305-84-0 | (2S)-2-(3-aminopropanamido)-3-(1H-imidazol-4-yl)propanoic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$8.00	$5.00
1g	95%	in stock	$13.00	$9.00
5g	95%	in stock	$19.00	$13.00
25g	95%	in stock	$42.00	$29.00
100g	95%	in stock	$130.00	$91.00
500g	95%	in stock	$563.00	$394.00

Description

• Catalog Number: AB40260
• Chemical Name: (2S)-2-(3-aminopropanamido)-3-(1H-imidazol-4-yl)propanoic acid
• CAS Number: 305-84-0
• Molecular Formula: C9H14N4O3
• Molecular Weight: 226.2325
• MDL Number: MFCD00005207
• SMILES: NCCC(=O)N[C@H](C(=O)O)Cc1nc[nH]c1

Computed Properties

• Complexity: 259
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 6
• XLogP3: -4

Literature

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  Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20111001

• Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats.

  Nutrition research and practice 20111001

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  European journal of pharmacology 20110930

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  Chemistry (Weinheim an der Bergstrasse, Germany) 20110816

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  Human & experimental toxicology 20110701

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  International journal of radiation oncology, biology, physics 20110701

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• Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians.

  Molecular genetics and metabolism 20110601

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• Concentration and fractionation by isoelectric trapping in a micropreparative-scale multicompartmental electrolyzer having orthogonal pH gradients. Part 2.

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• Measurement of carnosine, homocarnosine and anserine by FASI capillary electrophoresis UV detection: applications on biological samples.

  Talanta 20110515

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  Cancer investigation 20110501

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  Gan to kagaku ryoho. Cancer & chemotherapy 20110501

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  Fundamental & clinical pharmacology 20110401

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  Amino acids 20110401

• Stimulative effect of skipjack tuna soluble extract on pepsin-like protease in the stomach of rockfish (Sebastes schlegelii) using an in vitro perfusion method.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20110401

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  Gan to kagaku ryoho. Cancer & chemotherapy 20110401

• Carbonic anhydrase activators: gold nanoparticles coated with derivatized histamine, histidine, and carnosine show enhanced activatory effects on several mammalian isoforms.

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• Carnosine protects against the neurotoxic effects of a serotonin-derived melanoid.

  Neurochemical research 20110301

• Silencing of ferrochelatase enhances 5-aminolevulinic acid-based fluorescence and photodynamic therapy efficacy.

  British journal of cancer 20110301

• Enhanced reactivity of Lys182 explains the limited efficacy of biogenic amines in preventing the inactivation of glucose-6-phosphate dehydrogenase by methylglyoxal.

  Bioorganic & medicinal chemistry 20110301

• Glycation of the muscle-specific enolase by reactive carbonyls: effect of temperature and the protection role of carnosine, pyridoxamine and phosphatidylserine.

  The protein journal 20110301

• Utilization of adjuvant arthritis model for evaluation of new approaches in rheumatoid arthritis therapy focused on regulation of immune processes and oxidative stress.

  Interdisciplinary toxicology 20110301

• The effect of zinc sulphate and zinc carnosine on genome stability and cytotoxicity in the WIL2-NS human lymphoblastoid cell line.

  Mutation research 20110227

• Calcineurin inhibition by polaprezinc in rats with experimentally-induced colitis.

  Life sciences 20110227

• Neuroprotective properties of l-carnosine in the brain slices exposed to autoblood in the hemorrhagic stroke model in vitro.

  Regulatory peptides 20110225

• Histidine and carnosine alleviated hepatic steatosis in mice consumed high saturated fat diet.

  European journal of pharmacology 20110225

• Ocular pharmacokinetics of carnosine 5% eye drops following topical application in rabbit.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20110201

• Hormonal responses to resistance exercise after ingestion of carnosine and anserine.

  Journal of strength and conditioning research 20110201

• A survey and analysis of the role of molecular chaperone proteins and imidazole-containing dipeptide-based compounds as molecular escorts into the skin during stress, injury, water structuring and other types of cutaneous pathophysiology.

  International journal of cosmetic science 20110201

• Zinc-carnosine and vitamin E supplementation does not ameliorate gastrointestinal side effects associated with ciclosporin therapy of canine atopic dermatitis.

  Veterinary dermatology 20110201

• Electrophysiological evidence of biphasic action of carnosine on long-term potentiation in urethane-anesthetized rats.

  Neuropeptides 20110201

• Protective effect of carnosine on adriamycin-induced oxidative heart damage in rats.

  Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20110201

• New glycoside derivatives of carnosine and analogs resistant to carnosinase hydrolysis: synthesis and characterization of their copper(II) complexes.

  Journal of inorganic biochemistry 20110201

• Effect of Tinospora crispa on thioacetamide-induced liver cirrhosis in rats.

  Indian journal of pharmacology 20110201

• Anserine inhibits carnosine degradation but in human serum carnosinase (CN1) is not correlated with histidine dipeptide concentration.

  Clinica chimica acta; international journal of clinical chemistry 20110130

• Synthesis, physicochemical characterization, and biological activities of new carnosine derivatives stable in human serum as potential neuroprotective agents.

  Journal of medicinal chemistry 20110127

• The cytotoxic mechanism of malondialdehyde and protective effect of carnosine via protein cross-linking/mitochondrial dysfunction/reactive oxygen species/MAPK pathway in neurons.

  European journal of pharmacology 20110110

• Effects of zinc-L-carnosine and vitamin E on aspirin-induced gastroduodenal injury in dogs.

  Journal of veterinary internal medicine 20110101

• Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology.

  Lipids in health and disease 20110101

• The role of glyoxalases for sugar stress and aging, with relevance for dyskinesia, anxiety, dementia and Parkinson's disease.

  Aging 20110101

• Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease.

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• Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention.

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• Effects of dietary supplementation of carnosine on mitochondrial dysfunction, amyloid pathology, and cognitive deficits in 3xTg-AD mice.

  PloS one 20110101

• Levels of certain tumor markers as differential factors between bilharzial and non-biharzial bladder cancer among Egyptian patients.

  Cancer cell international 20110101

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  Izvestiia Akademii nauk. Seriia biologicheskaia 20110101

• Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-κB, iNOS, and TNF-α expression and reduction of MDA accumulation.

  Molecular vision 20110101

• Ozone acting on human blood yields a hormetic dose-response relationship.

  Journal of translational medicine 20110101

• Hepatoprotective Effects of Orthosiphon stamineus Extract on Thioacetamide-Induced Liver Cirrhosis in Rats.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Acute reduction of serum 8-iso-PGF2-alpha and advanced oxidation protein products in vivo by a polyphenol-rich beverage; a pilot clinical study with phytochemical and in vitro antioxidant characterization.

  Nutrition journal 20110101

• Demand for Zn2+ in acid-secreting gastric mucosa and its requirement for intracellular Ca2+.

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• Photo-products of retinal pigment epithelial bisretinoids react with cellular thiols.

  Molecular vision 20110101

• Carnosine prevents apoptosis of glomerular cells and podocyte loss in STZ diabetic rats.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Oral carnosine supplementation prevents vascular damage in experimental diabetic retinopathy.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Interactions of aging, overload, and creatine supplementation in rat plantaris muscle.

  Journal of aging research 20110101

• Suppression of breast tumor growth and metastasis by an engineered transcription factor.

  PloS one 20110101

• Duodenal and faecal microbiota of celiac children: molecular, phenotype and metabolome characterization.

  BMC microbiology 20110101

• Alteration of plasma glutamate and glutamine levels in children with high-functioning autism.

  PloS one 20110101

• Amelioration of nitrobenzene-induced nephrotoxicity by the ethanol extract of the herb Euphorbia hirta.

  Pharmacognosy research 20110101

• Proteases inhibition assessment on PC12 and NGF treated cells after oxygen and glucose deprivation reveals a distinct role for aspartyl proteases.

  PloS one 20110101

• Copper Inhibits NMDA Receptor-Independent LTP and Modulates the Paired-Pulse Ratio after LTP in Mouse Hippocampal Slices.

  International journal of Alzheimer's disease 20110101

• In vivo rescue of alveolar macrophages from SP-A knockout mice with exogenous SP-A nearly restores a wild type intracellular proteome; actin involvement.

  Proteome science 20110101

• Novel metabolic biomarkers related to sulfur-dependent detoxification pathways in autistic patients of Saudi Arabia.

  BMC neurology 20110101

• Choroid plexus transport: gene deletion studies.

  Fluids and barriers of the CNS 20110101

• Intratracheal instillation of cerium oxide nanoparticles induces hepatic toxicity in male Sprague-Dawley rats.

  International journal of nanomedicine 20110101

• Transport activity of the sodium bicarbonate cotransporter NBCe1 is enhanced by different isoforms of carbonic anhydrase.

  PloS one 20110101

• Carnosine ameliorates stress-induced glucose metabolism disorder in restrained mice.

  Journal of pharmacological sciences 20110101

• Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects.

  Medical gas research 20110101

• Profiling the human response to physical exercise: a computational strategy for the identification and kinetic analysis of metabolic biomarkers.

  Journal of clinical bioinformatics 20110101

• Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans.

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  Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20110101

• Dietary supplementation with carnosine improves antioxidant capacity and meat quality of finishing pigs.

  Journal of animal physiology and animal nutrition 20101201

• A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus.

  Diabetologia 20101201

• Modulation of PARP-1 and PARP-2 expression by L-carnosine and trehalose after LPS and INFγ-induced oxidative stress.

  Neurochemical research 20101201

• Ginger extract and polaprezinc exert gastroprotective actions by anti-oxidant and growth factor modulating effects in rats.

  Journal of gastroenterology and hepatology 20101201

• Toward next generation plasma profiling via heat-induced epitope retrieval and array-based assays.

  Molecular & cellular proteomics : MCP 20101101

• Advanced drug delivery of N-acetylcarnosine (N-acetyl-beta-alanyl-L-histidine), carcinine (beta-alanylhistamine) and L-carnosine (beta-alanyl-L-histidine) in targeting peptide compounds as pharmacological chaperones for use in tissue engineering, human disease management and therapy: from in vitro to the clinic.

  Recent patents on drug delivery & formulation 20101101

• Relationship between carnosinase gene CNDP1 leucine repeat polymorphism and the clinical outcome of Chinese PD patients.

  Clinical nephrology 20101101

• Polaprezinc prevents oral mucositis associated with radiochemotherapy in patients with head and neck cancer.

  International journal of cancer 20101015

• Ability of N-acetylcarnosine to protect lens crystallins from oxidation and oxidative damage by radical probe mass spectrometry (RP-MS).

  Rapid communications in mass spectrometry : RCM 20101015

• Quality characteristics and composition of the longissimus muscle in the short-loin from male and female farmed red deer in New Zealand.

  Meat science 20101001

• NT-020, a natural therapeutic approach to optimize spatial memory performance and increase neural progenitor cell proliferation and decrease inflammation in the aged rat.

  Rejuvenation research 20101001

• Important role of muscle carnosine in rowing performance.

  Journal of applied physiology (Bethesda, Md. : 1985) 20101001

• NMR metabolomic profiling reveals new roles of SUMOylation in DNA damage response.

