328-38-1 | (2R)-2-amino-4-methylpentanoic acid

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$7.00	$5.00
10g	98%	in stock	$9.00	$6.00
25g	≥98%	in stock	$18.00	$12.00
100g	≥98%	in stock	$43.00	$30.00
500g	98%	in stock	$135.00	$95.00

Description

• Catalog Number: AD50645
• Chemical Name: (2R)-2-amino-4-methylpentanoic acid
• CAS Number: 328-38-1
• Molecular Formula: C6H13NO2
• Molecular Weight: 131.1729
• MDL Number: MFCD00063088
• SMILES: N[C@@H](C(=O)O)CC(C)C

Computed Properties

• Complexity: 101
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: -1.5

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• Structural and functional studies of STAT1 from Atlantic salmon (Salmo salar).

  BMC immunology 20100101

• Efficacy of a spray compound containing a pool of collagen precursor synthetic aminoacids (l-proline, l-leucine, l-lysine and glycine) combined with sodium hyaluronate to manage chemo/radiotherapy-induced oral mucositis: preliminary data of an open trial.

  International journal of immunopathology and pharmacology 20100101

• Improved time to exhaustion following ingestion of the energy drink Amino Impact.

  Journal of the International Society of Sports Nutrition 20100101

• Inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells by the norsesterterpene peroxide, epimuqubilin A.

  Marine drugs 20100101

• Cyanobacterial cyclopeptides as lead compounds to novel targeted cancer drugs.

  Marine drugs 20100101

• Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides.

  Marine drugs 20100101

• Transcriptional control by two leucine-responsive regulatory proteins in Halobacterium salinarum R1.

  BMC molecular biology 20100101

• Evolution of nectarivory in phyllostomid bats (Phyllostomidae Gray, 1825, Chiroptera: Mammalia).

  BMC evolutionary biology 20100101

• Absence of functional TolC protein causes increased stress response gene expression in Sinorhizobium meliloti.

  BMC microbiology 20100101

• Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus.

  Nutrition & metabolism 20100101

• Compartmentalization of the Edinburgh Human Metabolic Network.

  BMC bioinformatics 20100101

• Characterization of substrate preference for Slc1p and Cst26p in Saccharomyces cerevisiae using lipidomic approaches and an LPAAT activity assay.

  PloS one 20100101

• Volatile profiling reveals intracellular metabolic changes in Aspergillus parasiticus: veA regulates branched chain amino acid and ethanol metabolism.

  BMC biochemistry 20100101

• Oral microencapsulated live Saccharomyces cerevisiae cells for use in renal failure uremia: preparation and in vivo analysis.

  Journal of biomedicine & biotechnology 20100101

• Proteome-wide search reveals unexpected RNA-binding proteins in Saccharomyces cerevisiae.

  PloS one 20100101

• TLRs in Hepatic Cellular Crosstalk.

  Gastroenterology research and practice 20100101

• Iodothyronine Interactions with the System L1 Amino Acid Exchanger in 3T3-L1 Adipocytes.

  Journal of thyroid research 20100101

• Impaired growth and force production in skeletal muscles of young partially pancreatectomized rats: a model of adolescent type 1 diabetic myopathy?

  PloS one 20100101

• Metabolomic profiling of cellular responses to carvedilol enantiomers in vascular smooth muscle cells.

  PloS one 20100101

• Cationic amino acid transporters and Salmonella Typhimurium ArgT collectively regulate arginine availability towards intracellular Salmonella growth.

  PloS one 20100101

• Identification and Partial Characterization of an L-Tyrosine Aminotransferase (TAT) from Arabidopsis thaliana.

  Biochemistry research international 20100101

• Peyer's Patches: The Immune Sensors of the Intestine.

  International journal of inflammation 20100101

• Leaf-cutting ant fungi produce cell wall degrading pectinase complexes reminiscent of phytopathogenic fungi.

  BMC biology 20100101

• The effect of oral leucine on protein metabolism in adolescents with type 1 diabetes mellitus.

  International journal of pediatric endocrinology 20100101

• [Synthesis and pharmacological activity of amides and ozonolysis product of maleopimaric acid].

  Bioorganicheskaia khimiia 20100101

• Preparation of antioxidant enzymatic hydrolysates from honeybee-collected pollen using plant enzymes.

  Enzyme research 20100101

• Translational selection on SHH genes.

  Genetics and molecular biology 20100101

• Intelligent chiral sensing based on supramolecular and interfacial concepts.

  Sensors (Basel, Switzerland) 20100101

• Studies of enthalpy-entropy compensation, partial entropies, and Kirkwood-Buff integrals for aqueous solutions of glycine, L-leucine, and glycylglycine at 298.15 K.

  The journal of physical chemistry. B 20091231

• A post-modification approach to peptide foldamers.

  Organic & biomolecular chemistry 20091221

• Simultaneously manufactured nano-in-micro (SIMANIM) particles for dry-powder modified-release delivery of antibodies.

  Journal of pharmaceutical sciences 20091101

• The mammalian target of rapamycin as novel central regulator of puberty onset via modulation of hypothalamic Kiss1 system.

  Endocrinology 20091101

• Statistical optimization for improved production of cyclosporin a in solid-state fermentation.

  Journal of microbiology and biotechnology 20091101

• Standard-free quantitation of mixtures using clusters formed by electrospray mass spectrometry.

  Analytical chemistry 20091015

• Sodium and potassium ion directed self-assembled multinuclear assembly of divalent nickel or copper and L-leucine derived ligand.

  Inorganic chemistry 20091005

• Luminal L-glutamate enhances duodenal mucosal defense mechanisms via multiple glutamate receptors in rats.

  American journal of physiology. Gastrointestinal and liver physiology 20091001

• Expression and mechanism of mammalian target of rapamycin in age-related renal cell senescence and organ aging.

  Mechanisms of ageing and development 20091001

• New Ras CAAX mimetics: design, synthesis, antiproliferative activity, and RAS prenylation inhibition.

  Bioorganic & medicinal chemistry letters 20090915

• Effect of L-leucine graft content on aqueous solution behavior and membrane-lytic activity of a pH-responsive pseudopeptide.

  Biomacromolecules 20090914

• Retraction note on: The influence of sodium hyaluronate, l-leucine and sodium taurocholate on the nebulization of aqueous betamethasone-17-valerate suspensions.

  AAPS PharmSciTech 20090901

• Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cells.

  Journal of veterinary science 20090901

• REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis.

  PLoS biology 20090901

• Static solid-state (14)N NMR and computational studies of nitrogen EFG tensors in some crystalline amino acids.

  Physical chemistry chemical physics : PCCP 20090828

• Mapping of the allosteric network in the regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis by the feedback inhibitor L-leucine: solution-phase H/D exchange monitored by FT-ICR mass spectrometry.

  Biochemistry 20090811

• Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake.

  Endocrinology 20090801

• Oral administration of Excitin-1 (beta-alanyl-L-leucine) alters behavior and brain monoamine and amino acid concentrations in rats.

  Nutritional neuroscience 20090801

• Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis.

  Neurobiology of disease 20090701

• Combination chemotherapeutic dry powder aerosols via controlled nanoparticle agglomeration.

  Pharmaceutical research 20090701

• Kokumi-active glutamyl peptides in cheeses and their biogeneration by Penicillium roquefortii.

  Journal of agricultural and food chemistry 20090513

• Biosynthesis of the cyclooligomer depsipeptide bassianolide, an insecticidal virulence factor of Beauveria bassiana.

  Fungal genetics and biology : FG & B 20090501

• Taurine supplementation enhances nutrient-induced insulin secretion in pancreatic mice islets.

