-
Enhanced NADPH oxidases and reactive oxygen species in the mechanism of methanol-initiated protein oxidation and embryopathies in vivo and in embryo culture.
Archives of toxicology 20160301
-
Deficient DNA repair exacerbates ethanol-initiated DNA oxidation and embryopathies in ogg1 knockout mice: gender risk and protection by a free radical spin trapping agent.
Archives of toxicology 20160201
-
Complement component 3 inhibition by an antioxidant is neuroprotective after cerebral ischemia and reperfusion in mice.
Journal of neurochemistry 20130201
-
Reactive oxygen species (ROS) modulate AMPA receptor phosphorylation and cell-surface localization in concert with pain-related behavior.
Pain 20120901
-
Inhibition of ROS-induced apoptosis in endothelial cells by nitrone spin traps via induction of phase II enzymes and suppression of mitochondria-dependent pro-apoptotic signaling.
Biochemical pharmacology 20120815
-
2-Benzazepine nitrones protect dopaminergic neurons against 6-hydroxydopamine-induced oxidative toxicity.
Archiv der Pharmazie 20120801
-
Synthesis of tris-hydroxymethyl-based nitrone derivatives with highly reactive nitronyl carbon.
The Journal of organic chemistry 20120120
-
Α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties.
Journal of medicinal chemistry 20120112
-
Up-regulation of NF-kB-sensitive miRNA-125b and miRNA-146a in metal sulfate-stressed human astroglial (HAG) primary cell cultures.
Journal of inorganic biochemistry 20111101
-
Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity.
The Journal of biological chemistry 20110916
-
Alpha-phenyl-N-tert-butylnitrone prevents oxidative stress in a haloperidol-induced animal model of tardive dyskinesia: investigating the behavioural and biochemical changes.
Brain research 20110915
-
Na-K-Cl cotransporter-1 in the mechanism of cell swelling in cultured astrocytes after fluid percussion injury.
Journal of neurochemistry 20110501
-
Anti-cancer activity of nitrones and observations on mechanism of action.
Anti-cancer agents in medicinal chemistry 20110501
-
Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release.
Pain 20110401
-
The effect of normoxia and hypoxia on a prostate (PC-3) CD44/CD41 cell side fraction.
Anticancer research 20110201
-
Synthesis, structure, theoretical and experimental in vitro antioxidant/pharmacological properties of α-aryl, N-alkyl nitrones, as potential agents for the treatment of cerebral ischemia.
Bioorganic & medicinal chemistry 20110115
-
Global inhibition of reactive oxygen species (ROS) inhibits paclitaxel-induced painful peripheral neuropathy.
PloS one 20110101
-
Cholesterol-based α-phenyl-N-tert-butyl nitrone derivatives as antioxidants against light-induced retinal degeneration.
Bioorganic & medicinal chemistry letters 20101215
-
Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice.
Neurobiology of aging 20101201
-
Determining radical penetration into membranes using ESR splitting constants.
Free radical biology & medicine 20100801
-
Sedentary aging increases resting and exercise-induced intramuscular free radical formation.
Journal of applied physiology (Bethesda, Md. : 1985) 20100801
-
Amphiphilic amide nitrones: a new class of protective agents acting as modifiers of mitochondrial metabolism.
Journal of medicinal chemistry 20100708
-
Interleukin-1beta-induced brain injury and neurobehavioral dysfunctions in juvenile rats can be attenuated by alpha-phenyl-n-tert-butyl-nitrone.
Neuroscience 20100616
-
Using cyclodextrins to encapsulate oxygen-centered and carbon-centered radical adducts: the case of DMPO, PBN, and MNP spin traps.
The journal of physical chemistry. A 20100603
-
Phenyl-alpha-tert-butyl-nitrone and benzonidazole treatment controlled the mitochondrial oxidative stress and evolution of cardiomyopathy in chronic chagasic Rats.
Journal of the American College of Cardiology 20100601
-
Decreased brainstem function following cardiac arrest and resuscitation in aged rat.
Brain research 20100430
-
Modulation of ethoxyquin genotoxicity by free radical scavengers and DNA damage repair in human lymphocytes.
Toxicology letters 20100315
-
Calicheamicin γ1(I) and phenyl tert-butyl nitrone (PBN): observation of a kinetic isotope effect by an ESR study.