  Journal of proteome research 20101001

• Protective effects of carnosine and homocarnosine on ferritin and hydrogen peroxide-mediated DNA damage.

  BMB reports 20101001

• Importance of luminal and mucosal zinc in the mechanism of experimental gastric ulcer healing.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20101001

• Drug off-target effects predicted using structural analysis in the context of a metabolic network model.

  PLoS computational biology 20100901

• Effects of polaprezinc on morphological change of the tongue in zinc-deficient rats.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20100901

• The effect of carnosine pretreatment on oxidative stress and hepatotoxicity in binge ethanol administered rats.

  Human & experimental toxicology 20100801

• N-glycosylation of carnosinase influences protein secretion and enzyme activity: implications for hyperglycemia.

  Diabetes 20100801

• Multi-channel microfluidic devices combined with electrospray ionization quadrupole time-of-flight mass spectrometry applied to the monitoring of glutamate release from neuronal cells.

  The Analyst 20100801

• Effect of anserine ingestion on hyperglycemia and the autonomic nerves in rats and humans.

  Nutritional neuroscience 20100801

• Effect of carnosine and its Trolox-modified derivatives on life span of Drosophila melanogaster.

  Rejuvenation research 20100801

• Alternative tasks of Drosophila tan in neurotransmitter recycling versus cuticle sclerotization disclosed by kinetic properties.

  The Journal of biological chemistry 20100702

• Effect of beta-alanine supplementation on muscle carnosine concentrations and exercise performance.

  Amino acids 20100701

• The impact of taurine- and beta-alanine-supplemented diets on behavioral and neurochemical parameters in mice: antidepressant versus anxiolytic-like effects.

  Amino acids 20100701

• Reactive oxygen species-quenching and anti-apoptotic effect of polaprezinc on indomethacin-induced small intestinal epithelial cell injury.

  Journal of gastroenterology 20100701

• Carnosine supplementation protects rat brain tissue against ethanol-induced oxidative stress.

  Molecular and cellular biochemistry 20100601

• NAD(+) and metabolic regulation of age-related proteoxicity: A possible role for methylglyoxal?

  Experimental gerontology 20100601

• Examination of association with candidate genes for diabetic nephropathy in a Mexican American population.

  Clinical journal of the American Society of Nephrology : CJASN 20100601

• Association between CNDP1 genotype and diabetic nephropathy is sex specific.

  Diabetes 20100601

• Effect of anserine ingestion on the hyperglycemia and autonomic nerves in rats and humans.

  Nutritional neuroscience 20100601

• Role of beta-alanine supplementation on muscle carnosine and exercise performance.

  Medicine and science in sports and exercise 20100601

• Telomere attrition in lens epithelial cells - a target for N-acetylcarnosine therapy.

  Frontiers in bioscience (Landmark edition) 20100601

• Effects of dietary protein level in the early fattening period on free amino acids and dipeptides in the blood and Longissimus thoracis muscle in Japanese Black steers.

  Animal science journal = Nihon chikusan Gakkaiho 20100601

• Accurate analysis of taurine, anserine, carnosine and free amino acids in a cattle muscle biopsy sample.

  Animal science journal = Nihon chikusan Gakkaiho 20100601

• Sensory-guided identification of N-(1-methyl-4-oxoimidazolidin-2-ylidene)-alpha-amino acids as contributors to the thick-sour and mouth-drying orosensation of stewed beef juice.

  Journal of agricultural and food chemistry 20100526

• Beta-alanyl peptide synthesis by Streptomyces S9 aminopeptidase.

  Journal of biotechnology 20100503

• Relevance of allosteric conformations and homocarnosine concentration on carnosinase activity.

  Amino acids 20100501

• Synthesis of functional dipeptide carnosine from nonprotected amino acids using carnosinase-displaying yeast cells.

  Applied microbiology and biotechnology 20100501

• Salsolinol, a catechol neurotoxin, induces modification of ferritin: Protection by histidine dipeptide.

  Environmental toxicology and pharmacology 20100501

• Molecular gastronomy: a new emerging scientific discipline.

  Chemical reviews 20100414

• Effects of zinc supplementation on serum zinc concentration and ratio of apo/holo-activities of angiotensin converting enzyme in patients with taste impairment.

  Auris, nasus, larynx 20100401

• Biological activity of novel synthetic derivatives of carnosine.

  Cellular and molecular neurobiology 20100401

• [SERS spectra of L-carnosine under the interaction of coordination with adsorbed SnCl2].

  Guang pu xue yu guang pu fen xi = Guang pu 20100401

• Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1).

  The Journal of biological chemistry 20100326

• Profiling histidine dipeptides in plasma and urine after ingesting beef, chicken or chicken broth in humans.

  Amino acids 20100301

• Traditional reactive carbonyl scavengers do not prevent the carbonylation of brain proteins induced by acute glutathione depletion.

  Free radical research 20100301

• Carnosine protects against permanent cerebral ischemia in histidine decarboxylase knockout mice by reducing glutamate excitotoxicity.

  Free radical biology & medicine 20100301

• Muscle carnosine metabolism and beta-alanine supplementation in relation to exercise and training.

  Sports medicine (Auckland, N.Z.) 20100301

• Reaction of ferritin with hydrogen peroxide induces lipid peroxidation.

  BMB reports 20100301

• A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen.

  The British journal of dermatology 20100301

• Neuropharmacology of vestibular system disorders.

  Current neuropharmacology 20100301

• The effect of carnosine treatment on prooxidant-antioxidant balance in liver, heart and brain tissues of male aged rats.

  Biogerontology 20100201

• Beta-alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise.

  European journal of applied physiology 20100201

• Carnosine inhibits ATP production in cells from malignant glioma.

  Neurological research 20100201

• Radiochemical synthesis and preliminary in vivo evaluation of new radioactive platinum complexes with carnosine.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20100201

• Sensitive determination of carnosine in urine by high-performance liquid chromatography using 4-(5,6-dimethoxy-2-phthalimidinyl)-2-methoxyphenylsulfonyl chloride as a fluorescent labeling reagent.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201

• The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters.

  The FEBS journal 20100201

• Biomarkers of meat intake and the application of nutrigenomics.

  Meat science 20100201

• [Protective effect of carnosine on the injury of rat vascular endothelial cells induced by hypoxia].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20100201

• The effect of beta-alanine supplementation on power performance during repeated sprint activity.

  Journal of strength and conditioning research 20100101

• Effect of carnosine against thioacetamide-induced liver cirrhosis in rat.

  Peptides 20100101

• Carnosine as a natural antioxidant and geroprotector: from molecular mechanisms to clinical trials.

  Rejuvenation research 20100101

• BJSM reviews: A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance Part 5.

  British journal of sports medicine 20100101

• Carnosine retards tumor growth in vivo in an NIH3T3-HER2/neu mouse model.

  Molecular cancer 20100101

• Zinc Supplementation with Polaprezinc Protects Mouse Hepatocytes against Acetaminophen-Induced Toxicity via Induction of Heat Shock Protein 70.

  Journal of clinical biochemistry and nutrition 20100101

• Treatment of Alzheimer's disease with a cholinesterase inhibitor combined with antioxidants.

  Neuro-degenerative diseases 20100101

• Nutraceutical augmentation of circulating endothelial progenitor cells and hematopoietic stem cells in human subjects.

  Journal of translational medicine 20100101

• Individual variation and intraclass correlation in arachidonic acid and eicosapentaenoic acid in chicken muscle.

  Lipids in health and disease 20100101

• Comparison of pre-workout nitric oxide stimulating dietary supplements on skeletal muscle oxygen saturation, blood nitrate/nitrite, lipid peroxidation, and upper body exercise performance in resistance trained men.

  Journal of the International Society of Sports Nutrition 20100101

• Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase.

  Journal of Alzheimer's disease : JAD 20100101

• New concept in nutrition for the maintenance of the aging eye redox regulation and therapeutic treatment of cataract disease; synergism of natural antioxidant imidazole-containing amino acid-based compounds, chaperone, and glutathione boosting agents: a systemic perspective on aging and longevity emerged from studies in humans.

  American journal of therapeutics 20100101

• Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation.

  PloS one 20100101

• Effect of beta-alanine supplementation on the onset of blood lactate accumulation (OBLA) during treadmill running: Pre/post 2 treatment experimental design.

  Journal of the International Society of Sports Nutrition 20100101

• Therapeutic uses of drug-carrier systems for imidazole-containing dipeptide compounds that act as pharmacological chaperones and have significant impact on the treatment of chronic diseases associated with increased oxidative stress and the formation of advanced glycation end products.

  Critical reviews in therapeutic drug carrier systems 20100101

• The TGF-beta-pseudoreceptor BAMBI is strongly expressed in COPD lungs and regulated by nontypeable Haemophilus influenzae.

  Respiratory research 20100101

• Effects of a chicken extract on food-deprived activity stress in rats.

  Bioscience, biotechnology, and biochemistry 20100101

• Aging, Proteotoxicity, Mitochondria, Glycation, NAD and Carnosine: Possible Inter-Relationships and Resolution of the Oxygen Paradox.

  Frontiers in aging neuroscience 20100101

• Basal protrusion of ulcers induced by endoscopic submucosal dissection (ESD) during treatment with proton pump inhibitors, and the suppressive effects of polaprezinc.

  Hepato-gastroenterology 20100101

• A role for taurine in mitochondrial function.

  Journal of biomedical science 20100101

• Antiglycating potential of Zingiber officinalis and delay of diabetic cataract in rats.

  Molecular vision 20100101

• Effect of carnosine treatment on oxidative stress in serum, apoB-containing lipoproteins fraction and erythrocytes of aged rats.

  Pharmacological reports : PR 20100101

• Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis.

  Arthritis research & therapy 20100101

• Characteristic metabolism of free amino acids in cetacean plasma: cluster analysis and comparison with mice.

  PloS one 20100101

• Carnosine inhibits degradation of hyaluronan induced by free radical processes in vitro and improves the redox imbalance in adjuvant arthritis in vivo.

  Neuro endocrinology letters 20100101

• Simple enzymatic procedure for L-carnosine synthesis: whole-cell biocatalysis and efficient biocatalyst recycling.

  Microbial biotechnology 20100101

• Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment.

  The open cardiovascular medicine journal 20100101

• Effects of beta-alanine on muscle carnosine and exercise performance: a review of the current literature.

  Nutrients 20100101

• Changes of the thiol levels in the corneas of the diabetic rats: effect of carnosine, aspirin and a combination eye drops.

  International journal of ophthalmology 20100101

• Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats.

  Indian journal of clinical biochemistry : IJCB 20100101

• Salt, pH and thermoresponsive supramolecular hydrogel of N-(4-n-tetradecyloxybenzoyl)-L-carnosine.

  Chemical communications (Cambridge, England) 20091207

• Molecular characterization and quantification using state of the art solid-state adiabatic TOBSY NMR in burn trauma.

  International journal of molecular medicine 20091201

• [Enzymetic synthesis and characterization of a carnosine analogue in non-aqueous solvent].

  Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20091201

• Polaprezinc, a zinc compound, is distributed to the lingual epithelium and increases its zinc concentration in zinc-deficient rats.

