34846-64-5 | 3-Quinolinecarbonitrile

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$15.00	$10.00
250mg	95%	in stock	$18.00	$12.00
1g	95%	in stock	$27.00	$19.00
5g	95%	in stock	$122.00	$86.00
10g	95%	in stock	$198.00	$139.00
25g	95%	in stock	$449.00	$315.00

Description

• Catalog Number: AB65560
• Chemical Name: 3-Quinolinecarbonitrile
• CAS Number: 34846-64-5
• Molecular Formula: C10H6N2
• Molecular Weight: 154.168
• MDL Number: MFCD00006766
• SMILES: N#Cc1cnc2c(c1)cccc2
• NSC Number: 44644

Computed Properties

• Complexity: 203
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 1.6

Literature

• Pharmacophore generation and atom-based 3D-QSAR of novel quinoline-3-carbonitrile derivatives as Tpl2 kinase inhibitors.

  Journal of enzyme inhibition and medicinal chemistry 20120801

• Development of a new epidermal growth factor receptor positron emission tomography imaging agent based on the 3-cyanoquinoline core: synthesis and biological evaluation.

  Bioorganic & medicinal chemistry 20100915

• 4-Anilino-7-pyridyl-3-quinolinecarbonitriles as Src kinase inhibitors.

  Bioorganic & medicinal chemistry letters 20090901

• Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment.

  Bioorganic & medicinal chemistry letters 20090101

• AXL is a potential target for therapeutic intervention in breast cancer progression.

  Cancer research 20080315

• Exploitation of the 3-quinolinecarbonitrile template for SRC tyrosine kinase inhibitors.

  Current topics in medicinal chemistry 20080101

• An efficient one-pot, three-component synthesis of indeno[1,2-b]quinoline-9,11(6H,10H)-dione, acridine-1,8(2H,5H)-dione and quinoline-3-carbonitrile derivatives from enaminones.

  Organic & biomolecular chemistry 20061007

• Synthesis and Src kinase inhibitory activity of 2-phenyl- and 2-thienyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles.

  Journal of medicinal chemistry 20050602

• Identification of 7-phenylaminothieno- [3,2-b]pyridine-6-carbonitriles as a new class of Src kinase inhibitors.

  Journal of medicinal chemistry 20041230

• Epidermal growth factor receptor tyrosine kinase inhibitors.

  British journal of cancer 20040614

• 4-anilino-3-quinolinecarbonitriles: an emerging class of kinase inhibitors.

  Current topics in medicinal chemistry 20020901

• Cleavage of carbon-carbon bonds in aromatic nitriles using nickel(0).

  Journal of the American Chemical Society 20020814

• Hydrogen bonding and dipolar interactions between quinolines and organic solvents. Nuclear magnetic resonance and ultraviolet-visible spectroscopic studies.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010701