Chemical communications (Cambridge, England) 20100207
-
Phenyl N-tert-butylnitrone, a free radical scavenger, reduces mechanical allodynia in chemotherapy-induced neuropathic pain in rats.
Anesthesiology 20100201
-
New heteroaryl nitrones with spin trap properties: Identification of a 4-furoxanyl derivative with excellent properties to be used in biological systems.
Bioorganic & medicinal chemistry 20100115
-
Involvement of reactive oxygen species in long-term potentiation in the spinal cord dorsal horn.
Journal of neurophysiology 20100101
-
Interleukin-1beta-induced brain injury in the neonatal rat can be ameliorated by alpha-phenyl-n-tert-butyl-nitrone.
Experimental neurology 20091101
-
Manganese inhibits the ability of astrocytes to promote neuronal differentiation.
Toxicology and applied pharmacology 20091015
-
Protection of DFP-induced oxidative damage and neurodegeneration by antioxidants and NMDA receptor antagonist.
Toxicology and applied pharmacology 20091015
-
Functional consequences of mitochondrial DNA deletions in human skin fibroblasts: increased contractile strength in collagen lattices is due to oxidative stress-induced lysyl oxidase activity.
The American journal of pathology 20090901
-
Preparation and evaluation of alpha-phenyl-n-tert-butyl nitrone (PBN)-encapsulated chitosan and PEGylated chitosan nanoparticles.
Die Pharmazie 20090701
-
The effect of exercise and oxidant-antioxidant intervention on the levels of neurotrophins and free radicals in spinal cord of rats.
Spinal cord 20090601
-
Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice.
Journal of neurochemistry 20090601
-
Serendipitous findings while researching oxygen free radicals.
Free radical biology & medicine 20090415
-
Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress.
Neurochemistry international 20090201
-
Persistent pain is dependent on spinal mitochondrial antioxidant levels.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20090107
-
Reactive oxygen species mediate TNFR1 increase after TRPV1 activation in mouse DRG neurons.
Molecular pain 20090101
-
Increased production of mitochondrial superoxide in the spinal cord induces pain behaviors in mice: the effect of mitochondrial electron transport complex inhibitors.
Neuroscience letters 20081205
-
Reactivity of superoxide radical anion and hydroperoxyl radical with alpha-phenyl-N-tert-butylnitrone (PBN) derivatives.
The journal of physical chemistry. A 20081204
-
Heteroarylnitrones as drugs for neurodegenerative diseases: synthesis, neuroprotective properties, and free radical scavenger properties.
Journal of medicinal chemistry 20081009
-
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice.
Aging cell 20081001
-
Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats.
Experimental biology and medicine (Maywood, N.J.) 20081001
-
Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke.
Bioorganic & medicinal chemistry 20081001
-
Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice.
Pain 20080915
-
Enhanced anodic Ru(bpy)3(2+) electrogenerated chemiluminescence by polyphenols.
Analytica chimica acta 20080905
-
Assessment of genotoxicity of methyl-tert-butyl ether, benzene, toluene, ethylbenzene, and xylene to human lymphocytes using comet assay.
Journal of hazardous materials 20080501
-
1Alpha,25-dihydroxyvitamin D3 attenuates cyanide-induced neurotoxicity by inhibiting uncoupling protein-2 up-regulation.
Journal of neuroscience research 20080501
-
Reactive oxygen species contribute to lipopolysaccharide-induced teratogenesis in mice.
Toxicological sciences : an official journal of the Society of Toxicology 20080501
-
Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla.
Free radical biology & medicine 20080501
-
Mechanistic studies of the reactions of nitrone spin trap PBN with glutathiyl radical.
The journal of physical chemistry. B 20080417
-
In vitro electron paramagnetic resonance characterization of free radicals: relevance to exercise-induced lipid peroxidation and implications of ascorbate prophylaxis.
Free radical research 20080401
-
Alpha-phenyl-n-tert-butyl-nitrone ameliorates hippocampal injury and improves learning and memory in juvenile rats following neonatal exposure to lipopolysaccharide.
The European journal of neuroscience 20080301
-
[Preparation of the spin trapping probe, N-tert-butyl-alpha-phenylnitrone, nanoparticle and its affinity to hepatoma cells].
