35404-50-3 | Cyclocreatine

Packsize	Purity	Availability	Price	Discounted Price
500mg	95%	in stock	$63.00	$45.00
1g	95%	in stock	$99.00	$70.00
5g	95%	in stock	$376.00	$263.00
10g	95%	in stock	$733.00	$513.00
25g	95%	in stock	$1,505.00	$1,054.00

Description

• Catalog Number: AB49279
• Chemical Name: Cyclocreatine
• CAS Number: 35404-50-3
• Molecular Formula: C5H9N3O2
• Molecular Weight: 143.1439
• MDL Number: MFCD00134455
• SMILES: NC1=NCCN1CC(=O)O
• NSC Number: 707961

Computed Properties

• Complexity: 178
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: -1.6

Literature

• Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency.

  The Journal of clinical investigation 20120801

• Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice.

  PloS one 20110101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Creatine kinase-mediated ATP supply fuels actin-based events in phagocytosis.

  PLoS biology 20080301

• Combinatorial approaches towards the discovery of new tryptase inhibitors.

  Bioorganic & medicinal chemistry letters 20050315

• Elevated creatine kinase activity in primary hepatocellular carcinoma.

  BMC gastroenterology 20050101

• Effects of creatine and cyclocreatine supplementation on kainate induced injury in pre-pubescent rats.

  Brain injury 20041201

• Isoleucine 69 and valine 325 form a specificity pocket in human muscle creatine kinase.

  Biochemistry 20041102

• Inhibition of the mitochondrial permeability transition by creatine kinase substrates. Requirement for microcompartmentation.

  The Journal of biological chemistry 20030516

• Hodgkin disease-derived cell lines expressing ubiquitous mitochondrial creatine kinase show growth inhibition by cyclocreatine treatment independent of apoptosis.

  International journal of cancer 20011101

• Mutagenesis of two acidic active site residues in human muscle creatine kinase: implications for the catalytic mechanism.

  Biochemistry 20010313

• Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits the replication of human herpes viruses.

  Antiviral research 19940401