug transporter inhibitors on the activity of Kv1.3 voltage-gated potassium channels.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090301

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  Annals of plastic surgery 20090201

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• Extraction of antioxidants from plants using ultrasonic methods and their antioxidant capacity.

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  Immunopharmacology and immunotoxicology 20090101

• Investigation of biosynthetic pathways to hydroxycoumarins during post-harvest physiological deterioration in Cassava roots by using stable isotope labelling.

  Chembiochem : a European journal of chemical biology 20081215

• Involvement of extracellular signal-related kinase signaling in esculetin induced G1 arrest of human leukemia U937 cells.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20081201

• Umbelliferone and esculetin: inhibitors or substrates for polyphenol oxidases?

  Biological & pharmaceutical bulletin 20081201

• Phenidone protects the nigral dopaminergic neurons from LPS-induced neurotoxicity.

  Neuroscience letters 20081107

• Protective effect of esculetin against oxidative stress-induced cell damage via scavenging reactive oxygen species.

  Acta pharmacologica Sinica 20081101

• Protective effects of dietary chamomile tea on diabetic complications.

  Journal of agricultural and food chemistry 20080910

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  Journal of pharmaceutical and biomedical analysis 20080512

• alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus.

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  Biochemical pharmacology 20080315

• Induction of apoptosis by esculetin in human leukemia U937 cells through activation of JNK and ERK.

  Toxicology and applied pharmacology 20080301

• Structural insights into hydroxycoumarin-induced apoptosis in U-937 cells.

  Bioorganic & medicinal chemistry 20080301

• Chemical and antibacterial constituents of Skimmia anquetelia.

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  Journal of insect physiology 20080101

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  BMC cancer 20080101

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  Communications in agricultural and applied biological sciences 20080101

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  Talanta 20071115

• Inhibitory effect of natural coumarin compounds, esculetin and esculin, on oxidative DNA damage and formation of aberrant crypt foci and tumors induced by 1,2-dimethylhydrazine in rat colons.

  Biological & pharmaceutical bulletin 20071101

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  European journal of medicinal chemistry 20070701

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  Journal of lipid research 20070701

• Eicosanoid biosynthesis inhibitors increase the susceptibility of Lymantria dispar to nucleopolyhedrovirus LdMNPV.

  Journal of invertebrate pathology 20070601

• Fluorescent dyes of the esculetin and alizarin families respond to zinc ions ratiometrically.

  Chemical communications (Cambridge, England) 20070521

• 12S-lipoxygenase protein associates with alpha-actin fibers in human umbilical artery vascular smooth muscle cells.

  Biochemical and biophysical research communications 20070511

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• Enterohaemorrhagic Escherichia coli O157 and non-O157 serovars differ in their mechanisms for iron supply.

  International journal of medical microbiology : IJMM 20070201

• Kinetic characterization of the oxidation of esculetin by polyphenol oxidase and peroxidase.

  Bioscience, biotechnology, and biochemistry 20070201

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  Guang pu xue yu guang pu fen xi = Guang pu 20070101

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  Phytochemical analysis : PCA 20070101

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  Obesity (Silver Spring, Md.) 20061001

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  Archives of biochemistry and biophysics 20060815

• Esculetin induces mitochondria-mediated apoptosis in 3T3-L1 adipocytes.

  Apoptosis : an international journal on programmed cell death 20060801

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

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  Journal of biochemistry 20060401

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  Plant physiology and biochemistry : PPB 20060401

• Enhancement of esculetin on Taxol-induced apoptosis in human hepatoma HepG2 cells.

  Toxicology and applied pharmacology 20060101

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  Biomedical chromatography : BMC 20051101

• Separation and simultaneous determination of rutin, puerarin, daidzein, esculin and esculetin in medicinal preparations by non-aqueous capillary.

  Journal of pharmaceutical and biomedical analysis 20050901

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  Cancer chemotherapy and pharmacology 20050801

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  Osteoarthritis and cartilage 20050401

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  Bioscience, biotechnology, and biochemistry 20041001

• A coumarin from Mallotus resinosus that mediates DNA cleavage.

  Journal of natural products 20040901

• Synthesis of microfolicoumarin, a constituent of Cedrelopsis microfoliata.