Yao xue xue bao = Acta pharmaceutica Sinica 20080301
-
alpha-Phenyl-n-tert-butyl-nitrone reduces lipopolysaccharide-induced white matter injury in the neonatal rat brain.
Developmental neurobiology 20080215
-
Maternally administered lipopolysaccharide (LPS) upregulates the expression of heme oxygenase-1 in fetal liver: the role of reactive oxygen species.
Toxicology letters 20080215
-
Alpha-Phenyl-n-tert-butyl-nitrone attenuates lipopolysaccharide-induced neuronal injury in the neonatal rat brain.
Neuroscience 20080206
-
Metal sulfate-mediated induction of pathogenic genes and repression by phenyl butyl nitrone and Feralex-G.
Neuroreport 20080122
-
Phenyl-tert-butylnitrone induces tumor regression and decreases angiogenesis in a C6 rat glioma model.
Free radical biology & medicine 20080101
-
Pharmacological interventions to decompression sickness in rats: comparison of five agents.
Aviation, space, and environmental medicine 20080101
-
Mitochondrial dysfunction in aging rat brain following transient global ischemia.
Advances in experimental medicine and biology 20080101
-
The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons.
Pain 20071215
-
Synergism in the repression of COX-2- and TNFalpha-induction in platelet activating factor-stressed human neural cells.
Neuroscience letters 20071009
-
Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain.
Pain 20071001
-
Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices.
Anesthesiology 20071001
-
Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats.
Free radical research 20070901
-
Investigating the free radical trapping ability of NXY-059, S-PBN and PBN.
Free radical research 20070901
-
A new amphiphilic derivative, N-{[4-(lactobionamido)methyl]benzylidene}-1,1-dimethyl-2-(octylsulfanyl)ethylamine N-oxide, has a protective effect against copper-induced fulminant hepatitis in Long-Evans Cinnamon rats at an extremely low concentration compared with its original form alpha-phenyl-N-(tert-butyl) nitrone.
Chemistry & biodiversity 20070901
-
Fine-tuning the amphiphilicity: a crucial parameter in the design of potent alpha-phenyl-N-tert-butylnitrone analogues.
Journal of medicinal chemistry 20070823
-
An Aging Interventions Testing Program: study design and interim report.
Aging cell 20070801
-
Alpha-phenyl-N-tert-butyl nitrone (PBN) derivatives: synthesis and protective action against microvascular damages induced by ischemia/reperfusion.
Bioorganic & medicinal chemistry 20070515
-
Involvement of oxidants and AP-1 in angiotensin II-activated NFAT3 transcription factor.
American journal of physiology. Cell physiology 20070401
-
Aryl radical involvement in amiodarone-induced pulmonary toxicity: investigation of protection by spin-trapping nitrones.
Toxicology and applied pharmacology 20070401
-
Delayed loss of cone and remaining rod photoreceptor cells due to impairment of choroidal circulation after acute light exposure in rats.
Investigative ophthalmology & visual science 20070401
-
Release of secondary free radicals during post-ischaemic reperfusion is not influenced by extracellular calcium levels in isolated rat hearts.
Molecular and cellular biochemistry 20070301
-
Bioaccumulation and ROS generation in liver of Carassius auratus, exposed to phenanthrene.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070301
-
Electron paramagnetic spectroscopic evidence of exercise-induced free radical accumulation in human skeletal muscle.
Free radical research 20070201
-
Antioxidants attenuate MK-801-induced cortical neurotoxicity in the rat.
Neurotoxicology 20070101
-
Gene expression in enhanced apoptosis of human lymphoma U937 cells treated with the combination of different free radical generators and hyperthermia.
Free radical research 20070101
-
Increased sensitivity to transient global ischemia in aging rat brain.
Advances in experimental medicine and biology 20070101
-
Alpha-phenyl-N-tert-butylnitrone-type derivatives bound to beta-cyclodextrins: syntheses, thermokinetics of self-inclusion and application to superoxide spin-trapping.
Chemistry (Weinheim an der Bergstrasse, Germany) 20070101
-
Reactive oxygen species are involved in lipopolysaccharide-induced intrauterine growth restriction and skeletal development retardation in mice.
