35354-74-6 | 2-[4-hydroxy-3-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol

Packsize	Purity	Availability	Price	Discounted Price
10mg	98%	in stock	$11.00	$8.00
50mg	98%	in stock	$13.00	$9.00
250mg	98%	in stock	$16.00	$11.00
1g	98%	in stock	$19.00	$14.00
5g	98%	in stock	$43.00	$30.00
100g	98%	in stock	$568.00	$398.00

Description

• Catalog Number: AB52231
• Chemical Name: 2-[4-hydroxy-3-(prop-2-en-1-yl)phenyl]-4-(prop-2-en-1-yl)phenol
• CAS Number: 35354-74-6
• Molecular Formula: C18H18O2
• Molecular Weight: 266.3343
• MDL Number: MFCD00016674
• SMILES: C=CCc1ccc(c(c1)c1ccc(c(c1)CC=C)O)O
• NSC Number: 293100

Computed Properties

• Complexity: 325
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 5
• XLogP3: 5

Literature

• Honokiol Inhibits DNA Polymerases β and λ and Increases Bleomycin Sensitivity of Human Cancer Cells.

  Chemical research in toxicology 20170220

• Protective effects of honokiol against methylglyoxal-induced osteoblast damage.

  Chemico-biological interactions 20160125

• The anti-inflammatory effect of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol by targeting Lyn kinase in human neutrophils.

  Chemico-biological interactions 20150705

• The mechanism of honokiol-induced intracellular Ca(2+) rises and apoptosis in human glioblastoma cells.

  Chemico-biological interactions 20140925

• Anti-hepatitis C virus dinorditerpenes from the roots of Flueggea virosa.

  Journal of natural products 20140124

• Trinorditerpenes from the roots of Flueggea virosa.

  Bioorganic & medicinal chemistry letters 20140115

• Honokiol: a non-adipogenic PPARγ agonist from nature.

  Biochimica et biophysica acta 20131001

• Surface enhancement of WO3 nanowires toward the oxidation and electrochemical detection of honokiol in traditional Chinese medicine.

  Colloids and surfaces. B, Biointerfaces 20121201

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Honokiol suppresses the development of post-ischemic glucose intolerance and neuronal damage in mice.

  Journal of natural medicines 20121001

• Honokiol promotes non-rapid eye movement sleep via the benzodiazepine site of the GABA(A) receptor in mice.

  British journal of pharmacology 20121001

• Modulation of P-glycoprotein expression by honokiol, magnolol and 4-O-methylhonokiol, the bioactive components of Magnolia officinalis.

  Anticancer research 20121001

• Targeting the intrinsic inflammatory pathway: honokiol exerts proapoptotic effects through STAT3 inhibition in transformed Barrett's cells.

  American journal of physiology. Gastrointestinal and liver physiology 20120901

• Effect of formula compatibility on the pharmacokinetics of components from Dachengqi Decoction [See Text] in rats.

  Chinese journal of integrative medicine 20120901

• A larval zebrafish model of bipolar disorder as a screening platform for neuro-therapeutics.

  Behavioural brain research 20120801

• Design, synthesis, and anti-proliferative evaluation of [1,1'-biphenyl]-4-ols as inhibitor of HUVEC migration and tube formation.

  Molecules (Basel, Switzerland) 20120705

• Multiple effects of Honokiol on the life cycle of hepatitis C virus.

  Liver international : official journal of the International Association for the Study of the Liver 20120701

• Honokiol induces cell cycle arrest and apoptosis via inhibition of survival signals in adult T-cell leukemia.

  Biochimica et biophysica acta 20120701

• Comparative studies on the interactions of honokiol and magnolol with human serum albumin.

  Journal of pharmaceutical and biomedical analysis 20120701

• Honokiol inhibits HIF pathway and hypoxia-induced expression of histone lysine demethylases.

  Biochemical and biophysical research communications 20120608

• Anti-HBV activities of Streblus asper and constituents of its roots.

  Fitoterapia 20120601

• The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABA(A) receptors.

  Neuropharmacology 20120601

• Time and dose-response effects of honokiol on UVB-induced skin cancer development.

  Drug discoveries & therapeutics 20120601

• Screening of anti-cancer agent using zebrafish: comparison with the MTT assay.

  Biochemical and biophysical research communications 20120525

• In vitro growth inhibition of human cancer cells by novel honokiol analogs.

  Bioorganic & medicinal chemistry 20120515

• Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.

  Journal of cellular physiology 20120501

• Honokiol attenuates the severity of acute pancreatitis and associated lung injury via acceleration of acinar cell apoptosis.

  Shock (Augusta, Ga.) 20120501

• [Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20120501

• Antimetastatic activity of honokiol in osteosarcoma.

  Cancer 20120415

• Honokiol attenuates torsion/detorsion-induced testicular injury in rat testis by way of suppressing endoplasmic reticulum stress-related apoptosis.

  Urology 20120401

• Honokiol in combination with radiation targets notch signaling to inhibit colon cancer stem cells.

  Molecular cancer therapeutics 20120401

• Bioactive polar compounds from stem bark of Magnolia officinalis.

  Fitoterapia 20120301

• Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrion-cytochrome c-caspase protease pathway.

  Neuro-oncology 20120301

• Synthesis and neurite growth evaluation of new analogues of honokiol, a neolignan with potent neurotrophic activity.

  Bioorganic & medicinal chemistry letters 20120201

• Year in review in Intensive Care Medicine 2011: I. Nephrology, epidemiology, nutrition and therapeutics, neurology, ethical and legal issues, experimentals.

  Intensive care medicine 20120201

• Anti-inflammatory effects of active constituents extracted from Chinese medicinal herbs against Propionibacterium acnes.

  Natural product research 20120101

• Quality assessment of commercial Magnoliae officinalis Cortex by ¹H-NMR-based metabolomics and HPLC methods.

  Phytochemical analysis : PCA 20120101

• The inhibitory effect of honokiol, a natural plant product, on vestibular schwannoma cells.

