3295-64-5 | 1,2,3,4-Tetrahydroacridine

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$47.00	$33.00
1g	97%	in stock	$123.00	$87.00
25g	97%	in stock	$2,345.00	$1,642.00

Description

• Catalog Number: AF85586
• Chemical Name: 1,2,3,4-Tetrahydroacridine
• CAS Number: 3295-64-5
• Molecular Formula: C13H13N
• Molecular Weight: 183.249
• MDL Number: MFCD00972211
• SMILES: C1CCc2c(C1)nc1c(c2)cccc1

Computed Properties

• Complexity: 201
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 1
• XLogP3: 3.4

Literature

• A hydrazide linker strategy for heterobivalent compounds as ortho- and allosteric ligands of acetylcholine-binding proteins.

  Current topics in medicinal chemistry 20111101

• Hybrids of oxoisoaporphine-tacrine congeners: novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors.

  European journal of medicinal chemistry 20111001

• Synthesis, biological activity and HPLC validation of 1,2,3,4-tetrahydroacridine derivatives as acetylcholinesterase inhibitors.

  European journal of medicinal chemistry 20110801

• Synthesis and biological activity of derivatives of tetrahydroacridine as acetylcholinesterase inhibitors.

  Bioorganic chemistry 20110801

• Anti-prion activities and drug-like potential of functionalized quinacrine analogs with basic phenyl residues at the 9-amino position.

  European journal of medicinal chemistry 20110701

• Discovery of potent nucleotide-mimicking competitive inhibitors of hepatitis C virus NS3 helicase.

  Bioorganic & medicinal chemistry letters 20110501

• A randomized controlled trail comparing the efficacy of 0.5% centbucridine to 2% lignocaine as local anesthetics in dental extractions.

  International journal of dentistry 20110101

• Synthesis and AChE inhibitory activity of new chiral tetrahydroacridine analogues from terpenic cyclanones.

  European journal of medicinal chemistry 20100201

• Multiple modes for coordination of phenazine to molybdenum: ring fusion promotes access to eta4-coordination, oxidative addition of dihydrogen and hydrogenation of aromatic nitrogen compounds.

  Journal of the American Chemical Society 20090610

• Tetrahydroacridine inhibits voltage-dependent Na(+) current in guinea-pig ventricular myocytes.

  Acta pharmacologica Sinica 20040901

• Prazosin-related compounds. Effect of transforming the piperazinylquinazoline moiety into an aminomethyltetrahydroacridine system on the affinity for alpha1-adrenoreceptors.

  Journal of medicinal chemistry 20031106

• EDT, a tetrahydroacridine derivative inhibits cerebral ischemia and protects rat cortical neurons against glutamate-induced cytotoxicity.

  Acta pharmacologica Sinica 20030501