  Diabetes/metabolism research and reviews 20090501

• Tuning the activation threshold of a kinase network by nested feedback loops.

  Science (New York, N.Y.) 20090424

• MITF-CM, a newly identified isoform of microphthalmia-associated transcription factor, is expressed in cultured mast cells.

  International journal of laboratory hematology 20090401

• The role of hydrophobic amino acid grafts in the enhancement of membrane-disruptive activity of pH-responsive pseudo-peptides.

  Biomaterials 20090401

• Effect of amino acids on tannase biosynthesis by Bacillus licheniformis KBR6.

  Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20090401

• Kinetic evidence for interdomain communication in the allosteric regulation of alpha-isopropylmalate synthase from Mycobacterium tuberculosis.

  Biochemistry 20090310

• Antigenic, microbicidal and antiparasitic properties of an l-amino acid oxidase isolated from Bothrops jararaca snake venom.

  Toxicon : official journal of the International Society on Toxinology 20090301

• Ten novel HMGCL mutations in 24 patients of different origin with 3-hydroxy-3-methyl-glutaric aciduria.

  Human mutation 20090301

• The identification of nonpeptide neurotensin receptor partial agonists from the potent antagonist SR48692 using a calcium mobilization assay.

  Bioorganic & medicinal chemistry letters 20090301

• Metabolic engineering of the L-valine biosynthesis pathway in Corynebacterium glutamicum using promoter activity modulation.

  Journal of biotechnology 20090205

• Universal and species-specific bacterial 'fungiphiles' in the mycospheres of different basidiomycetous fungi.

  Environmental microbiology 20090201

• Biodegradable polydepsipeptides.

  International journal of molecular sciences 20090201

• Cycloheximide treatment induces the uptake of neutral and dibasic amino acids via the activation of system b(0,+) in human intestinal Caco-2 cells.

  Journal of nutritional science and vitaminology 20090201

• Solid-state NMR studies of aminocarboxylic salt bridges in L-lysine modified cellulose.

  The journal of physical chemistry. B 20090129

• Effects of disintegration-promoting agent, lubricants and moisture treatment on optimized fast disintegrating tablets.

  International journal of pharmaceutics 20090105

• Aerosolization behavior of carrier-free L-leucine coated salbutamol sulphate powders.

  International journal of pharmaceutics 20090105

• Molecularly designed surfaces for blood deheparinization using an immobilized heparin-binding peptide.

  Journal of biomedical materials research. Part A 20090101

• Zyxin is a novel interacting partner for SIRT1.

  BMC cell biology 20090101

• Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes.

  PloS one 20090101

• The effect of high glucocorticoid administration and food restriction on rodent skeletal muscle mitochondrial function and protein metabolism.

  PloS one 20090101

• Aerosol performance of large respirable particles of amikacin sulfate produced by spray and freeze drying techniques.

  Current drug delivery 20090101

• Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids.

  BMC cell biology 20090101

• Exploring functional beta-cell heterogeneity in vivo using PSA-NCAM as a specific marker.

  PloS one 20090101

• PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis.

  Microbial cell factories 20090101

• Characterization of alpha-isopropylmalate synthases containing different copy numbers of tandem repeats in Mycobacterium tuberculosis.

  BMC microbiology 20090101

• Poly(ester amide) co-polymers promote blood and tissue compatibility.

  Journal of biomaterials science. Polymer edition 20090101

• Bacillus cereus spores release alanine that synergizes with inosine to promote germination.

  PloS one 20090101

• Potentials and limitations of microorganisms as renal failure biotherapeutics.

  Biologics : targets & therapy 20090101

• The formin-homology protein SmDia interacts with the Src kinase SmTK and the GTPase SmRho1 in the gonads of Schistosoma mansoni.

  PloS one 20090101

• Protein hydrolysates in sports nutrition.

  Nutrition & metabolism 20090101

• Conformational changes and loose packing promote E. coli Tryptophanase cold lability.

  BMC structural biology 20090101

• Dual localized AtHscB involved in iron sulfur protein biogenesis in Arabidopsis.

  PloS one 20090101

• Mechanisms of amino acid sensing in mTOR signaling pathway.

  Nutrition research and practice 20090101

• A taxonomy of epithelial human cancer and their metastases.

  BMC medical genomics 20090101

• MEF2C silencing attenuates load-induced left ventricular hypertrophy by modulating mTOR/S6K pathway in mice.

  PloS one 20090101

• Performance of the auxotrophic Saccharomyces cerevisiae BY4741 as host for the production of IL-1beta in aerated fed-batch reactor: role of ACA supplementation, strain viability, and maintenance energy.

  Microbial cell factories 20090101

• Heating improves poor compliance with branched chain amino acid-rich supplementation in patients with liver cirrhosis: A before-after pilot study.

  Molecular medicine reports 20090101

• Escherichia coli, an Intestinal Microorganism, as a Biosensor for Quantification of Amino Acid Bioavailability.

  Sensors (Basel, Switzerland) 20090101

• L-leucine increases [3H]-thymidine incorporation in chicken hepatocytes: involvement of the PKC, PI3K/Akt, ERK1/2, and mTOR signaling pathways.

  Journal of cellular biochemistry 20081215

• Novel mechanistic aspects on the reaction between low spin Fe(II) Schiff base amino acid complexes and hydrogen peroxide-spectrophotometric tracer of intraperoxo intermediate catalyzed reaction.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081201

• Solvent-free crystallizations of amino acids: the effects of the hydrophilicity/hydrophobicity of side-chains.

  Biophysical chemistry 20081201

• Spontaneous reaction silencing in metabolic optimization.

  PLoS computational biology 20081201

• Peripheral amino Acid levels in schizophrenia and antipsychotic treatment.

  Psychiatry investigation 20081201

• Synthesis, characterization and pharmacological evaluation of amide prodrugs of ketorolac.

  European journal of medicinal chemistry 20081101

• Cospray-dried unfractionated heparin with L-leucine as a dry powder inhaler mucolytic for cystic fibrosis therapy.

  Journal of pharmaceutical sciences 20081101

• The effects of age on uptake, serum half-life and bioavailability of mouse [D-Leu-4]OB3, a synthetic peptide amide with leptin-like activity, in male C57BL/6J mice.

  Regulatory peptides 20081009

• Synthesis, structure, and spectroscopic properties of chiral oxorhenium(V) complexes incorporating polydentate ligands derived from L-amino acids: a density functional theory/time-dependent density functional theory investigation.

  Inorganic chemistry 20081006

• Investigations on the humidity-induced transformations of salbutamol sulphate particles coated with L-leucine.

  Pharmaceutical research 20081001

• Water-soluble gambogic acid PEGylated prodrugs: synthesis, characterization, physicochemical properties and in vitro hydrolysis.

  Die Pharmazie 20081001

• Optimization of 12 chiral analytes with 8 polymeric surfactants.

  Journal of chromatographic science 20081001

• Glutamine-induced membrane currents in cultured rat hippocampal neurons.

  The European journal of neuroscience 20080801

• Inference of protein complex activities from chemical-genetic profile and its applications: predicting drug-target pathways.

  PLoS computational biology 20080801

• Protein properties of mackerel viscera extracted by supercritical carbon dioxide.

  Journal of environmental biology 20080701

• Simultaneous synthesis and coating of salbutamol sulphate nanoparticles with L-leucine in the gas phase.

  International journal of pharmaceutics 20080624

• Physico-chemical investigation of asymmetrical peptidolipidyl-cyclodextrins.

  Journal of colloid and interface science 20080601

• BCH, an inhibitor of system L amino acid transporters, induces apoptosis in cancer cells.