  The Laryngoscope 20120101

• An expedient synthesis of honokiol and its analogues as potential neuropreventive agents.

  Bioorganic & medicinal chemistry letters 20120101

• A naturally occurring rexinoid, honokiol, can serve as a regulator of various retinoid x receptor heterodimers.

  Biological & pharmaceutical bulletin 20120101

• Separation and determination of honokiol and magnolol in Chinese traditional medicines by capillary electrophoresis with the application of response surface methodology and radial basis function neural network.

  Journal of chromatographic science 20120101

• Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models.

  Journal of neuroinflammation 20120101

• Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis.

  Breast cancer research : BCR 20120101

• Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model.

  PloS one 20120101

• Therapeutic targeting of Krüppel-like factor 4 abrogates microglial activation.

  Journal of neuroinflammation 20120101

• Phyllanthus urinaria Induces Apoptosis in Human Osteosarcoma 143B Cells via Activation of Fas/FasL- and Mitochondria-Mediated Pathways.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• The metabolic syndrome and risk of chronic kidney disease: pathophysiology and intervention strategies.

  Journal of nutrition and metabolism 20120101

• Biodegradable thermosensitive hydrogel for SAHA and DDP delivery: therapeutic effects on oral squamous cell carcinoma xenografts.

  PloS one 20120101

• Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents.

  Frontiers in microbiology 20120101

• Porphyromonas gingivalis Fimbria-Induced Expression of Inflammatory Cytokines and Cyclooxygenase-2 in Mouse Macrophages and Its Inhibition by the Bioactive Compounds Fibronectin and Melatonin.

  ISRN dentistry 20120101

• Syk/Src pathway-targeted inhibition of skin inflammatory responses by carnosic acid.

  Mediators of inflammation 20120101

• NOXA-induced alterations in the Bax/Smac axis enhance sensitivity of ovarian cancer cells to cisplatin.

  PloS one 20120101

• Application of ionic liquids in the microwave-assisted extraction of proanthocyanidins from Larix gmelini bark.

  International journal of molecular sciences 20120101

• The effects of magnetite (Fe₃O₄) nanoparticles on electroporation-induced inward currents in pituitary tumor (GH₃) cells and in RAW 264.7 macrophages.

  International journal of nanomedicine 20120101

• Self-assembled mPEG-PCL-g-PEI micelles for simultaneous codelivery of chemotherapeutic drugs and DNA: synthesis and characterization in vitro.

  International journal of nanomedicine 20120101

• Magnolol Protects against MPTP/MPP(+)-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson's Disease.

  Parkinson's disease 20120101

• Treating acute cystitis with biodegradable micelle-encapsulated quercetin.

  International journal of nanomedicine 20120101

• Visualizing sweetness: increasingly diverse applications for fluorescent-tagged glucose bioprobes and their recent structural modifications.

  Sensors (Basel, Switzerland) 20120101

• Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes.

  BioFactors (Oxford, England) 20120101

• Honokiol inhibits vascular vessel formation of mouse embryonic stem cell-derived endothelial cells via the suppression of PECAM and MAPK/mTOR signaling pathway.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

• Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice.

  PloS one 20120101

• Modulating testosterone pathway: a new strategy to tackle male skin aging?

  Clinical interventions in aging 20120101

• Honokiol stimulates osteoblastogenesis by suppressing NF-κB activation.

  International journal of molecular medicine 20111201

• Honokiol protects osteoblastic MC3T3-E1 cells against antimycin A-induced cytotoxicity.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20111101

• Honokiol radiosensitizes colorectal cancer cells: enhanced activity in cells with mismatch repair defects.

  American journal of physiology. Gastrointestinal and liver physiology 20111101

• Honokiol, a chemopreventive agent against skin cancer, induces cell cycle arrest and apoptosis in human epidermoid A431 cells.

  Experimental biology and medicine (Maywood, N.J.) 20111101

• [Honokiol-induced apoptosis of human non-Hodgkin lymphoma Raji cells and its possible mechanism].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20111101

• Effect of honokiol on activity of GAD(65) and GAD(67) in the cortex and hippocampus of mice.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20111015

• Structural modification of honokiol, a biphenyl occurring in Magnolia officinalis: the evaluation of honokiol analogues as inhibitors of angiogenesis and for their cytotoxicity and structure-activity relationship.

  Journal of medicinal chemistry 20111013

• Honokiol isolated from Magnolia officinalis stimulates osteoblast function and inhibits the release of bone-resorbing mediators.

  International immunopharmacology 20111001

• Comparison of antioxidant abilities of magnolol and honokiol to scavenge radicals and to protect DNA.

  Biochimie 20111001

• Targeting apoptosis pathways in cancer with magnolol and honokiol, bioactive constituents of the bark of Magnolia officinalis.

  Drug discoveries & therapeutics 20111001

• Metabolic and pharmacokinetic studies of curcumin, demethoxycurcumin and bisdemethoxycurcumin in mice tumor after intragastric administration of nanoparticle formulations by liquid chromatography coupled with tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110915

• Honokiol produces anti-neoplastic effects on melanoma cells in vitro.

  Journal of surgical oncology 20110901

• Honokiol inhibits LPS-induced maturation and inflammatory response of human monocyte-derived dendritic cells.

  Journal of cellular physiology 20110901

• Honokiol attenuates vascular contraction through the inhibition of the RhoA/Rho-kinase signalling pathway in rat aortic rings.

  The Journal of pharmacy and pharmacology 20110901

• Magnolia dealbata Zucc and its active principles honokiol and magnolol stimulate glucose uptake in murine and human adipocytes using the insulin-signaling pathway.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20110815

• Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure-activity relationship.

  Journal of medicinal chemistry 20110811

• Preparation, characterization, pharmacokinetics, and bioactivity of honokiol-in-hydroxypropyl-β-cyclodextrin-in-liposome.

