32780-64-6 | 2-Hydroxy-5-(1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl)benzamide HCl

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$8.00	$5.00
1g	98%	in stock	$13.00	$9.00
5g	98%	in stock	$30.00	$21.00
25g	98%	in stock	$70.00	$49.00
100g	98%	in stock	$249.00	$175.00
500g	98%	in stock	$1,092.00	$765.00

Description

• Catalog Number: AB51207
• Chemical Name: 2-Hydroxy-5-(1-hydroxy-2-(4-phenylbutan-2-ylamino)ethyl)benzamide HCl
• CAS Number: 32780-64-6
• Molecular Formula: C19H25ClN2O3
• Molecular Weight: 364.8664
• MDL Number: MFCD00057663
• SMILES: CC(CCc1ccccc1)NCC(c1ccc(c(c1)C(=O)N)O)O.Cl

Computed Properties

• Complexity: 385
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 5
• Rotatable Bond Count: 8
• Undefined Atom Stereocenter Count: 2

Literature

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  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20041101

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  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20040501

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  International journal of obstetric anesthesia 20040401

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  BMC nephrology 20040101

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  Vascular and endovascular surgery 20040101

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  Journal of perinatal medicine 20040101

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  Advances in therapy 20040101

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  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20031201

• Fatality from administration of labetalol and crushed extended-release nifedipine.

  The Annals of pharmacotherapy 20031001

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  Journal of pain and symptom management 20030401

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  Italian heart journal : official journal of the Italian Federation of Cardiology 20030401

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• Cardiac arrest after labetalol and metoclopramide administration in a patient with scleroderma.

  Anesthesia and analgesia 20021201

• Factors influencing acute ischaemia-induced renal hypertension in rats.

  Journal of hypertension 20021201

• Spectrofluorometric determination of labetolol in pharmaceutical preparations and spiked human urine through the formation of coumarin derivative.

  Journal of pharmaceutical and biomedical analysis 20021107

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  Intensive care medicine 20020901

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  Hepatology (Baltimore, Md.) 20020601

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  Journal of cardiovascular pharmacology 20020501

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  Cephalalgia : an international journal of headache 20020501

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  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20020201

• Partial agonistic activity of labetalol, the arylethanolamine, on beta 3-adrenoceptors in the guinea-pig gastric fundus.

  Autonomic & autacoid pharmacology 20020201

• Remifentanil provides hemodynamic stability and faster awakening time in transsphenoidal surgery.

  Anesthesia and analgesia 20020101

• Pheochromocytoma.

  Cardiology in review 20020101

• Labetalol-induced hepatitis in a patient with chronic hepatitis B infection.

  Journal of clinical hypertension (Greenwich, Conn.) 20020101

• Effects of hemoconcentration and sympathetic activation on serum lipid responses to brief mental stress.

  Psychosomatic medicine 20020101

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  American journal of nephrology 20020101

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  Headache 20020101

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  Hypertension in pregnancy 20020101

• Comparative hemodynamic effects of urapidil and labetalol after electroconvulsive therapy.

  The journal of ECT 20011201

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  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20011001

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  Circulation 20010918

• Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage.

  Neurology 20010710

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  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010701

• Treatment of paroxysmal sympathetic storm with labetalol.

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  European journal of obstetrics, gynecology, and reproductive biology 20010201

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  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010201

• A case of renovascular hypertension due to bilateral renal artery microaneurysm who succeeded in baby delivery.

  Hypertension research : official journal of the Japanese Society of Hypertension 20010101

• Life-threatening hyperkalemia after intravenous labetolol injection for hypertensive emergency in a hemodialysis patient.

  American journal of nephrology 20010101

• Factor analysis, including antihypertensive medication, of the outcome of pregnancy in pregnancy-associated hypertension.

  Kidney & blood pressure research 20010101

• Stroke precipitated by moderate blood pressure reduction.

  The Journal of emergency medicine 20001101

• A comparative study between a calcium channel blocker (Nicardipine) and a combined alpha-beta-blocker (Labetalol) for the control of emergence hypertension during craniotomy for tumor surgery.

  Anesthesia and analgesia 20001001

• Pharmacological effects of an aldehyde type alpha/beta-adrenoceptor blocking agent with vasodilating properties.

  General pharmacology 20000601

• Effects of labetalol treatment on the physiological and subjective response to smoked cocaine.

  Pharmacology, biochemistry, and behavior 20000201

• Carvedilol and lacidipine prevent cardiac hypertrophy and endothelin-1 gene overexpression after aortic banding.