  Life sciences 20091118

• Sensory-directed identification of beta-alanyl dipeptides as contributors to the thick-sour and white-meaty orosensation induced by chicken broth.

  Journal of agricultural and food chemistry 20091111

• Neuroprotective effects of an alkaloid-free ethyl acetate extract from the root of Sophora flavescens Ait. against focal cerebral ischemia in rats.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20091101

• Current ocular drug delivery challenges for N-acetylcarnosine: novel patented routes and modes of delivery, design for enhancement of therapeutic activity and drug delivery relationships.

  Recent patents on drug delivery & formulation 20091101

• Carnosinase levels in aging brain: redox state induction and cellular stress response.

  Antioxidants & redox signaling 20091101

• Protective role of carnosine in mice with cadmium-induced acute hepatotoxicity.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20091101

• Carnosine facilitates nitric oxide production in endothelial f-2 cells.

  Biological & pharmaceutical bulletin 20091101

• Zinc supplementation improves the outcome of chronic hepatitis C and liver cirrhosis.

  Journal of clinical biochemistry and nutrition 20091101

• Dietary supplementation with cholesterol and docosahexaenoic acid affects concentrations of amino acids in tissues of young pigs.

  Amino acids 20091001

• A zinc-containing compound, Polaprezinc, is effective for patients with taste disorders: randomized, double-blind, placebo-controlled, multi-center study.

  Acta oto-laryngologica 20091001

• Quantification of carnosine-related peptides by microchip electrophoresis with chemiluminescence detection.

  Analytical biochemistry 20091001

• Synergistic antioxidative activities of hydroxycinnamoyl-peptides.

  Journal of peptide science : an official publication of the European Peptide Society 20091001

• Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD).

  Biochimica et biophysica acta 20091001

• Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium.

  Molecular bioSystems 20091001

• Protective effects from carnosine and histidine on acetaminophen-induced liver injury.

  Journal of food science 20091001

• Surface functionalization of bioactive glasses.

  Journal of biomedical materials research. Part A 20090915

• Efficacy of anti-aging products for periorbital wrinkles as measured by 3-D imaging.

  Journal of cosmetic dermatology 20090901

• Effects of carnosine on long-term plasticity of medial perforant pathway/dentate gyrus synapses in urethane-anesthetized rats: an in vivo model.

  Experimental brain research 20090801

• Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by l-carnosine in SH-SY5Y cells.

  Neuroscience letters 20090731

• Protective effects of L- and D-carnosine on alpha-crystallin amyloid fibril formation: implications for cataract disease.

  Biochemistry 20090714

• Ferritin enhances salsolinol-mediated DNA strand breakage: protection by carnosine and related compounds.

  Toxicology letters 20090710

• Distribution of carnosine-like peptides in the nervous system of developing and adult zebrafish (Danio rerio) and embryonic effects of chronic carnosine exposure.

  Cell and tissue research 20090701

• Inhibitory effect of carnosine and N-acetyl carnosine on LPS-induced microglial oxidative stress and inflammation.

  Peptides 20090701

• Polaprezinc (Zinc L-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1 - a new mechanism of gastric mucosal protection.

  Journal of pharmacological sciences 20090701

• Effects of carnosine on the evoked potentials in hippocampal CA1 region.

  Journal of Zhejiang University. Science. B 20090701

• Design, synthesis, and evaluation of carnosine derivatives as selective and efficient sequestering agents of cytotoxic reactive carbonyl species.

  ChemMedChem 20090601

• Induction of type 1 interferon receptor by zinc in U937 cells.

  Cytokine 20090601

• Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal.

  Chemical research in toxicology 20090601

• L-Carnosine: multifunctional dipeptide buffer for sustained-duration topical ophthalmic formulations.

  The Journal of pharmacy and pharmacology 20090601

• Zinc deficiency anemia and effects of zinc therapy in maintenance hemodialysis patients.

  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20090601

• Carnosine attenuates oxidative stress and apoptosis in transient cerebral ischemia in rats.

  Acta biologica Hungarica 20090601

• Molecular mechanisms of homocysteine toxicity.

  Biochemistry. Biokhimiia 20090601

• [Effects of L-carnosine in preventing and treating rat cataract induced by sodium selenite].

  [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20090601

• Discoidin domain receptor 1, a tyrosine kinase receptor, is upregulated in an experimental model of remyelination and during oligodendrocyte differentiation in vitro.

  Journal of molecular neuroscience : MN 20090501

• The effect of 4 weeks beta-alanine supplementation and isokinetic training on carnosine concentrations in type I and II human skeletal muscle fibres.

  European journal of applied physiology 20090501

• N-acetylcysteine suppresses oxidative stress in experimental rats with subarachnoid hemorrhage.

  Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090501

• Carnosine, diabetes and Alzheimer's disease.

  Expert review of neurotherapeutics 20090501

• Carnosine inhibits high glucose-induced mesangial cell proliferation through mediating cell cycle progression.

  Regulatory peptides 20090410

• Neuronal pentraxin receptor in cerebrospinal fluid as a potential biomarker for neurodegenerative diseases.

  Brain research 20090410

• On the enigma of carnosine's anti-ageing actions.

  Experimental gerontology 20090401

• Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.

  American journal of physiology. Regulatory, integrative and comparative physiology 20090401

• Beta-alanine improves sprint performance in endurance cycling.

  Medicine and science in sports and exercise 20090401

• N-Terminal 2,3-diaminopropionic acid (Dap) peptides as efficient methylglyoxal scavengers to inhibit advanced glycation endproduct (AGE) formation.

  Bioorganic & medicinal chemistry 20090315

• Occurrence of a novel acetylated amino acid, N(alpha)-acetylhistidine, in skeletal muscle of freshwater fish and other ectothermic vertebrates.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20090301

• Carnosine loading and washout in human skeletal muscles.

  Journal of applied physiology (Bethesda, Md. : 1985) 20090301

• Screening of dipeptides having central functions for excitation and sedation.

  Mini reviews in medicinal chemistry 20090301

• 5-S-GAD, a novel radical scavenging compound, prevents lens opacity development.

  Free radical biology & medicine 20090215

• Comparison of the carnosine and taurine contents of vastus lateralis of elderly Korean males, with impaired glucose tolerance, and young elite Korean swimmers.

  Amino acids 20090201

• The effects of beta-alanine supplementation and high-intensity interval training on neuromuscular fatigue and muscle function.

  European journal of applied physiology 20090201

• Proton MR spectroscopy of metabolite concentrations in temporal lobe epilepsy and effect of temporal lobe resection.

  Epilepsy research 20090201

• The protective effects of carnosine and melatonin in ischemia-reperfusion injury in the rat liver.

  Acta histochemica 20090101

• Transport mechanisms of carnosine in SKPT cells: contribution of apical and basolateral membrane transporters.

  Pharmaceutical research 20090101

• Do fatty acids help in overcoming reading difficulties? A double-blind, placebo-controlled study of the effects of eicosapentaenoic acid and carnosine supplementation on children with dyslexia.

  Child: care, health and development 20090101

• Synaptosomal toxicity and nucleophilic targets of 4-hydroxy-2-nonenal.

  Toxicological sciences : an official journal of the Society of Toxicology 20090101

• N-Acetylcarnosine and histidyl-hydrazide are potent agents for multitargeted ophthalmic therapy of senile cataracts and diabetic ocular complications.

  Journal of drug targeting 20090101

• Examination of a pre-exercise, high energy supplement on exercise performance.

  Journal of the International Society of Sports Nutrition 20090101

• State of the art clinical efficacy and safety evaluation of N-acetylcarnosine dipeptide ophthalmic prodrug. Principles for the delivery, self-bioactivation, molecular targets and interaction with a highly evolved histidyl-hydrazide structure in the treatment and therapeutic management of a group of sight-threatening eye diseases.

  Current clinical pharmacology 20090101

• Effects of beta-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial.

  Journal of the International Society of Sports Nutrition 20090101

• Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases.

  Frontiers in bioscience (Landmark edition) 20090101

• N-acetylcarnosine lubricant eyedrops possess all-in-one universal antioxidant protective effects of L-carnosine in aqueous and lipid membrane environments, aldehyde scavenging, and transglycation activities inherent to cataracts: a clinical study of the new vision-saving drug N-acetylcarnosine eyedrop therapy in a database population of over 50,500 patients.

  American journal of therapeutics 20090101

• N-Acetylcarnosine sustained drug delivery eye drops to control the signs of ageless vision: glare sensitivity, cataract amelioration and quality of vision currently available treatment for the challenging 50,000-patient population.

  Clinical interventions in aging 20090101

• NAD+ availability and proteotoxicity.

  Neuromolecular medicine 20090101

• Carnosine and its possible roles in nutrition and health.

  Advances in food and nutrition research 20090101

• Genome-wide transcription analysis of histidine-related cataract in Atlantic salmon (Salmo salar L).

  Molecular vision 20090101

• [The effect of apoptosis inductor dexamethasone on the energy exchange and ultrastructure of plant cells].

  Tsitologiia 20090101

• [Biological characteristics of microorganisms for prognosis of trophic ulcers course].

  Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20090101

• Effect of a combination of carnosine and aspirin eye drops on streptozotocin -- induced diabetic cataract in rats.

  Molecular vision 20090101

• Novel and emerging treatments for autism spectrum disorders: a systematic review.

  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20090101

• [Protective properties of L-carnosine studied in vitro on a hemorrhagic stroke model].

  Eksperimental'naia i klinicheskaia farmakologiia 20090101

• Potentiation of intraocular absorption and drug metabolism of N-acetylcarnosine lubricant eye drops: drug interaction with sight threatening lipid peroxides in the treatment for age-related eye diseases.

  Drug metabolism and drug interactions 20090101

• Preventive effect of L-carnosine on changes in the thermal nociceptive threshold in streptozotocin-induced diabetic mice.

  European journal of pharmacology 20081214

• Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis.

  Journal of gastroenterology and hepatology 20081201

• Cellular stress response: a novel target for chemoprevention and nutritional neuroprotection in aging, neurodegenerative disorders and longevity.

  Neurochemical research 20081201

• Adsorption of histidine-containing dipeptides on copper(II) immobilized chelating resin from saline solution.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081201

• Antioxidant combination inhibits reactive oxygen species mediated damage.

  Bioscience, biotechnology, and biochemistry 20081201

• Antioxidant activities of hydrolysates of Arca subcrenata prepared with three proteases.

  Marine drugs 20081201

• Leptin influences histidine dipeptides and nitric oxide release from anterior pituitary cells of sheep in vitro.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20081201

• Glial and endothelial blood-retinal barrier responses to amyloid-beta in the neural retina of the rat.

  Clinical ophthalmology (Auckland, N.Z.) 20081201

• Colocalization of a carnosine-splitting enzyme, tissue carnosinase (CN2)/cytosolic non-specific dipeptidase 2 (CNDP2), with histidine decarboxylase in the tuberomammillary nucleus of the hypothalamus.

  Neuroscience letters 20081114

• Anticonvulsant effect of carnosine on penicillin-induced epileptiform activity in rats.