  Journal of pharmaceutical sciences 20110801

• In vitro metabolism and disposition of honokiol in rat and human livers.

  Journal of pharmaceutical sciences 20110801

• Antimicrobial activity and cytotoxic effects of Magnolia dealbata and its active compounds.

  Natural product communications 20110801

• Honokiol enhances adipocyte differentiation by potentiating insulin signaling in 3T3-L1 preadipocytes.

  Journal of natural medicines 20110701

• Honokiol ameliorates renal fibrosis by inhibiting extracellular matrix and pro-inflammatory factors in vivo and in vitro.

  British journal of pharmacology 20110601

• Honokiol inhibits hypoxia-inducible factor-1 pathway.

  International journal of radiation biology 20110601

• Improved solubility and pharmacokinetics of PEGylated liposomal honokiol and human plasma protein binding ability of honokiol.

  International journal of pharmaceutics 20110530

• Therapeutic applications of compounds in the Magnolia family.

  Pharmacology & therapeutics 20110501

• Honokiol: an effective inhibitor of tumor necrosis factor-α-induced up-regulation of inflammatory cytokine and chemokine production in human synovial fibroblasts.

  Acta biochimica et biophysica Sinica 20110501

• [Study on transport characteristics of honokiol in Caco-2 cell model by HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110501

• Effect of traditional Chinese medicinal herbs on Candida spp. from patients with HIV/AIDS.

  Advances in dental research 20110401

• 5-Formylhonokiol exerts anti-angiogenesis activity via inactivating the ERK signaling pathway.

  Experimental & molecular medicine 20110331

• Inhibitory effects of honokiol on lipopolysaccharide-induced cellular responses and signaling events in human renal mesangial cells.

  European journal of pharmacology 20110301

• Honokiol, a phytochemical from Magnolia spp., inhibits breast cancer cell migration by targeting nitric oxide and cyclooxygenase-2.

  International journal of oncology 20110301

• Honokiol rescues sepsis-associated acute lung injury and lethality via the inhibition of oxidative stress and inflammation.

  Intensive care medicine 20110301

• Honokiol inhibits H(2)O(2)-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways.

  European journal of pharmacology 20110110

• Evaluation of oxygen radical absorbance capacity in kampo medicine.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Distinct photoacidity of honokiol from magnolol.

  Journal of fluorescence 20110101

• Protective Mechanism of KIOM-4 in Streptozotocin-Induced Pancreatic β-Cells Damage Is Involved in the Inhibition of Endoplasmic Reticulum Stress.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• KIOM-79 Prevents Lens Epithelial Cell Apoptosis and Lens Opacification in Zucker Diabetic Fatty Rats.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Electrochemical detection of honokiol and magnolol in traditional Chinese medicines using acetylene black nanoparticle-modified electrode.

  Phytochemical analysis : PCA 20110101

• Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages.

  Journal of neuroinflammation 20110101

• Honokiol: a promising small molecular weight natural agent for the growth inhibition of oral squamous cell carcinoma cells.

  International journal of oral science 20110101

• Metabolic syndrome and renal injury.

  Cardiology research and practice 20110101

• Honokiol crosses BBB and BCSFB, and inhibits brain tumor growth in rat 9L intracerebral gliosarcoma model and human U251 xenograft glioma model.

  PloS one 20110101

• Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.

  PloS one 20110101

• Particle Trajectories and Agglomeration/Accumulation in Branching Arteries subjected to Orbital Atherectomy.

  The open biomedical engineering journal 20110101

• Network target for screening synergistic drug combinations with application to traditional Chinese medicine.

  BMC systems biology 20110101

• Honokiol arrests cell cycle, induces apoptosis, and potentiates the cytotoxic effect of gemcitabine in human pancreatic cancer cells.

  PloS one 20110101

• Cathelicidin-BF, a snake cathelicidin-derived antimicrobial peptide, could be an excellent therapeutic agent for acne vulgaris.

  PloS one 20110101

• KIOM-4 Protects against Oxidative Stress-Induced Mitochondrial Damage in Pancreatic β-cells via Its Antioxidant Effects.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Hepatoprotective activity of the Phyllanthus species on tert-butyl hydroperoxide (t-BH)-induced cytotoxicity in HepG2 cells.

  Pharmacognosy magazine 20110101

• Doxorubicin-loaded PEG-PCL copolymer micelles enhance cytotoxicity and intracellular accumulation of doxorubicin in adriamycin-resistant tumor cells.

  International journal of nanomedicine 20110101

• Effect of herbal extract granules combined with probiotic mixture on irritable bowel syndrome with diarrhea: study protocol for a randomized controlled trial.

  Trials 20110101

• Effects of magnolol on UVB-induced skin cancer development in mice and its possible mechanism of action.

  BMC cancer 20110101

• PI3K functions in cancer progression, anticancer immunity and immune evasion by tumors.

  Clinical & developmental immunology 20110101

• Transcriptional and functional analysis of the effects of magnolol: inhibition of autolysis and biofilms in Staphylococcus aureus.

  PloS one 20110101

• Flavonoids: A versatile source of anticancer drugs.

  Pharmacognosy reviews 20110101

• Molecular determinants of magnolol targeting both RXRα and PPARγ.

  PloS one 20110101

• The prospective role of plant products in radiotherapy of cancer: a current overview.

  Frontiers in pharmacology 20110101

• Preparation and evaluation of poly (caprolactone fumarate) nanoparticles containing doxorubicin HCI.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101

• Neurotrophic activity of obovatol on the cultured embryonic rat neuronal cells by increase of neurotrophin release through activation of ERK pathway.

  European journal of pharmacology 20101215

• Honokiol: an effective inhibitor of high-glucose-induced upregulation of inflammatory cytokine production in human renal mesangial cells.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20101201

• Synthesis, structural and in vitro studies of well-dispersed monomethoxy-poly(ethylene glycol)-honokiol conjugate micelles.