  Hypertension (Dallas, Tex. : 1979) 19991201

• A randomized, double-blind trial of oral nifedipine and intravenous labetalol in hypertensive emergencies of pregnancy.

  American journal of obstetrics and gynecology 19991001

• Adverse neonatal effects of maternal labetalol treatment.

  Archives of disease in childhood. Fetal and neonatal edition 19980901

• An unusual toxic reaction to axillary block by mepivacaine with adrenaline.

  Acta anaesthesiologica Scandinavica 19980801

• Labetalol-induced hypotension decreases blood loss during uncontrolled hemorrhage.

  Resuscitation 19980701

• The preoperative management of phaeochromocytoma.

  Anaesthesia and intensive care 19980401

• Effect of antihypertensive agents on the arterial partial pressure of oxygen and venous admixture after cardiac surgery.

  Critical care medicine 19971101

• Cardiopulmonary compromise after use of topical and submucosal alpha-agonists: possible added complication by the use of beta-blocker therapy.

  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 19970701

• Use of glucagon to treat neonatal low-output congestive heart failure after maternal labetalol therapy.

  The Journal of pediatrics 19950701

• Angiotensin II maintains, but does not mediate, isoproterenol-induced cardiac hypertrophy in rats.

  The American journal of physiology 19941001

• Neonatal adrenergic blockade following single dose maternal labetalol administration.

  American journal of perinatology 19940301

• Comparison of the effects of dilevalol and propranolol on systemic and regional haemodynamics in healthy volunteers at rest and during exercise.

  European journal of clinical pharmacology 19940101

• Labetalol and other agents that block both alpha- and beta-adrenergic receptors.

  Cleveland Clinic journal of medicine 19940101

• Preliminary experience of using fixed dose of intravenous labetalol in surgical resection of pheochromocytoma.

  Ma zui xue za zhi = Anaesthesiologica Sinica 19931201

• Influence of labetalol on cocaine-induced coronary vasoconstriction in humans.

  The American journal of medicine 19930601

• Cerebral edema formation in dogs following hypotension induced with isoflurane and labetalol.

  Acta anaesthesiologica Belgica 19930101

• Effects of deliberate hypotension induced by labetalol with isoflurane on neuropsychological function.

  Acta anaesthesiologica Scandinavica 19930101

• [Cardiac arrest in newborn of mother treated with labetalol].

  Revista espanola de anestesiologia y reanimacion 19930101

• A case of labetalol-induced hepatitis.

  The Netherlands journal of medicine 19920401

• Hemodynamic collapse following labetalol administration in preeclampsia.

  Acta obstetricia et gynecologica Scandinavica 19920201

• Hypersensitivity immune reaction as a mechanism for dilevalol-associated hepatitis.

  The Annals of pharmacotherapy 19920101

• Labetalol attenuates the negative effects of deliberate hypotension induced by isoflurane.

  Acta anaesthesiologica Scandinavica 19920101

• Plasma renin, catecholamines, vasopressin and aldosterone during hypotension induced by labetalol with isoflurane.

  Acta anaesthesiologica Scandinavica 19910801

• Coronary vasospasm secondary to labetalol in a patient with aortic dissection.

  Chest 19910701

• The effects of labetalol and prazosin on exercise haemodynamics in hypertensive patients.

  Journal of human hypertension 19910201

• Effects of deliberate hypotension induced by labetalol on renal function.

  European journal of anaesthesiology 19910101

• The initial hemodynamic response to newer antihypertensive agents at rest and during exercise: review of visacor, doxazosin, nisoldipine, tiapamil, perindoprilat, pinacidil, dilevalol, and carvedilol.

  Cardiovascular drugs and therapy 19900801

• The pharmacodynamics of dilevalol.

  Journal of human hypertension 19900601

• A comparison of labetalol and nitroprusside for inducing hypotension during major surgery.

  Anesthesia and analgesia 19900501

• The hemodynamics and clinical effects of labetalol in hypotensive anesthesia.

  Zhonghua yi xue za zhi = Chinese medical journal; Free China ed 19900101

• Reversible myopathy due to labetalol.

  Pediatric neurology 19900101

• A multicenter double-blind study of the efficacy and safety of once and twice daily dilevalol compared to propranolol.

  American journal of hypertension 19891101

• The renal function and blood pressure effects of dilevalol in the normotensive and hypertensive elderly.

  Journal of clinical pharmacology 19890701

• Treatment of peripheral ischemia secondary to lidocaine containing epinephrine.