  Brain research 20081106

• The Effect of the Dried-Bonito Broth on Blood Pressure, 8-Hydroxydeoxyguanosine (8-OHdG), an Oxidative Stress Marker, and Emotional States in Elderly Subjects.

  Journal of clinical biochemistry and nutrition 20081101

• Transition metal ion binding studies of carnosine and histidine: biologically relevant antioxidants.

  Colloids and surfaces. B, Biointerfaces 20081015

• Differential neuroprotective effects of carnosine, anserine, and N-acetyl carnosine against permanent focal ischemia.

  Journal of neuroscience research 20081001

• G/T substitution in intron 1 of the UNC13B gene is associated with increased risk of nephropathy in patients with type 1 diabetes.

  Diabetes 20081001

• Ocular drug metabolism of the bioactivating antioxidant N-acetylcarnosine for vision in ophthalmic prodrug and codrug design and delivery.

  Drug development and industrial pharmacy 20081001

• Anti-aging medicine.

  Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India 20081001

• Composition and quality differences between the longissimus and infraspinatus muscles for several groups of pasture-finished cattle.

  Meat science 20081001

• Regulation of sympathetic nerve activity by L-carnosine in mammalian white adipose tissue.

  Neuroscience letters 20080815

• Chicken breast attenuates high-intensity-exercise-induced decrease in rat sarcoplasmic reticulum Ca2+ handling.

  International journal of sport nutrition and exercise metabolism 20080801

• Carnosine [corrected] increases efficiency of DOPA therapy of Parkinson's disease: a pilot study.

  Rejuvenation research 20080801

• Contents of creatine, creatinine and carnosine in porcine muscles of different metabolic types.

  Meat science 20080801

• Low-density lipoprotein has an enormous capacity to bind (E)-4-hydroxynon-2-enal (HNE): detection and characterization of lysyl and histidyl adducts containing multiple molecules of HNE.

  Chemical research in toxicology 20080721

• Protection by polaprezinc against radiation-induced apoptosis in rat jejunal crypt cells.

  Journal of radiation research 20080701

• New L-dopa codrugs as potential antiparkinson agents.

  Archiv der Pharmazie 20080701

• Neurotropic effect of exogenous L-carnosine in cultured slices of the olfactory cortex from rat brain.

  Bulletin of experimental biology and medicine 20080701

• Carnosine-induced antidepressant-like activity in rats.

  Pharmacology, biochemistry, and behavior 20080601

• Neuroimmunomodulatory compound for sensitive skin care: in vitro and clinical assessment.

  Journal of cosmetic dermatology 20080601

• Creatine supplementation augments skeletal muscle carnosine content in senescence-accelerated mice (SAMP8).

  Rejuvenation research 20080601

• [Involvement of zinc in taste disturbance occurring during treatment for malignant tumor in the chest and the effects of polaprezinc oral disintegrating tablets (a retrospective study)].

  Gan to kagaku ryoho. Cancer & chemotherapy 20080601

• Reverse structure of carnosine-induced sedative and hypnotic effects in the chick under acute stress.

  Life sciences 20080523

• Anserine and carnosine determination in meat samples by pure micellar liquid chromatography.

  Journal of chromatography. A 20080502

• The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition.

  Amino acids 20080501

• Beneficial effects of histidine and carnosine on ethanol-induced chronic liver injury.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080501

• Inhibitory effect of carnosine on interleukin-8 production in intestinal epithelial cells through translational regulation.

  Cytokine 20080501

• Protective effect of carnosine against cisplatin-induced nephrotoxicity in mice.

  Environmental toxicology and pharmacology 20080501

• Water-soluble precursors of beef flavour: I. Effect of diet and breed.

  Meat science 20080501

• Food restriction and refeeding in lambs influence muscle antioxidant status.

  Animal : an international journal of animal bioscience 20080501

• Carnosine attenuates mast cell degranulation and histamine release induced by oxygen-glucose deprivation.

  Cell biochemistry and function 20080401

• Changes in chemical components in the freshwater apple snail, Pomacea canaliculata (Gastropoda: Ampullariidae), in relation to the development of its cold hardiness.

  Cryobiology 20080401

• Therapeutic interruption of advanced glycation in diabetic nephropathy: do all roads lead to Rome?

  Annals of the New York Academy of Sciences 20080401

• Role of carnosine in preventing thioacetamide-induced liver injury in the rat.

  Peptides 20080301

• Cardioprotective effect of histidine-containing dipeptides in pharmacological cold cardioplegia.

  Bulletin of experimental biology and medicine 20080301

• Antithrombin activity is inhibited by acrolein and homocysteine thiolactone: Protection by cysteine.

  Life sciences 20080213

• Carnosine as molecular probe for sensitive detection of Cu(II) ions using localized 1H NMR spectroscopy.

  Journal of inorganic biochemistry 20080201

• Safety evaluation of chicken breast extract containing carnosine and anserine.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080201

• Energy metabolism, altered proteins, sirtuins and ageing: converging mechanisms?

  Biogerontology 20080201

• Carnosine protects against Abeta42-induced neurotoxicity in differentiated rat PC12 cells.

  Cellular and molecular neurobiology 20080201

• Long-term treatment with a Yang-invigorating Chinese herbal formula produces generalized tissue protection against oxidative damage in rats.

  Rejuvenation research 20080201

• Dietary supplementation exerts neuroprotective effects in ischemic stroke model.

  Rejuvenation research 20080201

• DNA-fiber EPR spectroscopy as a tool to study DNA-metal complex interactions: DNA binding of hydrated Cu(II) ions and Cu(II) complexes of amino acids and peptides.

  Journal of inorganic biochemistry 20080101

• Carnosine protects erythrocytes from the oxidative stress caused by homocysteic acid.

  Doklady. Biochemistry and biophysics 20080101

• [Search for chaperon-like anticataract drugs, the antiaggregants of lens crystallins. Communication. 1. Chaperon-like activity of N-acetyl carnosine dipeptide: in vitro study on a model of ultraviolet-induced aggregation of betaL-crystallin].

  Vestnik oftalmologii 20080101

• [Like anticataract agents, the antiaggregants of lens crystallin. Communication 2. Study of the impact of chaperon-like (protective) activity of short-chain peptides on the rate of UV-induced aggregation of betaL-crystallins by eximer laser].

  Vestnik oftalmologii 20080101

• [Chaperon-like anticataract agents, the antiaggregants of lens crystallin. Communication 4. Study of the effect of a mixture of di- and tetrapeptides on a prolonged rat model of UV-induced cataract].

  Vestnik oftalmologii 20080101

• Impaired erythrocytes deformability in H(2)O(2)-induced oxidative stress: protective effect of L-carnosine.

  Clinical hemorheology and microcirculation 20080101

• L-carnosine inhibits metastasis of SK-Hep-1 cells by inhibition of matrix metaoproteinase-9 expression and induction of an antimetastatic gene, nm23-H1.

  Nutrition and cancer 20080101

• The effect of beta-alanine supplementation on neuromuscular fatigue in elderly (55-92 Years): a double-blind randomized study.

  Journal of the International Society of Sports Nutrition 20080101

• Possible new antiaging strategies related to neuroendocrine-immune interactions.

  Neuroimmunomodulation 20080101

• Aqueous fish extract increases survival in the mouse model of cytostatic toxicity.

  Journal of experimental & clinical cancer research : CR 20080101

• Effect of carnosine, aminoguanidine, and aspirin drops on the prevention of cataracts in diabetic rats.

  Molecular vision 20080101

• Effects of dietary carnosine and vitamin E on antioxidant and oxidative status of rats.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20080101

• Absolute quantification of carnosine in human calf muscle by proton magnetic resonance spectroscopy.

  Physics in medicine and biology 20071207

• Effects of central injection of L-carnosine on sympathetic nerve activity innervating brown adipose tissue and body temperature in rats.

  Regulatory peptides 20071204

• The role of carcinine in signaling at the Drosophila photoreceptor synapse.

  PLoS genetics 20071201

• beta-Alanine supplementation augments muscle carnosine content and attenuates fatigue during repeated isokinetic contraction bouts in trained sprinters.

  Journal of applied physiology (Bethesda, Md. : 1985) 20071101

• Carnosine is neuroprotective against permanent focal cerebral ischemia in mice.

  Stroke 20071101

• The hepatoprotective effect of carnosine against ischemia/reperfusion liver injury in rats.

  European journal of pharmacology 20071015

• L-carnosine, a substrate of carnosinase-1, influences glucose metabolism.

  Diabetes 20071001

• Malondialdehyde scavenging and aldose-derived Schiff bases' transglycation properties of synthetic histidyl-hydrazide carnosine analogs.

  Bioorganic & medicinal chemistry 20070915

• A CTG polymorphism in the CNDP1 gene determines the secretion of serum carnosinase in Cos-7 transfected cells.

  Diabetes 20070901

• Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients.

  Clinica chimica acta; international journal of clinical chemistry 20070901

• Glycyl-histidyl-lysine (GHK) is a quencher of alpha,beta-4-hydroxy-trans-2-nonenal: a comparison with carnosine. insights into the mechanism of reaction by electrospray ionization mass spectrometry, 1H NMR, and computational techniques.

  Chemical research in toxicology 20070901

• Efficacy of zinc administration in patients with hepatitis C virus-related chronic liver disease.

  Scandinavian journal of gastroenterology 20070901

• Carnosine interaction with nitric oxide and astroglial cell protection.

  Journal of neuroscience research 20070801

• Carnosine ameliorates morphine-induced conditioned place preference in rats.

  Neuroscience letters 20070705

• Synthesis and antioxidant activity of new homocarnosine beta-cyclodextrin conjugates.

  European journal of medicinal chemistry 20070701

• The Biflow: an instrument for transfer-loop mediated, continuous, preparative-scale isoelectric trapping separations.

  Electrophoresis 20070701

• Hydrophilic chromatographic determination of carnosine, anserine, balenine, creatine, and creatinine.

  Journal of agricultural and food chemistry 20070613

• Oxidative stress of neural, hematopoietic, and stem cells: protection by natural compounds.

  Rejuvenation research 20070601

• Histidine maintenance requirement and efficiency of its utilization in young pigs.

  Archives of animal nutrition 20070601

• Zinc supplementation prevents the increase of transaminase in chronic hepatitis C patients during combination therapy with pegylated interferon alpha-2b and ribavirin.

  Journal of nutritional science and vitaminology 20070601

• Protective substances against zinc-induced neuronal death after ischemia: carnosine as a target for drug of vascular type of dementia.

  Recent patents on CNS drug discovery 20070601

• Carnosine-like immunoreactivity in neurons of the brain of an advanced teleost, the gray mullet (Chelon labrosus, Risso).

  Brain research 20070529

• Protective effect of orally administered carnosine on bleomycin-induced lung injury.

  American journal of physiology. Lung cellular and molecular physiology 20070501

• Neuroprotective actions of a histidine analogue in models of ischemic stroke.

  Journal of neurochemistry 20070501

• Could carnosine or related structures suppress Alzheimer's disease?

  Journal of Alzheimer's disease : JAD 20070501

• [On-line sample stacking for determination of carnosine-related peptides by capillary electrophoresis].

