32981-86-5 | 10-Deacetylbaccatin iii

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$12.00	$8.00
250mg	98%	in stock	$18.00	$12.00
500mg	98%	in stock	$30.00	$21.00
1g	98%	in stock	$55.00	$38.00
5g	98%	in stock	$209.00	$146.00

Description

• Catalog Number: AB53114
• Chemical Name: 10-Deacetylbaccatin iii
• CAS Number: 32981-86-5
• Molecular Formula: C29H36O10
• Molecular Weight: 544.5901
• MDL Number: MFCD09027979
• SMILES: CC(=O)O[C@@]12CO[C@@H]1C[C@@H]([C@@]1([C@@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](O)C(=C(C2(C)C)[C@H](C1=O)O)C)C)O

Computed Properties

• Complexity: 1090
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 9
• Heavy Atom Count: 39
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 5
• XLogP3: 0.6

Literature

• Isolation and characterization of Stemphylium sedicola SBU-16 as a new endophytic taxol-producing fungus from Taxus baccata grown in Iran.

  FEMS microbiology letters 20120301

• Fatal poisoning with Taxus baccata: quantification of paclitaxel (taxol A), 10-deacetyltaxol, baccatin III, 10-deacetylbaccatin III, cephalomannine (taxol B), and 3,5-dimethoxyphenol in body fluids by liquid chromatography-tandem mass spectrometry.

  Journal of analytical toxicology 20120101

• The relationship between TXS, DBAT, BAPT and DBTNBT gene expression and taxane production during the development of Taxus baccata plantlets.

  Plant science : an international journal of experimental plant biology 20110901

• [High performance liquid chromatographic fingerprints method for the analysis of chloroform extracts of Taxus wallichiana].

  Se pu = Chinese journal of chromatography 20101101

• Enhancement of taxane production in hairy root culture of Taxus x media var. Hicksii.

  Journal of plant physiology 20091115

• Anomalous microbial transformations on the taxane ring of 10-DAB by a strain of the fungus Curvularia lunata: transbenzoylation, transacetylation, and opening of the oxetane ring.

  Journal of natural products 20091101

• Production, purification and characterization of taxol and 10DAB III from a new endophytic fungus Gliocladium sp. isolated from the Indian yew tree, Taxus baccata.

  Journal of microbiology and biotechnology 20091101

• Preparative separation and enrichment of four taxoids from Taxus chinensis needles extracts by macroporous resin column chromatography.

  Journal of separation science 20090501

• Taxol and 10-deacetylbaccatinIII induce distinct changes in the dynamics of caveolae.

  FEBS letters 20081029

• Degradation of paclitaxel and related compounds in aqueous solutions II: Nonepimerization degradation under neutral to basic pH conditions.

  Journal of pharmaceutical sciences 20080801

• Separation of 7-xylosyl-10-deacetyl paclitaxel and 10-deacetylbaccatin III from the remainder extracts free of paclitaxel using macroporous resins.

  Journal of chromatography. A 20080104

• Taxanes from Shells and Leaves of Corylus avellana.

  Journal of natural products 20080101

• Microbial transformation of cephalomannine by Luteibacter sp.

  Journal of natural products 20071201

• In vitro activity of 10-deacetylbaccatin III against Leishmania donovani promastigotes and intracellular amastigotes.

  Planta medica 20070801

• Molecular cloning and heterologous expression of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus x media.

  Molecular biology reports 20070601

• Structure-activity relationships of some taxoids as multidrug resistance modulator.

  Bioorganic & medicinal chemistry letters 20070215

• Expression of an acetyl-CoA synthase and a CoA-transferase in Escherichia coli to produce modified taxanes in vivo.

  Biotechnology journal 20070201

• Enzymatic C-4 deacetylation of 10-deacetylbaccatin III.

  Biotechnology and applied biochemistry 20060901

• Rapid separation of four main taxoids in Taxus species by a combined LLP-SPE-HPLC (PAD) procedure.

  Journal of separation science 20060601

• [The extraction and separation of an active and available component from Taxus mairei].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060401

• Profiling a Taxol pathway 10beta-acetyltransferase: assessment of the specificity and the production of baccatin III by in vivo acetylation in E. coli.

  Chemistry & biology 20060301

• Conversion of taxane glycosides to 10-deacetylbaccatin III.

  Natural product research 20060201

• Taxane production in suspension culture of Taxus x media var. Hicksii carried out in flasks and bioreactor.

  Biotechnology letters 20050901

• Cytotoxic, antiviral (in-vitro and in-vivo), immunomodulatory activity and influence on mitotic divisions of three taxol derivatives: 10-deacetyl-baccatin III, methyl (N-benzoyl-(2'R,3'S)-3'-phenylisoserinate) and N-benzoyl-(2'R,3'S)-3'-phenylisoserine.

  The Journal of pharmacy and pharmacology 20050601

• Three new taxane diterpenoids from Taxus sumatrana.

  Journal of natural products 20050101

• Expression cloned cDNA for 10-deacetylbaccatin III-10-O-acetyltransferase in Escherichia coli: a comparative study of three fusion systems.

  Protein expression and purification 20040501

• Diastereoselective 14beta-hydroxylation of baccatin III derivatives.

  The Journal of organic chemistry 20031212

• Substrate specificity for the hydroxylation of polyoxygenated 4(20),11-taxadienes by Ginkgo cell suspension cultures.

  Bioorganic chemistry 20030801

• 13C NMR investigation of solid-state polymorphism in 10-deacetyl baccatin III.

  Journal of the American Chemical Society 20020904

• Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship.

  Drug metabolism and disposition: the biological fate of chemicals 20020401

• Production of taxoids with biological activity by plants and callus culture from selected Taxus genotypes.

  Phytochemistry 20020401

• Immunoaffinity chromatography for the sample pretreatment of Taxus plant and cell extracts prior to analysis of taxanes by high-performance liquid chromatography.

  Journal of chromatography. A 20020301

• Solid-phase extraction and simplified high-performance liquid chromatographic determination of 10-deacetylbaccatin III and related taxoids in yew species.

  Journal of pharmaceutical and biomedical analysis 20010801