  Biological & pharmaceutical bulletin 20080601

• Overall kinetic mechanism of saccharopine dehydrogenase (L-glutamate forming) from Saccharomyces cerevisiae.

  Biochemistry 20080513

• Pharmaceutical particle engineering via spray drying.

  Pharmaceutical research 20080501

• Conformational flexibility of a model protein upon immobilization on self-assembled monolayers.

  Biotechnology and bioengineering 20080501

• Diversification of an ancient theme: hydroxynitrile glucosides.

  Phytochemistry 20080501

• WITHDRAWN: Amino acids for amyotrophic lateral sclerosis / motor neuron disease.

  The Cochrane database of systematic reviews 20080416

• Characterization and astrocytic modulation of system L transporters in brain microvasculature endothelial cells.

  Cell biochemistry and function 20080401

• L-Amino acid oxidase from Naja naja oxiana venom.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20080401

• [Immunoresonance scattering spectral assay of complement factor 4(C4)].

  Guang pu xue yu guang pu fen xi = Guang pu 20080401

• An allylic ketyl radical intermediate in clostridial amino-acid fermentation.

  Nature 20080313

• Development of spray dried liposomal dry powder inhaler of Dapsone.

  AAPS PharmSciTech 20080301

• The influence of sodium hyaluronate, L-leucine and sodium taurocholate on the nebulization of aqueous betamethasone-17-valerate suspensions.

  AAPS PharmSciTech 20080301

• Production of L-leucine aminopeptidase by selected Streptomyces isolates.

  Journal of applied microbiology 20080201

• Biological and physiological characteristics of Neotyphodium gansuense symbiotic with Achnatherum inebrians.

  Microbiological research 20080101

• A novel gas phase method for the combined synthesis and coating of pharmaceutical particles.

  Pharmaceutical research 20080101

• In vitro modulation of alkaline phosphatase activity of Saccharomyces cerevisiae grown in low or high phosphate medium.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20080101

• Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women.

  PloS one 20080101

• Optimized two-dimensional thin layer chromatography to monitor the intracellular concentration of acetyl phosphate and other small phosphorylated molecules.

  Biological procedures online 20080101

• Comparative transcriptome analysis of Arabidopsis thaliana infested by diamond back moth (Plutella xylostella) larvae reveals signatures of stress response, secondary metabolism, and signalling.

  BMC genomics 20080101

• Limited functional conservation of a global regulator among related bacterial genera: Lrp in Escherichia, Proteus and Vibrio.

  BMC microbiology 20080101

• Microphthalmia and cataract in rats with a novel point mutation in connexin 50 - L7Q.

  Molecular vision 20080101

• The hidden universal distribution of amino acid biosynthetic networks: a genomic perspective on their origins and evolution.

  Genome biology 20080101

• Molecular evolution of B6 enzymes: binding of pyridoxal-5'-phosphate and Lys41Arg substitution turn ribonuclease A into a model B6 protoenzyme.

  BMC biochemistry 20080101

• Direct infection and replication of naturally occurring hepatitis C virus genotypes 1, 2, 3 and 4 in normal human hepatocyte cultures.

  PloS one 20080101

• MSDmotif: exploring protein sites and motifs.

  BMC bioinformatics 20080101

• Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies.

  Nutrition & metabolism 20080101

• Overexpression of the riboflavin biosynthetic pathway in Pichia pastoris.

  Microbial cell factories 20080101

• Pancreatic beta-cell purification by altering FAD and NAD(P)H metabolism.

  Experimental diabetes research 20080101

• Novel insights into the unfolded protein response using Pichia pastoris specific DNA microarrays.

  BMC genomics 20080101

• A genome-scale metabolic reconstruction of Pseudomonas putida KT2440: iJN746 as a cell factory.

  BMC systems biology 20080101

• P-loop mutations and novel therapeutic approaches for imatinib failures in chronic myeloid leukemia.

  Journal of hematology & oncology 20080101

• Size-specific, colorimetric detection of counteranions by using helical poly(phenylacetylene) conjugated to L-leucine groups through urea acceptors.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.

  PloS one 20080101

• Tripeptide tyroserleutide plus doxorubicin: therapeutic synergy and side effect attenuation.

  BMC cancer 20080101

• MFS transportome of the human pathogenic yeast Candida albicans.

  BMC genomics 20080101

• Dose- and Glucose-Dependent Effects of Amino Acids on Insulin Secretion from Isolated Mouse Islets and Clonal INS-1E Beta-Cells.

  The review of diabetic studies : RDS 20080101

• 13C-alpha-Ketoisocaproic acid breath test revisited: an in-depth reproducibility study advocates an extended breath sampling period.

  Digestive diseases and sciences 20071201

• Inhibitory effects of endogenous L-arginine analogues on nitric oxide synthesis in platelets: role in platelet hyperaggregability in hypertension.

  Clinical and experimental pharmacology & physiology 20071201

• Genetic interaction between the ero1-1 and leu2 mutations in Saccharomyces cerevisiae.

  Bioscience, biotechnology, and biochemistry 20071201

• Nano-liposomal dry powder inhaler of tacrolimus: preparation, characterization, and pulmonary pharmacokinetics.

  International journal of nanomedicine 20071201

• Inhibitory properties of nerve-specific human glutamate dehydrogenase isozyme by chloroquine.

  Journal of biochemistry and molecular biology 20071130

• Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase.

  Journal of neuroscience research 20071115

• Development and validation of a liquid chromatographic method for the determination of branched-chain amino acids in new dosage forms.

  Journal of pharmaceutical and biomedical analysis 20071105

• Molecular genetics of HMG-CoA lyase deficiency.

  Molecular genetics and metabolism 20071101

• Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush border membrane.

  The Journal of physiology 20071015

• Amino acids partitioning in aqueous two-phase system of polypropylene glycol and magnesium sulfate.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015

• Design of organocatalysts for asymmetric direct syn-aldol reactions.

  Organic letters 20071011

• Role of S-nitrosothiol transport in the cardioprotective effects of S-nitrosocysteine in rat hearts.

  Free radical biology & medicine 20071001

• Metabolic and digestive response to food ingestion in a binge-feeding lizard, the Gila monster (Heloderma suspectum).

  The Journal of experimental biology 20071001

• Enantioselective separation of all-E-astaxanthin and its determination in microbial sources.

  Journal of chromatography. A 20070928

• Suppression of myofibrillar proteolysis in chick skeletal muscles by alpha-ketoisocaproate.

  Amino acids 20070901

• Purification of branched-chain amino acid aminotransferase from Helicobacter pylori NCTC 11637.

  Amino acids 20070901

• Estrogen regulation and ion dependence of taurine uptake by MCF-7 human breast cancer cells.

  Cellular & molecular biology letters 20070901

• Antioxidant defenses preserve membrane transport activity in Chironomus riparius larvae exposed to anoxia.

  Archives of insect biochemistry and physiology 20070801

• Development of micellar electro kinetic chromatography for the separation and quantitation of L-valine, L-leucine, L-isoleucin and L-phenylalanine in human plasma and comparison with HPLC.

  Pakistan journal of biological sciences : PJBS 20070801

• Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro.

  The Journal of physiology 20070715

• Amino acid changes within antenna helix are responsible for different regulatory preferences of human glutamate dehydrogenase isozymes.

  The Journal of biological chemistry 20070706

• Spectral characterization of novel ternary zinc(II) complexes containing 1,10-phenanthroline and Schiff bases derived from amino acids and salicylaldehyde-5-sulfonates.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070701

• L-glutamine in vitro regulates rat aortic glutamate content and modulates nitric oxide formation and contractility responses.

  American journal of physiology. Cell physiology 20070701

• Physical characteristics and aerosolization performance of insulin dry powders for inhalation prepared by a spray drying method.

