34233-69-7 | Clozapine n-oxide

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$47.00	$33.00
5mg	98%	in stock	$80.00	$56.00
10mg	98%	in stock	$135.00	$95.00
100mg	98%	in stock	$249.00	$175.00
250mg	98%	in stock	$401.00	$281.00
1g	98%	in stock	$1,022.00	$716.00

Description

• Catalog Number: AF60412
• Chemical Name: Clozapine n-oxide
• CAS Number: 34233-69-7
• Molecular Formula: C18H19ClN4O
• Molecular Weight: 342.8227
• MDL Number: MFCD00210190
• SMILES: Clc1ccc2c(c1)N=C(N1CC[N+](CC1)([O-])C)c1c(N2)cccc1
• NSC Number: 750266

Computed Properties

• Complexity: 491
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 2.5

Upstream Synthesis Route

Clozapine N-oxide, also known as CNO, is a chemical compound that is widely used in chemical synthesis as a designer drug. Its unique properties make it an invaluable tool in research and development within the field of organic chemistry. In chemical synthesis, CNO serves as a precursor for the synthesis of a variety of novel compounds through a process called click chemistry. By undergoing specific reactions with other molecules, Clozapine N-oxide can be functionalized to introduce various chemical groups that are crucial for creating new materials, pharmaceuticals, and other complex organic compounds. Researchers utilize CNO to build structural frameworks and explore new pathways for creating innovative molecules with targeted properties. Its versatility and reactivity make Clozapine N-oxide an essential component in the toolkit of chemists striving to design and synthesize cutting-edge compounds for diverse applications in the fields of medicine, materials science, and beyond.

Literature

• What is the contribution of human FMO3 in the N-oxygenation of selected therapeutic drugs and drugs of abuse?

  Toxicology letters 20160906

• Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20081201

• Effects of clozapine and its metabolites on the 5-HT2 receptor system in cortical and hippocampal cells in vitro.

  Progress in neuro-psychopharmacology & biological psychiatry 20040301