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The associations of stroke, transient ischemic attack, and/or stroke-related recurrent vascular events with Lipoprotein-associated phospholipase A2: A systematic review and meta-analysis.
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Darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in diabetic macular edema: a 3-month placebo-controlled study.
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Effect of darapladib on major coronary events after an acute coronary syndrome: the SOLID-TIMI 52 randomized clinical trial.
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Darapladib for preventing ischemic events in stable coronary heart disease.
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Darapladib effect on circulating high sensitive troponin in patients with acute coronary syndromes.
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Relationship between cardiovascular risk factors and biomarkers with necrotic core and atheroma size: a serial intravascular ultrasound radiofrequency data analysis.
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Utility of Lp-PLA2 in lipid-lowering therapy.
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Lysophosphatidylcholine: A Novel Modulator of Trypanosoma cruzi Transmission.
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Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins.
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Therapeutic modulation of lipoprotein-associated phospholipase A2 (Lp-PLA2).
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The inhibition of lipoprotein-associated phospholipase A2 exerts beneficial effects against atherosclerosis in LDLR-deficient mice.
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Study design and rationale for the Stabilization of pLaques usIng Darapladib-Thrombolysis in Myocardial Infarction (SOLID-TIMI 52) trial in patients after an acute coronary syndrome.
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Lipoprotein-associated phospholipase A2: how effective as a risk marker of cardiovascular disease and as a therapeutic target?
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Peripheral artery disease, biomarkers, and darapladib.
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The role of lipoprotein-associated phospholipase a₂ as a marker and potential therapeutic target in atherosclerosis.
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IVUS-based imaging modalities for tissue characterization: similarities and differences.
The international journal of cardiovascular imaging 20110201
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Ultrasound and light: friend or foe? On the role of intravascular ultrasound in the era of optical coherence tomography.
The international journal of cardiovascular imaging 20110201
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Assessment of coronary atherosclerosis by IVUS and IVUS-based imaging modalities: progression and regression studies, tissue composition and beyond.
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Study design and rationale of 'Synergistic effect of combination therapy with cilostazol and ProbUcol on plaque stabilization and lesion REgression (SECURE)' study: a double-blind randomised controlled multicenter clinical trial.
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Focus on the research utility of intravascular ultrasound - comparison with other invasive modalities.
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Animal models of cardiovascular diseases.
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Carriage of the V279F null allele within the gene encoding Lp-PLA₂ is protective from coronary artery disease in South Korean males.
PloS one 20110101
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The vulnerable plaque: the real villain in acute coronary syndromes.
The open cardiovascular medicine journal 20110101
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Racial variation in lipoprotein-associated phospholipase A₂ in older adults.
BMC cardiovascular disorders 20110101
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Inhibition of lipoprotein-associated phospholipase A2 ameliorates inflammation and decreases atherosclerotic plaque formation in ApoE-deficient mice.
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Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A₂ (Lp-PLA₂): a review.
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Phospholipase A2 inhibition and atherosclerotic vascular disease: prospects for targeting secretory and lipoprotein-associated phospholipase A2 enzymes.
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Phospholipase A2s: developing drug targets for atherosclerosis.
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Study design and rationale for the clinical outcomes of the STABILITY Trial (STabilization of Atherosclerotic plaque By Initiation of darapLadIb TherapY) comparing darapladib versus placebo in patients with coronary heart disease.
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Darapladib: an emerging therapy for atherosclerosis.
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Editorial: why inhibition of lipoprotein-associated phospholipase A2 has the potential to improve patient outcomes.
Current opinion in cardiology 20100701
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Extracellular phospholipases in atherosclerosis.
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Impact of analyzing less image frames per segment for radiofrequency-based volumetric intravascular ultrasound measurements in mild-to-moderate coronary atherosclerosis.
The international journal of cardiovascular imaging 20100601
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Lipoprotein-associated phospholipase A2 activity and incident coronary heart disease among men and women with type 2 diabetes.
Diabetes 20100501
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Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies.
Lancet (London, England) 20100501
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A new method to measure necrotic core and calcium content in coronary plaques using intravascular ultrasound radiofrequency-based analysis.
The international journal of cardiovascular imaging 20100401
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Lipoprotein-associated phospholipase A2: role in atherosclerosis and utility as a cardiovascular biomarker.
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Lipoprotein-associated phospholipase A2: a new therapeutic target.
The Canadian journal of cardiology 20100301
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Lp-PLA2: A new target for statin therapy.
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Association of carotid plaque Lp-PLA(2) with macrophages and Chlamydia pneumoniae infection among patients at risk for stroke.
PloS one 20100101
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Impact of medical therapy on atheroma volume measured by different cardiovascular imaging modalities.
Cardiology research and practice 20100101
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Lipoprotein-associated phospholipase A(2) and atherosclerosis.
Current opinion in lipidology 20091001
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Phospholipase A2 inhibitors in the treatment of atherosclerosis: a new approach moves forward in the clinic.
Expert opinion on investigational drugs 20091001
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Darapladib, a reversible lipoprotein-associated phospholipase A2 inhibitor, for the oral treatment of atherosclerosis and coronary artery disease.
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Darapladib and atherosclerotic plaque: should lipoprotein-associated phospholipase A2 be a therapeutic target?
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Phospholipase A2 inhibitors.
Current opinion in lipidology 20090801
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Update on patented cholesterol absorption inhibitors.
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Lipoprotein-associated phospholipase A2 as a biomarker of coronary heart disease and a therapeutic target.
Current opinion in cardiology 20090701
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Low and high density lipoprotein--cholesterol and coronary atherothrombosis.
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Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development.
Nature medicine 20081001
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Effects of the direct lipoprotein-associated phospholipase A(2) inhibitor darapladib on human coronary atherosclerotic plaque.
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Inhibition of lipoprotein-associated phospholipase activity by darapladib: shifting gears in cardiovascular drug development: are antiinflammatory drugs the next frontier?
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The effect of darapladib on plasma lipoprotein-associated phospholipase A2 activity and cardiovascular biomarkers in patients with stable coronary heart disease or coronary heart disease risk equivalent: the results of a multicenter, randomized, double-blind, placebo-controlled study.
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Gateways to clinical trials. July-August 2008.
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Gateways to clinical trials.
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The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.
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Anti-inflammatory properties of a platelet-activating factor acetylhydrolase.
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