  Annals of plastic surgery 19890701

• Hemodynamic and humoral effects of intravenous dilevalol in patients with moderate hypertension.

  The American journal of cardiology 19890605

• Preclinical pharmacologic properties of dilevalol, an antihypertensive agent possessing selective beta 2 agonist-mediated vasodilation and beta antagonism.

  The American journal of cardiology 19890605

• Intravenous dilevalol in the treatment of severe hypertension.

  Journal of cardiovascular pharmacology 19890501

• Labetalol. A reappraisal of its pharmacology, pharmacokinetics and therapeutic use in hypertension and ischaemic heart disease.

  Drugs 19890501

• Deliberate hypotension induced by labetalol with halothane, enflurane or isoflurane for middle-ear surgery.

  Acta anaesthesiologica Scandinavica 19890501

• Effects of dilevalol, a beta-adrenoceptor antagonist with intrinsic sympathetic activity in asthmatic patients.

  Pulmonary pharmacology 19890101

• Safety of labetalol-induced controlled hypotension during middle ear microsurgery.

  Acta oto-rhino-laryngologica Belgica 19890101

• A randomized comparison of labetalol and nitroprusside for induced hypotension.

  Journal of clinical anesthesia 19890101

• Hemodynamic effects of labetalol in patients with combined hypertension and left ventricular failure.

  Journal of cardiovascular pharmacology 19880901

• Properties of labetalol, a combined alpha- and beta-blocking agent, relevant to the treatment of myocardial ischemia.

  Cardiovascular drugs and therapy 19880901

• Role of vasodilation in the antihypertensive and antianginal effects of labetalol: implications for therapy of combined hypertension and angina.

  Cardiovascular drugs and therapy 19880901

• Hemodynamic effects of hypotension induced by verapamil or labetalol in dogs.

  Chinese medical journal 19880201

• Labetalol blunts morning pressor surge in systolic hypertension.

  Hypertension (Dallas, Tex. : 1979) 19880201

• Ejaculatory failure and urinary dysfunction secondary to labetalol.

  The Journal of urology 19880201

• Control of cocaine-induced hypertension with labetalol.

  Anesthesia and analgesia 19880101

• Rebound hypertension following abrupt cessation of clonidine and metoprolol. Treatment with labetalol.

  Archives of internal medicine 19870201

• Studies on the mode of vasodilating action of carvedilol.

  Journal of cardiovascular pharmacology 19870101

• Clinical pharmacology of carvedilol in normal volunteers.

  Clinical pharmacology and therapeutics 19870101

• Acute renal failure after overdose of labetalol.

  British medical journal (Clinical research ed.) 19861101

• Pseudoephedrine-induced hypertensive emergency: treatment with labetalol.

  The American journal of emergency medicine 19860301

• Labetalol as monotherapy in hypertensive black patients.

  Journal of clinical hypertension 19851201

• Current status of labetalol, the first alpha- and beta-blocking agent.

  International journal of clinical pharmacology, therapy, and toxicology 19851101

• Labetalol for hypertension.

  JAMA 19850920

• Concomitant therapy with labetalol and hydrochlorothiazide in moderate to moderately severe essential hypertension.

  Journal of clinical pharmacology 19850901

• Successful treatment of a monoamine oxidase inhibitor-tyramine hypertensive emergency with intravenous labetalol.

  The New England journal of medicine 19850704

• Monotherapy with labetalol compared with propranolol. Differential effects by race.

  Journal of clinical hypertension 19850301

• Beta blockade and intermittent claudication.

  Acta medica Scandinavica. Supplementum 19850101

• Labetalol and phaeochromocytoma.

  British journal of anaesthesia 19841001

• [Hypertensive response to labetalol in pheochromocytoma].

  Masui. The Japanese journal of anesthesiology 19840901

• Bronchospasm and hypotension during cardiopulmonary bypass after preoperative cimetidine and labetalol therapy.

  British journal of anaesthesia 19840801

• Raynaud's phenomenon caused by beta-receptor blocking drugs. Improvement after treatment with a combined alpha- and beta-blocker.

  Acta medica Scandinavica 19840101

• Pharmacology of combined alpha-beta-blockade. II. Haemodynamic effects of labetalol.

  Drugs 19840101

• Combined alpha- and beta-receptor inhibition in the treatment of hypertension.

  Drugs 19840101

• [Atrioventricular block in controlled hypotension induced by labetalol during general anesthesia].