American journal of obstetrics and gynecology 20061201
-
Phenyl-alpha-tert-butyl nitrone reverses mitochondrial decay in acute Chagas' disease.
The American journal of pathology 20061201
-
Spin-trapping of the p-benzyne intermediates from ten-membered enediyne calicheamicin gamma1I.
Organic letters 20061123
-
Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice.
Behavioural brain research 20061016
-
Trimethyltin-induced apoptosis is associated with upregulation of inducible nitric oxide synthase and Bax in a hippocampal cell line.
Toxicology and applied pharmacology 20061001
-
Neuroprotection of alpha-phenyl-n-tert-butyl-nitrone on the neonatal white matter is associated with anti-inflammation.
Neuroscience letters 20060911
-
Ferritin levels in microglia depend upon activation: modulation by reactive oxygen species.
Biochimica et biophysica acta 20060801
-
Measurement of myocardial free radical production during exercise using EPR spectroscopy.
American journal of physiology. Heart and circulatory physiology 20060601
-
Alpha-tocopherol amplifies benzoyl peroxide free radical decomposition in a chemical system.
Free radical research 20060601
-
Fluorinated amphiphilic amino acid derivatives as antioxidant carriers: a new class of protective agents.
Journal of medicinal chemistry 20060504
-
High static pressure alters spin trapping rates in solution. Dependence on the structure of nitrone spin traps.
Organic & biomolecular chemistry 20060307
-
Effects of alpha-phenyl-N-tert-butyl nitrone and N-acetylcysteine on hydroxyl radical formation and dopamine depletion in the rat striatum produced by d-amphetamine.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060201
-
Enhancement of apoptosis by nitric oxide released from alpha-phenyl-tert-butyl nitrone under hyperthermic conditions.
Journal of cellular physiology 20060201
-
LPS-induced ROS generation and changes in glutathione level and their relation to the maturation of human monocyte-derived dendritic cells.
Life sciences 20060125
-
Differential nephron HO-1 expression following glomerular epithelial cell injury.
Nephron. Experimental nephrology 20060101
-
Comparison of neuroprotective effects induced by alpha-phenyl-N-tert-butyl nitrone (PBN) and N-tert-butyl-alpha-(2 sulfophenyl) nitrone (S-PBN) in lithium-pilocarpine status epilepticus.
Neurotoxicology 20051201
-
The effect of alpha-phenyl-N-t-butylnitrone on ionizing radiation-induced apoptosis in U937 cells.
Free radical research 20051201
-
Delay of photoreceptor cell degeneration in rd mice by systemically administered phenyl-N-tert-butylnitrone.
Korean journal of ophthalmology : KJO 20051201
-
Experimental treatment for focal hyperglycemic ischemic brain injury in the rat.
Experimental brain research 20051101
-
Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina.
Investigative ophthalmology & visual science 20051001
-
Electron paramagnetic resonance evidence of hydroxyl radical generation and oxidative damage induced by tetrabromobisphenol A in Carassius auratus.
Aquatic toxicology (Amsterdam, Netherlands) 20050930
-
Free radical generation during chemical depolymerization of heparin.
Analytical biochemistry 20050915
-
Perinatal lipopolysaccharide exposure downregulates pregnane X receptor and Cyp3a11 expression in fetal mouse liver.
Toxicological sciences : an official journal of the Society of Toxicology 20050901
-
Electron paramagnetic resonance investigation of in vivo free radical formation and oxidative stress induced by 2,4-dichlorophenol in the freshwater fish Carassius auratus.
Environmental toxicology and chemistry 20050901
-
Oxygen radicals photo-induced by ferric nitrilotriacetate complex.
Biochimica et biophysica acta 20050830
-
Antioxidant pool in beer and kinetics of EPR spin-trapping.
Journal of agricultural and food chemistry 20050824
-
Lipopolysaccharide treatment downregulates the expression of the pregnane X receptor, cyp3a11 and mdr1a genes in mouse placenta.
Toxicology 20050801
-
ESR spin trapping of a carbon-centered free radical from agonist-stimulated human platelets.
Free radical biology & medicine 20050715
-
Correlation of hippocampal morphological changes and morris water maze performance after cortical contusion injury in rats.