  Se pu = Chinese journal of chromatography 20070501

• Carnosine inhibits pentylenetetrazol-induced seizures by histaminergic mechanisms in histidine decarboxylase knock-out mice.

  Neuroscience letters 20070418

• Carnosine, taurine and enzyme activities of human skeletal muscle fibres from elderly subjects with osteoarthritis and young moderately active subjects.

  Biogerontology 20070401

• A leucine repeat in the carnosinase gene CNDP1 is associated with diabetic end-stage renal disease in European Americans.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070401

• Purification and characterization of a novel imidazole dipeptide synthase from the muscle of the Japanese eel Anguilla japonica.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20070401

• Neuroprotective effect of carnosine on necrotic cell death in PC12 cells.

  Neuroscience letters 20070306

• Carnosine and its constituents inhibit glycation of low-density lipoproteins that promotes foam cell formation in vitro.

  FEBS letters 20070306

• Demonstration of functional dipeptide transport with expression of PEPT2 in guinea pig cardiomyocytes.

  Pflugers Archiv : European journal of physiology 20070301

• Carnosine protects against NMDA-induced neurotoxicity in differentiated rat PC12 cells through carnosine-histidine-histamine pathway and H(1)/H(3) receptors.

  Biochemical pharmacology 20070301

• Effects of UVB radiation on 4-hydroxy-2-trans-nonenal metabolism and toxicity in human keratinocytes.

  Chemical research in toxicology 20070301

• Effect of carnosine on gentamicin-induced nephrotoxicity.

  Medical science monitor : international medical journal of experimental and clinical research 20070301

• [Carnosine and diseases of central nervous system].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070301

• Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes.

  Gut 20070201

• Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity.

  Amino acids 20070201

• Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects.

  Amino acids 20070201

• Protective effects of histidine dipeptides on the modification of neurofilament-L by the cytochrome c/hydrogen peroxide system.

  Journal of biochemistry and molecular biology 20070131

• New method to evaluate water-soluble antioxidant activity based on protein structural change.

  Journal of agricultural and food chemistry 20070110

• Effects of beta-alanine supplementation on the onset of neuromuscular fatigue and ventilatory threshold in women.

  Amino acids 20070101

• Decreased formation of advanced glycation end-products in peritoneal fluid by carnosine and related peptides.

  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20070101

• Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons.

  PloS one 20070101

• Central administration of dipeptides, beta-alanyl-BCAAs, induces hyperactivity in chicks.

  BMC neuroscience 20070101

• SELDI-TOF-MS ProteinChip array profiling of T-cell clones propagated in long-term culture identifies human profilin-1 as a potential bio-marker of immunosenescence.

  Proteome science 20070101

• [Carnosine--biological activity and perspectives in pharmacotherapy].

  Wiadomosci lekarskie (Warsaw, Poland : 1960) 20070101

• Antiglycation and antioxidant effect of carnosine against glucose degradation products in peritoneal mesothelial cells.

  Nephron. Clinical practice 20070101

• [Hyperfine structure analysis in magnetic resonance spectroscopy: from astrophysical measurements towards endogenous biosensors in human tissue].

  Zeitschrift fur medizinische Physik 20070101

• Medical treatment of cataract.

  Clinical & experimental ophthalmology 20070101

• [Carnosine: endogenous physiological corrector of antioxidative system activity].

  Uspekhi fiziologicheskikh nauk 20070101

• Brain type carnosinase in dementia: a pilot study.

  BMC neurology 20070101

• Oral administration of chicken breast extract increases brain carnosine and anserine concentrations in rats.

  Nutritional neuroscience 20070101

• [Diagnostic value of persistent characteristics of staphylococci during their carriage].

  Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20070101

• [Using carnosine and natural antioxidants for the prophylaxis of acute post-loading oxidative stress].

  Eksperimental'naia i klinicheskaia farmakologiia 20070101

• Oxidative stress and ischemia-reperfusion injury in gastrointestinal tract and antioxidant, protective agents.

  Journal of clinical biochemistry and nutrition 20070101

• Lipid oxidation and color change of salted pork patties.

  Meat science 20070101

• Evaluation of topical external medicine for 5-fluorouracil-induced oral mucositis in hamsters.

  European journal of pharmacology 20061203

• Enzymatic degradation of beta- and mixed alpha,beta-oligopeptides.

  Chemistry & biodiversity 20061201

• [Effect of carnosine on prevention of reperfusion liver injury during hemorrhagic shock and reperfusion in rats].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20061201

• Small peptides (<5kDa) found in ready-to-eat beef meat.

  Meat science 20061201

• Zinc L-carnosine protects colonic mucosal injury through induction of heat shock protein 72 and suppression of NF-kappaB activation.

  Life sciences 20061110

• Renoprotective effects of l-carnosine on ischemia/reperfusion-induced renal injury in rats.

  The Journal of pharmacology and experimental therapeutics 20061101

• Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72.

  Journal of gastroenterology and hepatology 20061101

• Changes in the forms of iron and in concentrations of taurine, carnosine, coenzyme Q(10), and creatine in beef longissimus muscle with cooking and simulated stomach and duodenal digestion.

  Meat science 20061101

• Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.

  Biochemical and biophysical research communications 20061020

• Polaprezinc protects human colon cells from oxidative injury induced by hydrogen peroxide: relevant to cytoprotective heat shock proteins.

  World journal of gastroenterology 20061014

• Taurine rescues hippocampal long-term potentiation from ammonia-induced impairment.

  Neurobiology of disease 20060901

• [Carnosine--an endogenous antioxidant and tissue protective factor].

  Medizinische Monatsschrift fur Pharmazeuten 20060901

• Strategies for designing novel functional meat products.

  Meat science 20060901

• Evidence for rapid inter- and intramolecular chlorine transfer reactions of histamine and carnosine chloramines: implications for the prevention of hypochlorous-acid-mediated damage.

  Biochemistry 20060704

• Expression of discoidin domain receptor 1 during mouse brain development follows the progress of myelination.

  Neuroscience 20060630

• Homology modeling of human serum carnosinase, a potential medicinal target, and MD simulations of its allosteric activation by citrate.

  Journal of medicinal chemistry 20060601

• [Preventive effect of carnosine on cataract development].

  Yan ke xue bao = Eye science 20060601

• Carnosine, a precursor of histidine, ameliorates pentylenetetrazole-induced kindled seizures in rat.

  Neuroscience letters 20060529

• Aminophospholipid glycation and its inhibitor screening system: a new role of pyridoxal 5'-phosphate as the inhibitor.

  Journal of lipid research 20060501

• The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis.

  Amino acids 20060501

• Does chronic glycolysis accelerate aging? Could this explain how dietary restriction works?

  Annals of the New York Academy of Sciences 20060501

• Would carnosine or a carnivorous diet help suppress aging and associated pathologies?

  Annals of the New York Academy of Sciences 20060501

• Field-amplified on-line sample stacking for determination of carnosine-related peptides by capillary electrophoresis.

  Journal of separation science 20060501

• Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and L-carnosine in ophthalmic and skin care products.

  Life sciences 20060411

• The functional evaluation of human peptide/histidine transporter 1 (hPHT1) in transiently transfected COS-7 cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060401

• Carnosine inhibits modifications and decreased molecular chaperone activity of lens alpha-crystallin induced by ribose and fructose 6-phosphate.

  Molecular vision 20060327

• Hydralazine inhibits rapid acrolein-induced protein oligomerization: role of aldehyde scavenging and adduct trapping in cross-link blocking and cytoprotection.

  Molecular pharmacology 20060301

• Brain homocarnosine and seizure control of patients taking gabapentin or topiramate.

  Epilepsia 20060301

• Effects of taurine, carnosine, and casomorphine on functional activity of rat peritoneal mast cells.

  Bulletin of experimental biology and medicine 20060301

• Triple therapy of interferon and ribavirin with zinc supplementation for patients with chronic hepatitis C: a randomized controlled clinical trial.

  World journal of gastroenterology 20060227

• Randomized controlled trial of consensus interferon with or without zinc for chronic hepatitis C patients with genotype 2.

  World journal of gastroenterology 20060214

• Nutraceuticals synergistically promote proliferation of human stem cells.

  Stem cells and development 20060201

• Carnosine and anserine ingestion enhances contribution of nonbicarbonate buffering.

  Medicine and science in sports and exercise 20060201

• Effect of lectins on the transport of food factors in caco-2 cell monolayers.

  Journal of agricultural and food chemistry 20060125

• A novel, quantitative assay for homocarnosine in cerebrospinal fluid using stable-isotope dilution liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118

• Spatial aspects of intracellular pH regulation in heart muscle.

  Progress in biophysics and molecular biology 20060101

• On the mechanisms of ageing suppression by dietary restriction-is persistent glycolysis the problem?

  Mechanisms of ageing and development 20060101

• Interactions between carnosine and captopril on free radical scavenging activity and angiotensin-converting enzyme activity in vitro.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060101

• Carnosine may reduce lung injury caused by radiation therapy.

  Medical hypotheses 20060101

• Age and immunity.

  Immunity & ageing : I & A 20060101

• Modulation of inhibitory glycine receptors in cultured embryonic mouse hippocampal neurons by zinc, thiol containing redox agents and carnosine.

  Neuroscience 20060101

• Exercise and functional foods.

  Nutrition journal 20060101

• [The effect of carnosine on inflammatory processes during contusion of the eyeball].

  Biomeditsinskaia khimiia 20060101

• [Conformers of carnosine].

  Biofizika 20060101

• Carnosine protects from the oxidative stress induced by prenatal hypoxia.

  Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20060101

• The effect of a topical antioxidant formulation including N-acetyl carnosine on canine cataract: a preliminary study.

  Veterinary ophthalmology 20060101

• [Anticarnosine activity of staphylococci as a criterion for assessment of their persistence potential].

  Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20060101

• Concentrations of carnosine, anserine, L-histidine and 3-methyl histidine in boar spermatozoa and sheep milk by a modified HPLC method.

  Polish journal of veterinary sciences 20060101

• [Carnosine and relative compounds protect double-stranded DNA from oxidative damage].

  Zhurnal evoliutsionnoi biokhimii i fiziologii 20060101

• Effect of polaprezinc on taste disorders in zinc-deficient rats.

  BioFactors (Oxford, England) 20060101

• Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators.

  Bioorganic & medicinal chemistry letters 20051201

• Protection of proteins from oxidative stress: a new illusion or a novel strategy?

  Annals of the New York Academy of Sciences 20051201

• Genotype and gender differences in carnosine extracts and antioxidant activities of chicken breast and thigh meats.

  Meat science 20051201

• Nitric oxide involves in carnosine-induced hyperactivity in chicks.

  European journal of pharmacology 20051107

• The carnosine content of vastus lateralis is elevated in resistance-trained bodybuilders.

  Journal of strength and conditioning research 20051101

• Drosophila tan encodes a novel hydrolase required in pigmentation and vision.

  PLoS genetics 20051101

• Polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc) ameliorates dextran sulfate sodium-induced colitis in mice.

  Scandinavian journal of gastroenterology 20051101

• Taste disorders: a survey of the examination methods and treatments used in Japan.

  Acta oto-laryngologica 20051101

• Effects of the addition of amino acids and peptides on lipid oxidation in a powdery model system.