  The Journal of pharmacy and pharmacology 20070701

• Effects of leucine and phenylalanine supplementation during intermittent periods of food restriction and refeeding in adult rats.

  Life sciences 20070613

• Tautomeric and microscopic protonation equilibria of some alpha-amino acids.

  Analytical biochemistry 20070601

• Polymeric alkenoxy amino acid surfactants: V. Comparison of carboxylate and sulfate head group polymeric surfactants for enantioseparation in MEKC.

  Electrophoresis 20070601

• The promoter activity of isovaleryl-CoA dehydrogenase-encoding gene (ivdA) from Aspergillus oryzae is strictly repressed by glutamic acid.

  Bioscience, biotechnology, and biochemistry 20070601

• The structure and transcriptional analysis of a global regulator from Neisseria meningitidis.

  The Journal of biological chemistry 20070511

• Inhibitory effect of TNF-alpha on the intestinal absorption of galactose.

  Journal of cellular biochemistry 20070501

• Properties and molecular evolution of human GLUD2 (neural and testicular tissue-specific) glutamate dehydrogenase.

  Journal of neuroscience research 20070401

• Combination of amino acids reduces pigmentation in B16F0 melanoma cells.

  Biological & pharmaceutical bulletin 20070401

• [Pathway analysis for production of L-leucine by Brevibacterium flavum TK0303].

  Wei sheng wu xue bao = Acta microbiologica Sinica 20070401

• Vibrational analysis of amino acids and short peptides in hydrated media. I. L-glycine and L-leucine.

  The journal of physical chemistry. B 20070215

• Intestinal D-galactose transport in an endotoxemia model in the rabbit.

  The Journal of membrane biology 20070201

• A cysteine proteinase in the penetration glands of the cercariae of Tylodelphys excavata (Trematoda, Diplostomidae).

  Parasitology research 20070101

• Initial experience with the radiotracer anti-1-amino-3-18F-fluorocyclobutane-1-carboxylic acid with PET/CT in prostate carcinoma.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070101

• Spatial and sex-specific dissection of the Anopheles gambiae midgut transcriptome.

  BMC genomics 20070101

• Strategy of transcription regulation in the budding yeast.

  PloS one 20070101

• Regulation of metabolic networks by small molecule metabolites.

  BMC bioinformatics 20070101

• Central administration of dipeptides, beta-alanyl-BCAAs, induces hyperactivity in chicks.

  BMC neuroscience 20070101

• Cation induced differential effect on structural and functional properties of Mycobacterium tuberculosis alpha-isopropylmalate synthase.

  BMC structural biology 20070101

• High susceptibility of Bt maize to aphids enhances the performance of parasitoids of lepidopteran pests.

  PloS one 20070101

• Bacillus anthracis secretome time course under host-simulated conditions and identification of immunogenic proteins.

  Proteome science 20070101

• [Biologically active substances in grated cocoa and cocoa butter].

  Voprosy pitaniia 20070101

• Overexpression of non-functional LAT1/4F2hc in renal proximal tubular epithelial cells from the spontaneous hypertensive rat.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• The effects of short-term alpha-ketoisocaproic acid supplementation on exercise performance: a randomized controlled trial.

  Journal of the International Society of Sports Nutrition 20070101

• Genetic subtraction profiling identifies genes essential for Arabidopsis reproduction and reveals interaction between the female gametophyte and the maternal sporophyte.

  Genome biology 20070101

• Inhibition of protein aggregation: supramolecular assemblies of arginine hold the key.

  PloS one 20070101

• Modulation of the cationic amino acid transport system y+L by surface potential, ouabain and thrombin in human platelets: effects of uremia.

  Nephron. Experimental nephrology 20070101

• Serotonin differentially regulates short- and long-term prediction of rewards in the ventral and dorsal striatum.

  PloS one 20070101

• Gender affects 13C-ketoisocaproic acid breath test.

  European review for medical and pharmacological sciences 20070101

• Membrane transport function in primary cultures of human proximal tubular cells.

  Toxicology 20061207

• Protease and esterase activity of staphylococci.

  International journal of food microbiology 20061201

• Oxo-4-methylpentanoic acid directs the metabolism of GABA into the Krebs cycle in rat pancreatic islets.

  The Biochemical journal 20061115

• L-proline transport by purified cell types of lobster hepatopancreas.

  Journal of experimental zoology. Part A, Comparative experimental biology 20061001

• A leuC mutation leading to increased L-lysine production and rel-independent global expression changes in Corynebacterium glutamicum.

  Applied microbiology and biotechnology 20061001

• The PKA-CREB system encoded by the honeybee genome.

  Insect molecular biology 20061001

• Stereoselective allyl transfer to chiral alpha-methoxycarbaldehydes: a model study related to the C-9/C-15 fragment of geldanamycin.

  Bioorganic & medicinal chemistry 20060915

• y+ LAT-1 mediates transport of the potent and selective iNOS inhibitor, GW274150, in control J774 macrophages.

  Amino acids 20060901

• Deuterium isotope effect on 13C chemical shifts of tetrabutylammonium salts of Schiff bases amino acids.

  Magnetic resonance in chemistry : MRC 20060901

• Bitterness suppression of BCAA solutions by L-ornithine.

  Chemical & pharmaceutical bulletin 20060901

• Electrocatalytic oxidation and highly selective voltammetric determination of L-cysteine at the surface of a 1-[4-(ferrocenyl ethynyl)phenyl]-1-ethanone modified carbon paste electrode.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20060901

• Amino acids as modulators of endothelium-derived nitric oxide.

  American journal of physiology. Renal physiology 20060801

• Characterization of cationic amino acid transport systems in rat erythrocytes: lack of effect of uraemia on L-arginine influx.

  Clinical and experimental pharmacology & physiology 20060801

• Isolation and identification of the icosalides--cyclic peptolides with selective antibiotic and cytotoxic activities.

  The Journal of antibiotics 20060801

• Kinetic and chemical mechanism of alpha-isopropylmalate synthase from Mycobacterium tuberculosis.

  Biochemistry 20060725

• Exploring the ability of frozen-density embedding to model induced circular dichroism.

  The journal of physical chemistry. A 20060720

• Effects of tetrabromobisphenol A on larval development and thyroid hormone-regulated biomarkers of the amphibian Xenopus laevis.

  Environmental research 20060701

• Study of electrolyte induced aggregation of gold nanoparticles capped by amino acids.

  Journal of colloid and interface science 20060701

• Synthesis, helicity, and chromism of optically active poly(phenylacetylene)s carrying different amino acid moieties and pendant terminal groups.

  The journal of physical chemistry. B 20060615

• Lanthanum(III) and praseodymium(III) derivatives with dithiocarbamates derived from alpha-amino acids.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060601

• Characterization of the initial enzymatic steps of barbamide biosynthesis.

  Journal of natural products 20060601

• Possible involvement of calcium signaling pathways in L-leucine-stimulated protein synthesis in L6 myotubes.

  Bioscience, biotechnology, and biochemistry 20060601

• [Obesity and progression of chronic renal insufficiency: a Czech long term prospective double-blind randomised multicentre study].

  Vnitrni lekarstvi 20060601

• Alkaline Phosphatases : Structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes.

  Purinergic signalling 20060601

• Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I.

  Organic & biomolecular chemistry 20060507

• Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction.

  Nutrition (Burbank, Los Angeles County, Calif.) 20060501

• Leptin biosynthetic pathway in white adipocytes.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20060401

• Adenine nucleotide pattern in rat pancreatic islets exposed to nutrient secretagogues.

  Endocrine 20060401

• Carbon catabolite repression regulates amino acid permeases in Saccharomyces cerevisiae via the TOR signaling pathway.