  Biomedical materials (Bristol, England) 20101201

• A novel drug and gene co-delivery system based on Poly(epsilon-caprolactone)-Poly(ethylene glycol)-Poly(epsilon-caprolactone) grafted polyethyleneimine micelle.

  Journal of nanoscience and nanotechnology 20101201

• Honokiol, a phytochemical from the Magnolia plant, inhibits photocarcinogenesis by targeting UVB-induced inflammatory mediators and cell cycle regulators: development of topical formulation.

  Carcinogenesis 20101101

• Anti-inflammatory effects of the neurotransmitter agonist Honokiol in a mouse model of allergic asthma.

  Journal of immunology (Baltimore, Md. : 1950) 20101101

• [Variation of phenolic compound contents of Magnolia officinalis at different levels].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101

• Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells.

  Phytotherapy research : PTR 20101001

• Separation of honokiol and magnolol by intermittent counter-current extraction.

  Journal of chromatography. A 20100917

• Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders.

  Molecules (Basel, Switzerland) 20100916

• The synergy of honokiol and fluconazole against clinical isolates of azole-resistant Candida albicans.

  Letters in applied microbiology 20100901

• Substituted dineolignans from Magnolia garrettii.

  Journal of natural products 20100827

• Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.

  Journal of natural products 20100827

• Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals.

  British journal of pharmacology 20100801

• Characterization of neurotoxic effects of NMDA and the novel neuroprotection by phytopolyphenols in mice.

  Behavioral neuroscience 20100801

• Hydrophobic ionic liquid-based ultrasound-assisted extraction of magnolol and honokiol from cortex Magnoliae officinalis.

  Journal of separation science 20100701

• [Effects of primary processing on quality of cortex Magnolia officinalis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100701

• Co-delivery honokiol and doxorubicin in MPEG-PLA nanoparticles.

  Journal of nanoscience and nanotechnology 20100701

• Honokiol induces paraptosis and apoptosis and exhibits schedule-dependent synergy in combination with imatinib in human leukemia cells.

  Toxicology mechanisms and methods 20100601

• Peroxyl radical scavenging capacity of extracts and isolated components from selected medicinal plants.

  Archives of pharmacal research 20100601

• Biodegradable self-assembled PEG-PCL-PEG micelles for hydrophobic honokiol delivery: I. Preparation and characterization.

  Nanotechnology 20100528

• Purification of honokiol derivatives from one-pot synthesis by high-performance counter-current chromatography.

  Journal of chromatography. A 20100514

• Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress.

  Cancer letters 20100501

• Honokiol inhibits epidermal growth factor receptor signaling and enhances the antitumor effects of epidermal growth factor receptor inhibitors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20100501

• Polymeric matrix for drug delivery: honokiol-loaded PCL-PEG-PCL nanoparticles in PEG-PCL-PEG thermosensitive hydrogel.

  Journal of biomedical materials research. Part A 20100401

• Honokiol inhibits HepG2 migration via down-regulation of IQGAP1 expression discovered by a quantitative pharmaceutical proteomic analysis.

  Proteomics 20100401

• A novel transdermal honokiol formulation based on Pluronic F127 copolymer.

  Drug delivery 20100401

• Anti-inflammatory bioactivities of honokiol through inhibition of protein kinase C, mitogen-activated protein kinase, and the NF-kappaB pathway to reduce LPS-induced TNFalpha and NO expression.

  Journal of agricultural and food chemistry 20100324

• Chemopreventive effects of honokiol on UVB-induced skin cancer development.

  Anticancer research 20100301

• Preparation of MPEG-PLA nanoparticle for honokiol delivery in vitro.

  International journal of pharmaceutics 20100215

• Micronization of magnolia bark extract with enhanced dissolution behavior by rapid expansion of supercritical solution.

  Chemical & pharmaceutical bulletin 20100201

• Honokiol and magnolol production by in vitro micropropagated plants of Magnolia dealbata, an endangered endemic Mexican species.

  Natural product communications 20100201

• Quality assurance for Chinese herbal formulae: standardization of IBS-20, a 20-herb preparation.

  Chinese medicine 20100101

• Effects of chronic treatment with honokiol in spontaneously hypertensive rats.

  Biological & pharmaceutical bulletin 20100101

• Honokiol inhibits osteoclast differentiation and function in vitro.

  Biological & pharmaceutical bulletin 20100101

• Synthesis and microbiological evaluation of honokiol derivatives as new antimicrobial agents.

  Archives of pharmacal research 20100101

• Downregulated expression of HSP27 in human low-grade glioma tissues discovered by a quantitative proteomic analysis.

  Proteome science 20100101

• Modulation of multidrug resistance p-glycoprotein activity by flavonoids and honokiol in human doxorubicin- resistant sarcoma cells (MES-SA/DX-5): implications for natural sedatives as chemosensitizing agents in cancer therapy.

  Journal of biological regulators and homeostatic agents 20100101

• Stem cell-based neuroprotective and neurorestorative strategies.

  International journal of molecular sciences 20100101

• Honokiol increases ABCA1 expression level by activating retinoid X receptor beta.

  Biological & pharmaceutical bulletin 20100101

• Quasi-drugs developed in Japan for the prevention or treatment of hyperpigmentary disorders.

  International journal of molecular sciences 20100101

• Honokiol inhibits the progression of collagen-induced arthritis by reducing levels of pro-inflammatory cytokines and matrix metalloproteinases and blocking oxidative tissue damage.

  Journal of pharmacological sciences 20100101

• A Validated RP HPLC-PAD Method for the Determination of Hederacoside C in Ivy-Thyme Cough Syrup.

  International journal of analytical chemistry 20100101

• Investigation of endocytosis and cytotoxicity of poly-d, l-lactide-poly(ethylene glycol) micro/nano-particles in osteoblast cells.

  International journal of nanomedicine 20100101

• Integrating findings of traditional medicine with modern pharmaceutical research: the potential role of linked open data.