  Journal of agricultural and food chemistry 20051019

• Carnosine and anserine act as effective transglycating agents in decomposition of aldose-derived Schiff bases.

  Biochemical and biophysical research communications 20051014

• Glycation, ageing and carnosine: are carnivorous diets beneficial?

  Mechanisms of ageing and development 20051001

• New synthetic method of zinc(II) complexes based on mixing.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20051001

• Physiological role of carnosine in contracting muscle.

  International journal of sport nutrition and exercise metabolism 20051001

• Carnosine protects the brain of rats and Mongolian gerbils against ischemic injury: after-stroke-effect.

  Neurochemical research 20051001

• Carnosine and homocarnosine, the forgotten, enigmatic peptides of the brain.

  Neurochemical research 20051001

• Heat and ultrafiltration extraction of broiler meat carnosine and its antioxidant activity.

  Meat science 20051001

• Synthesis and evaluation of neuroprotective alpha,beta-unsaturated aldehyde scavenger histidyl-containing analogues of carnosine.

  Journal of medicinal chemistry 20050922

• NMR and theoretical study on the coordination and solution structures of the interaction between diperoxovanadate complexes and histidine-like ligands.

  Inorganic chemistry 20050919

• Evaluation of radioprotective effect of carnosine (beta- alanyl-1- histidine) on the wound healing in rats.

  Journal of applied oral science : revista FOB 20050901

• Carnosine as a protective factor in diabetic nephropathy: association with a leucine repeat of the carnosinase gene CNDP1.

  Diabetes 20050801

• Glycyl-L-glutamine disposition in rat choroid plexus epithelial cells in primary culture: role of PEPT2.

  Pharmaceutical research 20050801

• Effect of neuroprotective drugs on gene expression in G93A/SOD1 mice.

  Annals of the New York Academy of Sciences 20050801

• Carnosine-induced changes in the development of spermatogenic epithelial cells in senescence accelerated SAM mice.

  Bulletin of experimental biology and medicine 20050801

• The effect of production system and age on levels of iron, taurine, carnosine, coenzyme Q(10), and creatine in beef muscles and liver.

  Meat science 20050801

• Carnosine protects against the inactivation of esterase induced by glycation and a steroid.

  Biochimica et biophysica acta 20050630

• Quantitation of carnosine in humans plasma after dietary consumption of beef.

  Journal of agricultural and food chemistry 20050615

• Carnosine: a versatile antioxidant and antiglycating agent.

  Science of aging knowledge environment : SAGE KE 20050504

• Antioxidant properties of carnosine re-evaluated with oxidizing systems involving iron and copper ions.

  Basic & clinical pharmacology & toxicology 20050501

• [The induction apoptosis of HL-60 cells by low molecular weight compounds of taurine, ornithine and carnosine from new born calf liver].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20050501

• Histidine and carnosine delay diabetic deterioration in mice and protect human low density lipoprotein against oxidation and glycation.

  European journal of pharmacology 20050418

• Biochemical modifications induced in rabbits by Schistosoma mansoni antigens and the beneficial effect of carnosine treatment.

  Journal of the Egyptian Society of Parasitology 20050401

• Beta-alanine suppresses heat inactivation of lactate dehydrogenase.

  Journal of enzyme inhibition and medicinal chemistry 20050401

• Interaction of soluble peptides and proteins from skeletal muscle with volatile compounds in model systems as affected by curing agents.

  Journal of agricultural and food chemistry 20050309

• Dose-dependent effects of L-carnosine on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20050201

• Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation.

  Amino acids 20050201

• Dietary supplementation of L-carnosine prevents ischemia/reperfusion-induced renal injury in rats.

  Biological & pharmaceutical bulletin 20050201

• Separation and determination of carnosine-related peptides using capillary electrophoresis with laser-induced fluorescence detection.

  Electrophoresis 20050201

• Identification and characterization of a mouse dipeptidase that hydrolyzes L-carnosine.

  Journal of biochemistry 20050201

• Noninvasive measurement of temperature and fractional dissociation of imidazole in human lower leg muscles using 1H-nuclear magnetic resonance spectroscopy.

  Journal of applied physiology (Bethesda, Md. : 1985) 20050101

• Can cognitive deterioration associated with Down syndrome be reduced?

  Medical hypotheses 20050101

• [Neurodegenerative alterations induced by MPTP neurotoxin in senescence accelerated mice essay].

  Uspekhi fiziologicheskikh nauk 20050101

• Intrinsic toxicity of glucose, due to non-enzymatic glycation, is controlled in-vivo by deglycation systems including: FN3K-mediated deglycation of fructosamines and transglycation of aldosamines.

  Medical hypotheses 20050101

• Could carnosine suppress zinc-mediated proteasome inhibition and neurodegeneration? Therapeutic potential of a non-toxic but non-patentable dipeptide.

  Biogerontology 20050101

• Effects of carnosine on amygdaloid-kindled seizures in Sprague-Dawley rats.

  Neuroscience 20050101

• Carnosine and carnosine-related antioxidants: a review.

  Current medicinal chemistry 20050101

• Protective effect of carnosine during nitrosative stress in astroglial cell cultures.

  Neurochemical research 20050101

• Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention.

  Drugs in R&D 20050101

• [Effect of carnosine and its combination with essentiale on lipid peroxidation and work capacity of experimental animals].

  Eksperimental'naia i klinicheskaia farmakologiia 20050101

• A Chronic Fatigue Syndrome - related proteome in human cerebrospinal fluid.

  BMC neurology 20050101

• [Biological role of carnosine and its use in ophthalmology (mini-review)].

  Biomeditsinskaia khimiia 20050101

• Carnosine and related dipeptides as quenchers of reactive carbonyl species: from structural studies to therapeutic perspectives.

  BioFactors (Oxford, England) 20050101

• Mechanistic pathways of formation of acrylamide from different amino acids.

  Advances in experimental medicine and biology 20050101

• Effect of beta-alanyl-L-histidinato zinc on the differentiation of C2C12 cells.

  Life sciences 20041217

• Reinvestigation of the copper(II)-carcinine equilibrium system: 'two-dimensional' EPR simulation and NMR relaxation studies for determining the formation constants and coordination modes.

  Journal of inorganic biochemistry 20041201

• Molecular dynamics and information on possible sites of interaction of intramyocellular metabolites in vivo from resolved dipolar couplings in localized 1H NMR spectra.

  Journal of magnetic resonance (San Diego, Calif. : 1997) 20041201

• Amyloid-beta induced cell death is independent of free radicals.

  Journal of Alzheimer's disease : JAD 20041201

• Influence of doxorubicin and carnosine on the standard 12-lead electrocardiogram in rabbits.

  Acta poloniae pharmaceutica 20041201

• L-carnosine reduces telomere damage and shortening rate in cultured normal fibroblasts.

  Biochemical and biophysical research communications 20041112

• Pharmacological effects of carcinine on histaminergic neurons in the brain.

  British journal of pharmacology 20041101

• Biologically active dietary peptides.

  Mini reviews in medicinal chemistry 20041001

• Natural antioxidant L-carnosine inhibits LPO intensification in structures of the auditory analyzer under conditions of chronic exposure to aminoglycoside antibiotics.

  Bulletin of experimental biology and medicine 20041001

• Effects of chicken extract on antioxidative status and liver protection under oxidative stress.

  Journal of nutritional science and vitaminology 20041001

• Cooking temperature effects on the forms of iron and levels of several other compounds in beef semitendinosus muscle.

  Meat science 20041001

• Effect of carnosine on immunocompetent cells from alcoholic patients.

  Bulletin of experimental biology and medicine 20040901

• The role of creatine in the generation of N-methylacrylamide: a new toxicant in cooked meat.

  Journal of agricultural and food chemistry 20040825

• Oxidative modification of neurofilament-L by the Cu,Zn-superoxide dismutase and hydrogen peroxide system.

  Biochimie 20040801

• Anti-crosslinking properties of carnosine: significance of histidine.

  Life sciences 20040730

• Carnosine disaggregates glycated alpha-crystallin: an in vitro study.

  Archives of biochemistry and biophysics 20040701

• Effect of carnosine on runt-related transcription factor-2/core binding factor alpha-1 and Sox9 expressions of human periodontal ligament cells.

  Journal of periodontal research 20040601

• Histidine dipeptides HPLC-based test for the detection of mammalian origin proteins in feeds for ruminants.

  Meat science 20040601

• Determination of carnosine in feed and meat by high-performance anion-exchange chromatography with integrated pulsed amperometric detection.

  Journal of chromatography. A 20040507

• Cleavage of the peptide bond of beta-alanyl-L-histidine (carnosine) induced by a Co(III)-amine complexes: reaction, structure and mechanism.

  Dalton transactions (Cambridge, England : 2003) 20040507

• [Effect of alahistidine on brain histamine content and seizure development].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20040501

• Effect of beta-alanyl-L-histidinato zinc on the differentiation pathway of human periodontal ligament cells.

  Life sciences 20040402

• New insights in dihydropyrimidine dehydrogenase deficiency: a pivotal role for beta-aminoisobutyric acid?

  The Biochemical journal 20040401

• Clinical aspects of the disorders of GABA metabolism in children.

  Current opinion in neurology 20040401

• Mechanism of a model dipeptide transport across blood-ocular barriers following systemic administration.

  Experimental eye research 20040401

• Carnosine uptake in rat choroid plexus primary cell cultures and choroid plexus whole tissue from PEPT2 null mice.

  Journal of neurochemistry 20040401

• Contribution of reactive oxygen species to isoflurane-induced sensitization of cardiac sarcolemmal adenosine triphosphate-sensitive potassium channel to pinacidil.

  Anesthesiology 20040301

• Effect of central administration of carnosine and its constituents on behaviors in chicks.

  Brain research bulletin 20040301

• Concentrations in beef and lamb of taurine, carnosine, coenzyme Q(10), and creatine.

  Meat science 20040301

• Apoptotic characteristics of cell death and the neuroprotective effect of homocarnosine on pheochromocytoma PC12 cells exposed to ischemia.

  Journal of neuroscience research 20040215

• Coordination features of difunctionalized beta-cyclodextrins with carnosine: ESI-MS and spectroscopic investigations on 6A,6D-di-(beta-alanyl-L-histidine)-6A,6D-dideoxy-beta-cyclodextrin and 6A,6C-di-(beta-alanyl-L-histidine)-6A,6C-dideoxy-beta-cyclodextrin and their copper(II) complexes.

  Journal of inorganic biochemistry 20040201

• Gender-related differences in carnosine, anserine and lysine content of murine skeletal muscle.

  Amino acids 20040201

• Protection of neuronal cells against reactive oxygen species by carnosine and related compounds.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20040101

• Determination of liposomal encapsulation efficiency using proton NMR spectroscopy.

  Chemistry and physics of lipids 20040101

• Down syndrome and epilepsy: a nutritional connection?

  Medical hypotheses 20040101

• Protective effect of carnosine on excitable structures of the auditory apparatus in albino rats with acute acoustic trauma.