  The Journal of biological chemistry 20060303

• A combined 17O RAPT and MQ-MAS NMR study of L-leucine.

  Solid state nuclear magnetic resonance 20060201

• Quantification of trimethylsilyl derivatives of amino acid disease biomarkers in neonatal blood samples by gas chromatography-mass spectrometry.

  Analytical and bioanalytical chemistry 20060201

• Estrogen-like activity of seafood related to environmental chemical contaminants.

  Environmental health : a global access science source 20060101

• Integrative investigation of metabolic and transcriptomic data.

  BMC bioinformatics 20060101

• Identification of a Bacillus thuringiensis Cry11Ba toxin-binding aminopeptidase from the mosquito, Anopheles quadrimaculatus.

  BMC biochemistry 20060101

• The influence of tumor oxygenation on (18)F-FDG (fluorine-18 deoxyglucose) uptake: a mouse study using positron emission tomography (PET).

  Radiation oncology (London, England) 20060101

• Brefeldin A decreases the activity of the general amino acid permease (GAP1) and the more specific systems for L-leucine uptake in Saccharomyces cerevisiae.

  Cellular & molecular biology letters 20060101

• Purification and characterization of a halotolerant intracellular protease from Bacillus subtilis strain FP-133.

  Journal of basic microbiology 20060101

• 'Nutritional and chemopreventive anti-cancer agents up-regulate expression of p27Kip1, a cyclin-dependent kinase inhibitor, in mouse JB6 epidermal and human MCF7, MDA-MB-321 and AU565 breast cancer cells'.

  Cancer cell international 20060101

• High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry.

  Journal of biology 20060101

• Optimization of formulation components and characterization of large respirable powders containing high therapeutic payload.

  Pharmaceutical development and technology 20060101

• Restructuring of pancreatic islets and insulin secretion in a postnatal critical window.

  PloS one 20060101

• Part III: Surface-enhanced Raman scattering of amino acids and their homodipeptide monolayers deposited onto colloidal gold surface.

  Applied spectroscopy 20051201

• L-type amino acids stimulate gastric acid secretion by activation of the calcium-sensing receptor in parietal cells.

  American journal of physiology. Gastrointestinal and liver physiology 20051001

• Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1.

  The Journal of biological chemistry 20050916

• Expression and function of LAT1, a neutral amino acid exchanger, in renal porcine epithelial cell line LLC-PK.

  Acta physiologica Scandinavica 20050901

• Cyanopeptolin 954, a chlorine-containing chymotrypsin inhibitor of Microcystis aeruginosa NIVA Cya 43.

  Journal of natural products 20050901

• Stereoselective synthesis of constrained azacyclic hydroxyethylene isosteres as aspartic protease inhibitors: dipolar cycloaddition and related methodologies toward branched pyrrolidine and pyrrolidinone carboxylic acids.

  The Journal of organic chemistry 20050819

• Surface properties of aqueous amino acid solutions II. Leucine-leucine hydrochloride and leucine-sodium leucinate mixtures.

  Journal of colloid and interface science 20050815

• Mouse oocytes regulate metabolic cooperativity between granulosa cells and oocytes: amino acid transport.

  Biology of reproduction 20050801

• Synthesis and X-ray crystal structure study of the hydroxyurea and hydantoin derivatives of L-valine.

  The journal of peptide research : official journal of the American Peptide Society 20050801

• alpha-Aminoalkylphosphonates as a tool in experimental optimisation of P1 side chain shape of potential inhibitors in S1 pocket of leucine- and neutral aminopeptidases.

  European journal of medicinal chemistry 20050801

• Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in oligodendrocyte cell line (OLN-93).

  Neurochemical research 20050801

• Slow-onset feedback inhibition: inhibition of Mycobacterium tuberculosis alpha-isopropylmalate synthase by L-leucine.

  Journal of the American Chemical Society 20050720

• Homocysteine, a risk factor for atherosclerosis, biphasically changes the endothelial production of kynurenic acid.

  European journal of pharmacology 20050711

• Regulation of leptin secretion from white adipocytes by insulin, glycolytic substrates, and amino acids.

  American journal of physiology. Endocrinology and metabolism 20050701

• Nephrotoxicity of organic solvents: biomarkers for early detection.

  International archives of occupational and environmental health 20050701

• L-type amino acid transporter 1-mediated L-leucine transport at the inner blood-retinal barrier.

  Investigative ophthalmology & visual science 20050701

• Asp578 in LEU4p is one of the key residues for leucine feedback inhibition release in sake yeast.

  Bioscience, biotechnology, and biochemistry 20050701

• Influence of leucine and valine on ramoplanin production by Actinoplanes sp. ATCC 33076.

  The Journal of antibiotics 20050701

• Studies on the application of immobilization technique for the production of cyclosporin A by a local strain of Aspergillus terreus.

  The Journal of general and applied microbiology 20050601

• Alkaline phosphatase retained in HepG2 hepatocarcinoma cells vs. alkaline phosphatase released to culture medium: difference of aberrant glycosylation.

  Biochemical and biophysical research communications 20050506

• Characterization and microbial utilization of dissolved organic carbon in groundwater contaminated with chlorophenols.

  Chemosphere 20050501

• A mathematical model for the branched chain amino acid biosynthetic pathways of Escherichia coli K12.

  The Journal of biological chemistry 20050325

• Quantitative analysis of enalapril by 1H NMR spectroscopy in tablets.

  Journal of pharmaceutical and biomedical analysis 20050309

• Molecular recognition of alpha-cyclodextrin (CD) to choral amino acids based on methyl orange as a molecular probe.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050301

• Effect of hyperglycaemic load on maternal-foetal transport of L-leucine in perfused human placental lobule: in vitro study.

  Acta diabetologica 20050301

• Testing the hypothesis that system y(+)L accounts for high- and low-transport phenotypes in chicken erythrocytes using L-leucine as substrate.

  The Journal of membrane biology 20050301

• Dual effect of DL-homocysteine and S-adenosylhomocysteine on brain synthesis of the glutamate receptor antagonist, kynurenic acid.

  Journal of neuroscience research 20050201

• A biosynthetic pathway to isovaleryl-CoA in myxobacteria: the involvement of the mevalonate pathway.

  Chembiochem : a European journal of chemical biology 20050201

• Improved production of isoamyl acetate by a sake yeast mutant resistant to an isoprenoid analog and its dependence on alcohol acetyltransferase activity, but not on isoamyl alcohol production.

  Journal of bioscience and bioengineering 20050201

• Comparison of the structure of key variants of microcystin to vasopressin.

  Environmental toxicology and pharmacology 20050201

• The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations.

  Journal of medicinal chemistry 20050127

• Glutamine is a key regulator for amino acid-controlled cell growth through the mTOR signaling pathway in rat intestinal epithelial cells.

  Biochemical and biophysical research communications 20050107

• Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.

  Journal of neuroscience research 20050101

• Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide.

  Biochemical pharmacology 20050101

• 3H-L-histidine and 65Zn(2+) are cotransported by a dipeptide transport system in intestine of lobster Homarus americanus.

  The Journal of experimental biology 20050101

• Transfection activity of polyamidoamine dendrimers having hydrophobic amino acid residues in the periphery.

  Bioconjugate chemistry 20050101

• Gluten-free diet may alleviate depressive and behavioural symptoms in adolescents with coeliac disease: a prospective follow-up case-series study.

  BMC psychiatry 20050101

• Evidence for functional asymmetry in the olfactory system of the Senegalese sole (Solea senegalensis).

  Physiological and biochemical zoology : PBZ 20050101

• Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin.