  Chinese medicine 20100101

• Pegylation of poly(γ-benzyl-L-glutamate) nanoparticles is efficient for avoiding mononuclear phagocyte system capture in rats.

  International journal of nanomedicine 20100101

• Apoptosis induced by Magnolia Grandiflora extract in chlorambucil-resistant B-chronic lymphocytic leukemia cells.

  Journal of cancer research and therapeutics 20100101

• Honokiol nanoparticles in thermosensitive hydrogel: therapeutic effects on malignant pleural effusion.

  ACS nano 20091222

• Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice.

  Brain research 20091211

• Neurite outgrowth effect of 4-O-methylhonokiol by induction of neurotrophic factors through ERK activation.

  Neurochemical research 20091201

• Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site-directed mutagenesis.

  Biochemical and biophysical research communications 20091106

• [Effects of tree ages and geographic area on quality of bark of Magnolia officinalis and M. officinalis var. biloba].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091001

• Inhibitory effects of honokiol on LPS and PMA-induced cellular responses of macrophages and monocytes.

  BMB reports 20090930

• Hangekobokuto (Banxia-houpo-tang), a Kampo Medicine that Treats Functional Dyspepsia.

  Evidence-based complementary and alternative medicine : eCAM 20090901

• Self-assembled hydrophobic honokiol loaded MPEG-PCL diblock copolymer micelles.

  Pharmaceutical research 20090901

• Improved therapeutic efficacy against murine carcinoma by combining honokiol with gene therapy of PNAS-4, a novel pro-apoptotic gene.

  Cancer science 20090901

• Combined administration of the mixture of honokiol and magnolol and ginger oil evokes antidepressant-like synergism in rats.

  Archives of pharmacal research 20090901

• Semi-synthesis and anti-proliferative activity evaluation of novel analogues of Honokiol.

  Bioorganic & medicinal chemistry letters 20090815

• Anti-inflammatory effect of 4-O-methylhonokiol, compound isolated from Magnolia officinalis through inhibition of NF-kappaB [corrected].

  Chemico-biological interactions 20090814

• A novel composite drug delivery system: honokiol nanoparticles in thermosensitive hydrogel based on chitosan.

  Journal of nanoscience and nanotechnology 20090801

• Novel composite drug delivery system for honokiol delivery: self-assembled poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) micelles in thermosensitive poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) hydrogel.

  The journal of physical chemistry. B 20090730

• Simultaneous determination of the 10 major components of Da-Cheng-Qi decoction in dog plasma by liquid chromatography tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715

• Antineoplastic effects of Magnoliae officinalis in tumours other than hepatomas.

  Liver international : official journal of the International Association for the Study of the Liver 20090701

• Protective effect of the ethanol extract of Magnolia officinalis and 4-O-methylhonokiol on scopolamine-induced memory impairment and the inhibition of acetylcholinesterase activity.

  Journal of natural medicines 20090701

• Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.

  Bioorganic & medicinal chemistry 20090701

• Production of honokiol and magnolol in suspension cultures of Magnolia dealbata Zucc.

  Natural product communications 20090701

• Reactive oxygen species production and Bax/Bcl-2 regulation in honokiol-induced apoptosis in human hepatocellular carcinoma SMMC-7721 cells.

  Environmental toxicology and pharmacology 20090701

• Poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL) nanoparticles for honokiol delivery in vitro.

  International journal of pharmaceutics 20090622

• Antidepressant-like synergism of extracts from magnolia bark and ginger rhizome alone and in combination in mice.

  Progress in neuro-psychopharmacology & biological psychiatry 20090615

• Liposomal honokiol inhibits VEGF-D-induced lymphangiogenesis and metastasis in xenograft tumor model.

  International journal of cancer 20090601

• Leoligin, the major lignan from Edelweiss, inhibits intimal hyperplasia of venous bypass grafts.

  Cardiovascular research 20090601

• Effects of neolignans from the stem bark of Magnolia obovata on plant pathogenic fungi.

  Journal of applied microbiology 20090601

• Effects of mixed herbal extracts from parched Puerariae radix, gingered Magnoliae cortex, Glycyrrhizae radix and Euphorbiae radix (KIOM-79) on cardiac ion channels and action potentials.

  Journal of Korean medical science 20090601

• Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-kappaB induced oxidative stress and inflammation.

  European journal of pharmacology 20090521

• Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells.

  Cancer letters 20090518

• Different redox states in malignant and nonmalignant esophageal epithelial cells and differential cytotoxic responses to bile acid and honokiol.

  Antioxidants & redox signaling 20090501

• Honokiol, a multifunctional antiangiogenic and antitumor agent.

  Antioxidants & redox signaling 20090501

• [Micronization of magnolia bark extract by RESS as well as dissolution and pharmacokinetics evaluation].

  Yao xue xue bao = Acta pharmaceutica Sinica 20090501

• Neolignans from North American Magnolia species with cyclooxygenase 2 inhibitory activity.

  Inflammopharmacology 20090401

• Honokiol reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element binding protein-1c and the expression of its downstream lipogenesis genes.

  Toxicology and applied pharmacology 20090401

• Magnolia officinalis reverses alcoholic fatty liver by inhibiting the maturation of sterol regulatory element-binding protein-1c.

  Journal of pharmacological sciences 20090401

• Preparation of honokiol-loaded chitosan microparticles via spray-drying method intended for pulmonary delivery.

  Drug delivery 20090401

• Self-assembled honokiol-loaded micelles based on poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) copolymer.

  International journal of pharmaceutics 20090318

• Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.

  Analytica chimica acta 20090202

• Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness.

  Nature chemical biology 20090201

• Simultaneous determination of 18alpha- and 18beta-glycyrrhetic acid in human plasma by LC-ESI-MS and its application to pharmacokinetics.

  Biomedical chromatography : BMC 20090101

• Phenolic constituents from the stem bark of Magnolia officinalis.

  Journal of natural products 20090101

• Combined xanthorrhizol-curcumin exhibits synergistic growth inhibitory activity via apoptosis induction in human breast cancer cells MDA-MB-231.