  Bulletin of experimental biology and medicine 20040101

• Comparison of colony-formation efficiency of bovine fetal fibroblast cell lines cultured with low oxygen, hydrocortisone, L-carnosine, bFGF, or different levels of FBS.

  Cloning and stem cells 20040101

• Lipid peroxidation and cataracts: N-acetylcarnosine as a therapeutic tool to manage age-related cataracts in human and in canine eyes.

  Drugs in R&D 20040101

• Carnosine modulates oxygen consumption and heat production by wheat root cells.

  Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20040101

• Effect of carnosine on excitation-contraction coupling in mechanically-skinned rat skeletal muscle.

  Journal of muscle research and cell motility 20040101

• Functional foods, herbs and nutraceuticals: towards biochemical mechanisms of healthy aging.

  Biogerontology 20040101

• Rejuvenation of visual functions in older adult drivers and drivers with cataract during a short-term administration of N-acetylcarnosine lubricant eye drops.

  Rejuvenation research 20040101

• Oxidative stress in autism.

  Alternative therapies in health and medicine 20040101

• Food-derived peptides and intestinal functions.

  BioFactors (Oxford, England) 20040101

• Characterization of carnosine uptake and its physiological function in human intestinal epithelial Caco-2 cells.

  BioFactors (Oxford, England) 20040101

• Is carnosine a naturally occurring suppressor of oxidative damage in olfactory neurones?

  Rejuvenation research 20040101

• [The significance of free radicals and antioxidants due to the load induced by sport activity].

  Ceskoslovenska fysiologie 20040101

• [Catalase activity as affected by carnosine and sodium nitrite in vitro].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20040101

• Carnosine inhibits (E)-4-hydroxy-2-nonenal-induced protein cross-linking: structural characterization of carnosine-HNE adducts.

  Chemical research in toxicology 20031201

• Effect of carnosine administration on the immune response of rabbit to Schistosoma mansoni antigens.

  Journal of the Egyptian Society of Parasitology 20031201

• Interactions of soluble peptides and proteins from skeletal muscle on the release of volatile compounds.

  Journal of agricultural and food chemistry 20031105

• Possible role of L-carnosine in the regulation of blood glucose through controlling autonomic nerves.

  Experimental biology and medicine (Maywood, N.J.) 20031101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20031101

• Proton MRS reveals frontal lobe metabolite abnormalities in idiopathic generalized epilepsy.

  Neurology 20031014

• Evidence for a dipolar-coupled AM system in carnosine in human calf muscle from in vivo 1H NMR spectroscopy.

  Journal of magnetic resonance (San Diego, Calif. : 1997) 20031001

• Acrolein-sequestering ability of endogenous dipeptides: characterization of carnosine and homocarnosine/acrolein adducts by electrospray ionization tandem mass spectrometry.

  Journal of mass spectrometry : JMS 20030901

• [Novel findings from an animal tourniquet shock model].

  Nihon hoigaku zasshi = The Japanese journal of legal medicine 20030901

• Effect of carnosine on self-organization of mitochondrial assemblies in rat liver homogenate.

  Biochemistry. Biokhimiia 20030901

• Modulation of the antioxidant activity of HO* scavengers by albumin binding: a 19F-NMR study.

  Biochemical and biophysical research communications 20030808

• Preventive effect of L-carnosine on ischemia/reperfusion-induced acute renal failure in rats.

  European journal of pharmacology 20030808

• [A case of polaprezinc-induced pneumonitis].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20030801

• [Switching off the estrogen effect and approaches to its correction].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20030801

• Neuromodulator role of zinc and copper during prolonged ATP applications to P2X4 purinoceptors.

  European journal of pharmacology 20030704

• Muscle interstitial potassium kinetics during intense exhaustive exercise: effect of previous arm exercise.

  American journal of physiology. Regulatory, integrative and comparative physiology 20030701

• DNA as an enzyme. The effect of imidazole derivatives as cofactors and metal ions as activators or inhibitors.

  Clinical biochemistry 20030701

• Vibrational characterisation and biological activity of carnosine and its metal complexes.

  The Italian journal of biochemistry 20030601

• Elevation of serum copper levels in Alzheimer's disease.

  Neurology 20030513

• The human prion octarepeat fragment prevents and reverses the inhibitory action of copper in the P2X4 receptor without modifying the zinc action.

  Journal of neurochemistry 20030501

• [The role of nonenzymatic glycation and glyco-oxidation in the development of diabetic vascular complications].

  Ceskoslovenska fysiologie 20030501

• Evaluation of the antioxidant ability of hydrazine-purified and untreated commercial carnosine in beef patties.

  Meat science 20030501

• The polyamines spermine and spermidine protect proteins from structural and functional damage by AGE precursors: a new role for old molecules?

  Life sciences 20030425

• A proton magnetic resonance spectroscopy study of metabolites in the occipital lobes in epilepsy.

  Epilepsia 20030401

• Antioxidant peptides with Angiotensin converting enzyme inhibitory activities and applications for Angiotensin converting enzyme purification.

  Journal of agricultural and food chemistry 20030312

• An unprecedented trans-oriented product from the cleavage of a dipeptide.

  Chemical communications (Cambridge, England) 20030307

• A practical method to study functional impairment of proteins by glycation and effects of inhibitors using current coagulation/fibrinolysis reagent kits.

  Clinical biochemistry 20030301

• Inhibition of ascorbic acid-induced modifications in lens proteins by peptides.

  Journal of peptide science : an official publication of the European Peptide Society 20030301

• Effect of taking chicken essence on stress and cognition of human volunteers.

  Malaysian journal of nutrition 20030301

• Enhanced oligomerization of the alpha-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system.

  Molecules and cells 20030227

• Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase.

  The Journal of biological chemistry 20030221

• The carnosine C-2 proton's chemical shift reports intracellular pH in oxidative and glycolytic muscle fibers.

  Magnetic resonance in medicine 20030201

• RSD931, a novel anti-tussive agent acting on airway sensory nerves.

  British journal of pharmacology 20030201

• Involvement of reactive oxygen species in cardiac preconditioning in rats.

  Antioxidants & redox signaling 20030201

• Protective effect of carnosine on Cu,Zn-superoxide dismutase during impaired oxidative metabolism in the brain in vivo.

  Bulletin of experimental biology and medicine 20030201

• Carnosine promotes the heat denaturation of glycated protein.

  Biochemical and biophysical research communications 20030103

• Ultraviolet spectrophotometric characterization of copper(II) complexes with imidazole N-methyl derivatives of L-histidine in aqueous solution.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20030101

• [Application of chemiluminescent analysis for comparative assessment of antioxidant activity of some pharmacological compounds].

  Eksperimental'naia i klinicheskaia farmakologiia 20030101

• Influence of carnosine on the cardiotoxicity of doxorubicin in rabbits.

  Polish journal of pharmacology 20030101

• The Maillard reaction inhibitors and their biological and therapeutic significance.

  Annales Universitatis Mariae Curie-Sklodowska. Sectio D: Medicina 20030101

• Practical uses for ecdysteroids in mammals including humans: an update.

  Journal of insect science (Online) 20030101

• Use of antioxidants to reduce lipid oxidation and off-odor volatiles of irradiated pork homogenates and patties.

  Meat science 20030101

• Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products.

  Toxicology 20021227

• tan and ebony genes regulate a novel pathway for transmitter metabolism at fly photoreceptor terminals.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20021215

• The botanical extracts of Achyrocline satureoides and Ilex paraguariensis prevent methylglyoxal-induced inhibition of plasminogen and antithrombin III.

  Life sciences 20021206

• Polaprezinc attenuates Helicobacter pylori-associated gastritis in Mongolian gerbils.

  Helicobacter 20021201

• Detoxification of cytotoxic alpha,beta-unsaturated aldehydes by carnosine: characterization of conjugated adducts by electrospray ionization tandem mass spectrometry and detection by liquid chromatography/mass spectrometry in rat skeletal muscle.

  Journal of mass spectrometry : JMS 20021201

• Induction of a 72-kDa heat-shock protein in cultured rat gastric mucosal cells and rat gastric mucosa by zinc L-carnosine.

  Digestive diseases and sciences 20021201

• Antioxidant properties of carnosine re-evaluated in a ferrylmyoglobin model system and in cooked pork patties.

  Journal of agricultural and food chemistry 20021120

• Carnosine is a quencher of 4-hydroxy-nonenal: through what mechanism of reaction?

  Biochemical and biophysical research communications 20021115

• Inhibitory effect of polaprezinc on the inflammatory response to Helicobacter pylori.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20021101

• Double-blind, placebo-controlled study of L-carnosine supplementation in children with autistic spectrum disorders.

  Journal of child neurology 20021101

• Modification of the uterotropic effect produced by estrogens in aging rats.

  Bulletin of experimental biology and medicine 20021101

• Effect of zinc-carnosine complex on muscular function in frail distrophin-deficient (mdx) mice.

  The Japanese journal of physiology 20021001

• Two broad-specificity dipeptide hydrolysing activities from cytoplasm of guinea pig brain, both of which contain prolinase but neither of which contain carnosinase activity.

  Neuroscience research 20020901

• Development of a new assay for the screening of hypochlorous acid scavengers based on reversed-phase high-performance liquid chromatography.

  Biomedical chromatography : BMC 20020901

• Transport characteristics of L-carnosine and the anticancer derivative 4-toluenesulfonylureido-carnosine in a human epithelial cell line.

  Pharmaceutical research 20020901

• Plasma carnosine concentration: diurnal variation and effects of age, exercise and muscle damage.

  Equine veterinary journal. Supplement 20020901

• Carnosine prevents methamphetamine-induced gliosis but not dopamine terminal loss in rats.

  European journal of pharmacology 20020719

• The ceruloplasmin and hydrogen peroxide system induces alpha-synuclein aggregation in vitro.

  Biochimie 20020701

• Carnosine modifies the incidence of genetically abnormal sex cells in the testes of senescence-accelerated mice.

  Bulletin of experimental biology and medicine 20020701

• Carnosine and related dipeptides protect human ceruloplasmin against peroxyl radical-mediated modification.

  Molecules and cells 20020630

• Enhanced delivery of drugs to the liver by adenovirus-mediated heterologous expression of the human oligopeptide transporter PEPT1.

  The Journal of pharmacology and experimental therapeutics 20020601

• Role of PEPT2 in peptide/mimetic trafficking at the blood-cerebrospinal fluid barrier: studies in rat choroid plexus epithelial cells in primary culture.

  The Journal of pharmacology and experimental therapeutics 20020601

• Effect of carnosine on Drosophila melanogaster lifespan.

  Bulletin of experimental biology and medicine 20020601

• Effects of L-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in rats.

  Autonomic neuroscience : basic & clinical 20020531

• Neuroprotective effects of carnosine and homocarnosine on pheochromocytoma PC12 cells exposed to ischemia.

  Journal of neuroscience research 20020515

• Carbonic anhydrase activators: human isozyme II is strongly activated by oligopeptides incorporating the carboxyterminal sequence of the bicarbonate anion exchanger AE1.

  Bioorganic & medicinal chemistry letters 20020422

• Effects of carnosine on volatile generation from Maillard reaction of ribose and cysteine.