  BMC neuroscience 20050101

• Whole cell matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and in situ structure analysis of streptocidins, a family of tyrocidine-like cyclic peptides.

  Rapid communications in mass spectrometry : RCM 20050101

• Effect of individual amino acids and glucose on activation and germination of Rhizopus oligosporus sporangiospores in tempe starter.

  Journal of applied microbiology 20050101

• Studies of the intermediary metabolism in cultured cells of the insect Spodoptera frugiperda using 13C- or 15N-labelled tracers.

  BMC biochemistry 20050101

• l-leucine aminopeptidase production by filamentous Aspergillus fungi.

  Letters in applied microbiology 20050101

• Generation of functional HLA-DR*1101 tetramers receptive for loading with pathogen- or tumour-derived synthetic peptides.

  BMC immunology 20050101

• Targeting the active site of the placental isozyme of alkaline phosphatase by phage-displayed scFv antibodies selected by a specific uncompetitive inhibitor.

  BMC biotechnology 20050101

• Pt based enzyme electrode probes assembled with Prussian Blue and conducting polymer nanostructures.

  Biosensors & bioelectronics 20041215

• Right-handed helical structure of expanded oligo(L-leucine) containing [Ru(terpyridine)2]2+ moieties.

  Journal of the American Chemical Society 20041215

• Effects of amino acids and its metabolites on prolidase activity against various iminodipeptides in erythrocytes from normal human and a patient with prolidase deficiency.

  Clinica chimica acta; international journal of clinical chemistry 20041201

• The effect of vehicle on physical properties and aerosolisation behaviour of disodium cromoglycate microparticles spray dried alone or with L-leucine.

  International journal of pharmaceutics 20041105

• Foxl1 null mice have abnormal intestinal epithelia, postnatal growth retardation, and defective intestinal glucose uptake.

  American journal of physiology. Gastrointestinal and liver physiology 20041001

• Atmospheric oxygen and other conditions affecting the production of cereulide by Bacillus cereus in food.

  International journal of food microbiology 20041001

• Cloning and gene silencing of LAT2, the L-3,4-dihydroxyphenylalanine (L-DOPA) transporter, in pig renal LLC-PK1 epithelial cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041001

• Prolonged oral treatment with an essential amino acid L-leucine does not affect female reproductive function and embryo-fetal development in rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040901

• A critical regulatory role of leucin zipper transcription factor c-Maf in Th1-mediated experimental colitis.

  Journal of immunology (Baltimore, Md. : 1950) 20040901

• Maternal-fetal transport kinetics of L-Leucine in vitro in gestational diabetic pregnancies.

  Diabetes & metabolism 20040901

• L-leucine transport in human breast cancer cells (MCF-7 and MDA-MB-231): kinetics, regulation by estrogen and molecular identity of the transporter.

  Biochimica et biophysica acta 20040830

• Examination of the rate of peptide biosynthesis in neuroendocrine cell lines using a stable isotopic label and mass spectrometry.

  Journal of neurochemistry 20040801

• High- and low-affinity transport of L-leucine and L-DOPA by the hetero amino acid exchangers LAT1 and LAT2 in LLC-PK1 renal cells.

  American journal of physiology. Renal physiology 20040801

• INFgamma stimulates arginine transport through system y+L in human monocytes.

  FEBS letters 20040730

• Novel dual inhibitors of calpain and lipid peroxidation.

  Bioorganic & medicinal chemistry letters 20040716

• Quercetin glucosides inhibit glucose uptake into brush-border-membrane vesicles of porcine jejunum.

  The British journal of nutrition 20040601

• Conversion into GABA (gamma-aminobutyric acid) may reduce the capacity of L-glutamine as an insulin secretagogue.

  The Biochemical journal 20040501

• Tacrolimus impairment of insulin secretion in isolated rat islets occurs at multiple distal sites in stimulus-secretion coupling.

  Endocrinology 20040501

• Purification, partial characterization, crystallization and structural determination of AHP-LAAO, a novel L-amino-acid oxidase with cell apoptosis-inducing activity from Agkistrodon halys pallas venom.

  Acta crystallographica. Section D, Biological crystallography 20040501

• Part I: surface-enhanced Raman spectroscopy investigation of amino acids and their homodipeptides adsorbed on colloidal silver.

  Applied spectroscopy 20040501

• Part II: surface-enhanced Raman spectroscopy investigation of methionine containing heterodipeptides adsorbed on colloidal silver.

  Applied spectroscopy 20040501

• Diversity of L-leucine catabolism in various microorganisms involved in dairy fermentations, and identification of the rate-controlling step in the formation of the potent flavour component 3-methylbutanal.

  Applied microbiology and biotechnology 20040401

• Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040401

• Arginine and Leucine regulate p70 S6 kinase and 4E-BP1 in intestinal epithelial cells.

  International journal of molecular medicine 20040401

• Effect of prenatal exposure to ethanol on postnatal development of intestinal transport functions in rats.

  European journal of nutrition 20040401

• No evidence of Neandertal mtDNA contribution to early modern humans.

  PLoS biology 20040301

• 3-methylglutaconic aciduria type I in a boy with fever-associated seizures.

  Pediatric neurology 20040301

• The present state of antineoplaston research (1).

  Integrative cancer therapies 20040301

• Prodrugs of HIV protease inhibitors-saquinavir, indinavir and nelfinavir-derived from diglycerides or amino acids: synthesis, stability and anti-HIV activity.

  Organic & biomolecular chemistry 20040207

• Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets.

  Diabetologia 20040201

• Spontaneous onset of homochirality in oligopeptide chains generated in the polymerization of N-carboxyanhydride amino acids in water.

  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 20040201

• Tissue-specific regulation of 4E-BP1 and S6K1 phosphorylation by alpha-ketoisocaproate.

  Journal of nutritional science and vitaminology 20040201

• Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclization.

  Gene 20040121

• Selected amino acids, dipeptides and arylalkylamine derivatives do not act as allosteric modulators at GABAB receptors.

  European journal of pharmacology 20040112

• Jejunal microvilli atrophy and reduced nutrient transport in rats with advanced liver cirrhosis: improvement by Insulin-like Growth Factor I.

  BMC gastroenterology 20040101

• Thirteen-week oral toxicity study of branched-chain amino acids in rats.

  International journal of toxicology 20040101

• External chirality-triggered helicity control promoted by introducing a beta-Ala residue into the N-terminus of chiral peptides.

  Biomacromolecules 20040101

• Rapid determination of amino acids in neonatal blood samples based on derivatization with isobutyl chloroformate followed by solid-phase microextraction and gas chromatography/mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20040101

• Characteristics of prolinase against various iminodipeptides in erythrocyte lysates from a normal human and a patient with prolidase deficiency.

  Clinical chemistry and laboratory medicine 20040101

• Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies.

  Brain research 20031114

• Synthesis and activity of HCO-Met-Leu-Phe-OMe analogues containing beta-alanine or taurine at the central position.

  Farmaco (Societa chimica italiana : 1989) 20031101

• Nitric oxide synthesis requires activity of the cationic and neutral amino acid transport system y+L in human umbilical vein endothelium.

  Experimental physiology 20031101

• L-leucine methyl ester: the female-produced sex pheromone of the scarab beetle, Phyllophaga lanceolata.

  Journal of chemical ecology 20031101

• Involvement of protein kinase C activation in L-leucine-induced stimulation of protein synthesis in l6 myotubes.

  Cytotechnology 20031101

• Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters.

  The Journal of biological chemistry 20031031

• Induction of oxidative stress in rat brain by the metabolites accumulating in maple syrup urine disease.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20031001

• (19)F NMR studies of the leucine-isoleucine-valine binding protein: evidence that a closed conformation exists in solution.

