35013-72-0 | Biotin-NHS

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$20.00	$14.00
1g	97%	in stock	$27.00	$19.00
5g	97%	in stock	$92.00	$64.00
25g	97%	in stock	$355.00	$248.00
100g	97%	in stock	$993.00	$695.00

Description

• Catalog Number: AI48595
• Chemical Name: Biotin-NHS
• CAS Number: 35013-72-0
• Molecular Formula: C14H19N3O5S
• Molecular Weight: 341.3828
• MDL Number: MFCD00078531
• SMILES: O=C(ON1C(=O)CCC1=O)CCCC[C@@H]1SC[C@H]2[C@@H]1NC(=O)N2

Computed Properties

• Complexity: 525
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 3
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 7
• XLogP3: -0.2

Upstream Synthesis Route

The (+)-Biotin N-hydroxysuccinimide ester is a versatile compound widely utilized in chemical synthesis as a valuable tool for the site-specific conjugation of biotin to target molecules. This reagent is particularly useful in the bioconjugation field for attaching biotin to amino groups under mild conditions, forming stable amide linkages. By utilizing this reagent, researchers can facilitate the selective biotinylation of proteins, peptides, oligonucleotides, and other biomolecules for various applications such as protein purification, protein immobilization, and biomolecule labeling. Moreover, the high specificity and efficiency of (+)-Biotin N-hydroxysuccinimide ester make it an essential component in the development of bioanalytical tools, biosensors, and drug delivery systems that rely on the strong and selective interaction between biotin and avidin/streptavidin.

Literature

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  Journal of chromatography 19930212