Neurosurgery 20050701
-
Nitrone derivatives of trolox as neuroprotective agents.
Bioorganic & medicinal chemistry letters 20050615
-
Study of the oxidative stress in a rat model of chronic brain hypoperfusion.
Neurochemistry international 20050601
-
Budesonide epimer R, LAU-8080 and phenyl butyl nitrone synergistically repress cyclooxygenase-2 induction in [IL-1beta+Abeta42]-stressed human neural cells.
Neuroscience letters 20050501
-
Donepezil, tacrine and alpha-phenyl-n-tert-butyl nitrone (PBN) inhibit choline transport by conditionally immortalized rat brain capillary endothelial cell lines (TR-BBB).
Archives of pharmacal research 20050401
-
Electron spin resonance spin trapping for analysis of lipid oxidation in oils: inhibiting effect of the spin trap alpha-phenyl-N-tert-butylnitrone on lipid oxidation.
Journal of agricultural and food chemistry 20050309
-
Analysis of gene expression in apoptosis of human lymphoma U937 cells induced by heat shock and the effects of alpha-phenyl N-tert-butylnitrone (PBN) and its derivatives.
Apoptosis : an international journal on programmed cell death 20050301
-
Nitric oxide produced by inducible nitric oxide synthase is associated with mammary tumorigenesis in irradiated rats.
Nitric oxide : biology and chemistry 20050201
-
Time course of oxidative stress, lesion and edema after intrastriatal injection of malonate in rat: effect of alpha-phenyl-N-tert-butylnitrone.
Fundamental & clinical pharmacology 20050201
-
Mechanism of protection from light-induced retinal degeneration by the synthetic antioxidant phenyl-N-tert-butylnitrone.
Investigative ophthalmology & visual science 20050201
-
Paradoxical increase in 3-nitropropionic acid neurotoxicity by alpha-phenyl-tert-butyl-nitrone, a spin-trapping agent.
Chang Gung medical journal 20050201
-
Alpha phenyl-tert-butyl nitrone (PBN) protects syngeneic marrow transplant recipients from the lethal cytokine syndrome occurring after agonistic CD40 antibody administration.
Blood 20050101
-
Effects of a free radical scavenger N-tert-butyl-alpha-phenylnitrone (PBN) on short-term recovery of immature rats after status epilepticus.
Physiological research 20050101
-
Vitamin E, aging and Leydig cell steroidogenesis.
Experimental gerontology 20050101
-
Electron spin resonance spectroscopy reveals alpha-phenyl-N-tert-butylnitrone spin-traps free radicals in rat striatum and prevents haloperidol-induced vacuous chewing movements in the rat model of human tardive dyskinesia.
Synapse (New York, N.Y.) 20041201
-
Genotoxicity of acrylamide in human lymphocytes.
Chemico-biological interactions 20041015
-
Electron spin resonance study of phosphorus-nitroxides from 1,3-additions of silicon-phosphorus reagents to nitrones.
Magnetic resonance in chemistry : MRC 20041001
-
Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain.
Pain 20040901
-
Effects of alpha-phenyl-N-tert-butyl nitrone (PBN)on brain cell membrane function and energy metabolism during transient global cerebral hypoxia-ischemia and reoxygenation-reperfusion in newborn piglets.
Journal of Korean medical science 20040601
-
The role of superoxide dismutase and alpha-tocopherol in the development of seizures and kindling induced by pentylenetetrazol - influence of the radical scavenger alpha-phenyl-N-tert-butyl nitrone.
Brain research 20040529
-
alpha-Phenyl-n-tert-butyl-nitrone attenuates hypoxic-ischemic white matter injury in the neonatal rat brain.
Brain research 20040508
-
In vivo monitoring of hydroxyl radical generation caused by x-ray irradiation of rats using the spin trapping/EPR technique.
Free radical biology & medicine 20040501
-
Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, L-amino acid-defined diet.
Cancer letters 20040331
-
Protein oxidation and the degradation of oxidized proteins in the rat oligodendrocyte cell line OLN 93-antioxidative effect of the intracellular spin trapping agent PBN.
Brain research. Molecular brain research 20040330
-
ESR study of spin-trapping with two glycosylated analogues of PBN able to target cell membrane lectins.