  Journal of biomolecular structure & dynamics 20031001

• Sublethal effects of copper on coho salmon: impacts on nonoverlapping receptor pathways in the peripheral olfactory nervous system.

  Environmental toxicology and chemistry 20031001

• Effect of heavy metals on the uptake of [3H]-L-histidine by the polychaete Nereis succinea.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20031001

• [Investigation of the influence of Fas antigen on Hep G2 cells, an erythropoietin producing cell line].

  Nihon Jinzo Gakkai shi 20031001

• Occurrence of two different glutamate dehydrogenase activities in the halophilic bacterium Salinibacter ruber.

  FEMS microbiology letters 20030912

• Uptake of [3H]L-serine in rat brain synaptosomal fractions.

  Brain research 20030905

• Expression and regulation of L-cystine transporter, system xc-, in the newly developed rat retinal Müller cell line (TR-MUL).

  Glia 20030901

• Dietary protein reduction in sheep and goats: different effects on L-alanine and L-leucine transport across the brush-border membrane of jejunal enterocytes.

  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20030801

• Diagnosis of maple syrup urine disease by determination of L-valine, L-isoleucine, L-leucine and L-phenylalanine in neonatal blood spots by gas chromatography-mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030725

• Manipulation of CD98 expression affects both trophoblast cell fusion and amino acid transport activity during syncytialization of human placental BeWo cells.

  The Journal of physiology 20030701

• Regulation of L-leucine transport in rat kidney by dexamethasone and triiodothyronine.

  Amino acids 20030701

• Sequence analysis and biochemical characterization of the nostopeptolide A biosynthetic gene cluster from Nostoc sp. GSV224.

  Gene 20030605

• Regulatory effects of 5'-deoxypyridoxal on glutamate dehydrogenase activity and insulin secretion in pancreatic islets.

  Biochimie 20030601

• Transport of L-arginine and nitric oxide formation in human platelets.

  European journal of biochemistry 20030501

• High cell density cultivation of Brevibacterium linens and formation of proteinases and lipase.

  Biotechnology letters 20030501

• L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses.

  Journal of neuroscience research 20030401

• Functional and molecular characteristics of system L in human breast cancer cells.

  Biochimica et biophysica acta 20030401

• Spinal gabapentin and antinociception: mechanisms of action.

  Journal of Korean medical science 20030401

• A comparative study on the rectal aminopeptidase enzymatic activities of different species.

  Die Pharmazie 20030301

• [Preparation and pharmaceutical properties of salcatonin dry powder inhalations].

  Yao xue xue bao = Acta pharmaceutica Sinica 20030301

• Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells.

  Biochemical and biophysical research communications 20030207

• Increased nitric oxide synthesis in uraemic platelets is dependent on L-arginine transport via system y(+)L.

  Pflugers Archiv : European journal of physiology 20030201

• Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B.

  Bioorganic & medicinal chemistry letters 20030106

• Involvement of the system L amino acid transporter on uptake of S-nitroso-L-cysteine, an endogenous S-nitrosothiol, in PC12 cells.

  European journal of pharmacology 20030101

• Noncovalent chiral domino effect on one-handed helix of nonapeptide containing a midpoint L-residue.

  Biomacromolecules 20030101

• Kynurenate production by cultured human astrocytes.

  Journal of neural transmission (Vienna, Austria : 1996) 20030101

• Proteolytic activity of a yeast cell wall lytic Arthrobacter species.

  Letters in applied microbiology 20030101

• Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.

  Neurochemistry international 20030101

• Effects of acute tryptophan depletion on executive function in healthy male volunteers.

  BMC psychiatry 20030101

• Amino acids for amyotrophic lateral sclerosis / motor neuron disease.

  The Cochrane database of systematic reviews 20030101

• Kinetics of sequential metabolism from D-leucine to L-leucine via alpha-ketoisocaproic acid in rat.

  Drug metabolism and disposition: the biological fate of chemicals 20021201

• Monitoring the structural consequences of Phe12-->D-Phe and Leu15-->Aib substitution in human/rat corticotropin releasing hormone. Implications for design of CRH antagonists.

  European journal of biochemistry 20021201

• Biochemical characterization of the soluble alkaline phosphatase isolated from the venomous snake W. aegyptia.

  Journal of natural toxins 20021201

• Substitution of Ser for Arg-443 in the regulatory domain of human housekeeping (GLUD1) glutamate dehydrogenase virtually abolishes basal activity and markedly alters the activation of the enzyme by ADP and L-leucine.

  The Journal of biological chemistry 20021129

• Protective effect of D-glucose, L-leucine and fetal calf serum against oxidative stress in neonatal pancreatic islets.

  Biochimica et biophysica acta 20021120

• Prediction of the bitterness of single, binary- and multiple-component amino acid solutions using a taste sensor.

  International journal of pharmaceutics 20021106

• 19F NMR study of the leucine-specific binding protein of Escherichia coli: mutagenesis and assignment of the 5-fluorotryptophan-labeled residues.

  Protein engineering 20021101

• Possible involvement of phospholipase C and protein kinase C in stimulatory actions of L-leucine and its keto acid, alpha-ketoisocaproic acid, on protein synthesis in RLC-16 hepatocytes.

  Cytotechnology 20021101

• Synthesis and conformational analysis of small peptides containing 6-endo-BT(t)L scaffolds as reverse turn mimetics.

  The Journal of organic chemistry 20021018

• The stimulus-secretion coupling of amino acid-induced insulin release. Insulinotropic action of L-alanine.

  Biochimica et biophysica acta 20021010

• Studies on the macroscopic protonation constants of some alpha-amino acids in ethanol-water mixtures.

  Analytical biochemistry 20021001

• [Studies on the cytological function of the biomembrane and the neurons].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20021001

• Cloning and characterization of an aromatic amino acid and leucine permease of Penicillium chrysogenum.

  Biochimica et biophysica acta 20020920

• Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.

  Journal of medicinal chemistry 20020912

• Lysine uptake by cloned hCAT-2B: comparison with hCAT-1 and with trophoblast surface membranes.

  The Journal of membrane biology 20020901

• A continuous 96-well plate spectrophotometric assay for branched-chain amino acid aminotransferases.

  Analytical biochemistry 20020901

• The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit.

  Gene 20020821

• A study of L-leucine, L-phenylalanine and L-alanine transport in the perfused rat mammary gland: possible involvement of LAT1 and LAT2.

  Biochimica et biophysica acta 20020819

• Peroxynitrite stimulates L-arginine transport system y(+) in glial cells. A potential mechanism for replenishing neuronal L-arginine.

  The Journal of biological chemistry 20020816

• Glial induction of blood-brain barrier-like L-system amino acid transport in the ECV304 cell line.

  Glia 20020801

• Genetic and physiological analysis of branched-chain alcohols and isoamyl acetate production in Saccharomyces cerevisiae.

  Applied microbiology and biotechnology 20020801

• Effects of epidermal growth factor on placental amino acids uptake in pregnant rats.

  The Journal of veterinary medical science 20020801

• Epithelial cells isolated from chicken jejunum: an experimental model for the study of the functional properties of amino acid transport system b(0,+).

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20020701

• Oral amino-acid provision does not affect muscle strength or size gains in older men.

  Medicine and science in sports and exercise 20020701

• Thermodynamic quantities of surface formation of aqueous electrolyte solutions. V. Aqueous solutions of aliphatic amino acids.

  Journal of colloid and interface science 20020615

• Tumor necrosis factor-alpha mediates inhibitory effect of lipopolysaccharide on L-leucine intestinal uptake.