  Cancer cell international 20090101

• In vitro drug release behavior from a novel thermosensitive composite hydrogel based on Pluronic f127 and poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) copolymer.

  BMC biotechnology 20090101

• [Simultaneous determination of seven effective component in Houpuwenzhong capsules using high performance liquid chromatography].

  Se pu = Chinese journal of chromatography 20090101

• Honokiol-mediated inhibition of PI3K/mTOR pathway: a potential strategy to overcome immunoresistance in glioma, breast, and prostate carcinoma without impacting T cell function.

  Journal of immunotherapy (Hagerstown, Md. : 1997) 20090101

• Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain.

  Journal of biomedical science 20090101

• Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity.

  Experimental & molecular medicine 20081231

• Simultaneous determination of 12 chemical constituents in the traditional Chinese Medicinal Prescription Xiao-Yao-San-Jia-Wei by HPLC coupled with photodiode array detection.

  Journal of pharmaceutical and biomedical analysis 20081215

• Involvement of p38 mitogen-activated protein kinase pathway in honokiol-induced apoptosis in a human hepatoma cell line (hepG2).

  Liver international : official journal of the International Association for the Study of the Liver 20081201

• Mechanisms underlying the honokiol inhibition of evoked glutamate release from glutamatergic nerve terminals of the rat cerebral cortex.

  Synapse (New York, N.Y.) 20081201

• LC-MS/MS method for the determination of cynandione A in rat plasma and tissues.

  Biomedical chromatography : BMC 20081001

• Obovatol inhibits colorectal cancer growth by inhibiting tumor cell proliferation and inducing apoptosis.

  Bioorganic & medicinal chemistry 20080915

• Anti-tumor effect of honokiol alone and in combination with other anti-cancer agents in breast cancer.

  European journal of pharmacology 20080904

• Liposomal honokiol, a promising agent for treatment of cisplatin-resistant human ovarian cancer.

  Journal of cancer research and clinical oncology 20080901

• Honokiol, a natural therapeutic candidate, induces apoptosis and inhibits angiogenesis of ovarian tumor cells.

  European journal of obstetrics, gynecology, and reproductive biology 20080901

• Honokiol is a potent scavenger of superoxide and peroxyl radicals.

  Biochemical pharmacology 20080901

• [Effects of storage time on magnolol and honokiol contents in bark of Magnolia officinalis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• Synergistic antitumor effects of liposomal honokiol combined with adriamycin in breast cancer models.

  Phytotherapy research : PTR 20080801

• Rapid simultaneous quantification of five active constituents in rat plasma by high-performance liquid chromatography/tandem mass spectrometry after oral administration of Da-Cheng-Qi decoction.

  Journal of pharmaceutical and biomedical analysis 20080715

• A novel injectable local hydrophobic drug delivery system: Biodegradable nanoparticles in thermo-sensitive hydrogel.

  International journal of pharmaceutics 20080709

• Preparation and characterization of honokiol nanoparticles.

  Journal of materials science. Materials in medicine 20080701

• Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080701

• The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.

  Molecular cancer therapeutics 20080701

• [Effects of honokiol on proliferation and apoptosis of human cervical carcinoma cell line Hela in vitro].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080701

• Inhibition of NADPH oxidase-related oxidative stress-triggered signaling by honokiol suppresses high glucose-induced human endothelial cell apoptosis.

  Free radical biology & medicine 20080615

• Differential proteomic analysis of HeLa cells treated with Honokiol using a quantitative proteomic strategy.

  Amino acids 20080601

• Enhanced effects of xanthohumol plus honokiol on apoptosis in 3T3-L1 adipocytes.

  Obesity (Silver Spring, Md.) 20080601

• Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents.

  Progress in neuro-psychopharmacology & biological psychiatry 20080401

• Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-kappaB.

  European journal of pharmacology 20080317

• Shb gene knockdown increases the susceptibility of SVR endothelial tumor cells to apoptotic stimuli in vitro and in vivo.

  The Journal of investigative dermatology 20080301

• Chlorogenic acid and its metabolite m-coumaric acid evoke neurite outgrowth in hippocampal neuronal cells.

  Bioscience, biotechnology, and biochemistry 20080301

• Magnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileum.

  Planta medica 20080301

• Honokiol, a constituent of oriental medicinal herb magnolia officinalis, inhibits growth of PC-3 xenografts in vivo in association with apoptosis induction.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080215

• [Phenols in seedling cortex of Magnolia officinalis from Enshi].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080201

• [Pharmacokinetics of honokiol in rat after oral administration of Cortex of Magnolia officinalis and its compound preparation Houpu Sanwu Decoction].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080201

• Preparative purification of anti-tumor derivatives of honokiol by high-speed counter-current chromatography.

  Journal of chromatography. A 20080118

• Enhancement of therapeutic effectiveness by combining liposomal honokiol with cisplatin in ovarian carcinoma.

  International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20080101

• Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.

  Acta pharmacologica Sinica 20080101

• Effect of a proprietary Magnolia and Phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial.

  Nutrition journal 20080101

• Simultaneous determination of eight major bioactive compounds in Dachengqi Tang (DT) by high-performance liquid chromatography.

  Chinese medicine 20080101

• JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin.

  Journal of inflammation (London, England) 20080101

• Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model.

  BMC cancer 20080101

• Antimicrobial and antioxidant activities of Cortex Magnoliae Officinalis and some other medicinal plants commonly used in South-East Asia.

  Chinese medicine 20080101

• Evaluation of the in vitro and in vivo genotoxicity of magnolia bark extract.

  Regulatory toxicology and pharmacology : RTP 20071201

• Compressed mints and chewing gum containing magnolia bark extract are effective against bacteria responsible for oral malodor.

  Journal of agricultural and food chemistry 20071114

• Magnolol and honokiol: inhibitors against mouse passive cutaneous anaphylaxis reaction and scratching behaviors.

