3621-36-1 | Columbamine

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$38.00	$27.00
5mg	95%	in stock	$102.00	$71.00
10mg	95%	in stock	$131.00	$92.00
25mg	95%	in stock	$169.00	$119.00
50mg	95%	in stock	$287.00	$201.00
100mg	95%	in stock	$489.00	$342.00
250mg	95%	in stock	$926.00	$648.00

Description

• Catalog Number: AF68124
• Chemical Name: Columbamine
• CAS Number: 3621-36-1
• Molecular Formula: C20H20NO4
• Molecular Weight: 338.3771
• MDL Number: MFCD01546522
• SMILES: COc1cc2CC[n+]3c(-c2cc1O)cc1c(c3)c(OC)c(cc1)OC

Computed Properties

• Complexity: 461
• Covalently-Bonded Unit Count: 1
• Formal Charge: 1
• Heavy Atom Count: 25
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: 3.4

Literature

• Columbamine suppresses the proliferation and neovascularization of metastatic osteosarcoma U2OS cells with low cytotoxicity.

  Toxicology letters 20121217

• Quality evaluation and species differentiation of Rhizoma coptidis by using proton nuclear magnetic resonance spectroscopy.

  Analytica chimica acta 20121017

• Coptis chinensis inflorescence extract protection against ultraviolet-B-induced phototoxicity, and HPLC-MS analysis of its chemical composition.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120701

• Metabolic discrimination of rhizoma coptidis from different species using 1H NMR spectroscopy and principal component analysis.

  Planta medica 20120401

• Cytotoxicity and antihyperglycemic effect of minor constituents from Rhizoma Coptis in HepG2 cells.

  Fitoterapia 20120101

• Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• [Chemical constituents from Corydalis yanhusuo].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

• [Dynamic accumulation of effective components and biomass of Coptis chinensis in Hongya county].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110801

• Metabolites of protoberberine alkaloids in human urine following oral administration of Coptidis Rhizoma decoction.

  Planta medica 20101101

• [Simultaneous determination of six alkaloids in Coptis chinensis of different regions by RP-HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101001

• Anti-inflammatory and anti-nociceptive activities of compounds from Tinospora sagittata (Oliv.) Gagnep.

  Archives of pharmacal research 20100701

• Alkaloids from Fissistigma latifolium (Dunal) Merr.

  Molecules (Basel, Switzerland) 20100624

• Metabolic diversification of benzylisoquinoline alkaloid biosynthesis through the introduction of a branch pathway in Eschscholzia californica.

  Plant & cell physiology 20100601

• Quaternary alkaloids of Argemone mexicana.

  Pharmaceutical biology 20100201

• Dig1 protects against cell death provoked by glyphosate-based herbicides in human liver cell lines.

  Journal of occupational medicine and toxicology (London, England) 20100101

• [A new flavonoid glucoside from Huanglianjiedutang decoction].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090501

• Inhibitory Effects of Coptidis rhizoma and Berberine on Cocaine-induced Sensitization.

  Evidence-based complementary and alternative medicine : eCAM 20090301

• Significant differences in alkaloid content of Coptis chinensis (Huanglian), from its related American species.

  Chinese medicine 20090101

• [Studies on chemical constituents in the anti-myocardial ischemia effective fraction of Corydalis yanhusuo].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20081101

• Isoquinoline alkaloids isolated from Corydalis yanhusuo and their binding affinities at the dopamine D1 receptor.

  Molecules (Basel, Switzerland) 20080925

• [Analysis of the main components of coptis-evodia herb couple by HPLC-DAD-MS].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080301

• Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria.

  Journal of natural products 20071201

• High performance liquid chromatography-mass spectrometry analysis of protoberberine alkaloids in medicine herbs.

  Journal of separation science 20070401

• Simultaneous determination of eight components in Radix Tinosporae by high-performance liquid chromatography coupled with diode array detector and electrospray tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20070219

• Free radical scavenging activity and lipoxygenase inhibition of Mahonia aquifolium extract and isoquinoline alkaloids.

  Journal of inflammation (London, England) 20070101

• Characterization of isoquinoline alkaloids, diterpenoids and steroids in the Chinese herb Jin-Guo-Lan (Tinospora sagittata and Tinospora capillipes) by high-performance liquid chromatography/electrospray ionization with multistage mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20060101

• Separation of protoberberine quaternary alkaloids from a crude extract of Enantia chlorantha by centrifugal partition chromatography.

  Journal of chromatography. A 20040702

• A comparative study on the anti-inflammatory, antinociceptive and antipyretic effects of isoquinoline alkaloids from the roots of Turkish Berberis species.

  Life sciences 20021227

• Molecular cloning of columbamine O-methyltransferase from cultured Coptis japonica cells.

  European journal of biochemistry 20021101

• Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

  Journal of natural products 19910101