  Digestive diseases and sciences 20020601

• Evaluation of the RBE4 cell line to explore carrier-mediated drug delivery to the CNS via the L-system amino acid transporter at the blood-brain barrier.

  Journal of drug targeting 20020601

• Synthesis and anti-Helicobacter pylori activity of pyloricidin derivatives II. The combination of amino acid residues in the dipeptidic moiety and its effect on the anti-Helicobacter pylori activity.

  The Journal of antibiotics 20020501

• NMR diffusion as a novel tool for measuring the association constant between cyclodextrin and guest molecules.

  Carbohydrate research 20020430

• The L-3,4-dihydroxyphenylalanine transporter in human and rat epithelial intestinal cells is a type 2 hetero amino acid exchanger.

  European journal of pharmacology 20020426

• Tumor necrosis factor alpha stimulates taurine uptake and transporter gene expression in human intestinal Caco-2 cells.

  FEBS letters 20020424

• Stabilization of neurotensin analogues: effect on peptide catabolism, biodistribution and tumor binding.

  Nuclear medicine and biology 20020401

• Protein phosphatase type 1 regulates ion homeostasis in Saccharomyces cerevisiae.

  Genetics 20020401

• Na+-independent transporters, LAT-2 and b0,+, exchange L-DOPA with neutral and basic amino acids in two clonal renal cell lines.

  The Journal of membrane biology 20020315

• Aortic leucine-to-glutamate pathway: metabolic route and regulation of contractile responses.

  American journal of physiology. Heart and circulatory physiology 20020301

• Stimulation of lipid peroxidation in vitro in rat brain by the metabolites accumulating in maple syrup urine disease.

  Metabolic brain disease 20020301

• Effects of cytochalasin B and D upon insulin release and pancreatic islet cell metabolism.

  International journal of molecular medicine 20020201

• Oral administration of leucine stimulates phosphorylation of 4E-bP1 and S6K 1 in skeletal muscle but not in liver of diabetic rats.

  Journal of nutritional science and vitaminology 20020201

• Exploring the interest of 1,2-dithiolane ring system in peptide chemistry. Synthesis of a chemotactic tripeptide and x-ray crystal structure of a 4-amino-1,2-dithiolane-4-carboxylic acid derivative.

  Bioorganic & medicinal chemistry 20020101

• Two-way arginine transport in human endothelial cells: TNF-alpha stimulation is restricted to system y(+).

  American journal of physiology. Cell physiology 20020101

• β-Adrenergics enhance brain extraction of levodopa.

  Movement disorders : official journal of the Movement Disorder Society 20020101

• Effects of leucine supplemented diet on intestinal absorption in tumor bearing pregnant rats.

  BMC cancer 20020101

• Structure of the Lrp-regulated serA promoter of Escherichia coli K-12.

  Molecular microbiology 20020101

• Cellular mechanism underlying LPS-induced inhibition of in vitro L-leucine transport across rabbit jejunum.

  Journal of endotoxin research 20020101

• Synthesis and asymmetric reducing performance of chitin/dihydronicotinamide conjugates having glycine or L-leucine spacer arms.

  Biomacromolecules 20020101

• The administration of lipopolysaccharide, in vivo, induces alteration in L-leucine intestinal absorption.

  Life sciences 20011228

• Myc/Max/Mad regulate the frequency but not the duration of productive cell cycles.

  EMBO reports 20011215

• Regulation of human glutamate dehydrogenases: implications for glutamate, ammonia and energy metabolism in brain.

  Journal of neuroscience research 20011201

• Determination of free D-proline and D-leucine in the brains of mutant mice lacking D-amino acid oxidase activity.

  Analytical biochemistry 20011115

• Analysis of conformationally restricted alpha-ketoglutarate analogues as substrates of dehydrogenases and aminotransferases.

  Analytical biochemistry 20011115

• Chiral analysis of amino acids using electrochemical composite bienzyme biosensors.

  Analytical biochemistry 20011115

• Conversion of a glutamate dehydrogenase into methionine/norleucine dehydrogenase by site-directed mutagenesis.

  European journal of biochemistry 20011101

• Comparison of vaginal aminopeptidase enzymatic activities in various animals and in humans.

  The Journal of pharmacy and pharmacology 20011101

• Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines.

  Biochimica et biophysica acta 20011001

• Leucine transport in membrane vesicles from Chironomus riparius larvae displays a mélange of crown-group features.

  Archives of insect biochemistry and physiology 20011001

• System y+L-like activities account for high and low amino-acid transport phenotypes in chicken erythrocytes.

  The Journal of membrane biology 20011001

• Possible involvement of amino acid transporters on S-nitroso-cysteine-induced inhibition of arachidonic acid release in PC12 cells.

  Neuroscience letters 20010928

• Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation.

  The Biochemical journal 20010915

• Amino acid supplementation affects hematological and biochemical parameters in elite rugby players.

  Bioscience, biotechnology, and biochemistry 20010901

• Effects of ADP on different inhibitory properties of brain glutamate dehydrogenase isoproteins by perphenazine.

  Biochimie 20010901

• The stability constants of copper(II) complexes with some alpha-amino acids in dioxan-water mixtures.

  Analytical biochemistry 20010815

• Synthesis of natural flutimide and analogous fully substituted pyrazine-2,6-diones, endonuclease inhibitors of influenza virus.

  The Journal of organic chemistry 20010810

• Psychrophilic valine dehydrogenase of the antarctic psychrophile, Cytophaga sp. KUC-1: purification, molecular characterization and expression.

  European journal of biochemistry 20010801

• Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome.

  The Journal of clinical endocrinology and metabolism 20010801

• Production of pyridoxal phosphate by a mutant strain of Schizosaccharomyces pombe.

  Bioscience, biotechnology, and biochemistry 20010801

• Time course of leucine-induced 4E-BP1 and S6K1 phosphorylation in the liver and skeletal muscle of rats.

  Journal of nutritional science and vitaminology 20010801

• Comparison of monomeric and polymeric amino acid based surfactants for chiral separations.

  Journal of chromatography. A 20010713

• Influence of neutral cyclodextrin concentration on plate numbers in capillary electrophoresis.

  Electrophoresis 20010601

• Synthesis and characterization of N,N-dichlorinated amino acids: taurine, homotaurine, GABA and L-leucine.

  Neurochemical research 20010601

• Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.

  The Journal of biological chemistry 20010518

• Reduction of large neutral amino acid levels in plasma and brain of hyperleucinemic rats.

  Neurochemistry international 20010501

• Whole-body L-leucine oxidation in patients with variant form of maple syrup urine disease.

  Pediatric research 20010501

• Effect of lipopolysaccharide on small intestinal L-leucine transport in rabbit.

  Digestive diseases and sciences 20010501

• L-leucine transport in rat heart under normal conditions and effects of a simulated hypoxia.

  Molecular and cellular biochemistry 20010501

• Characterisation of L-tryptophan transporters in human placenta: a comparison of brush border and basal membrane vesicles.

  The Journal of physiology 20010301

• Effect of a leucine-supplemented diet on body composition changes in pregnant rats bearing Walker 256 tumor.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20010301

• [Enantioseparation of twelve pharmaceutical racemates with high performance capillary electrophoresis using L-leucine as chiral selector].

  Se pu = Chinese journal of chromatography 20010301

• Fragmentary form of thermostable leucine dehydrogenase of Bacillus stearothermophilus: its construction and reconstitution of active fragmentary enzyme.

  Biochemical and biophysical research communications 20010202

• Molecular characterization of L-amino acid oxidase from Agkistrodon halys blomhoffii with special reference to platelet aggregation.

  Biochimica et biophysica acta 20010112

• Effects of vitamins on hepatic nuclear binding of L-tryptophan.

  Amino acids 20010101