34188-11-9 | Amino-peg5-alcohol

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$15.00	$10.00
250mg	95%	in stock	$25.00	$17.00
1g	95%	in stock	$76.00	$54.00
5g	95%	in stock	$291.00	$204.00
10g	95%	in stock	$579.00	$405.00

Description

• Catalog Number: AB51566
• Chemical Name: Amino-peg5-alcohol
• CAS Number: 34188-11-9
• Molecular Formula: C10H23NO5
• Molecular Weight: 237.2933
• MDL Number: MFCD28950782
• SMILES: NCCOCCOCCOCCOCCO

Computed Properties

• Complexity: 126
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 16
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 13
• XLogP3: -2

Upstream Synthesis Route

The upstream synthesis route for amino-PEG5-alcohol, systematically referred to as 5-(2-aminoethoxy)pentane-1,5-diol, typically involves the following steps:

1. Polymerization of ethylene oxide: Begin by polymerizing ethylene oxide to create a polyethylene glycol (PEG) with the desired number of units; in this case, PEG5 is targeted which corresponds to a pentamer.

2. Activation of PEG terminal hydroxyl group: Transform one of the terminal hydroxyl groups into a leaving group, such as a mesylate or tosylate, to make it more amenable for nucleophilic substitution. This is usually accomplished by reacting the hydroxyl with methanesulfonyl chloride (MsCl) or p-toluenesulfonyl chloride (TsCl) in the presence of a base like triethylamine.

3. Nucleophilic substitution with ethanolamine: Once the tosylate or mesylate ester is formed, it can undergo nucleophilic substitution with ethanolamine. This step extends the PEG chain with an additional two-carbon linker terminated by an amino group, thereby yielding the amino-peg5-alcohol.

4. Purification: Following the substitution reaction, the reaction mixture is typically subjected to purification steps such as dialysis or size-exclusion chromatography to isolate the pure amino-PEG5-alcohol product.

5. Characterization: The final product is characterized using analytical techniques such as nuclear magnetic resonance (NMR) spectroscopy, high-performance liquid chromatography (HPLC), and mass spectrometry (MS) to confirm the structure and purity before use in further applications.

Throughout the process, reaction conditions such as temperature, solvent choice, and reaction time should be carefully optimized to achieve maximum yield and product purity.