  Journal of agricultural and food chemistry 20020410

• Protective effect of L-carnosine against 12-O-tetradecanoylphorbol-13-acetate- or hydrogen peroxide-induced apoptosis on v-myc transformed rat liver epithelial cells.

  Cancer letters 20020408

• Reaction of carnosine with aged proteins: another protective process?

  Annals of the New York Academy of Sciences 20020401

• Increase of gamma-glutamyl-beta-alanyl-histidine isopeptide in the macromolecular fraction of model chicken extract during heating and distribution in commercial chicken extracts.

  Poultry science 20020401

• Olfactory neuroepithelioma in a dog: an immunohistochemical and electron microscopic study.

  The Journal of veterinary medical science 20020401

• High level of skeletal muscle carnosine contributes to the latter half of exercise performance during 30-s maximal cycle ergometer sprinting.

  The Japanese journal of physiology 20020401

• Analysis of products of animal origin in feeds by determination of carnosine and related dipeptides by high-performance liquid chromatography.

  Journal of agricultural and food chemistry 20020327

• Distribution of gamma-glutamyl-beta-alanylhistidine isopeptide in the macromolecular fractions of commercial meat extracts and correlation with the color of the macromolecular fractions.

  Journal of agricultural and food chemistry 20020327

• Protective effects of carnosine, homocarnosine and anserine against peroxyl radical-mediated Cu,Zn-superoxide dismutase modification.

  Biochimica et biophysica acta 20020315

• l-carnosine and verapamil inhibit hypoxia-induced expression of hypoxia inducible factor (HIF-1 alpha) in H9c2 cardiomyoblasts.

  Pharmacological research 20020301

• Effects of carnosine on bilharzial infestation in hamsters: biochemical and histochemical studies.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20020301

• Prevention of peroxynitrite-dependent damage by carnosine and related sulphonamido pseudodipeptides.

  Cellular and molecular life sciences : CMLS 20020301

• Effects of thermal denaturation on protein glycation.

  Life sciences 20020301

• [Efficacy and safety of polaprezinc as a preventive drug for radiation-induced stomatitis].

  Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica 20020301

• Protection by carnosine-related dipeptides against hydrogen peroxide-mediated ceruloplasmin modification.

  Molecules and cells 20020227

• Formation of carnosine-Cu(II) complexes prevents and reverts the inhibitory action of copper in P2X4 and P2X7 receptors.

  Journal of neurochemistry 20020201

• [New therapeutic approaches to peptic ulcer using mucosal protective agents].

  Nihon rinsho. Japanese journal of clinical medicine 20020201

• [Chaperon-induction therapy for peptic ulcers].

  Nihon rinsho. Japanese journal of clinical medicine 20020201

• [Polaprezinc].

  Nihon rinsho. Japanese journal of clinical medicine 20020201

• Effect of zinc-carnosine chelate compound on muscle function in mdx mouse.

  The Japanese journal of physiology 20020201

• Protective effect of Biolan during ischemic damages to cultured cerebellar granular cells.

  Bulletin of experimental biology and medicine 20020201

• Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.

  Journal of medicinal chemistry 20020117

• Interaction of copper(II) with imidazole pyridine nitrogen-containing ligands in aqueous medium: a spectroscopic study.

  Journal of inorganic biochemistry 20020101

• Characterization of dioxygenated cobalt(II)-carnosine complexes by Raman and IR spectroscopy.

  Biopolymers 20020101

• Effect of carnosine and related compounds on the inactivation of human Cu,Zn-superoxide dismutase by modification of fructose and glycolaldehyde.

  Bioscience, biotechnology, and biochemistry 20020101

• Electrospray mass spectrometric studies of L-carnosine (beta-alanyl-L-histidine) complexes with copper(II) or zinc ions in aqueous solution.

  Rapid communications in mass spectrometry : RCM 20020101

• Zinc suppresses IL-6 synthesis by prostaglandin F2alpha in osteoblasts: inhibition of phospholipase C and phospholipase D.

  Journal of cellular biochemistry 20020101

• [Do the glutamate excitotoxicity theory and potential free radicals implication in schizophrenia aetiopathogenesis provide a new enlightenment to links between: genome, environment and biology in the determinism of that disorder?].

  L'Encephale 20020101

• Efficacy of N-acetylcarnosine in the treatment of cataracts.

  Drugs in R&D 20020101

• Could carnosine be a naturally-occurring scavenger for acrolein and other reactive aldehydes in the brain?

  Neurobiology of aging 20020101

• Monocarboxylate transporters and lactate metabolism in equine athletes: a review.

  Acta veterinaria Scandinavica 20020101

• Induction of the estrogen effect-switching phenomenon by ethanol and its correction.

  Neuroscience and behavioral physiology 20020101

• The meat in the diet of aged subjects and the antioxidant effects of carnosine.

  Archives of gerontology and geriatrics. Supplement 20020101

• Transporter-mediated Drug Interactions.

  Drug metabolism and pharmacokinetics 20020101

• In vitro 1H-NMR spectroscopic analysis of metabolites in fast- and slow-twitch muscles of young rats.

  Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine 20020101

• Chelating activity of advanced glycation end-product inhibitors.

  The Journal of biological chemistry 20011228

• The natural substrate for nitric oxide synthase activity.

  Cell biochemistry and function 20011201

• Differential expression of carnosine, homocarnosine and N-acetyl-L-histidine hydrolytic activities in cultured rat macroglial cells.

  Journal of molecular neuroscience : MN 20011201

• Effect of L-carnosine on the hyperglycemia caused by intracranial injection of 2-deoxy-D-glucose in rats.

  Neuroscience letters 20011102

• Molecular mechanisms of regulation of the activity of sarcoplasmic reticulum Ca-release channels (ryanodine receptors), muscle fatigue, and Severin's phenomenon.

  Biochemistry. Biokhimiia 20011001

• Antioxidant systems in tissues of senescence accelerated mice.

  Biochemistry. Biokhimiia 20011001

• Peculiarities of carnosine metabolism in a patient with pronounced homocarnosinemia.

  Bulletin of experimental biology and medicine 20011001

• Carnosine, the anti-ageing, anti-oxidant dipeptide, may react with protein carbonyl groups.

  Mechanisms of ageing and development 20010915

• Zinc supplementation enhances the response to interferon therapy in patients with chronic hepatitis C.

  Journal of viral hepatitis 20010901

• In vitro and in vivo inhibition of muscle lipid and protein oxidation by carnosine.

  Molecular and cellular biochemistry 20010901

• Expression of the intermediate filament protein nestin by sustentacular cells in mature olfactory neuroepithelium.

  The Journal of comparative neurology 20010820

• Modification of uterotropic effect of estrogens by whole-body gamma-irradiation.

  Bulletin of experimental biology and medicine 20010801

• Influence of dietary protein levels on beta-alanine aminotransferase expression and activity in rats.

  Journal of nutritional science and vitaminology 20010801

• The effects of ascorbic acid, taurine, carnosine and rosemary powder on colour and lipid stability of beef patties packaged in modified atmosphere.

  Meat science 20010801

• Cell culture model for antiulcerogenic agents.

  Microscopy research and technique 20010615

• Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopy.

  Archives of general psychiatry 20010601

• N-Acetylcarnosine, a natural histidine-containing dipeptide, as a potent ophthalmic drug in treatment of human cataracts.

  Peptides 20010601

• PEPT2-mediated uptake of neuropeptides in rat choroid plexus.

  Pharmaceutical research 20010601

• Hepatic uptake of solutes from the preservation solution during hypothermic storage: a (1)H NMR study in rat liver.

  Cryobiology 20010601

• Cloning of a lymphatic peptide/histidine transporter.

  The Biochemical journal 20010515

• Identification of a novel form of renal glucosuria with overexcretion of arginine, carnosine, and taurine.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20010501

• Polaprezinc attenuates the Helicobacter pylori-induced gastric mucosal leucocyte activation in Mongolian gerbils--a study using intravital videomicroscopy.

  Alimentary pharmacology & therapeutics 20010501

• Effect of carnosine administration on metabolic parameters in bilharzia-infected hamsters.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20010501

• Estimating intestinal mucosal permeation of compounds using Caco-2 cell monolayers.

  Current protocols in pharmacology 20010501

• Dipolar coupling and ordering effects observed in magnetic resonance spectra of skeletal muscle.

  NMR in biomedicine 20010401

• Effects of polaprezinc on lipid peroxidation, neutrophil accumulation, and TNF-alpha expression in rats with aspirin-induced gastric mucosal injury.

  Digestive diseases and sciences 20010401

• Topiramate rapidly raises brain GABA in epilepsy patients.

  Epilepsia 20010401

• [Induction by ethanol of 'phenomenon of switching estrogen effect' and its correction].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20010401

• Homocarnosine elevations: a cause or a sign of seizure control?

  Neurology 20010327

• Homocarnosine and seizure control in juvenile myoclonic epilepsy and complex partial seizures.

  Neurology 20010327

• Carnosine as a modulator of endogenous Zn(2+) effects.

  Trends in pharmacological sciences 20010301

• On the anti-aging activities of aminoguanidine and N-t-butylhydroxylamine.

  Mechanisms of ageing and development 20010201

• Effects of vigabatrin on brain GABA+/CR signals in patients with epilepsy monitored by 1H-NMR-spectroscopy: responder characteristics.

  Epilepsia 20010101

• Effect of polaprezinc on impaired healing of chronic gastric ulcers in adjuvant-induced arthritic rats--role of insulin-like growth factors (IGF)-1.

  Medical science monitor : international medical journal of experimental and clinical research 20010101

• Low taurine, gamma-aminobutyric acid and carnosine levels in plasma of diabetic pregnant rats: consequences for the offspring.

  Journal of perinatal medicine 20010101

• [Effect of natural radioprotector carnosine on histamine-diamine oxidase system of rat's myocardium after action of various extreme factors].

  Radiatsionnaia biologiia, radioecologiia 20010101

• Inhibition of low-density lipoprotein oxidation by carnosine histidine.

  Journal of agricultural and food chemistry 20010101

• AGES in brain ageing: AGE-inhibitors as neuroprotective and anti-dementia drugs?

  Biogerontology 20010101

• On the 'struggle between chemistry and biology during aging'--implications for DNA repair, apoptosis and proteolysis, and a novel route of intervention.

  Biogerontology 20010101

• Protection by polaprezinc, an anti-ulcer drug, against indomethacin-induced apoptosis in rat gastric mucosal cells.

  Japanese journal of pharmacology 20000901

• Effect of polaprezinc (N-(3-aminopropionyl)-L-histidinato zinc), a novel antiulcer agent containing zinc, on cellular proliferation: role of insulin-like growth factor I.

  Biochemical pharmacology 19990715

• hPepT1-mediated epithelial transport of bacteria-derived chemotactic peptides enhances neutrophil-epithelial interactions.

  The Journal of clinical investigation 19981201

• Apical uptake of radiolabelled ochratoxin A into Madin-Darby canine kidney cells.

  Toxicology 19981116

• Cloning and functional expression of a brain peptide/histidine transporter.

  The Journal of biological chemistry 19970411

• The use of alternative substrates in the characterization of actin-methylating and carnosine-methylating enzymes.

  European journal of biochemistry 19921115