  Annales francaises d'anesthesie et de reanimation 19840101

• Alpha-adrenoceptor blockade by labetalol during long-term dosing.

  Clinical pharmacology and therapeutics 19830301

• Antihypertensive actions of an isomer of labetalol and other vasodilator-beta-adrenoceptor blockers.

  Federation proceedings 19830201

• Beneficial effect of labetalol in hypertensive patients with angina pectoris.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19830115

• Side-effects with long-term labetalol: an open study of 251 patients in a single centre.

  Pharmatherapeutica 19830101

• I.V. Labetalol during coronary artery surgery.

  Acta anaesthesiologica Belgica 19830101

• [Vasospastic angina pectoris complicated by ventricular fibrillation during treatment with propranolol and labetalol].

  Kardiologia polska 19830101

• Treatment of severe hypertension with intravenous labetalol.

  Clinical pharmacology and therapeutics 19821001

• Prolactin stimulation by intravenous labetalol is mediated inside the central nervous system.

  Clinical endocrinology 19820601

• Labetalol in resistant hypertension.

  Acta medica Scandinavica. Supplementum 19820101

• Labetalol in the treatment of hypertension in patients with normal and impaired renal function.

  Acta medica Scandinavica. Supplementum 19820101

• Labetalol-induced toxic myopathy.

  British medical journal (Clinical research ed.) 19810606

• Haemodynamic effects of labetalol-induced hypotension in the anaesthetized dog.

  British journal of anaesthesia 19810601

• Use of labetalol in hypertensive patients during discontinuation of clonidine therapy.

  European journal of clinical pharmacology 19810101

• [Ergometric control in hypertension treatment with labetalol].

  Wiener medizinische Wochenschrift. Supplement 19810101

• Intravenous labetalol in severe hypertension. Effects on blood pressure, plasma renin activity and catecholamines.

  Arzneimittel-Forschung 19810101

• A comparison of scalp tingling, thirst and polyuria in patients on labetalol and metoprolol.

  The New Zealand medical journal 19791114

• Hemiparesis after single minibolus of labetalol for hypertensive encephalopathy.

  British medical journal 19790915

• Left ventricular failure with labetalol.

  Postgraduate medical journal 19790801

• Failure of labetalol to prevent hypertension due to clonidine withdrawal.

  British medical journal 19790428

• Synergism between halothane and labetalol.

  Anaesthesia 19790301

• The relationships between the cardiovascular effects, alpha- and beta-adrenoceptor blocking actions and plasma concentration of labetalol in doca hypertensive rats.

  Clinical and experimental hypertension 19790101

• Comparison of effects on cerebral blood flow of rapid reduction in systemic arterial pressure by diazoxide and labetalol in hypertensive patients: preliminary findings.

  British journal of clinical pharmacology 19790101

• Randomised study of six beta-blockers and a thiazide diuretic in essential hypertension.

  British medical journal 19780805

• Intravenous labetalol in hypertensive patients given by fast and slow injection.

  British journal of clinical pharmacology 19780501

• The effect of labetalol in the treatment of severe drug-resistant hypertension.

  The Medical journal of Australia 19780408

• Circumoral paraesthesiae and labetalol.

  British medical journal 19780304

• Labetalol in hypertension.

  Lancet (London, England) 19780225

• Scalp tingling and difficulty in micturition in patients on labetalol.

  Lancet (London, England) 19771001

• Pressor response after intravenous labetalol.

  British medical journal 19770917

• Scalp tingling in patients on labetalol.

  Lancet (London, England) 19770806

• Labetalol in hypertension.

  Lancet (London, England) 19770528

• Pharmacological basis for antihypertensive effects of intravenous labetalol.

  British heart journal 19770101

• Pharmacological effects of labetalol in man.

  British journal of clinical pharmacology 19760801

• Labetalol (AH5158), a competitive alpha- and beta-receptor blocking drug, in the management of hypertension.

  Australian and New Zealand journal of medicine 19760801

• Haemodynamic effects of long-term oral labetalol.

  British journal of clinical pharmacology 19760801

• Labetalol in resistant hypertension.

  British journal of clinical pharmacology 19760801

• Acute effect of intravenous labetalol in the treatment of systemic arterial hypertension.

  British journal of clinical pharmacology 19760801

• Treatment of phaeochromocytoma and of clonidine withdrawal hypertension with labetalol.

  British journal of clinical pharmacology 19760801

• Letter: Emergency treatment of hypertensive crisis following clonidine withdrawal.

  British medical journal 19760529