Organic & biomolecular chemistry 20040321
-
Bicarbonate enhances alpha-synuclein oligomerization and nitration: intermediacy of carbonate radical anion and nitrogen dioxide radical.
The Biochemical journal 20040301
-
A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway.
Antioxidants & redox signaling 20040201
-
[Effect of phenyl-tert-butylnitrone, mexidol and nooglutil on the ischemic lesion zone and memory in rats following middle cerebral artery occlusion].
Eksperimental'naia i klinicheskaia farmakologiia 20040101
-
The stability studies and in vitro hepatic microsomal metabolism of some alpha-phenyl-N-substituted nitrones in rats.
European journal of drug metabolism and pharmacokinetics 20040101
-
Different mechanisms of hypoxic injury on white matter and gray matter as revealed by dynamic changes in glucose metabolism in rats.
Neuroscience letters 20031219
-
Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone.
The Journal of biological chemistry 20031205
-
Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum.
Journal of neurochemistry 20031201
-
Protective effect of phenyl-t-butylnitrone in rats with focal cerebral ischemia.
Bulletin of experimental biology and medicine 20031201
-
Synthesis and preliminary biological evaluations of ionic and nonionic amphiphilic alpha-phenyl-N-tert-butylnitrone derivatives.
Journal of medicinal chemistry 20031120
-
Free radical-dependent nuclear localization of Bcl-2 in the central nervous system of aged rats is not associated with Bcl-2-mediated protection from apoptosis.
Journal of neurochemistry 20031101
-
The effects of PBN (phenyl-butyl-nitrone) on GLT-1 levels and on the extracellular levels of amino acids and energy metabolites in a model of iron-induced posttraumatic epilepsy.
Epilepsy research 20031001
-
Optimizing electron spin resonance detection of hydroxyl radical in water.
Chemosphere 20030901
-
Synthesis and antioxidant efficiency of a new amphiphilic spin-trap derived from PBN and lipoic acid.
Bioorganic & medicinal chemistry letters 20030818
-
Effect of two new PBN-derived phosphorylated nitrones against postischaemic ventricular dysrhythmias.
Fundamental & clinical pharmacology 20030801
-
Nitric oxide counteracts the senescence of rice leaves induced by abscisic acid.
Journal of plant physiology 20030801
-
Free radical trap phenyl-N-tert-butylnitrone protects against light damage but does not rescue P23H and S334ter rhodopsin transgenic rats from inherited retinal degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030709
-
An inducible nitric oxide synthase-luciferase reporter system for in vivo testing of anti-inflammatory compounds in transgenic mice.
Journal of immunology (Baltimore, Md. : 1950) 20030615
-
Rapid reduction of ATP synthesis and lack of free radical formation by MPP+ in rat brain synaptosomes and mitochondria.
Brain research 20030613
-
Ischemia and reperfusion of skeletal muscle lead to the appearance of a stable lipid free radical in the circulation.
American journal of physiology. Heart and circulatory physiology 20030601
-
EPR spectroscopic detection of free radical outflow from an isolated muscle bed in exercising humans.
Journal of applied physiology (Bethesda, Md. : 1985) 20030501
-
In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20030315
-
In vitro genotoxicity of lead acetate: induction of single and double DNA strand breaks and DNA-protein cross-links.
Mutation research 20030303
-
Antioxidant amplifies antibiotic protection in the cecal ligation and puncture model of microbial sepsis through interleukin-10 production.
Shock (Augusta, Ga.) 20030301
-
Free radical scavengers can differentially modulate the genotoxicity of amsacrine in normal and cancer cells.
Mutation research 20030205
-
Pharmacokinetics and metabolism of the reactive oxygen scavenger alpha-phenyl-N-tert-butylnitrone in the male Sprague-Dawley rat.
Drug metabolism and disposition: the biological fate of chemicals 20030201
-
Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants.
Brain research. Molecular brain research 20030131
-
Cocaine treatment increases expression of a 40 kDa catecholamine-regulated protein in discrete brain regions.
Synapse (New York, N.Y.) 20030101
-
Effects of phenyl N-tert-butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline-deficient, L-amino acid-defined diet.
Cancer science 20030101
-
In vitro neuroprotection against oxidative stress by pre-treatment with a combination of dihydrolipoic acid and phenyl-butyl nitrones.
