33332-28-4 | 2-Amino-6-chloropyrazine

Packsize	Purity	Availability	Price	Discounted Price
5g	95%	in stock	$10.00	$7.00
10g	95%	in stock	$12.00	$8.00
25g	95%	in stock	$22.00	$15.00
100g	95%	in stock	$82.00	$57.00

Description

• Catalog Number: AB43968
• Chemical Name: 2-Amino-6-chloropyrazine
• CAS Number: 33332-28-4
• Molecular Formula: C4H4ClN3
• Molecular Weight: 129.5477
• MDL Number: MFCD00055024
• SMILES: Nc1cncc(n1)Cl

Computed Properties

• Complexity: 77.7
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• XLogP3: 0.9

Upstream Synthesis Route

2-Chloro-6-Aminopyrazine is a versatile compound commonly utilized in chemical synthesis as a key building block. This compound is particularly valuable in the pharmaceutical industry, where it can be used as an intermediate for the synthesis of various biologically active compounds. Its unique structure allows for the introduction of functional groups at multiple positions, making it a valuable tool for medicinal chemists working on drug discovery projects. Additionally, 2-Chloro-6-Aminopyrazine can serve as a precursor for the preparation of heterocyclic compounds with diverse pharmacological properties. Its reactivity and versatility make it an essential reagent for researchers and synthetic chemists looking to design and develop new chemical entities with potential therapeutic applications.

Literature

• Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing.

  Journal of medicinal chemistry 20111222

• Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.

  Journal of medicinal chemistry 20080828

• Fragment-based lead discovery using X-ray crystallography.

  Journal of medicinal chemistry 20050127