  Bioscience, biotechnology, and biochemistry 20040901

• Suppression of 8-oxo-2'-deoxyguanosine formation and carcinogenesis induced by N-nitrosobis (2-oxopropyl)amine in hamsters by esculetin and esculin.

  Free radical research 20040801

• Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis.

  British journal of cancer 20040719

• Phenylpropanoids, phenylalanine ammonia lyase and peroxidases in elicitor-challenged cassava (Manihot esculenta) suspension cells and leaves.

  Annals of botany 20040701

• Effects of esculin and esculetin on the survival of Escherichia coli O157 in human faecal slurries, continuous-flow simulations of the rumen and colon and in calves.

  The British journal of nutrition 20040501

• Hydrogen sulfide as an endogenous regulator of vascular smooth muscle tone in trout.

  American journal of physiology. Regulatory, integrative and comparative physiology 20040401

• Inhibitory effects of esculetin on melanin biosynthesis.

  Biological & pharmaceutical bulletin 20040301

• Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase.

  European journal of biochemistry 20040301

• Phytochemical studies and effect on urine volume of Glossostemon bruguieri Desf. constituents.

  Indian journal of experimental biology 20040201

• [Lipoxygenase inhibition and protection of cardiovascular system].

  Nihon rinsho. Japanese journal of clinical medicine 20040101

• In vitro proliferation of fibrosarcoma cells depends on intact functions of lipoxygenases and cytochrome P-450-monooxygenase.

  Cancer investigation 20040101

• Studies on coumarins and coumarin-related compounds to determine their therapeutic role in the treatment of cancer.

  Current pharmaceutical design 20040101

• Natural and synthetic coumarin derivatives with anti-inflammatory/ antioxidant activities.

  Current pharmaceutical design 20040101

• Dietary antioxidant compounds and liver health.

  Critical reviews in food science and nutrition 20040101

• P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1.

  Proceedings of the National Academy of Sciences of the United States of America 20031209

• New coumarins from Cedrelopsis grevei.

  Fitoterapia 20031201

• Lipoxygenase inhibitors enhance tumor suppressive effects of jun proteins on v-myb-transformed monoblasts BM2.

  Prostaglandins & other lipid mediators 20031101

• Lipoxygenase and cyclo-oxygenase products in the control of regional kidney blood flow in rabbits.

  Clinical and experimental pharmacology & physiology 20031101

• Prostaglandins, not lipoxygenase products, mediate insect microaggregation reactions to bacterial challenge in isolated hemocyte preparations.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20031001

• High-performance liquid chromatography determination of methionine adenosyltransferase activity using catechol-O-methyltransferase-coupled fluorometric detection.

  Analytical biochemistry 20030801

• Esculetin inhibits Ras-mediated cell proliferation and attenuates vascular restenosis following angioplasty in rats.

  Biochemical pharmacology 20030601

• Suppression of lipid hydroperoxide-induced oxidative damage to cellular DNA by esculetin.

  Biological & pharmaceutical bulletin 20030601

• Mushroom tyrosinase inhibitory activity of esculetin isolated from seeds of Euphorbia lathyris L.

  Bioscience, biotechnology, and biochemistry 20030301

• Protection of coumarins against linoleic acid hydroperoxide-induced cytotoxicity.

  Chemico-biological interactions 20030106

• Potential functional foods in the traditional Maori diet.

  Mutation research 20030101

• Lipoxygenase inhibitors suppress proliferation of G5:113 fibrosarcoma cells in vitro but they have no anticancer activity in vivo.

  Neoplasma 20030101

• Structure-cytotoxic activity relationships of simple hydroxylated coumarins.

  Anticancer research 20030101

• HIV gp41 binding phenolic components from Fraxinus sieboldiana var. angustata.

  Planta medica 20021101

• Inhibition of cell cycle progression in human leukemia HL-60 cells by esculetin.

  Cancer letters 20020926

• Eicosanoids mediate Manduca sexta cellular response to the fungal pathogen Beauveria bassiana: a role for the lipoxygenase pathway.

  Archives of insect biochemistry and physiology 20020901

• Arachidonic acid metabolism in growth control of A549 human lung adenocarcinoma cells.

  Biochemistry. Biokhimiia 20020901

• [Studies on the phenolic acid constituents from Chinese medicine 'sheng-ma', rhizome of Cimicifuga foetida L].