  Biological & pharmaceutical bulletin 20071101

• Protective action of honokiol, administered orally, against oxidative stress in brain of mice challenged with NMDA.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20071001

• Cytotoxic lignans from the stem bark of Magnolia officinalis.

  Journal of natural products 20071001

• Honokiol causes G0-G1 phase cell cycle arrest in human prostate cancer cells in association with suppression of retinoblastoma protein level/phosphorylation and inhibition of E2F1 transcriptional activity.

  Molecular cancer therapeutics 20071001

• Effects of honokiol and magnolol on acute and inflammatory pain models in mice.

  Life sciences 20070908

• Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.

  Journal of medicinal chemistry 20070823

• Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol.

  Bioorganic & medicinal chemistry letters 20070815

• Honokiol, a neuroprotectant against mouse cerebral ischaemia, mediated by preserving Na+, K+-ATPase activity and mitochondrial functions.

  Basic & clinical pharmacology & toxicology 20070801

• Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis.

  Journal of immunology (Baltimore, Md. : 1950) 20070715

• Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615

• Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.

  International journal of oncology 20070601

• [Effects of the active compounds of M. officinalis on cariogenic bacteria].

  Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070601

• Honokiol induces a necrotic cell death through the mitochondrial permeability transition pore.

  Cancer research 20070515

• Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells.

  Cancer 20070401

• Rapid purification and scale-up of honokiol and magnolol using high-capacity high-speed counter-current chromatography.

  Journal of chromatography. A 20070223

• Analysis of magnolol and honokiol in biological fluids by capillary zone electrophoresis.

  Journal of chromatography. A 20070223

• Honokiol up-regulates prostacyclin synthease protein expression and inhibits endothelial cell apoptosis.

  European journal of pharmacology 20070105

• Antiproliferative and pro-apoptotic activity of eugenol-related biphenyls on malignant melanoma cells.

  Molecular cancer 20070101

• Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line.

  BMC neuroscience 20070101

• Liquid chromatographic determination of honokiol and magnolol in hou po (Magnolia officinalis) as the raw herb and dried aqueous extract.

  Journal of AOAC International 20070101

• Honokiol induces calpain-mediated glucose-regulated protein-94 cleavage and apoptosis in human gastric cancer cells and reduces tumor growth.

  PloS one 20070101

• [Investigate into of effective constituent transference of herba Ephedrae and cortex Magnoliae officinalis in preparation course of Shujin Kechuan capsule].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201

• Down-regulation of P-glycoprotein expression in MDR breast cancer cell MCF-7/ADR by honokiol.

  Cancer letters 20061118

• Determination of liquiritin, naringin, hesperidin, thymol, imperatorin, honokiol, isoimperatorin, and magnolol in the traditional Chinese medicinal preparation Huoxiang-zhengqi liquid using high-performance liquid chromatography.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20061101

• Honokiol causes the p21WAF1-mediated G(1)-phase arrest of the cell cycle through inducing p38 mitogen activated protein kinase in vascular smooth muscle cells.

  FEBS letters 20061002

• Simultaneous determination of honokiol and magnolol in Magnolia officinalis by liquid chromatography with tandem mass spectrometric detection.

  Biomedical chromatography : BMC 20061001

• [Evaluation of antioxidant activity of Radix Linderae and other two Chinese drugs using TLC-bioautography].

  Yao xue xue bao = Acta pharmaceutica Sinica 20061001

• [Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061001

• Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway.

  Molecular cancer research : MCR 20060901

• Honokiol, a small molecular weight natural product, alleviates experimental mesangial proliferative glomerulonephritis.

  Kidney international 20060801

• Carbon nanotube/poly(methyl methacrylate) composite electrode for capillary electrophoretic measurement of honokiol and magnolol in Cortex Magnoliae Officinalis.

  Electrophoresis 20060801

• Neuropharmacological effects of an ethanol extract of the Magnolia dealbata Zucc. leaves in mice.

  Journal of ethnopharmacology 20060630

• Determination of honokiol and magnolol in cortex Magnoliae Officinalis by capillary electrophoresis with electrochemical detection.

  Journal of pharmaceutical and biomedical analysis 20060616

• Facile purification of honokiol and its antiviral and cytotoxic properties.

  Journal of medicinal chemistry 20060601

• Honokiol reduces oxidative stress, c-jun-NH2-terminal kinase phosphorylation and protects against glycochenodeoxycholic acid-induced apoptosis in primary cultured rat hepatocytes.

  Planta medica 20060601

• Protective effects of honokiol against oxidized LDL-induced cytotoxicity and adhesion molecule expression in endothelial cells.

  Chemico-biological interactions 20060515

• Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage.

  European journal of pharmacology 20060510

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Separation and determination of honokiol and magnolol in herbal medicines by flow injection-capillary electrophoresis.

  Analytical and bioanalytical chemistry 20060401

• A comparative study of upright counter-current chromatography and high-performance liquid chromatograpohy for preparative isolation and purification ofphenolic compounds from Magnoliae officinalis.

  Journal of separation science 20060201

• Natural health products that inhibit angiogenesis: a potential source for investigational new agents to treat cancer-Part 1.

  Current oncology (Toronto, Ont.) 20060201

• Ethnoveterinary medicines used for horses in Trinidad and in British Columbia, Canada.

  Journal of ethnobiology and ethnomedicine 20060101

• Honokiol inhibits TNF-alpha-stimulated NF-kappaB activation and NF-kappaB-regulated gene expression through suppression of IKK activation.

  Biochemical pharmacology 20051115

• Honokiol protects against carbon tetrachloride induced liver damage in the rat.

  Phytotherapy research : PTR 20051101

• Prokinetic effect of a Kampo medicine, Hange-koboku-to (Banxia-houpo-tang), on patients with functional dyspepsia.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20051101

• Honokiol overcomes conventional drug resistance in human multiple myeloma by induction of caspase-dependent and -independent apoptosis.

