3430-10-2 | 3-Aminopicoline

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$8.00	$6.00
5g	98%	in stock	$20.00	$14.00
10g	98%	in stock	$30.00	$21.00
100g	98%	in stock	$196.00	$137.00

Description

• Catalog Number: AB44406
• Chemical Name: 3-Aminopicoline
• CAS Number: 3430-10-2
• Molecular Formula: C6H8N2
• Molecular Weight: 108.1411
• MDL Number: MFCD03788195
• SMILES: Nc1cccnc1C

Computed Properties

• Complexity: 72.9
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 0.6

Upstream Synthesis Route

The synthesis route for 3-aminopicoline (3-amino-2-methylpyridine) typically begins with the starting material 2-methyl-5-ethylpyridine. The process involves the following key steps:

1. **N-oxidation**: The 2-methyl-5-ethylpyridine is subjected to N-oxidation using an oxidizing agent such as hydrogen peroxide (H_2O_2) to form the corresponding N-oxide.

2. **Ammoxidation**: This N-oxide intermediate is then treated under ammoxidation conditions, which involves reacting with ammonia (NH_3) in the presence of a catalyst, commonly vanadium oxides, at elevated temperatures around 350-400°C. Oxygen is also present in this step, ensuring the conversion of the ethyl group to an amino group alongside the formation of water and nitrogen oxide by-products.

3. **Purification**: The crude 3-aminopicoline formed through the ammoxidation is purified through conventional methods like distillation or crystallization after neutralizing any acids formed.

This synthetic pathway is efficient as it minimizes the formation of regioisomers, targeting the substitution on the desired carbon atom adjacent to the nitrogen in the pyridine ring.

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