330161-87-0 | SU 6656

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$33.00	$23.00
5mg	95%	in stock	$121.00	$85.00
10mg	95%	in stock	$225.00	$158.00
25mg	95%	in stock	$362.00	$253.00

Description

• Catalog Number: AF60859
• Chemical Name: SU 6656
• CAS Number: 330161-87-0
• Molecular Formula: C19H21N3O3S
• Molecular Weight: 371.4533
• MDL Number: MFCD10565928
• SMILES: O=C1Nc2c(C1=Cc1cc3c([nH]1)CCCC3)cc(cc2)S(=O)(=O)N(C)C

Computed Properties

• Complexity: 697
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 2.1

Literature

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

  The Biochemical journal 20130415

• Hepatocytes display a compensatory survival response against cadmium toxicity by a mechanism mediated by EGFR and Src.

  Toxicology in vitro : an international journal published in association with BIBRA 20130401

• A small molecule inhibitor of SRC family kinases promotes simple epithelial differentiation of human pluripotent stem cells.

  PloS one 20130101

• Novel oxazolo[4,5-g]quinazolin-2(1H)-ones: dual inhibitors of EGFR and Src protein tyrosine kinases.

  European journal of medicinal chemistry 20120901

• Src family tyrosine kinase regulates acrosome reaction but not motility in porcine spermatozoa.

  Reproduction (Cambridge, England) 20120701

• Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells.

  Cellular signalling 20120601

• Apoptosis induced by SRC-family tyrosine kinase inhibitors in cultured rat cortical cells.

  Neurotoxicity research 20120401

• SU-6656, a selective Src kinase inhibitor, attenuates mecamylamine-precipitated nicotine withdrawal syndrome in mice.

  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20120401

• Differential effects on cell motility, embryonic stem cell self-renewal and senescence by diverse Src kinase family inhibitors.

  Experimental cell research 20120215

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• Plasticity of synaptic GluN receptors is required for the Src-dependent induction of long-term potentiation at CA3-CA1 synapses.

  Hippocampus 20111001

• Virtual screening and further development of novel ALK inhibitors.

  Bioorganic & medicinal chemistry 20110515

• The Src family kinase inhibitors PP2 and PP1 block TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors.

  Current cancer drug targets 20110501

• Caspase-3-dependent mitotic checkpoint inactivation by the small-molecule inducers of mitotic slippage SU6656 and geraldol.

  Molecular cancer therapeutics 20110501

• c-Yes regulates cell adhesion at the blood-testis barrier and the apical ectoplasmic specialization in the seminiferous epithelium of rat testes.

  The international journal of biochemistry & cell biology 20110401

• Modulation of src-kinase attenuates naloxone-precipitated opioid withdrawal syndrome in mice.

  Behavioural pharmacology 20110401

• c-Src in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats.

  Pflugers Archiv : European journal of physiology 20110401

• An image-based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cells.

  Molecular cancer research : MCR 20110301

• Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor.

  Oncogene 20110113

• Characterization of tyrosine kinase and screening enzyme inhibitor by capillary electrophoresis with laser-induced fluoresce detector.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110101

• Adaptor protein Shc acts as an immune-regulator for the LPS-stimulated maturation of bone marrow-derived dendritic cells.

  BMC immunology 20110101

• Ouabain stimulates a Na+/K+-ATPase-mediated SFK-activated signalling pathway that regulates tight junction function in the mouse blastocyst.

  PloS one 20110101

• Involvement of Src family kinase activation in angiotensin II-induced hyperresponsiveness of rat bronchial smooth muscle.

  Peptides 20101201

• Human remyelination promoting antibody inhibits apoptotic signaling and differentiation through Lyn kinase in primary rat oligodendrocytes.

  Glia 20101115

• Native low-density lipoprotein uptake by macrophage colony-stimulating factor-differentiated human macrophages is mediated by macropinocytosis and micropinocytosis.

  Arteriosclerosis, thrombosis, and vascular biology 20101001

• Src-dependent phosphorylation of ROCK participates in regulation of focal adhesion dynamics.

  Journal of cell science 20101001

• The involvement of Fyn kinase in resumption of the first meiotic division in mouse oocytes.

  Cell cycle (Georgetown, Tex.) 20100415

• Comprehensive screening of human genes with inhibitory effects on yeast growth and validation of a yeast cell-based system for screening chemicals.

