3093-35-4 | (1S,2S,4R,8S,9S,11S,12R,13S)-8-(2-chloroacetyl)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-17-en-16-one

Packsize	Purity	Availability	Price	Discounted Price
10mg	98%	in stock	$42.00	$29.00
25mg	98%	in stock	$90.00	$63.00
50mg	98%	in stock	$150.00	$105.00
100mg	98%	in stock	$264.00	$185.00

Description

• Catalog Number: AI47124
• Chemical Name: (1S,2S,4R,8S,9S,11S,12R,13S)-8-(2-chloroacetyl)-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-17-en-16-one
• CAS Number: 3093-35-4
• Molecular Formula: C24H32ClFO5
• Molecular Weight: 454.9593
• MDL Number: MFCD00866006
• SMILES: ClCC(=O)[C@@]12OC(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@]2([C@H]1CCC1=CC(=O)CC[C@]21C)F)(C)C

Computed Properties

• Complexity: 887
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 8
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 3.6

Literature

• Demonstration of the biphasic release of 0.1% halcinonide cream.

  Journal of drugs in dermatology : JDD 20150101

• Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation.

  PloS one 20150101

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

  Journal of medicinal chemistry 20110714

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Allergic contact dermatitis from dichlorobenzyl alcohol in a patient with multiple contact allergies.

  Contact dermatitis 20090501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Dead Sea extract sold under-the-counter.

  The British journal of dermatology 20030701

• Tropical application of halcinonide cream reduces the severity and incidence of intraperitoneal adhesions in a rat model.

  American journal of surgery 20020701

• Clobetasol propionate cream versus halcinonide cream in psoriasis.

  International journal of dermatology 19860601

• A comparative study of amcinonide and halcinonide in the treatment of eczematous dermatitis.

  Cutis 19840801

• A controlled comparison of amcinonide cream 0.1 percent and halcinonide cream 0.1 percent in the treatment of eczematous dermatitis.

  Cutis 19811001