Neurotoxicity research 20030101
-
Maternal treatment with alpha-phenyl-N-tert-butylnitrone attenuates secondary mitochondrial dysfunction after transient intrauterine asphyxia in the fetal rat brain.
Gynecologic and obstetric investigation 20030101
-
Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain.
Brain research 20021213
-
Lipid peroxidation-mediated cytotoxicity and DNA damage in U937 cells.
Biochimie 20021201
-
Windows of therapeutic opportunity on fetal growth retardation induced by transient intrauterine ischemia in rats.
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20021201
-
Antioxidant balance and free radical generation in vitamin e-deficient mice after dermal exposure to cumene hydroperoxide.
Chemical research in toxicology 20021101
-
Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide.
Developmental dynamics : an official publication of the American Association of Anatomists 20021001
-
Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species.
European journal of biochemistry 20021001
-
Effect of traumatic brain injury and nitrone radical scavengers on relative changes in regional cerebral blood flow and glucose uptake in rats.
Journal of neurotrauma 20021001
-
ESR characterization of a novel spin-trapping agent, 15N-labeled N-tert-butyl-alpha-phenylnitrone, as a nitric oxide donor.
Bioscience, biotechnology, and biochemistry 20021001
-
Assessment of neuroprotective ability of a spin trap, alpha-phenyl-N-tert-butylnitrone, against malonate-induced ischemic injury of rat brain by apparent water diffusion coefficient mapping.
Neuroscience letters 20020906
-
Analysis of tert-butyl hydroperoxide induced constrictions of perfused vascular beds in vitro.
Life sciences 20020802
-
Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain.
Journal of neurochemistry 20020801
-
Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis.
Journal of neuropathology and experimental neurology 20020701
-
The spin trapping agent PBN stimulates H2 O2 -induced Erk and Src kinase activity in human neuroblastoma cells.
Neuroreport 20020612
-
Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs?
Epilepsia 20020501
-
Nitrones, their value as therapeutics and probes to understand aging.
Mechanisms of ageing and development 20020430
-
Differential ototoxicities induced by lead acetate and tetraethyl lead.
Hearing research 20020401
-
The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors.
Journal of pineal research 20020401
-
The nitrone spin trap PBN alters the cellular response to H(2)O(2): activation of the EGF receptor/ERK pathway.
Free radical biology & medicine 20020315
-
Effects of adenosine pretreatment on detection of free radicals in ischemic and reperfused canine gracilis muscle flaps by use of spin-trapping electron paramagnetic resonance spectroscopy.
American journal of veterinary research 20020201
-
alpha-Phenyl-N-tert-butylnitrone provides protection from dextran sulfate sodium-induced colitis in mice.
Antioxidants & redox signaling 20020201
-
Amyloid-beta-protein (A beta) (25-35)-associated free radical generation is strongly influenced by the aggregational state of the peptides.
Life sciences 20020104
-
Prevention of radiation-induced mammary tumors.
International journal of radiation oncology, biology, physics 20020101
-
Combined antibiotic and free radical trap treatment is effective at combating Staphylococcus-aureus-induced septic arthritis.
Arthritis research 20020101
-
Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition.
Molecular and cellular biochemistry 20020101
-
DNA damage in human colonic mucosa cells evoked by nickel and protective action of quercetin - involvement of free radicals?
Cell biology and toxicology 20020101
-
Multiple pathways of neuroprotection against oxidative stress and excitotoxic injury in immature primary hippocampal neurons.
Brain research. Developmental brain research 20011231
-
Early effects on restoration of evoked field potentials in the hippocampal CA(1) region after reversible hypoxia/hypoglycemia by the radical scavenger N-tert.-butyl-alpha-phenylnitron.
Brain research 20011213
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A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain.
British journal of pharmacology 20011201
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Reactive oxygen species mediate pyridostigmine-induced neuronal apoptosis: involvement of muscarinic and NMDA receptors.
Toxicology and applied pharmacology 20011115
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Effects of the nitrone radical scavengers PBN and S-PBN on in vivo trapping of reactive oxygen species after traumatic brain injury in rats.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20011101
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Direct administration of interleukin-1 and interferon-gamma to rat pancreas leads to the in vivo production of nitric oxide and expression of inducible nitric oxide synthase and inducible cyclooxygenase.