  Journal of biomolecular screening 20100401

• Inhibition of Ser/Thr phosphatases induces capacitation-associated signaling in the presence of Src kinase inhibitors.

  The Journal of biological chemistry 20100312

• Colony stimulating factor-1 receptor as a target for small molecule inhibitors.

  Bioorganic & medicinal chemistry 20100301

• Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors.

  Bioorganic & medicinal chemistry 20100215

• Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1.

  Cell metabolism 20100203

• Apoptosis induction in BEFV-infected Vero and MDBK cells through Src-dependent JNK activation regulates caspase-3 and mitochondria pathways.

  Veterinary research 20100101

• Bacillus anthracis spore entry into epithelial cells is an actin-dependent process requiring c-Src and PI3K.

  PloS one 20100101

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• Phosphate-affinity electrophoresis on a microchip for determination of protein kinase activity.

  Electrophoresis 20091001

• Effects of chemical manipulation of mitotic arrest and slippage on cancer cell survival and proliferation.

  Cell cycle (Georgetown, Tex.) 20090915

• Enhanced ex vivo expansion of human adipose tissue-derived mesenchymal stromal cells by fibroblast growth factor-2 and dexamethasone.

  Tissue engineering. Part A 20090901

• Inhibition of imatinib-mediated apoptosis by the caspase-cleaved form of the tyrosine kinase Lyn in chronic myelogenous leukemia cells.

  Leukemia 20090801

• Superoxide constricts rat pulmonary arteries via Rho-kinase-mediated Ca(2+) sensitization.

  Free radical biology & medicine 20090301

• Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling.

  Toxicology and applied pharmacology 20090301

• Role of nonreceptor protein tyrosine kinases during phospholipase C-gamma 1-related uterine contractions in the rat.

  Reproductive sciences (Thousand Oaks, Calif.) 20090301

• FAK activation and the role of epithelial membrane protein 2 (EMP2) in collagen gel contraction.

  Investigative ophthalmology & visual science 20090101

• Characterization of STAT3 activation and expression in canine and human osteosarcoma.

  BMC cancer 20090101

• Non-receptor tyrosine kinase Src is required for ischemia-stimulated neuronal cell proliferation via Raf/ERK/CREB activation in the dentate gyrus.

  BMC neuroscience 20090101

• Role of src-family kinases in hypoxic vasoconstriction of rat pulmonary artery.

  Cardiovascular research 20081201

• Src activation triggers capacitation and acrosome reaction but not motility in human spermatozoa.

  Human reproduction (Oxford, England) 20081201

• Cell cycle-dependent regulation of SFK, JAK1 and STAT3 signalling by the protein tyrosine phosphatase TCPTP.

  Cell cycle (Georgetown, Tex.) 20081101

• Dual acylation and lipid raft association of Src-family protein tyrosine kinases are required for SDF-1/CXCL12-mediated chemotaxis in the Jurkat human T cell lymphoma cell line.

  Journal of leukocyte biology 20081001

• Intracellular tyrosine kinases as novel targets for anti-fibrotic therapy in systemic sclerosis.

  Rheumatology (Oxford, England) 20081001

• A genomic approach to identify molecular pathways associated with chemotherapy resistance.

  Molecular cancer therapeutics 20081001

• Molecular mechanism underlying the association of Coronin-7 with Golgi membranes.

  Cellular and molecular life sciences : CMLS 20080801

• TGFbeta-induced RhoA activation and fibronectin production in mesangial cells require caveolae.

  American journal of physiology. Renal physiology 20080701

• Regulation of mTORC1 signaling by Src kinase activity is Akt1-independent in RSV-transformed cells.

  Neoplasia (New York, N.Y.) 20080201

• Cdk5 regulates the phosphorylation of tyrosine 1472 NR2B and the surface expression of NMDA receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080109

• Effects of inhibitor of Src kinases, SU6656, on differentiation of megakaryocytic progenitors and activity of alpha1,6-fucosyltransferase.

  Acta biochimica Polonica 20080101

• [Src kinases in the process of maturation megakryocyte progenitors].

  Postepy biochemii 20080101

• A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

  Proceedings of the National Academy of Sciences of the United States of America 20071218

• The selectivity of protein kinase inhibitors: a further update.

  The Biochemical journal 20071215

• Mechanisms of integrin-vascular endothelial growth factor receptor cross-activation in angiogenesis.

