328-90-5 | 2-Hydroxy-4-(trifluoromethyl)benzoic acid

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$6.00	$4.00
10g	97%	in stock	$8.00	$6.00
25g	97%	in stock	$11.00	$8.00
100g	97%	in stock	$37.00	$26.00
500g	97%	in stock	$159.00	$111.00

Description

• Catalog Number: AD50501
• Chemical Name: 2-Hydroxy-4-(trifluoromethyl)benzoic acid
• CAS Number: 328-90-5
• Molecular Formula: C8H5F3O3
• Molecular Weight: 206.11870960000002
• MDL Number: MFCD01529657
• SMILES: OC(=O)c1ccc(cc1O)C(F)(F)F

Computed Properties

• Complexity: 226
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 3.5

Literature

• A phase I study to characterize the multiple-dose pharmacokinetics, pharmacodynamics and safety of new enteric-coated triflusal formulations in healthy male volunteers.

  Expert opinion on drug metabolism & toxicology 20111201

• Comparative effects of triflusal, S-adenosylmethionine, and dextromethorphan over intestinal ischemia/reperfusion injury.

  TheScientificWorldJournal 20110101

• Electrochemical behavior of triflusal, aspirin and their metabolites at glassy carbon and boron doped diamond electrodes.

  Combinatorial chemistry & high throughput screening 20100801

• Eicosanoids in the innate immune response: TLR and non-TLR routes.

  Mediators of inflammation 20100101

• Photonucleophilic addition of the epsilon-amino group of lysine to a triflusal metabolite as a mechanistic key to photoallergy mediated by the parent drug.

  ChemMedChem 20090701

• Protective effects of triflusal on secondary thrombus growth and vascular cyclooxygenase-2.

  Journal of thrombosis and haemostasis : JTH 20080801

• Salicylates increase insulin secretion in healthy obese subjects.

  The Journal of clinical endocrinology and metabolism 20080701

• Spectroscopic and chromatographic characterization of triflusal delivery systems prepared by using supercritical impregnation technologies.

  Journal of pharmaceutical and biomedical analysis 20080213

• A randomized, double-blind, placebo controlled-trial of triflusal in mild cognitive impairment: the TRIMCI study.

  Alzheimer disease and associated disorders 20080101

• The study of the influence of surfactant charge on alkaline hydrolysis reactions of acetylsalicylic acid (ASA) and triflusal (TFL) using spectrophotometric methods.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070701

• Inhibition of cardiac hypertrophy by triflusal (4-trifluoromethyl derivative of salicylate) and its active metabolite.

  Molecular pharmacology 20060401

• Access of HTB, main metabolite of triflusal, to cerebrospinal fluid in healthy volunteers.

  European journal of clinical pharmacology 20050401

• Protective effect of triflusal and its main metabolite HTB in an in vitro model of anoxia-reoxygenation in rat brain slices: comparison with acetylsalicylic and salicylic acids.

  Naunyn-Schmiedeberg's archives of pharmacology 20050101

• Simultaneous determination of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in rat and human plasma by high-performance liquid chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031225

• Activation of monocytic cells through Fc gamma receptors induces the expression of macrophage-inflammatory protein (MIP)-1 alpha, MIP-1 beta, and RANTES.

  Journal of immunology (Baltimore, Md. : 1950) 20020915

• Effects of the nuclear factor-kappaB inhibitors 2-hydroxy-4-trifluoromethylbenzoic acid and aspirin on micturition in rats with normal and inflamed bladder.

  The Journal of urology 20011101

• Photochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensitizing platelet antiaggregant drug triflusal.

  Photochemistry and photobiology 20010501

• Inhibition of cyclooxygenase-2 expression by 4-trifluoromethyl derivatives of salicylate, triflusal, and its deacetylated metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid.

  Molecular pharmacology 19990401