Pancreas 20011001
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Changes in reactive oxygen species (ROS) production in rat brain during global perinatal asphyxia: an ESR study.
Brain research 20010928
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Oxidative stress in brain during experimental bacterial meningitis: differential effects of alpha-phenyl-tert-butyl nitrone and N-acetylcysteine treatment.
Free radical biology & medicine 20010915
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In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies.
The American journal of pathology 20010901
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Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway.
The Journal of biological chemistry 20010831
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Alterations in cytochrome c oxidase activity and energy metabolites in response to kainic acid-induced status epilepticus.
Brain research 20010831
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Free radical scavenger posttreatment improves functional and morphological outcome after fluid percussion injury in the rat.
Journal of neurotrauma 20010801
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Nitric oxide modulates high-energy phosphates in brain regions of rats intoxicated with diisopropylphosphorofluoridate or carbofuran: prevention by N-tert-butyl-alpha-phenylnitrone or vitamin E.
Archives of toxicology 20010801
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Evidence for isoniazid-dependent free radical generation catalyzed by Mycobacterium tuberculosis KatG and the isoniazid-resistant mutant KatG(S315T).
Biochemistry 20010731
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N-tert-butyl-alpha-phenylnitrone, a free radical scavenger with anticholinesterase activity does not improve the cognitive performance of scopolamine-challenged rats.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20010601
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Methylmercury-mediated inhibition of 3H-D-aspartate transport in cultured astrocytes is reversed by the antioxidant catalase.
Brain research 20010525
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p38 activation is required upstream of potassium current enhancement and caspase cleavage in thiol oxidant-induced neuronal apoptosis.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20010515
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Strategies for neuroprotection against L-trans-2,4-pyrrolidine dicarboxylate-induced neuronal damage during energy impairment in vitro.
Journal of neuroscience research 20010515
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Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis.
Brain research 20010511
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Systemic administration of phenyl-N-tert-butylnitrone protects the retina from light damage.
Investigative ophthalmology & visual science 20010501
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Bioactivation and cytotoxicity of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123) in isolated rat hepatocytes.
Pharmacology & toxicology 20010401
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Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059.
Free radical research 20010401
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Depletion of energy metabolites following acetylcholinesterase inhibitor-induced status epilepticus: protection by antioxidants.
Neurotoxicology 20010401
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Developmental changes in tolerance to transient intrauterine ischemia in rat cerebral mitochondria.
American journal of obstetrics and gynecology 20010301
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Oxidative-stress-dependent up-regulation of Bcl-2 expression in the central nervous system of aged Fisher-344 rats.
Journal of neurochemistry 20010201
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The free radical scavenger alpha-phenyl-tert-butyl nitrone aggravates hippocampal apoptosis and learning deficits in experimental pneumococcal meningitis.
The Journal of infectious diseases 20010115
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Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6, 6-tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: combination studies with the thrombolytic tissue plasminogen activator.
Stroke 20010101
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alpha-Phenyl-tert-N-butyl nitrone (PBN) improves functional and morphological outcome after cortical contusion injury in the rat.
Acta neurochirurgica 20010101
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The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions?
Advances in experimental medicine and biology 20010101
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Evaluation of the effects of alpha-phenyl-N-tert-butyl nitrone pretreatment on the neurobehavioral effects of methamphetamine.
Life sciences 20000818
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Spin trapping agent phenyl-N-tert-butylnitrone prevents diisopropylphosphorofluoridate-induced excitotoxicity in skeletal muscle of the rat.
Neuroscience letters 20000107
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Reductive activation of 1,1-dichloro-1-fluoroethane (HCFC-141b) by phenobarbital- and pyridine-induced rat liver microsomal cytochrome P450.
Xenobiotica; the fate of foreign compounds in biological systems 19960401
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Role of oxygen free radicals in cocaine-induced vascular disruption in mice.
Teratology 19940301
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Protective effects of spin-trapping agents on adriamycin-induced cardiotoxicity in isolated rat atria.
Free radical research communications 19910101
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Halothane-induced liver injury as a consequence of enhanced microsomal lipid peroxidation in guinea pigs.
Research communications in chemical pathology and pharmacology 19880801