  Blood 20050901

• Differential inhibitory effects of honokiol and magnolol on excitatory amino acid-evoked cation signals and NMDA-induced seizures.

  Neuropharmacology 20050901

• Honokiol inhibits arterial thrombosis through endothelial cell protection and stimulation of prostacyclin.

  Acta pharmacologica Sinica 20050901

• Anxiolytic agent, dihydrohonokiol-B, recovers amyloid beta protein-induced neurotoxicity in cultured rat hippocampal neurons.

  Neuroscience letters 20050801

• Effects of magnolol and honokiol derived from traditional Chinese herbal remedies on gastrointestinal movement.

  World journal of gastroenterology 20050728

• The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells.

  Blood 20050715

• [Studies on HPLC chromatogram of phenolic constituents of Cortex Magnoliae Officinalis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050701

• Honokiol-induced neurite outgrowth promotion depends on activation of extracellular signal-regulated kinases (ERK1/2).

  European journal of pharmacology 20050601

• Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of the downstream pathway of MEKK-1 in NF-kappaB activation signaling.

  Planta medica 20050401

• Determination of honokiol and magnolol by micro HPLC with electrochemical detection and its application to the distribution analysis in branches and leaves of Magnolia obovata.

  Chemical & pharmaceutical bulletin 20050301

• Magnolol and honokiol enhance HL-60 human leukemia cell differentiation induced by 1,25-dihydroxyvitamin D3 and retinoic acid.

  The international journal of biochemistry & cell biology 20050201

• Cytotoxic neolignans: an SAR study.

  Bioorganic & medicinal chemistry letters 20050103

• Honokiol induces apoptosis via cytochrome c release and caspase activation in activated rat hepatic stellate cells in vitro.

  Planta medica 20050101

• Anti-arrhythmic effects of herbal medicine.

  Indian heart journal 20050101

• Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cells.

  BMC cancer 20050101

• Honokiol: a potent chemotherapy candidate for human colorectal carcinoma.

  World journal of gastroenterology 20041201

• In vitro antibacterial and anti-inflammatory effects of honokiol and magnolol against Propionibacterium sp.

  European journal of pharmacology 20040802

• Honokiol induces apoptosis through p53-independent pathway in human colorectal cell line RKO.

  World journal of gastroenterology 20040801

• Isolation and purification of honokiol and magnolol from cortex Magnoliae officinalis by high-speed counter-current chromatography.

  Journal of chromatography. A 20040521

• Efficient synthesis and structure-activity relationship of honokiol, a neurotrophic biphenyl-type neolignan.

  Bioorganic & medicinal chemistry letters 20040517

• Inhibition of MAO A and B by some plant-derived alkaloids, phenols and anthraquinones.

  Journal of ethnopharmacology 20040401

• Antimicrobial and cytotoxic activities of neolignans from Magnolia officinalis.

  Chemistry & biodiversity 20040301

• [Pharmacokinetics of honokiol in rats].

  Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20040201

• Effects of Magnolol and Honokiol on the activities of streptococcal glucosyltransferases both in solution and adsorbed on an experimental pellicle.

  Letters in applied microbiology 20040101

• Honokiol protects rat brain from focal cerebral ischemia-reperfusion injury by inhibiting neutrophil infiltration and reactive oxygen species production.

  Brain research 20031205

• The mechanism of honokiol-induced and magnolol-induced inhibition on muscle contraction and Ca2+ mobilization in rat uterus.

  Naunyn-Schmiedeberg's archives of pharmacology 20031001

• Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo.

  The Journal of biological chemistry 20030912

• The anti-inflammatory effect of honokiol on neutrophils: mechanisms in the inhibition of reactive oxygen species production.

  European journal of pharmacology 20030815

• Honokiol and magnolol induce Ca2+ mobilization in rat cortical neurons and human neuroblastoma SH-SY5Y cells.

  European journal of pharmacology 20030808

• Inhibition of smooth muscle contraction by magnolol and honokiol in porcine trachea.

  Planta medica 20030601

• Honokiol ameliorates cerebral infarction from ischemia-reperfusion injury in rats.

  Planta medica 20030201

• High-performance liquid chromatographic method for simultaneous determination of honokiol and magnolol in rat plasma.

  Talanta 20030102

• Protective effects of honokiol and magnolol on tertiary butyl hydroperoxide- or D-galactosamine-induced toxicity in rat primary hepatocytes.

  Planta medica 20030101

• [Study on HPLC-FPS of cortex magnoliae officinalis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020901

• Anti-platelet effect of the constituents isolated from the barks and fruits of Magnolia obovata.

  Archives of pharmacal research 20020601

• Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells.

  Biochemical pharmacology 20020501

• Neurotrophic activity of honokiol on the cultures of fetal rat cortical neurons.

  Bioorganic & medicinal chemistry letters 20020422

• [Quality evaluation and utilization of germplasm resources of Magnolia officinalis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020201

• Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080. Invasiveness in vitro.

  Planta medica 20011101

• Effects of the extract of the bark of Magnolia obovata and its biphenolic constituents magnolol and honokiol on histamine release from peritoneal mast cells in rats.

  Planta medica 20011101

• An anxiolytic agent, dihydrohonokiol-B, inhibits ammonia-induced increases in the intracellular Cl(-) of cultured rat hippocampal neurons via GABA(c) receptors.

  Neuroscience letters 20011019

• Honokiol and magnolol selectively interact with GABAA receptor subtypes in vitro.

  Pharmacology 20010701

• Effects of constituents from the bark of Magnolia obovata on nitric oxide production in lipopolysaccharide-activated macrophages.

  Chemical & pharmaceutical bulletin 20010601

• Antimicrobial activity of honokiol and magnolol isolated from Magnolia officinalis.

  Phytotherapy research : PTR 20010301

• Antifungal activity of magnolol and honokiol.

  Archives of pharmacal research 20000201

• Myocardial protective effect of honokiol: an active component in Magnolia officinalis.

  Planta medica 19961201