  Yao xue xue bao = Acta pharmaceutica Sinica 20020701

• Eicosanoids and the regulation of cardiac glucose transport.

  Annals of the New York Academy of Sciences 20020601

• Role of mitochondrial complexes I and II, reactive oxygen species and arachidonic acid metabolism in deoxycholate-induced apoptosis.

  Cancer letters 20020328

• Hibiscus protocatechuic acid or esculetin can inhibit oxidative LDL induced by either copper ion or nitric oxide donor.

  Journal of agricultural and food chemistry 20020327

• A natural protective mechanism against hyperglycaemia in vascular endothelial and smooth-muscle cells: role of glucose and 12-hydroxyeicosatetraenoic acid.

  The Biochemical journal 20020301

• Multiple biological effects of inhibitors of arachidonic acid metabolism on human keratinocytes.

  Archives of dermatological research 20020201

• Inhibitory effects of phenylpropanoid metabolites on copper-induced protein oxidative modification of mice brain homogenate, in vitro.

  Biological trace element research 20020201

• Modulation by eicosanoid biosynthesis inhibitors of immune responses by the insect Manduca sexta to the pathogenic fungus Metarhizium anisopliae.

  Journal of invertebrate pathology 20020201

• Lipoxygenase inhibitors induce arrest of tumor cells in S-phase of the cell cycle.

  Neoplasma 20020101

• [Constituents of the leaves of Ligustrum delavayanum Hariot].

  Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20011101

• Eicosanoids participate in the regulation of cardiac glucose transport by contribution to a rearrangement of actin cytoskeletal elements.

  The Biochemical journal 20011001

• Dietary polyunsaturated fatty acid and antioxidant modulation of vascular dysfunction in the spontaneously hypertensive rat.

  Prostaglandins, leukotrienes, and essential fatty acids 20010801

• Studies on the hepatocyte protective activity and the structure-activity relationships of quinic acid and caffeic acid derivatives from the flower buds of Lonicera bournei.

  Planta medica 20010601

• The role of 15-lipoxygenase in disruption of the peroxisomal membrane and in programmed degradation of peroxisomes in normal rat liver.

  The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20010501

• Induction of apoptosis by esculetin in human leukemia cells.

  European journal of pharmacology 20010323

• Esculetin inhibits cartilage resorption induced by interleukin 1alpha in combination with oncostatin M.

  Annals of the rheumatic diseases 20010201

• Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase.

  Molecular pharmacology 20010201

• Novel effects of 5,8,11-eicosatriynoic acid, a lipoxygenase inhibitor, on Ca2+ mobilization in Madin Darby canine kidney cells.

  Pharmacology & toxicology 20010101

• [Sensitization and crossreaction of simple coumarins].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010101

• Dietary n-3 and n-6 polyunsaturated oils and airway contractility.

  Prostaglandins, leukotrienes, and essential fatty acids 20010101

• Effects of 1alpha,25-(OH)(2)D(3) on rat growth zone chondrocytes are mediated via cyclooxygenase-1 and phospholipase A(2).

  Journal of cellular biochemistry. Supplement 20010101

• [Features of lipoxygenase from cells of Mortierella species mushrooms].

  Prikladnaia biokhimiia i mikrobiologiia 20010101

• Structure-activity relationship of antioxidants for inhibitors of linoleic acid hydroperoxide-induced toxicity in cultured human umbilical vein endothelial cells.

  Cytotechnology 20010101

• 24R,25-(OH)(2)D(3) mediates its membrane receptor-dependent effects on protein kinase C and alkaline phosphatase via phospholipase A(2) and cyclooxygenase-1 but not cyclooxygenase-2 in growth plate chondrocytes.

  Journal of cellular physiology 20000301

• Cloning and expression of a rat liver phenobarbital-inducible UDP-glucuronosyltransferase (2B12) with specificity for monoterpenoid alcohols.

  Archives of biochemistry and biophysics 19951001

• Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates.

  Drug metabolism and disposition: the biological fate of chemicals 19940101

• Effect of BN 52256 and other mediator antagonists on ouabain-induced ventricular fibrillation in sensitized guinea-pigs and on ischemia-induced fibrillation in rats.

  Agents and actions. Supplements 19920101