  Circulation research 20070914

• ERK-dependent and -independent pathways trigger human neural progenitor cell migration.

  Toxicology and applied pharmacology 20070515

• Preferential phosphorylation of focal adhesion kinase tyrosine 861 is critical for mediating an anti-apoptotic response to hyperosmotic stress.

  The Journal of biological chemistry 20070406

• Cellular transformation and activation of the phosphoinositide-3-kinase-Akt cascade by the ETV6-NTRK3 chimeric tyrosine kinase requires c-Src.

  Cancer research 20070401

• Inhibition of Src family tyrosine kinases prevents lipopolysaccharide-induced hyporeactivity in isolated rat tail arteries.

  Vascular pharmacology 20070301

• Human B lymphocytes and non-Hodgkin's lymphoma cells become polyploid in response to the protein kinase inhibitor SU6656.

  Blood cells, molecules & diseases 20070101

• Avian reovirus activates a novel proapoptotic signal by linking Src to p53.

  Apoptosis : an international journal on programmed cell death 20061201

• Nitric oxide produced in response to engagement of beta2 integrins on human neutrophils activates the monomeric GTPases Rap1 and Rap2 and promotes adhesion.

  The Journal of biological chemistry 20061117

• Tyrosine phosphorylation of p145met mediated by EGFR and Src is required for serum-independent survival of human bladder carcinoma cells.

  Journal of cell science 20061115

• Involvement of the STAT5 signaling pathway in the regulation of mouse preimplantation development.

  Biology of reproduction 20061001

• Regulation of androgen receptor activity by tyrosine phosphorylation.

  Cancer cell 20061001

• Identification of SRC as a key PKA-stimulated tyrosine kinase involved in the capacitation-associated hyperactivation of murine spermatozoa.

  Journal of cell science 20060801

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• SRC family kinase inhibitor SU6656 enhances antiangiogenic effect of irradiation.

  International journal of radiation oncology, biology, physics 20060315

• Effects of tyrosine phosphorylation of cortactin on podosome formation in A7r5 vascular smooth muscle cells.

  American journal of physiology. Cell physiology 20060201

• B cell proliferation following CD40 stimulation results in the expression and activation of Src protein tyrosine kinase.

  International immunology 20060201

• Src activation is not necessary for transforming growth factor (TGF)-beta-mediated epithelial to mesenchymal transitions (EMT) in mammary epithelial cells. PP1 directly inhibits TGF-beta receptors I and II.

  The Journal of biological chemistry 20060106

• Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor.

  British journal of haematology 20050701

• Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injury.

  American journal of respiratory and critical care medicine 20050415

• Ephrin-A1 binding to CD4+ T lymphocytes stimulates migration and induces tyrosine phosphorylation of PYK2.

  Blood 20050401

• Src family kinase inhibitors block amphiregulin-mediated autocrine ErbB signaling in normal human keratinocytes.

  Molecular pharmacology 20050401

• Platelet-derived growth factor stimulates Src-dependent mRNA stabilization of specific early genes in fibroblasts.

  The Journal of biological chemistry 20050318

• The Src kinase pathway promotes tamoxifen agonist action in Ishikawa endometrial cells through phosphorylation-dependent stabilization of estrogen receptor (alpha) promoter interaction and elevated steroid receptor coactivator 1 activity.

  Molecular endocrinology (Baltimore, Md.) 20050301

• Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis.

  The Journal of clinical investigation 20050201

• A novel strategy for generating platelet-like fragments from megakaryocytic cell lines and human progenitor cells.

  Blood cells, molecules & diseases 20050101

• Tyrosine phosphatase epsilonM stimulates migration and survival of porcine aortic endothelial cells by activating c-Src.

  Biochemical and biophysical research communications 20041203

• FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity.

  Journal of cell science 20041201

• Roles of mitogen activated protein kinases and EGF receptor in arsenite-stimulated matrix metalloproteinase-9 production.

  Toxicology and applied pharmacology 20041101

• The Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95.

  The Journal of biological chemistry 20040604

• Menstrual effluent induces epithelial-mesenchymal transitions in mesothelial cells.

  Human reproduction (Oxford, England) 20040101

• Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.

  The Journal of biological chemistry 20030905

• The specificities of protein kinase inhibitors: an update.

  The Biochemical journal 20030401

• Src family kinases are involved in the differential signaling from two splice forms of c-Kit.

  The Journal of biological chemistry 20030314

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419